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Longer titles found: Non-competitive inhibition (view), Uncompetitive inhibition (view)

searching for Competitive inhibition 79 found (152 total)

Semzuvolimab (338 words) [view diff] exact match in snippet view article find links to article

attachment to the host T cell and entry into the host immune cell via a competitive inhibition mechanism. The antibody is unlikely to promote resistance to itself

Chlorzoxazone (507 words) [view diff] exact match in snippet view article find links to article

chlorzoxazone may reduce the liver toxicity of acetaminophen by competitive inhibition. It is available as a generic medication. Like metaxalone, its mechanism

Histrionicotoxins (1,413 words) [view diff] exact match in snippet view article find links to article

frogs, yet their distinct structure acts as a neurotoxin by non-competitive inhibition of nicotinic acetylcholine receptors. The first record of histrionicotoxins

Leonor Michaelis (1,510 words) [view diff] exact match in snippet view article find links to article

non-competitive. In competitive inhibition the apparent value of K m {\displaystyle K_{\mathrm {m} }} is increased, and in non-competitive inhibition the apparent

BOMT (1,220 words) [view diff] exact match in snippet view article find links to article

possess weak antigonadotropic effects. Due to its selectivity for and competitive inhibition of the AR, BOMT has been described as a pure or "true" antiandrogen

Receptor theory (2,007 words) [view diff] no match in snippet view article find links to article

Receptor theory is the application of receptor models to explain drug behavior. Pharmacological receptor models preceded accurate knowledge of receptors

Essential fatty acid interactions (2,975 words) [view diff] exact match in snippet view article find links to article

inflammatory effects of AA's eicosanoids in three ways: displacement, competitive inhibition, and direct counteraction. Dietary ω-3 decreases tissue concentrations

Thromboregulation (1,047 words) [view diff] exact match in snippet view article find links to article

mechanisms in how a primary clot is regulated. These mechanisms include, competitive inhibition or negative feedback. It includes primary hemostasis, which is the

H-89 (545 words) [view diff] exact match in snippet view article find links to article

potent at inhibiting protein kinase G. It achieves this through competitive inhibition of the adenosine triphosphate (ATP) site on the PKA catalytic subunit

Michaelis–Menten kinetics (6,227 words) [view diff] exact match in snippet view article find links to article

{iu} }} the resulting special case is pure non-competitive inhibition. Pure non-competitive inhibition is very rare, being mainly confined to effects

Quinazoline (1,247 words) [view diff] exact match in snippet view article find links to article

domains inhibits signal mechanism activation (through reversible, competitive inhibition). In May 2013, erlotinib, a drug manufactured by Astellas, was approved

Direct thrombin inhibitor (821 words) [view diff] exact match in snippet view article find links to article

allosteric inhibition of thrombin for fibrinogen, while providing a competitive inhibition of thrombin interaction with platelet glycoprotein Ibα (GPIbα),

8-Phenyltheophylline (285 words) [view diff] exact match in snippet view article find links to article

"Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline". Xenobiotica; the Fate of Foreign Compounds

Orotidine 5'-phosphate decarboxylase (1,182 words) [view diff] exact match in snippet view article find links to article

studies investigating kinetic isotope effects in conjunction with competitive inhibition and active site mutagenesis. In this mechanism the short-lived carbanion

Bithionol (662 words) [view diff] exact match in snippet view article find links to article

binding site of soluble adenylyl cyclase efficiently enough to cause competitive inhibition with the usual bicarbonate substrate. The side chain of arginine

Morpheus (Marvel Comics) (433 words) [view diff] exact match in snippet view article

York City. He had an unprecedented viral infection that caused competitive inhibition of certain segments in his DNA in the process of replication. He

Rift Valley fever (3,058 words) [view diff] exact match in snippet view article find links to article

mechanism is believed to be due to several reasons, the first being, competitive inhibition of the formation of the transcription factor. On this transcription

MKNK1 (1,031 words) [view diff] exact match in snippet view article find links to article

PMID 14702039. Cuesta R, Xi Q, Schneider RJ (2004). "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein"

Xanthine oxidase (1,932 words) [view diff] exact match in snippet view article find links to article

reduce this protein is through XO's superoxide anion byproduct, with competitive inhibition by carbonic anhydrase. Another reaction catalyzed by xanthine oxidase

Anesthetic (2,208 words) [view diff] exact match in snippet view article find links to article

agents, which prevent acetylcholine receptor activation through competitive inhibition. Depolarizing muscle relaxants Succinylcholine (also known as suxamethonium

TBC domain (1,127 words) [view diff] exact match in snippet view article find links to article

catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2". The Journal of

Reuptake (1,897 words) [view diff] exact match in snippet view article find links to article

inhibitor can have drastic effects on cognition and behavior. Non-competitive inhibition of the bacterial homologue LeuT by tricyclic antidepressants resulted

LR-5182 (455 words) [view diff] exact match in snippet view article find links to article

PMID 460546. S2CID 38863316. Wong DT, Bymaster FP, Reid LR (June 1980). "Competitive inhibition of catecholamine uptake in synaptosomes of rat brain by rigid bicyclo-octanes"

2,2,2-Trifluoroethanol (626 words) [view diff] exact match in snippet view article find links to article

Syntheses. 80: 184. doi:10.15227/orgsyn.080.0184. Taber RL (1998). "The competitive inhibition of yeast alcohol dehydrogenase by 2,2,2-trifluoroethanol". Biochemical

Daniel E. Koshland Jr. (1,727 words) [view diff] case mismatch in snippet view article find links to article

Retrieved August 3, 2017. Thoma, John A.; Koshland, D. E. (1960). "Competitive Inhibition by Substrate during Enzyme Action. Evidence for the Induced-fit

Malcolm Dixon (biochemist) (869 words) [view diff] exact match in snippet view article

Malcolm; Kleppe, Kjell (1965). "D-amino acid oxidase II. Specificity, competitive inhibition and reaction sequence". Biochimica et Biophysica Acta (BBA) - Nucleic

11-Hydroxy-Δ-8-THC (392 words) [view diff] exact match in snippet view article find links to article

Kamei A, Yoshida H, Watanabe K, Ho IK, Yoshimura H (April 1998). "Competitive inhibition of delta8-tetrahydrocannabinol and its active metabolites for cannabinoid

DAHP synthase (1,722 words) [view diff] exact match in snippet view article find links to article

DAHP synthase, while the enzyme is inhibited by tyrosine through competitive inhibition with respect to D-erythrose 4-phosphate, the second substrate of

Nicholas Franks (1,008 words) [view diff] exact match in snippet view article find links to article

1007/s00424-014-1654-4. PMC 4428837. PMID 25482669. Dickinson, R (2007). "Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor by the

Hok/sok system (1,446 words) [view diff] exact match in snippet view article find links to article

Faridani OR, Nikravesh A, Pandey DP, Gerdes K, Good L (2006). "Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated

Cryptosporidium parvum (1,305 words) [view diff] exact match in snippet view article find links to article

C. parvum sporozoites into MDCK cell monolayers. Additionally, competitive inhibition using native GP900 or purified GP900 fragments reduces cell invasion

Donald Devereux Woods (265 words) [view diff] exact match in snippet view article find links to article

antibacterial action of sulphonamides allowed him to propose the theory of competitive inhibition of essential metabolites by substances of similar constitution which

Sistrurus miliarius barbouri (1,121 words) [view diff] exact match in snippet view article find links to article

platelets, which then leads to the formation of a blood clot – competitive inhibition of this receptor by barbourin will decrease platelet aggregation

ACES (buffer) (262 words) [view diff] exact match in snippet view article

"Anal. Biochem.", 291(1):149-154. Tunnicliff, G., and Smith, J.A., "Competitive inhibition of γ-aminobutyric acid receptor binding by N-2-hydroxyethylpipe

Tomatine (2,070 words) [view diff] exact match in snippet view article find links to article

present. The other known action of the compound is the pH-dependent competitive inhibition of the enzyme acetylcholinesterase. The majority of synthetic pesticides

Lapatinib (1,504 words) [view diff] exact match in snippet view article find links to article

ditosylate is classified as S/NM (a synthetic compound showing competitive inhibition of the natural product) that is naturally derived or inspired substrate

Branched chain amino acid–cation symporter (327 words) [view diff] exact match in snippet view article find links to article

Klein, Jeannette; Schneider, Erwin; Meyer, Thomas F. (2008-03-01). "Competitive inhibition of amino acid uptake suppresses chlamydial growth: involvement of

Adenosine deaminase (3,060 words) [view diff] exact match in snippet view article find links to article

which all face the B-side of the purine ring of the substrate. Competitive inhibition has been observed for ADA, where the product inosine acts at the

8-amino-7-oxononanoate synthase (324 words) [view diff] exact match in snippet view article find links to article

Breyne O, Carillon S, Marquet A (January 1999). "Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent

Hydroxymethylglutaryl-CoA reductase (175 words) [view diff] exact match in snippet view article find links to article

coenzyme A reductase. Fimognari GM, Rodwell VW (1965). "Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase

Drug interaction (2,971 words) [view diff] exact match in snippet view article find links to article

Effects of the competitive inhibition of an agonist by increases in the concentration of an antagonist. A drug's potency can be affected (the response

Receptor (biochemistry) (2,672 words) [view diff] exact match in snippet view article

(September 1954). "Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory". Archives Internationales de Pharmacodynamie

Desmetramadol (1,364 words) [view diff] exact match in snippet view article find links to article

5-HT2C receptor, at pharmacologically relevant concentrations, via competitive inhibition. This suggests that the apparent anti-depressant properties of tramadol

Growth hormone-binding protein (2,742 words) [view diff] exact match in snippet view article find links to article

ultimately proteolytic activity. Another function is that GHBP displays competitive inhibition for GH against the GHR receptor. Studies elucidate another aspect

Secondary metabolite (4,054 words) [view diff] exact match in snippet view article find links to article

mushrooms, red yeast rice, and Pu-erh. Lovastatin's mode of action is competitive inhibition of HMG-CoA reductase, and a rate-limiting enzyme responsible for

Bovine malignant catarrhal fever (2,923 words) [view diff] case mismatch in snippet view article find links to article

Uwe U.; Crawford, Timothy B. (2001). "A Simpler, More Sensitive Competitive Inhibition Enzyme-Linked Immunosorbent Assay for Detection of Antibody to Malignant

Biohydrogen (2,463 words) [view diff] exact match in snippet view article find links to article

photosynthetic hydrogen production by accumulation of a proton gradient. Competitive inhibition of photosynthetic hydrogen production by carbon dioxide. Requirement

Pediococcus acidilactici (957 words) [view diff] exact match in snippet view article find links to article

levels while also reducing the number of oocysts shed by possible competitive inhibition and pediocin production, which inhibit pathogenic bacteria and other

Voclosporin (2,300 words) [view diff] exact match in snippet view article find links to article

linked to nephropathy (nephrotoxicity). There should be little competitive inhibition of the parent drug by its less active metabolite due to the low

Cholinergic blocking drug (2,197 words) [view diff] exact match in snippet view article find links to article

(depolarisation block), i.e. stimulation then block stimulation Competitive inhibition of nicotinic receptor Neuromuscular blockers act at neuromuscular

Plant matrix metalloproteinase (1,632 words) [view diff] exact match in snippet view article find links to article

unwanted proteolysis by denaturing their target proteases through non-competitive inhibition at an allosteric site. Five novel Lupinus albus MPIs were found

Hepatotoxicity (4,135 words) [view diff] exact match in snippet view article find links to article

There is usually a delay before enzyme activity increases. 3. Competitive inhibition: Some drugs may share the same P-450 specificity and thus competitively

5α-Reductase (4,152 words) [view diff] exact match in snippet view article find links to article

5α-reductase, Finasteride works to inhibit 5α-reductase through competitive inhibition which is why the mechanism shows the NADP+ getting attacked by the

Cerebral folate deficiency (1,334 words) [view diff] exact match in snippet view article find links to article

"Transport of folate compounds from the intestine to the brain and competitive inhibition of 5MTHF transport by FA. Conversion of FA to 5MTHF is limited in

NMDA receptor antagonist (4,196 words) [view diff] exact match in snippet view article find links to article

PMID 15634735. Banks P, Franks NP, Dickinson R (March 2010). "Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates

Lysozyme (4,298 words) [view diff] exact match in snippet view article find links to article

complex with some residues (in or outside active center) to achieve a competitive inhibition of lysozyme. In Gram-negative bacteria, the lipopolysaccharide acts

Piperacillin (4,767 words) [view diff] exact match in snippet view article find links to article

uncontrolled dosages of the drug can cause renal dysfunction and competitive inhibition of excretion, delaying piperacillin-tazobactam excretion, and endangering

ME2 (gene) (871 words) [view diff] exact match in snippet view article

S2CID 23469024. Yang Z, Batra R, Floyd DL, et al. (2000). "Potent and competitive inhibition of malic enzymes by lanthanide ions". Biochem. Biophys. Res. Commun

Angiotensin II receptor blocker (5,341 words) [view diff] exact match in snippet view article find links to article

and π-π interactions within the active site of AT1R. Then through competitive inhibition these antihypertensive compounds render the AT1R inactive and therefore

Aripiprazole (9,684 words) [view diff] exact match in snippet view article find links to article

non-dopaminergic receptors, while in amphetamine this is caused by non-competitive inhibition of dopamine reuptake and agonism of intracellular TAAR1. Therefore

Robert K. Crane (2,414 words) [view diff] exact match in snippet view article find links to article

1954, pp. 925–936. Robert K. Crane and Alberto Sols. "The non-competitive inhibition of brain hexokinase by glucose 6-phosphate and related compounds"

CYLD cutaneous syndrome (4,092 words) [view diff] exact match in snippet view article find links to article

C, Slotboom AJ, Gancet C, Verger R, De Haas GH (January 1992). "Competitive inhibition of lipolytic enzymes. V. A monolayer study using enantiomeric acylamino

Bacterial one-hybrid system (1,925 words) [view diff] exact match in snippet view article find links to article

expression (HIS3) at a sufficient level to overcome the resulting competitive inhibition. Finally, positive clones are sequenced and examined with preexisting

Eicosanoid (9,651 words) [view diff] exact match in snippet view article find links to article

concentrations of AA, so there is less to form ω−6 eicosanoids. Competitive inhibition—DGLA and EPA compete with AA for access to the cyclooxygenase and

Xenon (12,196 words) [view diff] exact match in snippet view article find links to article

PMID 27530275. Banks, P.; Franks, N. P.; Dickinson, R. (2010). "Competitive inhibition at the glycine site of the N-methyl-D-aspartate receptor mediates

Convolutional neural network (15,556 words) [view diff] exact match in snippet view article find links to article

not trainable in the original neocognitron. The downsampling and competitive inhibition help to classify features and objects in visual scenes even when

Prymnesin-2 (1,149 words) [view diff] exact match in snippet view article find links to article

the blood cell surface. This is supported by the observation of competitive inhibition by the prymnesin-2 analogues, which assume the presence of a specific

John Postgate (microbiologist) (3,257 words) [view diff] exact match in snippet view article

National Biography doi:10.1093/ref:odnb/51771 Postgate (1949). "Competitive inhibition of sulphate reduction by selenate". Nature. 164 (4172): 670–671

Precoccinelline (616 words) [view diff] case mismatch in snippet view article find links to article

Hong; Braekman, Jean-Claude; Kem, William R. (October 2015). "Non-competitive Inhibition of Nicotinic Acetylcholine Receptors by Ladybird Beetle Alkaloids"

Respiratory complex I (6,680 words) [view diff] exact match in snippet view article find links to article

PMID 18599602. S2CID 1844073. Zharova TV, Vinogradov AD (July 1997). "A competitive inhibition of the mitochondrial NADH-ubiquinone oxidoreductase (complex I)

Lambertella corni-maris (1,050 words) [view diff] exact match in snippet view article find links to article

replacement of Monilinia fructigena with Lambertella corni-maris without competitive inhibition on agar media". Bioorganic & Medicinal Chemistry. 22 (8): 2489–2495

List of benzodiazepines (3,088 words) [view diff] exact match in snippet view article find links to article

benzodiazepines and Z-drugs from binding to the GABAA receptors via competitive inhibition which the flumazenil creates. Clinical observation notating the

Biotic Ligand Model (2,421 words) [view diff] exact match in snippet view article find links to article

surfaces have a determinate interaction capacity per unit weight. Competitive inhibition occurs between the calcium and magnesium and the toxicants which

Triple-stranded DNA (6,098 words) [view diff] exact match in snippet view article find links to article

complex (TFO complex) downregulates the transcription of mRNA through competitive inhibition. Direct inhibition of gene expression from H-DNA is key to mutagenesis

Toxin-antitoxin system (5,971 words) [view diff] exact match in snippet view article find links to article

Faridani OR, Nikravesh A, Pandey DP, Gerdes K, Good L (2006). "Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated

Drug antagonism (3,742 words) [view diff] exact match in snippet view article find links to article

delivery may also lessen the toxin's effects on organs through competitive inhibition, receptor blockage, or direct antagonistic interaction. The therapeutic

Intracellular delivery (8,788 words) [view diff] exact match in snippet view article find links to article

mechanisms including modification of pre-mRNA processing and splicing, competitive inhibition, steric blockade of translational machinery, and degradation of

Magnesium transporter (12,027 words) [view diff] exact match in snippet view article find links to article

protein and this toxicity stems from the blocking of Mg2+ uptake (competitive inhibition) and the accumulation of these ions inside the cell. Co2+ and Ni2+

Early Mitotic Inhibitor 1 (2,167 words) [view diff] exact match in snippet view article find links to article

various inhibitory domains. EMI1 inhibits APC/C activity both by competitive inhibition of substrate binding to APC/C and by inhibiting ubiquitylation.