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searching for CYP3A 58 found (280 total)

alternate case: cYP3A

Erythromycin breath test (1,055 words) [view diff] exact match in snippet view article find links to article

ERMBT has been widely used and verified as a reliable method for measuring CYP3A activity in real time. Its non-invasive nature makes it useful for researching

Xenobiotic-sensing receptor (530 words) [view diff] exact match in snippet view article find links to article

glucocorticoids induction of CYP3A were perceived to utilize glucocorticoid receptor. This was explained by the induction of the CYP3A relationships obtained

EMBiology (227 words) [view diff] exact match in snippet view article find links to article

chemical reaction CYP3A has a "ChemicalReaction" relationship with ticagrelor Molecular Synthesis Changes the concentration of the target CYP3A has a "MolSynthesis"

OR2AE1 (253 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347

Pregnane X receptor (1,978 words) [view diff] exact match in snippet view article find links to article

"Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction". Proceedings of the National Academy of Sciences of the United

Venetoclax (2,575 words) [view diff] exact match in snippet view article find links to article

because they contain CYP3A inhibitors. Additionally, while using venetoclax it is not recommended to use other drugs which contain CYP3A inhibitors (i.e.:

Banpeiyu (446 words) [view diff] exact match in snippet view article find links to article

Friedl's Blog "Inhibitory effects of citrus fruits on cytochrome P450 3A (CYP3A) activity in humans" "Production of Haploid Plant of 'Banpeiyu' Pummelo

Slavery hypertension hypothesis (878 words) [view diff] exact match in snippet view article find links to article

received considerable media attention. In December 2004, a paper titled CYP3A Variation and the Evolution of Salt-Sensitivity Variants was published which

Ethylmorphine (445 words) [view diff] exact match in snippet view article find links to article

"Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes". Toxicology Letters. 94 (2): 115–25

Drug-induced QT prolongation (2,307 words) [view diff] exact match in snippet view article find links to article

prolongation and TdP. Erythromycin works inhibiting the CYP3A protein. Patients who have low CYP3A activity and are also concurrently taking other medications

Simnotrelvir/ritonavir (334 words) [view diff] exact match in snippet view article find links to article

drug of simnotrelvir, an inhibitor of SARS-CoV-2 3CLpro, and ritonavir, a CYP3A inhibitor. It was developed by Simcere Pharmaceutical and conditionally

Afimoxifene (473 words) [view diff] exact match in snippet view article find links to article

biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6". The Journal of Pharmacology and Experimental Therapeutics.

ZNF655 (585 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347

Grapefruit–drug interactions (5,694 words) [view diff] exact match in snippet view article find links to article

lead to increased imatinib plasma concentrations via inhibition of the CYP3A isoenzymes. Seville orange juice is not usually consumed as a juice because

Bioavailability (2,749 words) [view diff] exact match in snippet view article find links to article

inhibition (decreased rate of metabolism), e.g., grapefruit juice inhibits CYP3A → higher nifedipine concentrations Individual variation in metabolic differences

3-Methoxymorphinan (193 words) [view diff] exact match in snippet view article find links to article

metabolic ratio of dextromethorphan and 3-methoxymorphinan as a probe for CYP3A activity and prediction of cyclosporine clearance in healthy volunteers"

Zonisamide (2,038 words) [view diff] exact match in snippet view article find links to article

catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells". Biochimica et Biophysica Acta (BBA) -

Naringin (830 words) [view diff] exact match in snippet view article find links to article

Bernier SM (January 1996). "Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice". Life Sciences. 59 (13): 1025–1030. doi:10

Clementine (1,577 words) [view diff] exact match in snippet view article find links to article

interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance". European Journal of Pharmaceutical Sciences

6β-Hydroxycortisol (716 words) [view diff] exact match in snippet view article find links to article

on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies". Xenobiotica. 51 (10): 1199–1206

Tadalafil (3,246 words) [view diff] exact match in snippet view article find links to article

Hall SD (February 2003). "Droperidol is predominantly metabolized by human CYP3A enzymes". Clinical Pharmacology & Therapeutics. 73 (2): P16. doi:10

Lesinurad (896 words) [view diff] exact match in snippet view article find links to article

by microsomal epoxide hydrolase (mEH). The enzymes CYP1A1, CYP2C19 and CYP3A only play minor roles in its metabolization. Glucuronidation by the enzymes

Levobupivacaine (2,303 words) [view diff] exact match in snippet view article find links to article

biotransformation in the liver by the cytochrome P450 enzyme, specifically CYP1A2 and CYP3A isoforms as part of phase one biotransformation, thereby producing inactive

Triamcinolone (1,514 words) [view diff] exact match in snippet view article find links to article

(February 2013). "Metabolic pathways of inhaled glucocorticoids by the CYP3A enzymes". Drug Metabolism and Disposition. 41 (2): 379–389. doi:10.1124/dmd

Constitutive androstane receptor (2,238 words) [view diff] exact match in snippet view article find links to article

Examples for CAR-regulated genes are members of the CYP2B, CYP2C, and CYP3A subfamilies, sulfotransferases, and glutathione-S-transferases. Ligands

Guggulsterone (520 words) [view diff] exact match in snippet view article find links to article

(2004). "Guggulsterone Activates Multiple Nuclear Receptors and Induces CYP3A Gene Expression through the Pregnane X Receptor". Journal of Pharmacology

Calanolide A (2,249 words) [view diff] exact match in snippet view article find links to article

drug has half-life of 20 hours. The drug is metabolised by cytochrome P450 CYP3A. Calanolide A is unique among non-nucleoside reverse transcriptase inhibitor

Norketamine (1,150 words) [view diff] exact match in snippet view article find links to article

by the superfamily of cytochrome P450 enzymes, particularly CYP2B6 and CYP3A. Though these enzymes are predominantly found in the liver, they are present

ZKSCAN5 (478 words) [view diff] exact match in snippet view article find links to article

et al. (2006). "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. doi:10.1038/sj.tpj.6500347

Irinotecan (2,315 words) [view diff] exact match in snippet view article find links to article

converted by CES1 and CES2 in the liver to SN-38. Induction or inhibition of CYP3A enzymes by smoking, some herbs and medications may result in interactions

Quinine 3-monooxygenase (305 words) [view diff] exact match in snippet view article find links to article

Birkett, DJ; Wanwimolruk, S (1997). "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine". Br. J. Clin. Pharmacol. 43 (3): 245–52

Ondansetron (3,291 words) [view diff] exact match in snippet view article find links to article

Zhang L, Kleine-Brueggeney M, Fimmers R, et al. (July 2011). "CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia

Hydrocodone (5,233 words) [view diff] exact match in snippet view article find links to article

8.0 hours. Ritonavir is a strong CYP3A4 inhibitor as well as inducer of CYP3A and other enzymes, and the other antivirals are known to inhibit drug transporters

Lovastatin (3,310 words) [view diff] exact match in snippet view article find links to article

Pharmacokinetic data Bioavailability <5% Protein binding >98% Metabolism Liver (CYP3A and CYP2C8 substrate) Elimination half-life 2–5 hours Excretion Faeces (83%)

Cystic fibrosis (18,316 words) [view diff] exact match in snippet view article find links to article

the disease as well. The combination drug is also known to interact with CYP3A inducers, such as carbamazepine used in the treatment of bipolar disorder

Dextrorphan (648 words) [view diff] exact match in snippet view article find links to article

vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?". Drug Metabolism and Disposition. 29 (11): 1514–20. PMID 11602530

Lonafarnib (1,147 words) [view diff] exact match in snippet view article find links to article

Lonafarnib is contraindicated for co-administration with strong or moderate CYP3A inhibitors and inducers, as well as midazolam and certain cholesterol-lowering

Dextromethorphan (4,625 words) [view diff] exact match in snippet view article find links to article

vitro: can dextromethorphan be used as a dual probe for both CTP2D6 and CYP3A activities?". Drug Metabolism and Disposition. 29 (11): 1514–1520. PMID 11602530

Mitragyna speciosa (8,811 words) [view diff] exact match in snippet view article find links to article

G-protein linked second messenger activation, and calcium channel blocker. Metabolism: Cytochrome P-450, inhibitor of CYP2D6 and CYP3A Excretion: Renally

Docetaxel (4,765 words) [view diff] exact match in snippet view article find links to article

Anticonvulsants induce some metabolic pathways relevant to docetaxel. CYP450 and CYP3A show increased expression in response to the use of anticonvulsants and

Cortisol (8,617 words) [view diff] exact match in snippet view article find links to article

on voriconazole exposure and effect of voriconazole on the activity of CYP3A in patients with haematological malignancies". Xenobiotica. 51 (10): 1199–1206

Haloperidol (5,448 words) [view diff] exact match in snippet view article find links to article

is metabolized into HPP+, a monoaminergic neurotoxin related to MPTP, by CYP3A enzymes. Haloperidol is a crystalline material with a melting temperature

Amitriptyline (8,716 words) [view diff] exact match in snippet view article find links to article

von Moltke LL, Graf JA, et al. (October 2001). "Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies". Journal

Epoxydocosapentaenoic acid (1,976 words) [view diff] exact match in snippet view article find links to article

to epoxides include: CYP1A, CYP2B, CYP2C, CYP2E, CYP2J, and within the CYP3A subfamily, CYP3A4. In humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly

Mycoestrogen (1,243 words) [view diff] exact match in snippet view article find links to article

Lichti K, Staudinger JL (June 2006). "The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor". Toxicological Sciences.

Sean Ekins (2,665 words) [view diff] exact match in snippet view article find links to article

Ekins, S. et al. (2002) Pharmacophore insights into the active sites of the CYP3A enzymes. The Pharmacologist 44 Supplement, 114. Ethell, B.T.; et al. (2002)

List of MeSH codes (D08) (15,232 words) [view diff] case mismatch in snippet view article

972 – cytochrome p-450 cyp2e1 MeSH D08.244.453.040.986 – cytochrome p-450 cyp3a MeSH D08.244.453.085 – camphor 5-monooxygenase MeSH D08.244.453.915 – steroid

Epoxyeicosatrienoic acid (5,915 words) [view diff] exact match in snippet view article find links to article

subfamilies including CYP1A, CYP2B, CYP2C, CYP2E, CYP2J, and within the CYP3A sub family, CYP3A4; in humans, CYP2C8, CYP2C9, CYP2C19, CYP2J2, and possibly

COVID-19 drug development (13,287 words) [view diff] exact match in snippet view article find links to article

Nirmatrelvir inhibits SARS-CoV-2 main protease, while ritonavir is a strong CYP3A inhibitor, slowing down nirmatrelvir metabolism and therefore boosting its

Epoxyeicosatetraenoic acid (2,531 words) [view diff] exact match in snippet view article find links to article

(i.e.CYP1A), CYP2B, CYP2C, CYP2E, and CYP2J subfamilies, and within the CYP3A subfamily, CYP3A4. In humans, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19

Cyproterone acetate (14,112 words) [view diff] exact match in snippet view article find links to article

M (December 2005). "Functional interactions between P-glycoprotein and CYP3A in drug metabolism". Expert Opinion on Drug Metabolism & Toxicology. 1 (4):

Physiologically based pharmacokinetic modelling (3,156 words) [view diff] exact match in snippet view article find links to article

bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution". Journal of Pharmacy

Selegiline (20,202 words) [view diff] exact match in snippet view article find links to article

anticonvulsant carbamazepine, which is known to act as a strong inducer of CYP3A enzymes, has paradoxically been found to increase exposure to selegiline

Leon Aarons (1,599 words) [view diff] exact match in snippet view article find links to article

formulations can have [when there are] clinically-relevant DDI involving CYP3A substrates...[and that]... this aspect is generally overlooked when evaluating

Suzetrigine (1,002 words) [view diff] exact match in snippet view article find links to article

effectively than a placebo. Concomitant use of suzetrigine with strong CYP3A inhibitors is contraindicated. Common adverse effects of suzetrigine may

List of MeSH codes (D12.776) (7,397 words) [view diff] case mismatch in snippet view article

cytochrome p-450 cyp2e1 MeSH D12.776.422.220.453.040.972 – cytochrome p-450 cyp3a MeSH D12.776.422.220.453.085 – camphor 5-monooxygenase MeSH D12.776.422

Pharmacology of cyproterone acetate (14,472 words) [view diff] exact match in snippet view article find links to article

M (December 2005). "Functional interactions between P-glycoprotein and CYP3A in drug metabolism". Expert Opinion on Drug Metabolism & Toxicology. 1 (4):

Pharmacology of selegiline (14,235 words) [view diff] exact match in snippet view article find links to article

metabolism of selegiline have not been fully elucidated. CYP2B6, CYP2C9, and CYP3A are thought to be significantly involved in the metabolism of selegiline