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searching for Chromosomal translocation 72 found (179 total)

alternate case: chromosomal translocation

Small nucleolar RNA SNORD50 (451 words) [view diff] exact match in snippet view article find links to article

snoRNA gene located on chromosome 6q15, at the breakpoint of chromosomal translocation t(3;6)(q27;q15). The U50HG gene is composed of six exons, whose

LMO1 (1,258 words) [view diff] exact match in snippet view article find links to article

transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more

Emanuel syndrome (816 words) [view diff] exact match in snippet view article find links to article

It can occur in offspring of carriers of the constitutional chromosomal translocation t(11;22)(q23;q11), owing to a 3:1 meiotic malsegregation event

Paracaspase (704 words) [view diff] exact match in snippet view article find links to article

Paracaspase has been first identified in a recurrent t(11;18)(q21;q21) chromosomal translocation associated with a subset of MALT lymphoma. This leads to a fusion

NCKIPSD (986 words) [view diff] exact match in snippet view article find links to article

formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid

ERG (gene) (2,303 words) [view diff] exact match in snippet view article

domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation

TLX1 (1,104 words) [view diff] exact match in snippet view article find links to article

lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)". Blood. 78 (11): 2996–3003. doi:10.1182/blood.V78.11

Terence Rabbitts (675 words) [view diff] exact match in snippet view article find links to article

the late Michael Neuberger). He discovered the LMO and HOX11 chromosomal translocation oncogene families in T cell leukaemia and the first fusion gene

C12orf42 (979 words) [view diff] exact match in snippet view article find links to article

the finding of a chromosomal translocation t(12;14)(q23;q11.2) in T-lymphoblastic lymphoma (T-LBL). The chromosomal translocation occurs during T-receptor

FET protein family (2,705 words) [view diff] exact match in snippet view article find links to article

inversion. For example, the EWSR1-FL1 fusion gene is made by a chromosomal translocation which merges part of the EWSR1 gene normally located on band 12

PAX3 (4,308 words) [view diff] exact match in snippet view article find links to article

and is usually characterized by a recurrent t(2;13)(q35;q14) chromosomal translocation. This 2;13 translocation breaks and rejoins portions of the PAX3

Aggressive angiomyxoma (631 words) [view diff] exact match in snippet view article find links to article

Sornberger, K; Tallini, G; Morton, C. C.; Quade, B. J. (2001). "Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma

Iduronate-2-sulfatase (1,051 words) [view diff] exact match in snippet view article find links to article

(Nov 1983). "Hunter's disease in a girl: association with X:5 chromosomal translocation disrupting the Hunter gene". Archives of Disease in Childhood

RhoH (1,032 words) [view diff] exact match in snippet view article find links to article

protein, fuses to the lymphoma-associated LAZ3 gene by t(3;4) chromosomal translocation". Oncogene. 10 (11): 2171–8. PMID 7784061. Dallery-Prudhomme E

Cleft lip and palate transmembrane protein 1 (790 words) [view diff] exact match in snippet view article find links to article

1998). "Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate". Genomics

ID4 (3,045 words) [view diff] exact match in snippet view article find links to article

JF (September 2003). "Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia". Haematologica

Clear cell sarcoma (721 words) [view diff] exact match in snippet view article find links to article

cutaneous conditions Hyalinizing clear cell carcinoma - has the same chromosomal translocation Barry, G; Nielsen, T (June 2012). "Clear Cell Sarcoma of Soft

Cyclin D1 (5,694 words) [view diff] exact match in snippet view article find links to article

amplification of the CCND1 gene / overexpression of cyclin D1; chromosomal translocation of the CCND1 gene; mutations in the degradation motif recognized

SHFM3P1 (368 words) [view diff] exact match in snippet view article find links to article

gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation". Genomics. 27 (1): 67–82. doi:10.1006/geno.1995.1008. PMID 7665185

LYL1 (633 words) [view diff] exact match in snippet view article find links to article

Smith SD, Cleary ML (July 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix

BRCC3 (968 words) [view diff] exact match in snippet view article find links to article

Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (Dec 1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within

MLLT1 (655 words) [view diff] exact match in snippet view article find links to article

chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–52. doi:10

RNA-binding protein FUS (3,968 words) [view diff] exact match in snippet view article find links to article

domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation

HOXA11 (863 words) [view diff] exact match in snippet view article find links to article

NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood. 99 (4): 1428–33. doi:10.1182/blood.V99

Pritzker School of Medicine (1,093 words) [view diff] exact match in snippet view article find links to article

American human geneticist and the first scientist to identify a chromosomal translocation as the cause of leukemia and other cancers. Arthur K. Shapiro

Immunoglobulin class switching (1,530 words) [view diff] exact match in snippet view article find links to article

10 to 20% of cases, depending upon the Ig class) as an inter-chromosomal translocation mixing immunoglobulin heavy chain genes from both alleles. T cell

PSAT1 (546 words) [view diff] exact match in snippet view article find links to article

Hashimoto K, Muir WJ, Blackwood DH, Sawa A (2011). "A novel balanced chromosomal translocation found in subjects with schizophrenia and schizotypal personality

BCR (gene) (1,541 words) [view diff] exact match in snippet view article

Schematic of the BCR-ABL formation through chromosomal translocation

NUP98 (1,515 words) [view diff] exact match in snippet view article find links to article

Ahuja HG, Felix CA, Aplan PD (1999). "The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results

HOXA13 (972 words) [view diff] exact match in snippet view article find links to article

NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood. 99 (4): 1428–1433. doi:10.1182/blood

SS18L1 (643 words) [view diff] exact match in snippet view article find links to article

joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene

LHX4 (549 words) [view diff] exact match in snippet view article find links to article

Kawamata N, Sakajiri S, Sugimoto KJ, et al. (2002). "A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves

SMARCD2 (599 words) [view diff] exact match in snippet view article find links to article

chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23

ARID1B (1,445 words) [view diff] case mismatch in snippet view article find links to article

Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23

Cyclin D (4,605 words) [view diff] exact match in snippet view article find links to article

Src, Ras, ErbB2, STAT3, STAT5, impaired protein degradation, or chromosomal translocation. Gene amplification is responsible for overproduction of cyclin

Myeloid sarcoma (1,927 words) [view diff] exact match in snippet view article find links to article

variation of acute myelogenous leukemia associated with 8;21 chromosomal translocation and blast expression of the neural cell adhesion molecule". Cancer

RUNX1T1 (1,732 words) [view diff] exact match in snippet view article find links to article

nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation". Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7521–7526. Bibcode:2000PNAS

DEK (gene) (1,036 words) [view diff] exact match in snippet view article

Grosveld G, Markovitz DM (1997). "DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer". Proc

PAX5 (1,433 words) [view diff] exact match in snippet view article find links to article

Chaganti RS, Dalla-Favera R (Dec 1996). "The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5

PBX1 (1,803 words) [view diff] exact match in snippet view article find links to article

Wilkinson J, Stanbridge E, Smith SD, et al. (February 1990). "Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes

ARID1A (1,805 words) [view diff] exact match in snippet view article find links to article

chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–2952. doi:10

Nuclear receptor 4A3 (1,326 words) [view diff] exact match in snippet view article find links to article

(May 1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator"

ILF3 (1,995 words) [view diff] exact match in snippet view article find links to article

Vij R, Tomasson MH (August 2012). "Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress". The

HAP1 cells (919 words) [view diff] exact match in snippet view article find links to article

except for chromosomes 8 and 15. It also possesses a reciprocal chromosomal translocation of Chromosomes 9 and 22 which created a Philadelphia chromosome

MTCP1 (1,126 words) [view diff] exact match in snippet view article find links to article

Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within

Exosome component 2 (1,045 words) [view diff] exact match in snippet view article find links to article

gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation". Genomics. 27 (1): 67–82. doi:10.1006/geno.1995.1008. PMID 7665185

SMARCC1 (1,285 words) [view diff] case mismatch in snippet view article find links to article

Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23

Raji cell (535 words) [view diff] exact match in snippet view article find links to article

"Synthesis of kappa light chains by cell lines containing an 8;22 chromosomal translocation derived from a male homosexual with Burkitt's lymphoma". Science

LDB1 (1,074 words) [view diff] exact match in snippet view article find links to article

LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene. 17 (24): 3199–202. doi:10.1038/sj

SMARCD1 (970 words) [view diff] exact match in snippet view article find links to article

chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23

Microhomology-mediated end joining (1,373 words) [view diff] exact match in snippet view article find links to article

suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation". Nature Structural & Molecular Biology. 17 (4): 410–416

Ceritinib (1,264 words) [view diff] exact match in snippet view article find links to article

the development and function of nervous system tissue. However, chromosomal translocation and fusion give rise to an oncogenic form of ALK that has been

SMARCC2 (1,312 words) [view diff] case mismatch in snippet view article find links to article

Chromatin-Remodeling Complexes Contain a Mixed-Lineage Leukemia Chromosomal Translocation Partner". Mol. Cell. Biol. 23 (8): 2942–52. doi:10.1128/MCB.23

Bromodomain-containing protein 3 (1,230 words) [view diff] exact match in snippet view article find links to article

aggregates. BRD2 and BRD3 perform overlapping cellular functions. Chromosomal translocation of BRD3 with the NUT gene has been implicated in NUT midline carcinoma

NOV (gene) (1,878 words) [view diff] exact match in snippet view article

activity of BCR-ABL, a chimeric protein generated through the chromosomal translocation between chromosome 9 and 22. Forced expression of NOV inhibits

B-cell prolymphocytic leukemia (2,500 words) [view diff] exact match in snippet view article find links to article

Fernandez JA, Caceres W (May 2007). "Complex karyotype including chromosomal translocation (8;14) (q24;q32) in one case with B-cell prolymphocytic leukemia"

FOXO4 (2,764 words) [view diff] exact match in snippet view article find links to article

– FOXO4 has been shown to interact with PIN1 and Mdm2. CIC – chromosomal translocation resulting in a fusion CIC-FOXO4 protein is observed in some tumors

POU2AF1 (1,485 words) [view diff] exact match in snippet view article find links to article

"Fusion of the LAZ3/BCL6 and BOB1/OBF1 genes by t(3; 11) (q27; q23) chromosomal translocation". Comptes Rendus de l'Académie des Sciences, Série III. 318 (11):

MALT1 (2,753 words) [view diff] exact match in snippet view article find links to article

"Mucosa-associated lymphoid tissue (MALT) lymphoma of the rectum with chromosomal translocation of the t(11;18)(q21;q21) and an additional aberration of trisomy

ZFPM2 (1,776 words) [view diff] exact match in snippet view article find links to article

"Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis". Clin

KIAA0825 (1,749 words) [view diff] exact match in snippet view article find links to article

Vij R, Tomasson MH (August 2012). "Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress". The

SWI/SNF (3,947 words) [view diff] exact match in snippet view article find links to article

chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–2952. doi:10

LL-100 panel (4,749 words) [view diff] exact match in snippet view article find links to article

(March 1991). "A new non-Hodgkin's B-cell line (DoHH2) with a chromosomal translocation t(14;18)(q32;q21)". Leukemia. 5 (3): 221–4. PMID 1849602. Chang

ETV6 (4,620 words) [view diff] exact match in snippet view article find links to article

ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation". Cell. 77 (2): 307–16. doi:10.1016/0092-8674(94)90322-0. PMID 8168137

STIL (2,251 words) [view diff] exact match in snippet view article find links to article

"Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints". J. Biol. Chem. 276 (31): 29126–33. doi:10.1074/jbc

Hsp90 (5,551 words) [view diff] exact match in snippet view article find links to article

(November 2008). "Hsp90n - An accidental product of a fortuitous chromosomal translocation rather than a regular Hsp90 family member of human proteome".

C8orf48 (1,583 words) [view diff] exact match in snippet view article find links to article

regulator of ventral neuroectodermal progenitor cell fate and chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic

Gene desert (3,459 words) [view diff] exact match in snippet view article find links to article

regularly. The study postulates that the 8q region, which underwent a chromosomal translocation in humans, could have moved an essential enhancer for the MYC

MECOM (4,864 words) [view diff] exact match in snippet view article find links to article

megakaryocytes. The chimeric gene of AML1-MDS1-EVI1 (AME) formed by the chromosomal translocation (3;21)(q26;q22) has also been shown in vitro to upregulate the

DNA repair protein XRCC4 (5,681 words) [view diff] exact match in snippet view article find links to article

B-cell lymphomas, and these lymphomas often had a "reciprocal chromosomal translocation" fusing IgH to Myc (and also had "large chromosomal deletions

Indolent T cell lymphoproliferative disorder of the gastrointestinal tract (3,069 words) [view diff] exact match in snippet view article find links to article

T-cell lymphoma of low-grade malignancy associated with a new chromosomal translocation". Cancer. 73 (4): 1286–91. doi:10.1002/1097-0142(19940215)73:

Sclerosing epithelioid fibrosarcoma (2,718 words) [view diff] exact match in snippet view article find links to article

EWSR1-CREB3L1 fusion gene expressed by SEF neoplastic cells is made by a chromosomal translocation which unites part of the EWSR1 gene normally located on band 12