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searching for CYP2D6 48 found (388 total)

alternate case: cYP2D6

Solanidine (1,389 words) [view diff] exact match in snippet view article find links to article

concentrations in CYP2D6 poor metabolizers as well as in patients utilizing CYP2D6 inhibitors compared with rapid metabolizers. Using paroxetine, a CYP2D6 inhibitor

Pyrithyldione (255 words) [view diff] exact match in snippet view article find links to article

Agranulocytosis was sometimes reported as adverse effect. Pyrithyldione is also a CYP2D6 inducer but is not as potent as glutethimide. In studies, it increased the

Aconitine (3,643 words) [view diff] exact match in snippet view article find links to article

Lv C, Zheng Z, Gong Y, Liu Z (April 2011). "Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant

3',4'-Methylenedioxy-α-pyrrolidinobutiophenone (511 words) [view diff] exact match in snippet view article find links to article

well as ring opening to the corresponding carboxylic acid. CYP2C19 and CYP2D6 have been identified as the isoenzymes mainly responsible for demethylenation

H1 antagonist (1,847 words) [view diff] exact match in snippet view article find links to article

Diphenhydramine 50 mg 2–3 hours 2–9 hours CYP2D6, others Yes Doxylamine 25 mg 2–3 hours 10–12 hours CYP2D6, others Yes Hydroxyzine 25–100 mg 2 hours 20

Deuterated drug (1,404 words) [view diff] exact match in snippet view article find links to article

(deutetrabenazine) (SD-809) Approved Reduce formation of toxic metabolite by CYP2D6 ALK-001 (d3-vitamin A) Phase 3 Slows the dimerization rate of vitamin A

Xanomeline (1,751 words) [view diff] exact match in snippet view article find links to article

M1 and M4 receptor activation. CYP2D6 significantly contributes to the metabolism of xanomeline. As a result, CYP2D6 polymorphisms are expected to affect

Ethnopsychopharmacology (955 words) [view diff] exact match in snippet view article find links to article

isoenzyme, leading to a greater risk of side effects and toxicity. The CYP2D6 enzyme, important for the way in which the liver clears many drugs from

Afimoxifene (470 words) [view diff] exact match in snippet view article find links to article

the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1062–1075

Repinotan (2,572 words) [view diff] exact match in snippet view article find links to article

WAY 100135 and its primary metabolizer is CYP2D6. Ethnic differences are known to have an effect on CYP2D6. Repinotan is believed to operate through neuronal

Deutetrabenazine (712 words) [view diff] exact match in snippet view article find links to article

Retrieved 5 November 2017. Dean L (May 2019). "Deutetrabenazine Therapy and CYP2D6 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical

N-Desmethyltamoxifen (244 words) [view diff] exact match in snippet view article find links to article

(March 2015). "Individualization of tamoxifen therapy: much more than just CYP2D6 genotyping". Cancer Treat Rev. 41 (3): 289–99. doi:10.1016/j.ctrv.2015.01

Benzhydrocodone (1,175 words) [view diff] exact match in snippet view article find links to article

hydrocodone by intestinal enzymes. Hydrocodone can undergo O-demethylation via CYP2D6, N-demethylation via CYP3A4 and 6-keto reduction. O-methylation of hydrocodone

List of investigational agitation drugs (822 words) [view diff] exact match in snippet view article find links to article

modulator, ionotropic glutamate NMDA receptor antagonist, other actions, and CYP2D6 inhibitor combination Deudextromethorphan/quinidine (AVP-786; CTP-786; d-DM)

Bruce Pollock (2,016 words) [view diff] exact match in snippet view article find links to article

examining bupropion's metabolism in relation to CYP2D6, he found that it is neither metabolized by nor inhibits CYP2D6, though hydroxybupropion levels were higher

Vijayalakshmi Ravindranath (800 words) [view diff] exact match in snippet view article find links to article

Vijayalakshmi (2014). "Occurrence, distribution and potential actions of CYP2D6 in the brain". pp. 102–116. doi:10.2217/fmeb2013.14.9. ISBN 978-1-78084-462-6

Coricidin (631 words) [view diff] exact match in snippet view article find links to article

Clinical data Trade names Coricidin 'D' Pharmacokinetic data Metabolism CYP2D6 isozyme of Cytochrome P450 Identifiers CAS Number 125-71-3 Y UNII 7355X3ROTS

Norpropoxyphene (804 words) [view diff] exact match in snippet view article find links to article

to nordextropropoxyphene: human in vitro and in vivo studies and lack of CYP2D6 involvement". Xenobiotica; the Fate of Foreign Compounds in Biological Systems

Dominance (genetics) (2,826 words) [view diff] exact match in snippet view article

Ingelman-Sundberg, M. (2005). "Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity"

Hydrocodone/paracetamol (1,873 words) [view diff] exact match in snippet view article find links to article

cytochrome P450 2D6. For individuals who have a defect in the gene encoding CYP2D6, the clearance of the drug will be lower and less metabolite such as hydromorphone

Hemolytic anemia (3,563 words) [view diff] exact match in snippet view article find links to article

Pirmohamed, Munir; Esquivel, Bernard (eds.), "Primaquine Therapy and G6PD and CYP2D6 Genotype", Medical Genetics Summaries, Bethesda (MD): National Center for

Nevirapine (3,017 words) [view diff] exact match in snippet view article find links to article

(April 2004). "Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females"

Para-Methoxyphenylpiperazine (558 words) [view diff] exact match in snippet view article find links to article

only) NZ: Class C Pharmacokinetic data Metabolism The human liver P450 CYP2D6 converts para-methoxyphenylpiperazine by demethylation to para-hydroxyphenylpiperazine

Latin Americans (5,319 words) [view diff] exact match in snippet view article find links to article

Network of Pharmacogenetics and Pharmacogenomics (2020). "Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans". Clinical Pharmacology and Therapeutics

Moxifloxacin (3,369 words) [view diff] exact match in snippet view article find links to article

(CYP) P450 enzymes indicate that moxifloxacin does not inhibit 80 CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2, suggesting that moxifloxacin is unlikely to

Urs A. Meyer (812 words) [view diff] exact match in snippet view article find links to article

team identified the genes and mutations for the enzyme cytochrome P450 CYP2D6 and for N-acetyltransferase 2 and developed the first pharmacogenetic DNA

Pramipexole (4,584 words) [view diff] exact match in snippet view article find links to article

showing no signs of any metabolism. Pramipexole has been shown to inhibit CYP2D6 with a Ki of 30μM which is significantly higher than the maximum approved

Disulfiram (3,187 words) [view diff] exact match in snippet view article find links to article

chronic disulfiram administration on the activities of CYP1A2, CYP2C19, CYP2D6, CYP2E1, and N-acetyltransferase in healthy human subjects". British Journal

Cytochrome P450 reductase (2,455 words) [view diff] exact match in snippet view article find links to article

"Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro". Pharmacogenetics and Genomics. 20 (11): 677–86. doi:10.1097/FPC

Atenolol (3,692 words) [view diff] exact match in snippet view article find links to article

hepatically metabolized; whereas metoprolol and carvedilol are metabolized by CYP2D6. DDIs are mainly observed with those β-blockers that are metabolized via

Rachel Tyndale (694 words) [view diff] exact match in snippet view article find links to article

Thesis Genetically polymorphic P450IID1 (sparteine/debrisoquine - type CYP2D6): neuronal characterization and structural variants (1992) Academic work

Discovery and development of triptans (2,837 words) [view diff] exact match in snippet view article find links to article

7 MAO-A Urine Almotriptan Tablets 6.25, 12.5 25 60–180 Short 7.8 MAO-A CYP2D6 CYP3A4 Urine (40%), Feces (13%) Eletriptan Tablets 20, 40 80 <60 – 8.9 CYP3A4

22q13 deletion syndrome (4,022 words) [view diff] exact match in snippet view article find links to article

ARFGAP3 A4GALT ATP5L2 DL490307 CYB5R3 RNU12 POLDIP3 SERHL2 RRP7A NFAM1 TCF20 CYP2D6 NDUFA6 SMDT1 FAM109B NAGA WBP2NL CENPM TNFRSF13C SHISA8 SREBF2 CCDC134 MEI1

Collen Masimirembwa (1,024 words) [view diff] exact match in snippet view article find links to article

Hasler; M, Ingelman-Sundberg (1996). "A novel mutant variant of the CYP2D6 gene (CYP2D6*17) common in a black African population: association with diminished

Medical cannabis (10,232 words) [view diff] exact match in snippet view article find links to article

CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. Similar to delta-9-THC, a majority of CBD is excreted in feces and some

Nanopore sequencing (4,661 words) [view diff] exact match in snippet view article find links to article

PMID 27457073. Ammar R, Paton TA, Torti D, Shlien A, Bader GD (2015). "CYP2D6 variants and haplotypes". F1000Research. 4: 17. doi:10.12688/f1000research

Somatic evolution in cancer (9,928 words) [view diff] exact match in snippet view article find links to article

estrogen agonist. Reduced metabolic activation of tamoxifen Polymorphisms in CYP2D6 show variable rates of conversion of tamoxifen to its activated, anti-estrogenic

Sean Ekins (2,665 words) [view diff] exact match in snippet view article find links to article

dimensional-quantitative structure activity relationship (3D / 4D-QSAR) analyses of CYP2D6 inhibitors". Pharmacogenetics. 9 (4): 477–489. PMID 10780267. Ekins, S.;

List of investigational antidepressants (11,540 words) [view diff] exact match in snippet view article find links to article

inhibitor, ionotropic glutamate NMDA receptor antagonist, other actions, and CYP2D6 inhibitor combination Dimethyltryptamine (N,N-Dimethyltryptamine; DMT; N

Opioid use disorder (15,043 words) [view diff] exact match in snippet view article find links to article

patients) because of their effects on inducing CYP enzymes. Genotyping of CYP2D6 in particular may play a role in helping patients with individualized treatment

Mestizos in Mexico (5,591 words) [view diff] exact match in snippet view article find links to article

Francisco; Alanis-Bañuelos, Ruth E.; Lares-Asseff, Ismael (May 2006). "CYP2D6 Genotype and Phenotype in Amerindians of Tepehuano Origin and Mestizos of

White Mexicans (12,050 words) [view diff] exact match in snippet view article find links to article

Francisco; Alanis-Bañuelos, Ruth E.; Lares-Asseff, Ismael (May 2006). "CYP2D6 Genotype and Phenotype in Amerindians of Tepehuano Origin and Mestizos of

Epoxyeicosatetraenoic acid (2,531 words) [view diff] exact match in snippet view article find links to article

consisting of 17R,18S-EEQ but no detectable 17S,18R-EEQ and those made by CYP2D6 consisting principally of 17R,18S-EEQ with far smaller amounts of 17S,18R-EEQ

Robert J. Desnick (3,726 words) [view diff] exact match in snippet view article find links to article

Edelmann, L, Kornreich, R, Erazo, M and Desnick, RJ: CYP2C9, CYP2C19, and CYP2D6 allele frequencies in the Ashkenazi Jewish population. Pharmacogenomics

Hugo Barrera Saldaña (1,115 words) [view diff] exact match in snippet view article find links to article

12/2013; 506(7488). Comparative study of polymorphism frequencies of the CYP2D6, CYP3A5, CYP2C8 and IL-10 genes in Mexican and Spanish women with breast

Adrenergic blocking agent (3,639 words) [view diff] exact match in snippet view article find links to article

Ludwig; Wein, Martina; Michel, Martin C (2011-08-01). "Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics

N,O-Didesmethyltramadol (305 words) [view diff] exact match in snippet view article find links to article

(2): 116–121. doi:10.1007/s002100000266. PMID 10961373. Leppert W (2011). "CYP2D6 in the metabolism of opioids for mild to moderate pain". Pharmacology. 87

List of investigational hallucinogens and entactogens (12,087 words) [view diff] exact match in snippet view article find links to article

modulator, ionotropic glutamate NMDA receptor antagonist, other actions, CYP2D6 inhibitor, and dissociative hallucinogen combination – major depressive