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searching for Chromosomal translocation 71 found (165 total)

alternate case: chromosomal translocation

Small nucleolar RNA SNORD50 (448 words) [view diff] exact match in snippet view article find links to article

snoRNA gene located on chromosome 6q15, at the breakpoint of chromosomal translocation t(3;6)(q27;q15). The U50HG gene is composed of six exons, whose
LMO1 (1,248 words) [view diff] exact match in snippet view article find links to article
transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more
Paracaspase (672 words) [view diff] exact match in snippet view article find links to article
Paracaspase has been first identified in a recurrent t(11;18)(q21;q21) chromosomal translocation associated with a subset of MALT lymphoma. This leads to a fusion
Aggressive angiomyxoma (679 words) [view diff] exact match in snippet view article find links to article
Sornberger, K; Tallini, G; Morton, C. C.; Quade, B. J. (2001). "Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma
Emanuel syndrome (755 words) [view diff] exact match in snippet view article find links to article
It can occur in offspring of carriers of the constitutional chromosomal translocation t(11;22)(q23;q11), owing to a 3:1 meiotic malsegregation event
NCKIPSD (978 words) [view diff] exact match in snippet view article find links to article
formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid
Extraskeletal myxoid chondrosarcoma (1,233 words) [view diff] exact match in snippet view article find links to article
differs from other sarcomas by unique histology and characteristic chromosomal translocation. There is an uncertain differentiation (there is no evidence yet
ERG (gene) (2,303 words) [view diff] exact match in snippet view article
domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation
TLX1 (1,073 words) [view diff] exact match in snippet view article find links to article
lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11
Terence Rabbitts (569 words) [view diff] exact match in snippet view article find links to article
the late Michael Neuberger). He discovered the LMO and HOX11 chromosomal translocation families in T cell leukaemia and the first fusion gene in a solid
C12orf42 (958 words) [view diff] exact match in snippet view article find links to article
the finding of a chromosomal translocation t(12;14)(q23;q11.2) in  T-lymphoblastic lymphoma (T-LBL). The chromosomal translocation occurs during T-receptor
Cleft lip and palate transmembrane protein 1 (661 words) [view diff] exact match in snippet view article find links to article
1999). "Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate". Genomics
Iduronate-2-sulfatase (953 words) [view diff] exact match in snippet view article find links to article
(Nov 1983). "Hunter's disease in a girl: association with X:5 chromosomal translocation disrupting the Hunter gene". Archives of Disease in Childhood
Clear cell sarcoma (609 words) [view diff] exact match in snippet view article find links to article
cutaneous conditions Hyalinizing clear cell carcinoma - has the same chromosomal translocation Barry, G; Nielsen, T (June 2012). "Clear Cell Sarcoma of Soft
PAX3 (4,303 words) [view diff] exact match in snippet view article find links to article
and is usually characterized by a recurrent t(2;13)(q35;q14) chromosomal translocation. This 2;13 translocation breaks and rejoins portions of the PAX3
RhoH (1,024 words) [view diff] exact match in snippet view article find links to article
protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation". Oncogene. 10 (11): 2171–8. PMID 7784061. Dallery-Prudhomme E
BRCC3 (813 words) [view diff] exact match in snippet view article find links to article
Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (Dec 1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within
ID4 (3,026 words) [view diff] exact match in snippet view article find links to article
JF (September 2003). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia". Haematologica
LYL1 (632 words) [view diff] exact match in snippet view article find links to article
Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix
ID4 (3,026 words) [view diff] exact match in snippet view article find links to article
JF (September 2003). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia". Haematologica
Cyclin D1 (5,768 words) [view diff] exact match in snippet view article find links to article
amplification of the CCND1 gene / overexpression of cyclin D1; chromosomal translocation of the CCND1 gene; mutations in the degradation motif recognized
SHFM3P1 (360 words) [view diff] exact match in snippet view article find links to article
gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation". Genomics. 27 (1): 67–82. doi:10.1006/geno.1995.1008. PMID 7665185
HOXA11 (845 words) [view diff] exact match in snippet view article find links to article
NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood. 99 (4): 1428–33. doi:10.1182/blood.V99
BCR (gene) (1,461 words) [view diff] exact match in snippet view article
Schematic of the BCR-ABL formation through chromosomal translocation
SS18L1 (643 words) [view diff] exact match in snippet view article find links to article
joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene
RNA-binding protein FUS (3,838 words) [view diff] exact match in snippet view article find links to article
domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation
LHX4 (546 words) [view diff] exact match in snippet view article find links to article
Kawamata N, Sakajiri S, Sugimoto KJ, et al. (2002). "A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves
NUP98 (1,495 words) [view diff] exact match in snippet view article find links to article
Ahuja HG, Felix CA, Aplan PD (1999). "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results
SMARCD2 (596 words) [view diff] exact match in snippet view article find links to article
chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23
Pritzker School of Medicine (953 words) [view diff] exact match in snippet view article find links to article
American human geneticist and the first scientist to identify a chromosomal translocation as the cause of leukemia and other cancers. Richard Kekuni Blaisdell
Immunoglobulin class switching (1,416 words) [view diff] exact match in snippet view article find links to article
10 to 20% of cases, depending upon the Ig class) as an inter-chromosomal translocation mixing immunoglobulin heavy chain genes from both alleles. T cell
HOXA13 (1,024 words) [view diff] exact match in snippet view article find links to article
NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood. 99 (4): 1428–33. doi:10.1182/blood.V99
PAX5 (1,410 words) [view diff] exact match in snippet view article find links to article
Chaganti RS, Dalla-Favera R (Dec 1996). "The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5
DEK (gene) (1,016 words) [view diff] exact match in snippet view article
Grosveld G, Markovitz DM (1997). "DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer". Proc
PBX1 (1,468 words) [view diff] exact match in snippet view article find links to article
Wilkinson J, Stanbridge E, Smith SD, Cleary ML (Feb 1990). "Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes
ARID1B (1,435 words) [view diff] case mismatch in snippet view article find links to article
Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23
Cyclin D (4,579 words) [view diff] exact match in snippet view article find links to article
Src, Ras, ErbB2, STAT3, STAT5, impaired protein degradation, or chromosomal translocation. Gene amplification is responsible for overproduction of cyclin
ARID1A (1,591 words) [view diff] exact match in snippet view article find links to article
chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10
RUNX1T1 (1,724 words) [view diff] exact match in snippet view article find links to article
nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7521–7526. doi:10.1073/pnas
Myeloid sarcoma (1,916 words) [view diff] exact match in snippet view article find links to article
variation of acute myelogenous leukemia associated with 8;21 chromosomal translocation and blast expression of the neural cell adhesion molecule". Cancer
Nuclear receptor 4A3 (1,321 words) [view diff] exact match in snippet view article find links to article
(May 1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator"
Exosome component 2 (1,039 words) [view diff] exact match in snippet view article find links to article
gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation". Genomics. 27 (1): 67–82. doi:10.1006/geno.1995.1008. PMID 7665185
PSAT1 (868 words) [view diff] exact match in snippet view article find links to article
Hashimoto K, Muir WJ, Blackwood DH, Sawa A (2011). "A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality
FLI1 (1,994 words) [view diff] exact match in snippet view article find links to article
chromosomal abnormalities in humans. In pediatric Ewing’s sarcoma a chromosomal translocation generates a fusion of the 5’ transactivation domain of EWSR1 (also
Microhomology-mediated end joining (1,299 words) [view diff] exact match in snippet view article find links to article
suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation". Nature Structural & Molecular Biology. 17 (4): 410–6
ILF3 (1,988 words) [view diff] exact match in snippet view article find links to article
Vij R, Tomasson MH (August 2012). "Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress". The
HAP1 cells (908 words) [view diff] exact match in snippet view article find links to article
except for chromosomes 8 and 15. It also possesses a reciprocal chromosomal translocation of Chromosomes 9 and 22 which created a Philadelphia chromosome
MTCP1 (1,090 words) [view diff] exact match in snippet view article find links to article
Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within
Bromodomain-containing protein 3 (1,228 words) [view diff] exact match in snippet view article find links to article
aggregates. BRD2 and BRD3 perform overlapping cellular functions. Chromosomal translocation of BRD3 with the NUT gene has been implicated in NUT midline carcinoma
SMARCD1 (994 words) [view diff] exact match in snippet view article find links to article
chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23
NOV (gene) (1,784 words) [view diff] exact match in snippet view article
activity of BCR-ABL, a chimeric protein generated through the chromosomal translocation between chromosome 9 and 22. Forced expression of NOV inhibits
LDB1 (1,068 words) [view diff] exact match in snippet view article find links to article
LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene. 17 (24): 3199–202. doi:10.1038/sj
SMARCC1 (1,342 words) [view diff] case mismatch in snippet view article find links to article
Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23
STIL (1,031 words) [view diff] exact match in snippet view article find links to article
"Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints". J. Biol. Chem. 276 (31): 29126–33. doi:10.1074/jbc
Ceritinib (1,202 words) [view diff] exact match in snippet view article find links to article
the development and function of nervous system tissue. However, chromosomal translocation and fusion give rise to an oncogenic form of ALK that has been
SMARCC2 (1,348 words) [view diff] case mismatch in snippet view article find links to article
Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23
B-cell prolymphocytic leukemia (2,383 words) [view diff] exact match in snippet view article find links to article
Fernandez JA, Caceres W (May 2007). "Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia"
FOXO4 (2,773 words) [view diff] exact match in snippet view article find links to article
– FOXO4 has been shown to interact with PIN1 and Mdm2. CIC – chromosomal translocation resulting in a fusion CIC-FOXO4 protein is observed in some tumors
POU2AF1 (1,460 words) [view diff] exact match in snippet view article find links to article
"Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation". Comptes Rendus de l'Académie des Sciences, Série III. 318 (11):
SWI/SNF (2,555 words) [view diff] exact match in snippet view article find links to article
chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10
KIAA0825 (1,741 words) [view diff] exact match in snippet view article find links to article
Vij R, Tomasson MH (August 2012). "Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress". The
MALT1 (2,634 words) [view diff] exact match in snippet view article find links to article
"Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy
ZFPM2 (1,760 words) [view diff] exact match in snippet view article find links to article
"Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis". Clin
ETV6 (4,615 words) [view diff] exact match in snippet view article find links to article
ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation". Cell. 77 (2): 307–16. doi:10.1016/0092-8674(94)90322-0. PMID 8168137
Hsp90 (5,412 words) [view diff] exact match in snippet view article find links to article
(November 2008). "Hsp90n - An accidental product of a fortuitous chromosomal translocation rather than a regular Hsp90 family member of human proteome".
C8orf48 (1,564 words) [view diff] exact match in snippet view article find links to article
regulator of ventral neuroectodermal progenitor cell fate and chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic
Indolent lymphoma (3,008 words) [view diff] exact match in snippet view article find links to article
center B cells. About 85% of the cases show t(14;18)(q32;q21) chromosomal translocation, which causes the overexpression of the anti-apoptotic protein
MECOM (4,856 words) [view diff] exact match in snippet view article find links to article
megakaryocytes. The chimeric gene of AML1-MDS1-EVI1 (AME) formed by the chromosomal translocation (3;21)(q26;q22) has also been shown in vitro to upregulate the
Gene desert (3,440 words) [view diff] exact match in snippet view article find links to article
regularly. The study postulates that the 8q region, which underwent a chromosomal translocation in humans, could have moved an essential enhancer for the MYC
DNA repair protein XRCC4 (5,687 words) [view diff] exact match in snippet view article find links to article
B-cell lymphomas, and these lymphomas often had a "reciprocal chromosomal translocation" fusing IgH to Myc (and also had "large chromosomal deletions
Indolent T cell lymphoproliferative disorder of the gastrointestinal tract (3,054 words) [view diff] exact match in snippet view article find links to article
T-cell lymphoma of low-grade malignancy associated with a new chromosomal translocation". Cancer. 73 (4): 1286–91. doi:10.1002/1097-0142(19940215)73: