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Longer titles found: Programmed cell death (view), Programmed cell death protein 1 (view), Ischemic cell death (view), Immunogenic cell death (view), Activation-induced cell death (view), Cell Death & Differentiation (view), Identification of cell death (view)

searching for Cell death 276 found (3365 total)

alternate case: cell death

Reoviridae (1,841 words) [view diff] exact match in snippet view article find links to article

movement, cell to cell movement, and existing in occlusion bodies after cell death and remaining infectious until finding another host. Multiplicity reactivation
Reactive oxygen species (8,477 words) [view diff] exact match in snippet view article find links to article
is present in mitochondria, a cell undergoes apoptosis or programmed cell death. In addition, ROS are produced in immune cell signaling via the NOX pathway
Neurotoxicity (2,052 words) [view diff] exact match in snippet view article find links to article
neurotoxicity and death (apoptosis). Some of the symptoms that result from cell death include loss of motor control, cognitive deterioration and autonomic nervous
Autoschizis (789 words) [view diff] exact match in snippet view article find links to article
split". It was introduced in 1998 to describe a novel form of cancer cell death characterized by a reduction in cell size that occurs due to the loss
Bcl-2 (4,655 words) [view diff] exact match in snippet view article find links to article
founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inhibiting (anti-apoptotic) or inducing (pro-apoptotic)
Necroptosis (1,568 words) [view diff] exact match in snippet view article find links to article
form of necrosis, or inflammatory cell death. Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration
H. Robert Horvitz (1,925 words) [view diff] exact match in snippet view article find links to article
concerning the genetic regulation of organ development and programmed cell death" were "important for medical research and have shed new light on the pathogenesis
GPR65 (1,705 words) [view diff] exact match in snippet view article find links to article
this gene was found to be associated with T-cell death (apoptosis), it was named TDAG8, or T Cell Death Associated Gene 8. Proton-sensing G protein-coupled
Granzyme (1,786 words) [view diff] exact match in snippet view article find links to article
cytotoxic T cells and natural killer (NK) cells. They induce programmed cell death (apoptosis) in the target cell, thus eliminating cells that have become
Protein serine/threonine phosphatase (215 words) [view diff] exact match in snippet view article find links to article
regulates many cellular pathways involved in cell proliferation, programmed cell death (apoptosis), embryonic development, and cell differentiation. There are
Suicide gene (1,435 words) [view diff] exact match in snippet view article find links to article
relatively civil. Many cells undergo programmed cell death, or apoptosis, during fetal development. A form of cell death in which a programmed sequence of events
Cytochrome c (3,645 words) [view diff] exact match in snippet view article find links to article
Wang to have an intermediate role in apoptosis, a controlled form of cell death used to kill cells in the process of development or in response to infection
Inhibitor of apoptosis (1,521 words) [view diff] exact match in snippet view article find links to article
proteins that mainly act on the intrinsic pathway that block programmed cell death, which can frequently lead to cancer or other effects for the cell if
P2 receptor (308 words) [view diff] exact match in snippet view article find links to article
Nucleotides if get released into the extracellular environment can lead to cell death or some other harmful cellular consequences. To avoid harm nucleotides
MXD3 (304 words) [view diff] exact match in snippet view article find links to article
to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels. GRCh38: Ensembl release 89:
ASK1 (2,212 words) [view diff] exact match in snippet view article find links to article
signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death". The Journal of Biological Chemistry. 280 (44): 37033–40. doi:10.1074/jbc
Bcl-2-associated X protein (2,112 words) [view diff] exact match in snippet view article find links to article
heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death". Cell. 74 (4): 609–19. doi:10.1016/0092-8674(93)90509-O. PMID 8358790
Thymidylate synthase inhibitor (375 words) [view diff] exact match in snippet view article find links to article
deoxythymidine monophosphate (dTMP). The downstream effect is promotion of cell death because cells would not be able to properly undergo DNA synthesis if they
IKK2 (2,043 words) [view diff] no match in snippet view article find links to article
(12): 1322–9. doi:10.1038/nm1323. PMID 16286924. S2CID 28490303. "Stroke 'cell-death trigger' found". BBC News. 14 November 2005. Retrieved June 28, 2007.
Oxidopamine (294 words) [view diff] exact match in snippet view article find links to article
proteins via cysteine modification, implying an additional cause of neuronal cell death. Oxidopamine toxicity in neonatal rodents is also used as an animal model
Denaturation (biochemistry) (3,127 words) [view diff] exact match in snippet view article
disruption of cell activity and possibly cell death. Protein denaturation is also a consequence of cell death. Denatured proteins can exhibit a wide range
DNA polymerase V (1,099 words) [view diff] exact match in snippet view article find links to article
is not repaired or bypassed the replication fork can stall and lead to cell death. However, Y polymerases have low sequence fidelity during replication
XIAP (2,618 words) [view diff] exact match in snippet view article find links to article
repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene
NFKB1 (2,718 words) [view diff] case mismatch in snippet view article find links to article
PMID 16305395. Courtois G, Smahi A (2006). "NF-kappaB-related genetic diseases". Cell Death Differ. 13 (5): 843–51. doi:10.1038/sj.cdd.4401841. PMID 16397577. Mattson
Perforin (1,324 words) [view diff] no match in snippet view article find links to article
Perforin-1 is a protein that in humans is encoded by the PRF1 gene and the Prf1 gene in mice. Perforin is a pore forming cytolytic protein found in the
CP 55,940 (457 words) [view diff] exact match in snippet view article find links to article
release and reducing hippocampal cell death in cultured neurons subjected to high levels of NMDA. CP 55,940 induced cell death in NG 108-15 Mouse neuroblastoma
KLF9 (1,163 words) [view diff] exact match in snippet view article find links to article
cell to oxidative stress and ROS-related cell death. Klf9 is upregulated by ROS and promotes ROS-related cell death. Klf9 exhibits similarities to other known
VDAC2 (2,629 words) [view diff] exact match in snippet view article find links to article
important role in the mitochondrial cell death pathway transduction hereby regulating apoptotic signaling and cell death. The VDAC2 protein has been linked
Inflammasome (5,942 words) [view diff] exact match in snippet view article find links to article
resulting from this cleavage induces a pro-inflammatory form of programmed cell death distinct from apoptosis, referred to as pyroptosis, and is responsible
Apert syndrome (2,457 words) [view diff] exact match in snippet view article find links to article
called selective cell death, or apoptosis, causing separation of the digits. In the case of acrocephalosyndactyly, selective cell death does not occur and
Bleb (cell biology) (1,781 words) [view diff] exact match in snippet view article
intercellular matrix. Most commonly, blebs are seen in apoptosis (programmed cell death) but are also seen in other non-apoptotic functions. Blebbing, or zeiosis
Prion (9,236 words) [view diff] exact match in snippet view article find links to article
accumulate in infected tissue and are associated with tissue damage and cell death. Amyloids are also responsible for several other neurodegenerative diseases
Egg cell (1,440 words) [view diff] exact match in snippet view article find links to article
organelles to the oocytes. This transfer is followed by the programmed cell death (apoptosis) of the nurse cells. During oogenesis, 15 nurse cells die for
Parkinson's disease (16,791 words) [view diff] exact match in snippet view article find links to article
region of the midbrain, leading to a dopamine deficit. The cause of this cell death is poorly understood, but involves the build-up of misfolded proteins
Kaitocephalin (976 words) [view diff] exact match in snippet view article find links to article
protects neurons by inhibiting excitotoxicity, a mechanism which causes cell death by overloading neurons with glutamate. Because of this, it is of interest
Death-inducing signaling complex (992 words) [view diff] exact match in snippet view article find links to article
the DISC assembles, it allows APO-1 signaling to occur, which triggers cell death. In order to do this, downstream targets such as FLICE must be activated
Bcl-2 family (2,011 words) [view diff] exact match in snippet view article find links to article
most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion. The Bcl-2 family proteins consists of members that
14-3-3 protein (1,162 words) [view diff] no match in snippet view article find links to article
14-3-3 proteins are a family of conserved regulatory molecules that are expressed in all eukaryotic cells. 14-3-3 proteins have the ability to bind a multitude
Polyamine (1,366 words) [view diff] exact match in snippet view article find links to article
In addition, they are directly involved in regulation of programmed cell death. Polyamines promote homologous recombination (HR)-mediated double-strand
Neuroprotection (3,658 words) [view diff] exact match in snippet view article find links to article
disorders. Not only can oxidative stress and excitotoxicity trigger neuron cell death but when combined they have synergistic effects that cause even more degradation
CARD domain (1,440 words) [view diff] no match in snippet view article find links to article
Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically
Staphylococcus aureus alpha toxin (802 words) [view diff] exact match in snippet view article find links to article
function, development of pores in the cellular membrane, eventually causing cell death. Alpha-toxin has been shown to play a role in pathogenesis of disease
Durvalumab (1,227 words) [view diff] exact match in snippet view article find links to article
(IgG1κ) monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 (CD279). Durvalumab is known as a checkpoint
Spindle poison (677 words) [view diff] exact match in snippet view article find links to article
microtubules, resulting in the G2/M arrest within the cell cycle and eventually cell death. In contrast, the taxanes arrest the mitotic cell cycle by stabilizing
ADP/ATP translocase 2 (1,932 words) [view diff] exact match in snippet view article find links to article
mitochondrial death pathway and cardiac myocyte apoptosis signaling. Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans.
FADD (4,183 words) [view diff] exact match in snippet view article find links to article
essential for autophagic cell death, which is induced by IFN-γ. In contrast, it has also been found to inhibit autophagic cell death and therefore promote
Polyene antimycotic (455 words) [view diff] exact match in snippet view article find links to article
causing leakage of K+ and Na+ ions, which could contribute to fungal cell death. However, more detailed studies of polyene molecular properties have challenged
Bavituximab (680 words) [view diff] exact match in snippet view article find links to article
or dies, and when cells are infected with hepatitis C. The process of cell death is highly controlled and so there usually no immune response to phosphatidylserine
VDAC3 (2,533 words) [view diff] exact match in snippet view article find links to article
important role in the mitochondrial cell death pathway transduction hereby regulating apoptotic signaling and cell death. As VDAC3 is a regulator of sperm
Maddika Subba Reddy (786 words) [view diff] case mismatch in snippet view article find links to article
Subba Reddy is an Indian cell biologist and the head of the Laboratory of Cell Death and Cell Survival (LCDCS) of the Centre for DNA Fingerprinting and Diagnostics
VDAC1 (4,089 words) [view diff] exact match in snippet view article find links to article
mitochondrion and the cell mediating the balance between cell metabolism and cell death. Besides metabolic permeation, VDAC1 also acts as a scaffold for proteins
Oncogene (2,122 words) [view diff] exact match in snippet view article find links to article
high levels. Most normal cells will undergo programmed form of rapid cell death (apoptosis) when critical functions are altered and malfunctioning. Activated
Epirubicin (411 words) [view diff] exact match in snippet view article find links to article
DNA cleavage by topoisomerase II, resulting in mechanisms that lead to cell death. Binding to cell membranes and plasma proteins may be involved in the
Caenorhabditis elegans (9,060 words) [view diff] exact match in snippet view article find links to article
contributed to the elucidation of some apoptotic genes. Cell death-promoting genes and a single cell-death inhibitor have been identified. RNA interference (RNAi)
Cryoablation (2,458 words) [view diff] exact match in snippet view article find links to article
tissue in turn causing ischemia and cell death; and induction of apoptosis, the so-called programmed cell death cascade. The most common application
Hydantoin (719 words) [view diff] no match in snippet view article find links to article
Hydantoin, or glycolylurea, is a heterocyclic organic compound with the formula CH2C(O)NHC(O)NH. It is a colorless solid that arises from the reaction
Reversine (300 words) [view diff] exact match in snippet view article find links to article
cell dedifferentiation. It also has the potential to induce selectively cell death of cancer cells. Reversine is known to act as an antagonist of the adenosine
Apoptosis-inducing factor (1,120 words) [view diff] exact match in snippet view article find links to article
condensation and DNA fragmentation in a cell in order to induce programmed cell death. The mitochondrial AIF protein was found to be a caspase-independent death
Calliphora vomitoria (3,215 words) [view diff] exact match in snippet view article find links to article
tremendous amount of change for the fly, such as cell death. While it is commonly believed that programmed cell death and apoptosis are the same, they are not
Bcl-xL (918 words) [view diff] exact match in snippet view article find links to article
cytochrome c, which leads to caspase activation and ultimately, programmed cell death. It is a well-established concept in the field of apoptosis that relative
Solasonine (255 words) [view diff] exact match in snippet view article find links to article
loss of membrane integrity which puts the cell at risk for apoptosis (cell death) due to the ability of any chemical coming into contact with the cell
Eliprodil (269 words) [view diff] exact match in snippet view article find links to article
concentration. High Ca2+ causes fatal metabolic consequences, including neuronal cell death. The Pharma Letter. 2 December 1996 Synthelabo's Eliprodil Fails In Stroke
Type IV hypersensitivity (463 words) [view diff] exact match in snippet view article find links to article
and overproduction of cytokines damage tissues, cause inflammation, and cell death. Type IV hypersensitivity can usually be resolved with topical corticosteroids
Nuclease S1 (828 words) [view diff] exact match in snippet view article find links to article
prokaryotes and eukaryotes and are thought to be associated in programmed cell death and also in tissue differentiation. Furthermore, they are secreted extracellular
Caspase 3 (3,361 words) [view diff] case mismatch in snippet view article find links to article
(January 2002). "Caspases: opening the boxes and interpreting the arrows". Cell Death and Differentiation. 9 (1): 3–5. doi:10.1038/sj.cdd.4400963. PMID 11803369
Enrofloxacin (505 words) [view diff] exact match in snippet view article find links to article
of enrofloxacin is concentration-dependent, with susceptible bacteria cell death occurring within 20–30 minutes of exposure. Enrofloxacin has demonstrated
CAMK (884 words) [view diff] exact match in snippet view article find links to article
genes. CAMK also works to regulate the cell life cycle (i.e. programmed cell death), rearrangement of the cell's cytoskeletal network, and mechanisms involved
Leelamine (144 words) [view diff] exact match in snippet view article find links to article
intracellular cholesterol transport, autophagy and endocytosis followed by cell death. Abietic acid "Leelamine - Dehydroabietylamine - Cayman Chemical". Retrieved
Staphylococcus aureus delta toxin (904 words) [view diff] exact match in snippet view article find links to article
contact and forms short-lived pores, causing cell lysis and subsequent cell death. S. aureus delta toxin is encoded for by the hld gene. The hld gene, of
TNF receptor superfamily (496 words) [view diff] exact match in snippet view article find links to article
fact that they seemed to play an important role in apoptosis (programmed cell death), although they are now known to play other roles as well. In the strict
DNA laddering (722 words) [view diff] exact match in snippet view article find links to article
; Groscurth, P. (1994-12-01). "Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA". Cell and Tissue Research. 278
Elesclomol (650 words) [view diff] exact match in snippet view article find links to article
(INN, codenamed STA-4783) is a drug that triggers apoptosis (programmed cell death) in cancer cells. It is being developed by Synta Pharmaceuticals and GlaxoSmithKline
Awesome (band) (392 words) [view diff] exact match in snippet view article
"addressing, among other topics, technical difficulties, recurring dreams, cell death, regeneration and bees." Bio Archived 2010-08-04 at the Wayback Machine
Sarcoplasmic reticulum (1,811 words) [view diff] exact match in snippet view article find links to article
certain intracellular structures, including the mitochondria, leading to cell death. Therefore, it is vital that calcium ion levels are controlled tightly
Ceragenin (399 words) [view diff] exact match in snippet view article find links to article
and are able to rapidly disrupt the target membranes leading to rapid cell death. While CSAs have a mechanism of action that is also seen in antimicrobial
Cerebrovascular disease (3,917 words) [view diff] exact match in snippet view article find links to article
calcium into cell walls. In the end the apoptosis pathway is initiated and cell death occurs. There are several arteries that supply oxygen to different areas
Polymyxin B (904 words) [view diff] exact match in snippet view article find links to article
breaking down the cytoplasmic membrane which generally results in bacterial cell death. Polymyxin B was approved for medical use in the United States in 1964
Gemcitabine (2,439 words) [view diff] exact match in snippet view article find links to article
medication. It works by blocking the creation of new DNA, which results in cell death. Gemcitabine was patented in 1983 and was approved for medical use in
Bcl-2 homologous antagonist killer (2,595 words) [view diff] exact match in snippet view article find links to article
which activates BAK to carry out membrane permeabilization, leading to cell death. Consequently, drugs that regulate BAK1 activity present promising treatments
APAF1 (1,588 words) [view diff] exact match in snippet view article find links to article
Roth KA, Gruss P (Sep 1998). "Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development". Cell. 94 (6): 727–37. doi:10.1016/S0092-8674(00)81732-8
Virulence factor (1,816 words) [view diff] exact match in snippet view article find links to article
inhibition of the host's immune response (this includes leukocidin-mediated cell death) entry into and exit out of cells (if the pathogen is an intracellular
Virulence factor (1,816 words) [view diff] exact match in snippet view article find links to article
inhibition of the host's immune response (this includes leukocidin-mediated cell death) entry into and exit out of cells (if the pathogen is an intracellular
Teratology (3,377 words) [view diff] exact match in snippet view article find links to article
canonical Wnt/B-catenin signaling and an increase in cell death was observed. The thalidomide induced cell death was significantly reduced when the introduction
P2RX7 (3,289 words) [view diff] exact match in snippet view article find links to article
pattern recognition receptor for extracellular ATP-mediated apoptotic cell death, regulation of receptor trafficking, mast cell degranulation, and inflammation
Hemolysis (2,832 words) [view diff] exact match in snippet view article find links to article
the red blood cell's cytoplasmic membrane, causing lysis and eventually cell death. From hemo- + -lysis, from Ancient Greek αἷμα (haîma, “blood”) + λύσις
Caspase-9 (4,319 words) [view diff] exact match in snippet view article find links to article
domain. This, in turn, induces expression of caspase-9, which triggers cell death of the CAR T cells. Through alternative splicing, four difference caspase-9
BH3 interacting-domain death agonist (1,246 words) [view diff] case mismatch in snippet view article find links to article
mediates the Atr-directed DNA damage response to replicative stress". Cell Death Differ. 18 (5): 841–52. doi:10.1038/cdd.2010.151. PMC 3074003. PMID 21113148
CHEK1 (3,416 words) [view diff] exact match in snippet view article find links to article
initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle. In 1993
TFCP2 (1,482 words) [view diff] exact match in snippet view article find links to article
inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death. TFCP2 has been shown to interact with APBB1 and RNF2. GRCh38: Ensembl
Lymphotoxin beta receptor (1,507 words) [view diff] exact match in snippet view article find links to article
of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB". Proc. Natl. Acad. Sci. U.S.A
Tropomyosin receptor kinase C (3,847 words) [view diff] exact match in snippet view article find links to article
to corticosterone protein autophosphorylation negative regulation of cell death heart development positive regulation of apoptotic process peptidyl-tyrosine
TUNEL assay (747 words) [view diff] exact match in snippet view article find links to article
has become one of the main methods for detecting apoptotic programmed cell death. However, for years there has been a debate about its accuracy, due to
Terbinafine (1,778 words) [view diff] exact match in snippet view article find links to article
the ability of fungi to make sterols. It appears to result in fungal cell death. Terbinafine was discovered in 1991. It is on the World Health Organization's
Tat (HIV) (1,611 words) [view diff] exact match in snippet view article
are not infected with HIV, and can act directly as a toxin producing cell death via apoptosis in uninfected "bystander" T cells, assisting in progression
EIF4G2 (1,110 words) [view diff] exact match in snippet view article find links to article
isolated as a putative modulator of gamma interferon-induced programmed cell death". Mol. Cell. Biol. 17 (3): 1615–25. doi:10.1128/mcb.17.3.1615. PMC 231887
Axolemma (485 words) [view diff] exact match in snippet view article find links to article
number of different cellular processes that may lead to cell damage or cell death.[citation needed] Axolemma is involved in preventing the hyperexcitability
Foix–Alajouanine syndrome (159 words) [view diff] exact match in snippet view article find links to article
dysfunction), and pathological examination reveals disseminated nerve cell death in the spinal cord and abnormally dilated and tortuous vessels situated
Gap junction (8,042 words) [view diff] exact match in snippet view article find links to article
Finocchiaro, Gaetano (June 1995). "The "bystander effect": association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect
Callus (cell biology) (1,520 words) [view diff] no match in snippet view article
Plant callus (plural calluses or calli) is a growing mass of unorganized plant parenchyma cells. In living plants, callus cells are those cells that cover
Calcium-binding mitochondrial carrier protein SCaMC-1 (360 words) [view diff] case mismatch in snippet view article find links to article
permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering". Cell Death and Differentiation. 19 (4): 650–60. doi:10.1038/cdd.2011.139. PMC 3307981
Cry6Aa (1,445 words) [view diff] exact match in snippet view article find links to article
D. (2009) "Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009". Cell death & differentiation. 16, 3-11 Narva
PARP inhibitor (1,771 words) [view diff] exact match in snippet view article find links to article
blocking their catalytic action. This interferes with replication, causing cell death preferentially in cancer cells, which grow faster than non-cancerous cells
Caspase 2 (918 words) [view diff] exact match in snippet view article find links to article
appears to be a very versatile caspase with multiple functions beyond cell death induction. Caspase 2 has been shown to interact with: BH3 interacting
Synthetic lethality (2,839 words) [view diff] exact match in snippet view article find links to article
genetic interaction where the combination of two genetic events results in cell death or death of an organism. Although the foregoing explanation is wider than
Mitosis (7,067 words) [view diff] exact match in snippet view article find links to article
multiplication). Other errors during mitosis can induce apoptosis (programmed cell death) or cause mutations. Certain types of cancer can arise from such mutations
Synthetic lethality (2,839 words) [view diff] exact match in snippet view article find links to article
genetic interaction where the combination of two genetic events results in cell death or death of an organism. Although the foregoing explanation is wider than
Cryotherapy (2,369 words) [view diff] exact match in snippet view article find links to article
Cryotherapy decreases the temperature of tissue surface to minimize hypoxic cell death, edema accumulation, and muscle spasms, all of which ultimately alleviate
PDCD4 (1,022 words) [view diff] exact match in snippet view article find links to article
Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene. It is one of the targets of an oncomiR, MIRN21. This gene encodes
Death effector domain (2,404 words) [view diff] exact match in snippet view article find links to article
the active caspase form which results in the initiation of apoptosis (cell death). Structurally the DED domain are a subclass of protein motif known as
Abemaciclib (1,228 words) [view diff] exact match in snippet view article find links to article
inducing apoptosis (cell death). In vitro analysis using cancer cell lines, it is reported that abemaciclib induces non‐apoptotic cell death characterized by
Sjögren syndrome (7,751 words) [view diff] exact match in snippet view article find links to article
lymphomagenesis (origin of lymphoma). Dysregulation of apoptosis (programmed cell death) is believed to play a role in the pathogenesis of a variety of autoimmune
Amylin (3,717 words) [view diff] exact match in snippet view article find links to article
amyloid formation might be a major mediator of apoptosis, or programmed cell death, in the islet β-cells. Initially, the proIAPP aggregates within secretory
Eosinophilic granulomatosis with polyangiitis (2,506 words) [view diff] exact match in snippet view article find links to article
The third stage consists of vasculitis, which can eventually lead to cell death and can be life-threatening. This condition is now called "eosinophilic
Bisphosphonate (3,422 words) [view diff] exact match in snippet view article find links to article
digestion of bone by encouraging osteoclasts to undergo apoptosis, or cell death, thereby slowing bone loss. The uses of bisphosphonates include the prevention
Granzyme B (1,915 words) [view diff] exact match in snippet view article find links to article
mitochondrial reactive oxygen species (ROS) to mediate cell death. The caspase independent pathways of cell death are thought to have arisen to overcome viruses
Proteasome (12,317 words) [view diff] exact match in snippet view article find links to article
external signals can lead to the induction of apoptosis, or programmed cell death. The resulting deconstruction of cellular components is primarily carried
Ingenol mebutate (1,201 words) [view diff] exact match in snippet view article find links to article
plant Euphorbia peplus, commonly known as milkweed, and is an inducer of cell death. A gel formulation of the drug has been approved by the U.S. Food and
Mitochondrion (15,492 words) [view diff] exact match in snippet view article find links to article
involved in other tasks, such as signaling, cellular differentiation, and cell death, as well as maintaining control of the cell cycle and cell growth. Mitochondrial
SOD2 (3,219 words) [view diff] exact match in snippet view article find links to article
reactive oxygen species (ROS) and, as a result, confer protection against cell death. As a result, this protein plays an antiapoptotic role against oxidative
Interleukin 24 (2,023 words) [view diff] exact match in snippet view article find links to article
healing, arthritis, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. The gene
Choroideremia (3,072 words) [view diff] exact match in snippet view article find links to article
understood, the lack of a functional protein in the retina results in cell death and the gradual deterioration of the retinal pigment epithelium (RPE)
Rituximab (3,807 words) [view diff] exact match in snippet view article find links to article
surface of immune system B cells. When it binds to this protein it triggers cell death. Rituximab was approved for medical use in 1997. It is on the World Health
Complement component 9 (765 words) [view diff] exact match in snippet view article find links to article
polymerize to form pores in target cell membranes, causing lysis and cell death. C9 is one member of the complement membrane attack complex (MAC), which
Apoptosome (3,899 words) [view diff] exact match in snippet view article find links to article
mitochondria in response to an internal (intrinsic) or external (extrinsic) cell death stimulus. Stimuli can vary from DNA damage and viral infection to developmental
Tropomyosin receptor kinase A (3,264 words) [view diff] exact match in snippet view article find links to article
neural proliferation, nociceptor response, and avoidance of programmed cell death. The binding of NGF to TrkA leads to a ligand-induced dimerization, and
Jun dimerization protein (4,319 words) [view diff] exact match in snippet view article find links to article
be involved in the inhibition of apoptosis. Depletion of JDP2 induces cell death similar to apoptosis. A study also demonstrated that UV irradiation induces
Axotomy (1,226 words) [view diff] exact match in snippet view article find links to article
better understand nervous system diseases. Axotomy may cause neuronal cell death, especially in embryonic or neonatal animals, as this is the period in
Safingol (825 words) [view diff] exact match in snippet view article find links to article
co-administer with cisplatin. The underlying mechanism by which safingol induces cell death is poorly understood. It is believed to exert a variety of inhibitory
Pulp necrosis (3,376 words) [view diff] exact match in snippet view article find links to article
partially necrosed for a period of time and if left untreated, the area of cell death expands until the entire pulp necroses. The most common clinical signs
DAPK1 (1,168 words) [view diff] exact match in snippet view article find links to article
kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine
BNIP3 (2,667 words) [view diff] exact match in snippet view article find links to article
BNIP3 is a member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival. Like many of the Bcl-2 family
SK channel (2,729 words) [view diff] exact match in snippet view article find links to article
SK channel activation can mediate neuroprotection in various models of cell death. SK channels control action potential discharge frequency in hippocampal
Imatinib (5,975 words) [view diff] exact match in snippet view article find links to article
Bcr-Abl tyrosine-kinase. This can slow growth or result in programmed cell death of certain types of cancer cells. Imatinib was approved for medical use
SK channel (2,729 words) [view diff] exact match in snippet view article find links to article
SK channel activation can mediate neuroprotection in various models of cell death. SK channels control action potential discharge frequency in hippocampal
BNIP3 (2,667 words) [view diff] exact match in snippet view article find links to article
BNIP3 is a member of the apoptotic Bcl-2 protein family. It can induce cell death while also assisting with cell survival. Like many of the Bcl-2 family
GPR37 (770 words) [view diff] exact match in snippet view article find links to article
parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". Journal of Biological Chemistry. 278 (51): 51901–10. doi:10.1074/jbc
DNA fragmentation (1,478 words) [view diff] exact match in snippet view article find links to article
1970 when he observed discrete oligomeric fragments occurring during cell death in primary neonatal liver cultures. He described the cytoplasmic DNA isolated
ABCA3 (950 words) [view diff] exact match in snippet view article find links to article
development of resistance to xenobiotics and engulfment during programmed cell death. Mutations in ABCA3 are associated to cataract-microcornea syndrome. It
Edelfosine (1,371 words) [view diff] exact match in snippet view article find links to article
apoptosis, sparing healthy cells. Edelfosine can activate the Fas/CD95 cell death receptor, can inhibit the MAPK/ERK mitogenic pathway and the Akt/protein
Fustin (161 words) [view diff] exact match in snippet view article find links to article
Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. Unlike fisetin, fustin has no double bond in the C-ring. This makes fustin
Asif Mohmmed (428 words) [view diff] no match in snippet view article find links to article
Plasmodium falciparum proteases with regard to cellular Stress and parasite cell-death and protein-trafficking machinery in the pathogen, as well as the development
Protein C (5,115 words) [view diff] exact match in snippet view article find links to article
plays an important role in regulating anticoagulation, inflammation, and cell death and maintaining the permeability of blood vessel walls in humans and other
Protein isoform (1,909 words) [view diff] exact match in snippet view article find links to article
function of one isoform can promote cell survival, while another promotes cell death—or can have similar basic functions but differ in their sub-cellular localization
HtrA serine peptidase 2 (1,926 words) [view diff] case mismatch in snippet view article find links to article
(Mar 2008). "The mitochondrial serine protease HtrA2/Omi: an overview". Cell Death and Differentiation. 15 (3): 453–60. doi:10.1038/sj.cdd.4402291. PMID 18174901
Mebendazole (1,594 words) [view diff] exact match in snippet view article find links to article
allows pro-apoptotic protein Bax to dimerize and initiate programmed cell death. Mebendazole is available as a generic medication. Mebendazole is distributed
MAP3K7 (1,644 words) [view diff] exact match in snippet view article find links to article
Ninomiya-Tsuji J, Morioka S (November 2014). "TAK1 control of cell death". Cell Death and Differentiation. 21 (11): 1667–76. doi:10.1038/cdd.2014.123
Lupus (11,780 words) [view diff] exact match in snippet view article find links to article
specificity through somatic hypermutation. Necrosis, a pro-inflammatory form of cell death, is increased in T lymphocytes, due to mitochondrial dysfunction, oxidative
KCNB1 (3,743 words) [view diff] exact match in snippet view article find links to article
earlier, oxidative and nitrosative injurious stimuli also activate a cell death-inducing cascade that promotes to a zinc and calcium/clamodulin-dependent
PTPN13 (1,142 words) [view diff] exact match in snippet view article find links to article
the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and
Paramethasone (138 words) [view diff] exact match in snippet view article find links to article
gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes". Cell Death and Differentiation. 6 (12): 1182–9
Photodynamic therapy (8,873 words) [view diff] exact match in snippet view article find links to article
chemical substance, used in conjunction with molecular oxygen to elicit cell death (phototoxicity). PDT is popularly used in treating acne. It is used clinically
BCL2-like 1 (2,210 words) [view diff] exact match in snippet view article find links to article
bcl-2-related gene that functions as a dominant regulator of apoptotic cell death" (PDF). Cell. 74 (4): 597–608. doi:10.1016/0092-8674(93)90508-N. hdl:2027
Mir-885 microRNA precursor family (820 words) [view diff] case mismatch in snippet view article find links to article
CDK2 and MCM5, activates p53 and inhibits proliferation and survival". Cell Death Differ. 18 (6): 974–84. doi:10.1038/cdd.2010.164. PMC 3131937. PMID 21233845
SDHA (1,967 words) [view diff] exact match in snippet view article find links to article
chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death". Cell Death and Differentiation
Andrew Wyllie (376 words) [view diff] exact match in snippet view article find links to article
at the University of Aberdeen he realised the significance of natural cell death. He and his colleagues John Kerr and Alastair Currie called this process
Autoimmune regulator (3,081 words) [view diff] exact match in snippet view article find links to article
TRA) and T cells that respond to those proteins are eliminated through cell death (apoptosis). Thus AIRE drives negative selection of self-recognizing T
Cyclic guanosine monophosphate–adenosine monophosphate (706 words) [view diff] exact match in snippet view article find links to article
synthesised, activating CapV which degrades the cell's membrane and triggers cell death before the phage can complete its replicatory cycle. Wu, J; Sun, L; Chen
HSPA1A (3,264 words) [view diff] exact match in snippet view article find links to article
phagocytes, thereby preventing an inflammatory response. It is a mode of cell death defined by characteristic morphological, biochemical and molecular changes
C5-convertase (1,455 words) [view diff] exact match in snippet view article find links to article
innate immunity. It participates in the complement system ending with cell death. There are four different C5 convertases able to specifically convert
Cyclic guanosine monophosphate–adenosine monophosphate (706 words) [view diff] exact match in snippet view article find links to article
synthesised, activating CapV which degrades the cell's membrane and triggers cell death before the phage can complete its replicatory cycle. Wu, J; Sun, L; Chen
Giardiasis (5,092 words) [view diff] exact match in snippet view article find links to article
to the microvillus, increased intestinal permeability, and programmed cell death of small intestinal epithelial cells. Both trophozoites and cysts are
PANoptosis (822 words) [view diff] exact match in snippet view article find links to article
PANoptosis is defined as an inflammatory programmed cell death pathway regulated by the PANoptosome complex. PANoptosomes are innate immune complexes consisting
Neurogenin-3 (1,717 words) [view diff] case mismatch in snippet view article find links to article
β-cell neogenesis and proliferation in injured adult mouse pancreas". Cell Death & Disease. 4 (3): e523. doi:10.1038/cddis.2013.52. PMC 3613830. PMID 23470530
Nerve tissue protein (1,062 words) [view diff] exact match in snippet view article find links to article
NAIP and hippocalcin caused neuroblastoma cells to be protected from cell death through the induction of increased calcium levels. NAIP has been shown
Penumbra (medicine) (973 words) [view diff] exact match in snippet view article
cells near the location of the original insult. This can lead to hypoxic cell death (infarction) and amplify the original damage from the ischemia; however
Pridopidine (1,512 words) [view diff] exact match in snippet view article find links to article
ALS Pridopidine exhibits a neuroprotective effect against mHTT-induced cell death in mouse primary HD neurons and human HD iPSCs (ED50 is 20-50 nM). . It
Cephalic disorder (516 words) [view diff] exact match in snippet view article find links to article
the process during which cells acquire individual characteristics; and cell death, a natural process in which cells die.[citation needed] Damage to the
MAPK phosphatase (1,868 words) [view diff] exact match in snippet view article find links to article
homeostasis. This can involve gene regulation, cell proliferation, programmed cell death and stress responses. MAPK phosphatases are therefore important regulator
P2RX4 (2,250 words) [view diff] exact match in snippet view article find links to article
have been implicated in the regulation of cardiac function, ATP-mediated cell death, synaptic strengthening, and activating of the inflammasome in response
Sunburn (4,749 words) [view diff] no match in snippet view article find links to article
radiation. When the cells' DNA is overly damaged by UV radiation, type I cell-death is triggered and the tissue is replaced. Sun protective measures including
IFNA16 (925 words) [view diff] case mismatch in snippet view article find links to article
identities of gp120 relevant to the molecular basis of AIDS pathogenesis?". Cell Death Differ. 2 (1): 23–32. PMID 17180012. Myers MP, Andersen JN, Cheng A, et al
Retinal degeneration (rhodopsin mutation) (3,933 words) [view diff] exact match in snippet view article
eventual photoreceptor death. In RP photoreceptor cell death is believed to occur by programmed cell death or apoptosis. Retinitis pigmentosa is a progressive
Botryotinia (321 words) [view diff] exact match in snippet view article find links to article
bulb rots in the field and in stored products. The fungi induce host cell death resulting in progressive decay of infected plant tissue, whence they take
Mapatumumab (743 words) [view diff] exact match in snippet view article find links to article
technology. Early work by the two companies indicated that mapatumumab induced cell death in multiple tumor types both in vitro and in vivo. A phase 1 clinical
Cell fate determination (2,679 words) [view diff] exact match in snippet view article find links to article
cell proliferation, differentiation, cellular movement and programmed cell death. Each cell in an embryo receives molecular signals from neighboring cells
Anticancer gene (6,286 words) [view diff] exact match in snippet view article find links to article
to apoptosis and cell death. NS1 activates cell death through two different pathways, apoptosis/lysosomal-like programed cell death and necrosis/cytolysis
F-box protein (733 words) [view diff] exact match in snippet view article find links to article
signaling to affect the seed germination. ACRE189/ACIF1 can regulate cell death and defense when the pathogen is recognized in the Tobacco and Tomato
Positive feedback (6,831 words) [view diff] no match in snippet view article find links to article
Positive feedback (exacerbating feedback, self-reinforcing feedback) is a process that occurs in a feedback loop which exacerbates the effects of a small
RE1-silencing transcription factor (2,006 words) [view diff] exact match in snippet view article find links to article
protected from dementia. It is assumed that REST represses genes that promote cell death and Alzheimer's disease pathology, and induces the expression of stress
PAC-1 (1,828 words) [view diff] exact match in snippet view article find links to article
effects of procaspase-3 activating compounds in the induction of cancer cell death". Mol. Pharmaceutics. 9 (5): 1425–1434. doi:10.1021/mp200673n. PMC 3348238
PPP1R15A (1,393 words) [view diff] exact match in snippet view article find links to article
playing a role in ER stress-induced cell death, being a target of ATF4 that plays a role in ER-mediated cell death via promoting protein dephosphorylation
George McLendon (234 words) [view diff] exact match in snippet view article find links to article
Guggenheim Fellowships. His publications range from solar nanotechnology to cell death pathways. His most recent research has direct implications for the diagnosis
Topoisomerase inhibitor (9,767 words) [view diff] exact match in snippet view article find links to article
double stranded DNA breaks that they cause can lead to apoptosis and cell death. Because of this ability to induce apoptosis, topoisomerase inhibitors
Cerebral hypoxia (3,377 words) [view diff] exact match in snippet view article find links to article
infarction, and global cerebral ischemia. Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury. Cases of total oxygen
Lomerizine (1,473 words) [view diff] exact match in snippet view article find links to article
activation of calcium-dependent signal transduction. These processes lead to cell death through either apoptosis or necrosis. Lomerizine's role in blocking Ca2+
Trastuzumab emtansine (2,656 words) [view diff] exact match in snippet view article find links to article
are released and subsequently bind tubulin to cause mitotic arrest and cell death. Trastuzumab binding to HER2 prevents homodimerization or heterodimerization
P14arf (2,856 words) [view diff] exact match in snippet view article find links to article
mitochondria membrane potential and structure, and leading to autophagic cell death. The translation of the truncated ARF, smARF, is initiated at an internal
Thapsigargin (1,371 words) [view diff] exact match in snippet view article find links to article
unfolded protein response. Non-resolved ER stress can cumulatively lead to cell death. Prolonged store depletion can protect against ferroptosis via remodeling
PDCD10 (1,652 words) [view diff] exact match in snippet view article find links to article
Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene. This gene encodes a protein, originally identified in a premyeloid
Baculoviral IAP repeat-containing protein 2 (1,876 words) [view diff] case mismatch in snippet view article find links to article
inhibitor of apoptosis 1 (c-IAP1) is required for cell differentiation". Cell Death Differ. 15 (5): 859–66. doi:10.1038/cdd.2008.5. PMID 18239673. Verhagen
PDCD10 (1,652 words) [view diff] exact match in snippet view article find links to article
Programmed cell death protein 10 is a protein that in humans is encoded by the PDCD10 gene. This gene encodes a protein, originally identified in a premyeloid
Relative biological effectiveness (1,791 words) [view diff] exact match in snippet view article find links to article
the energies involved, the biological effects being considered such as cell death, and the oxygen tension of the tissues or so-called oxygen effect. The
PDCD6IP (1,242 words) [view diff] exact match in snippet view article find links to article
Programmed cell death 6-interacting protein also known as ALIX is a protein that in humans is encoded by the PDCD6IP gene. This gene encodes a protein
ZNF217 (962 words) [view diff] exact match in snippet view article find links to article
Mills GB, Stokoe D, Yaswen P, Collins C (Nov 2005). "ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction". Human Molecular
Bacteriocyte (1,519 words) [view diff] exact match in snippet view article find links to article
of cell death, the digestion of endosymbionts by lysosomes. Other bacteriocytes, like those found in weevils, undergo a different form of cell death. Unlike
Osteocyte (2,364 words) [view diff] exact match in snippet view article find links to article
and cartilage formation. Osteonecrosis refers to the classic pattern of cell death and complex osteogenesis and bone resorption processes. Osteocyte necrosis
Isoniazid (3,415 words) [view diff] exact match in snippet view article find links to article
disrupting the formation of the bacteria's cell wall which results in cell death. Isoniazid was first made in 1952. It is on the World Health Organization's
NDUFA13 (1,899 words) [view diff] exact match in snippet view article find links to article
known as GRIM-19, a cell-death regulatory protein. It is involved in interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This form of apoptotic
PRKD2 (932 words) [view diff] exact match in snippet view article find links to article
kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells". Int.
Bafilomycin (3,939 words) [view diff] exact match in snippet view article find links to article
K+ across biological membranes and leading to mitochondrial damage and cell death. Bafilomycin A1 specifically targets the vacuolar-type H+ -ATPase (V-ATPase)
Leaf spot (2,422 words) [view diff] exact match in snippet view article find links to article
These discoloured spots or lesions often have a centre of necrosis or cell death. Symptoms can overlap across causal agents, however differing signs and
List of types of proteins (2,439 words) [view diff] exact match in snippet view article find links to article
rather than simply deteriorating gradually over time, which culminates in cell death." "The directed movement of substances (such as macromolecules, small
NAD+ kinase (1,443 words) [view diff] exact match in snippet view article find links to article
apoptosis, there are also cases where NADK activity appears to potentiate cell death. Genetic studies done in human haploid cell lines indicate that knocking
Chrysophanol (1,423 words) [view diff] exact match in snippet view article find links to article
organisms. It has been reported that chrysophanol causes necrosis-like cell death in renal cancer cells. It also has expressed the capability to be classes
Spalax (1,185 words) [view diff] exact match in snippet view article find links to article
apoptosis. One study showed that in adaptation to a higher tendency of cell death, blind mole rats evolved a mutation in the tumor suppressor protein p53
Caspase 6 (1,617 words) [view diff] case mismatch in snippet view article find links to article
apoptosis pathway: absolute requirement for removal of caspase-6 prodomain". Cell Death Differ. 9 (10): 1046–56. doi:10.1038/sj.cdd.4401065. PMID 12232792. Guo
Phorbol-12-myristate-13-acetate-induced protein 1 (1,208 words) [view diff] exact match in snippet view article find links to article
molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death". J. Biol. Chem. 278 (48): 48292–9. doi:10.1074/jbc.M308785200. PMID 14500711
Ballooning degeneration (332 words) [view diff] exact match in snippet view article find links to article
name is derived from the fact that the cells undergoing this form of cell death increase in size (balloon). It is generally considered a form of apoptosis
JAK-STAT signaling pathway (6,571 words) [view diff] exact match in snippet view article find links to article
a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. The pathway communicates information from chemical
Stingray (3,537 words) [view diff] exact match in snippet view article find links to article
the venom are cystatins, peroxiredoxin, and galectin. Galectin induces cell death in its victims and cystatins inhibit defense enzymes. In humans, these
Caspase 14 (1,095 words) [view diff] case mismatch in snippet view article find links to article
(May 1999). "Identification of a new caspase homologue: caspase-14". Cell Death Differ. 5 (10): 838–46. doi:10.1038/sj.cdd.4400444. PMID 10203698. Hu
Death-associated protein 6 (1,526 words) [view diff] exact match in snippet view article find links to article
normally regulates stress-induced cell death. It is also essential for development of nerval system by programmed cell death. The real apoptotic process starts
IKZF3 (1,203 words) [view diff] exact match in snippet view article find links to article
Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization"
ENDOG (2,403 words) [view diff] exact match in snippet view article find links to article
effect apoptosis. Therefore, maintaining low levels of EndoG could prevent cell death caused by stress conditions. In epithelial cells, the nuclear localization
Neurogenins (2,628 words) [view diff] case mismatch in snippet view article find links to article
β-cell neogenesis and proliferation in injured adult mouse pancreas". Cell Death & Disease. 4 (3): e523. doi:10.1038/cddis.2013.52. PMC 3613830. PMID 23470530
Pyrococcus furiosus (2,014 words) [view diff] exact match in snippet view article find links to article
produce reactive oxygen species which can result in cell death. If these free radicals are removed, cell death can be delayed. Enzymes in plants called superoxide
Jerry Adams (571 words) [view diff] exact match in snippet view article find links to article
student, David Vaux, made the connection between apoptosis (programmed cell death) and cancer, while studying the bcl-2 gene in follicular lymphoma, the
CIDEA (741 words) [view diff] exact match in snippet view article find links to article
Cell death activator CIDE-A is a protein that in humans is encoded by the CIDEA gene. Cidea is an essential transcriptional coactivator regulating mammary
Promyelocytic leukemia protein (4,041 words) [view diff] exact match in snippet view article find links to article
of regulatory cellular functions, including involvement in programmed cell death, genome stability, antiviral effects and controlling cell division. PML
Ras GTPase (3,661 words) [view diff] exact match in snippet view article find links to article
and as cell death occurs, progeny virus particles are free to infect surrounding cancer cells. This cycle of infection, replication and cell death is believed
Farnesene (516 words) [view diff] exact match in snippet view article find links to article
The oxidation products injure cell membranes which eventually causes cell death in the outermost cell layers of the fruit, resulting in a storage disorder
PDCD2 (959 words) [view diff] exact match in snippet view article find links to article
Programmed cell death protein 2 is a protein that in humans is encoded by the PDCD2 gene. This gene encodes a nuclear protein expressed in a variety of
MAPK14 (5,241 words) [view diff] exact match in snippet view article find links to article
implicated in diverse cellular functions, from gene expression to programmed cell death through a network of signaling molecules and transcription factors. Pharmacological
T helper cell (7,443 words) [view diff] exact match in snippet view article find links to article
(oligosaccharides), which makes them less susceptible to some inducers of cell death. While we know about the types of cytokine patterns helper T cells tend
Ebola viral protein 24 (1,627 words) [view diff] exact match in snippet view article find links to article
more susceptible to said pathogen. STAT1 has also been shown to regulate cell death by the inhibition of anti-apoptotic proteins Bcl-2 and Bcl-xL. STAT1 also
Oleocanthal (1,341 words) [view diff] exact match in snippet view article find links to article
This is a result of lysosome membrane permeabilization promoting cancer cell death. Lysosomal membrane permeabilization is not activated by oleocanthal in
STAT5 (1,215 words) [view diff] exact match in snippet view article find links to article
controlled cell growth and division, or cell proliferation programmed cell death, or apoptosis cell specialization, or differentiation and inflammation
Cytotoxicity (1,141 words) [view diff] exact match in snippet view article find links to article
viability), or the cells can activate a genetic program of controlled cell death (apoptosis). Cells undergoing necrosis typically exhibit rapid swelling
Acid-sensing ion channel (2,771 words) [view diff] exact match in snippet view article find links to article
in intracellular calcium that results in cell death. A possible mechanism of ASIC1a channel-mediated cell death is due to the activation of other channels
PDCD6 (1,225 words) [view diff] exact match in snippet view article find links to article
Programmed cell death protein 6 is a protein that in humans is encoded by the PDCD6 gene. This gene encodes a calcium-binding protein belonging to the
Danger zone (food safety) (685 words) [view diff] exact match in snippet view article
must be minimized. A logarithmic relationship exists between microbial cell death and temperature, that is, a small decrease of cooking temperature can
Dichlorophenolindophenol (367 words) [view diff] exact match in snippet view article find links to article
cancer cells in an animal model of human melanoma; DCPIP-induced cancer cell death occurs by depletion of intracellular glutathione and upregulation of oxidative
HAMLET (protein complex) (1,430 words) [view diff] exact match in snippet view article
oleic acid that has been shown in cell culture experiments to induce cell death in tumor cells, but not in healthy cells. HAMLET is a possible chemotherapeutic
SOX4 (1,172 words) [view diff] exact match in snippet view article find links to article
(syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid
ASAH1 (1,271 words) [view diff] exact match in snippet view article find links to article
"Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death". The Journal of Experimental Medicine. 192 (5): 601–12. doi:10.1084/jem
Cardioplegia (1,389 words) [view diff] exact match in snippet view article find links to article
preventing cell death during the ischemic period of time. Cardioplegic solution is the means by which the ischemic myocardium is protected from cell death. This
IFI16 (1,363 words) [view diff] exact match in snippet view article find links to article
helper CD4 T cells by pyroptosis, a highly inflammatory form of programmed cell death. Recently, it has been shown how IFI16, once extracellularly released
TRAF3 (2,073 words) [view diff] exact match in snippet view article find links to article
receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection
Caspase 7 (666 words) [view diff] exact match in snippet view article find links to article
cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript
John Savill (784 words) [view diff] exact match in snippet view article find links to article
Careers. John Savill's research interests revolve around the role of cell death and macrophages in resolution and repair of inflammation, especially inflammatory
Dengue virus (6,268 words) [view diff] exact match in snippet view article find links to article
autophagy, virus replication and protection from cell death require ER stress (PERK) pathway activation". Cell Death & Disease. 7 (e2127): e2127. doi:10.1038/cddis
Mir-872 microRNA precursor family (258 words) [view diff] exact match in snippet view article find links to article
increases oxidative damage and through this results in enhanced apoptosis and cell death. Insulin infusion in rats has seen increased levels of heme-oxygenase
NMDA receptor (11,273 words) [view diff] exact match in snippet view article find links to article
much discussion on how these receptors can affect both cell survival and cell death. Recent evidence supports the hypothesis that overstimulation of extrasynaptic
Cavernous hemangioma (3,083 words) [view diff] exact match in snippet view article find links to article
K-Rev interaction trapped 1 (ССМ1), Malcavernin (CCM2) and Programmed cell death protein 10 (ССМ3) – have been identified as having mutations thought to
Beta dispersion (647 words) [view diff] exact match in snippet view article find links to article
the cell surface. This property maintains ions within the cell. Upon cell death, the insulating property of the cell membrane is lost. He also hypothesized
Colistin (4,221 words) [view diff] exact match in snippet view article find links to article
breaking down the cytoplasmic membrane, which generally results in bacterial cell death. Colistin was discovered in 1947 and colistimethate sodium was approved
Glial cell line-derived neurotrophic factor (2,580 words) [view diff] exact match in snippet view article find links to article
S2CID 2480120. Oo TF, Kholodilov N, Burke RE (June 2003). "Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell
Angiopoietin (2,100 words) [view diff] exact match in snippet view article find links to article
migration, and survival. Angiopoietin-2, on the other hand, promotes cell death and disrupts vascularization. Yet, when it is in conjunction with vascular
Jasmonate (2,619 words) [view diff] exact match in snippet view article find links to article
herbivory. Following its role in defense, JAs have also been implicated in cell death and leaf senescence. JA can interact with many kinases and transcription
Beta dispersion (647 words) [view diff] exact match in snippet view article find links to article
the cell surface. This property maintains ions within the cell. Upon cell death, the insulating property of the cell membrane is lost. He also hypothesized
DNA Repair (journal) (103 words) [view diff] exact match in snippet view article
reviews, and book reviews concerning DNA repair, cell cycle regulation, cell death, and other biological responses to genetic damage. According to the Journal
Anticonvulsant (4,526 words) [view diff] exact match in snippet view article find links to article
alone and in combination with MK-801, phenobarbital, or phenytoin on cell death in the neonatal rat brain". J Pharmacol Exp Ther. 322 (2): 494–500. doi:10
Checkpoint inhibitor (1,838 words) [view diff] exact match in snippet view article find links to article
molecules CTLA4, PD-1, and PD-L1. PD-1 is the transmembrane programmed cell death 1 protein (also called PDCD1 and CD279), which interacts with PD-L1 (PD-1
Germinal center B-cell like diffuse large B-cell lymphoma (2,442 words) [view diff] exact match in snippet view article find links to article
proteins prevent the activation of the caspases that lead to programmed cell death (apoptosis). Activation of the nuclear factor kappa-light-chain-enhancer
Midkine (2,364 words) [view diff] exact match in snippet view article find links to article
resistance to chemotherapy is conferred to the wild type cells, and thus no cell death or senescence occurs in either cell type, despite the chemotherapeutic
Spermatogonium (279 words) [view diff] exact match in snippet view article find links to article
exposure of spermatogonia to doxorubicin can also induce programmed cell death (apoptosis). Transverse section of a tubule of the testis of a rat. X
DAD1 (682 words) [view diff] exact match in snippet view article find links to article
the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7
Forkhead box protein O1 (3,323 words) [view diff] exact match in snippet view article find links to article
upregulates Fas ligand (FasL) transcriptionally resulting in apoptotic cell death. Additionally, FOXO1 trans-activate Bim protein, which a member of the
Glutamate (neurotransmitter) (2,177 words) [view diff] exact match in snippet view article
leading to neuronal damage and eventual cell death, and is called excitotoxicity. The mechanisms of cell death include Ca2+-concentration regulates different
Microphthalmia-associated transcription factor (4,815 words) [view diff] exact match in snippet view article find links to article
locus in mice, and its protumorogenic targets include factors involved in cell death, DNA replication, repair, mitosis, microRNA production, membrane trafficking
Mir-11 microRNA precursor family (206 words) [view diff] case mismatch in snippet view article find links to article
of microRNAs in control of apoptosis during Drosophila embryogenesis". Cell Death & Differentiation. 19 (5): 839–46. doi:10.1038/cdd.2011.161. PMC 3321623
Eosinophil cationic protein (2,267 words) [view diff] exact match in snippet view article find links to article
like activity. Accordingly, cytotoxic RNases play an important role in cell death. However, the mechanism of ECP-induced apoptosis is still not fully verified
Feathery degeneration (150 words) [view diff] exact match in snippet view article find links to article
hepatocyte) death associated with cholestasis. Cells undergoing this form of cell death have a flocculant appearing cytoplasm, and are larger than normal hepatocytes
Antimicrobial polymer (5,549 words) [view diff] exact match in snippet view article find links to article
drinking water. Antimicrobial polymers inhibit cell growth and initiate cell death through two primary mechanisms. The first mechanism is utilized by contact-active
Isatuximab (3,093 words) [view diff] exact match in snippet view article find links to article
apoptotic pathway and the lysosomal mediated cell death pathway in MM cells is induced by isatuximab. The MM cell death follows the downstream reactions of the
Stroke (disambiguation) (287 words) [view diff] exact match in snippet view article
a medical condition in which poor blood flow to the brain results in cell death. A stroke or stroking may also refer to: Stroke (journal), a cardiology
Methyl jasmonate (862 words) [view diff] exact match in snippet view article find links to article
mitochondria of cancer cells, leading to cell death, but does not harm normal cells. To be specific, it can cause cell death in B-cell chronic lymphocytic leukemia
CAPN3 (1,371 words) [view diff] exact match in snippet view article find links to article
"NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain"
PDCD5 (742 words) [view diff] exact match in snippet view article find links to article
Programmed cell death protein 5 is a protein that in humans is encoded by the PDCD5 gene. This gene encodes a protein expressed in tumor cells during apoptosis
TMEM123 (689 words) [view diff] exact match in snippet view article find links to article
antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized
Mir-383 microRNA precursor family (353 words) [view diff] case mismatch in snippet view article find links to article
testicular embryonal carcinoma cell proliferation by targeting IRF1". Cell Death & Disease. 1 (11): e94. doi:10.1038/cddis.2010.70. PMC 3032325. PMID 21368870
NAD(+)—diphthamide ADP-ribosyltransferase (300 words) [view diff] exact match in snippet view article
T cell migration or (at high extracellular levels of NAD+) can induce cell death by ART2. Rivas-Yáñez E, Barrera-Avalos C, Bono R, Sauma D (2020). "P2X7
Ewing's sarcoma (3,791 words) [view diff] exact match in snippet view article find links to article
(4-hydroxy(phenyl)retinamide) has been reported to induce high levels of cell death in Ewing sarcoma cell lines in vitro and to delay growth of xenografts
Mir-14 microRNA precursor family (299 words) [view diff] exact match in snippet view article find links to article
Guo M, Hay BA (April 2003). "The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism" (PDF). Current Biology. 13
HSPA1B (557 words) [view diff] exact match in snippet view article find links to article
negative regulation of cell death positive regulation of gene expression viral entry into host cell regulation of cell death ATP metabolic process negative
Mir-145 (1,757 words) [view diff] exact match in snippet view article find links to article
Orntoft TF (Feb 2010). "miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature