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searching for CYP2C9 32 found (208 total)

alternate case: cYP2C9

Tienilic acid (614 words) [view diff] exact match in snippet view article find links to article

had liver failure after taking this drug contained antibodies recognizing CYP2C9 able to hydroxylate the drug and to give covalent binding. The above explanation

Tecarfarin (520 words) [view diff] exact match in snippet view article find links to article

warfarin patients (pint=0.16); among patients who had both a CYP2C9 variant allele and taking a CYP2C9 interacting drug, TTR was 76.5% and 69.5% for the tecarfarin

Gliclazide (1,454 words) [view diff] exact match in snippet view article find links to article

in human beings, mainly methylhydroxygliclazide and carboxygliclazide. CYP2C9 is involved in the formation of hydroxygliclazide in human liver microsomes

Coronaric acid (1,139 words) [view diff] exact match in snippet view article find links to article

linoleic acid by cytochrome P450 (CYP) epoxygenase enzymes. These CYPs (CYP2C9 and probably other CYPs that metabolize polyunsaturated fatty acids to epoxides)

Lobeglitazone (582 words) [view diff] exact match in snippet view article find links to article

South Korea Pharmacokinetic data Protein binding >99% Metabolism liver (CYP2C9, 2C19, and 1A2) Elimination half-life 7.8–9.8 hours Identifiers IUPAC name

Aconitine (3,598 words) [view diff] exact match in snippet view article find links to article

16-O-Demethyl-aconitine CYP3A4, CYP3A5, CYP2D6, CYP2C9 M3 N-deethyl-aconitine CYP3A4, CYP3A5, CYP2D6, CYP2C9 M4 O-didemethyl-aconitine CYP3A5, CYP2D6 M5

Robert J. Desnick (3,726 words) [view diff] exact match in snippet view article find links to article

PMID 17533632 Scott, SA, Edelmann, L, Kornreich, R, Erazo, M and Desnick, RJ: CYP2C9, CYP2C19, and CYP2D6 allele frequencies in the Ashkenazi Jewish population

Flavones (976 words) [view diff] exact match in snippet view article find links to article

PMID 17073577. Si D, Wang Y, Zhou YH, et al. (March 2009). "Mechanism of CYP2C9 inhibition by flavones and flavonols". Drug Metab. Dispos. 37 (3): 629–34

Umbralisib (1,275 words) [view diff] exact match in snippet view article find links to article

status Legal status US: ℞-only / withdrawn Pharmacokinetic data Metabolism CYP2C9, CYP3A4, and CYP1A2 Elimination half-life 91 h Excretion Feces, urine Identifiers

Macrolide (2,804 words) [view diff] exact match in snippet view article find links to article

Another option is to use fluvastatin, a statin that is metabolized by CYP2C9, an enzyme that is not inhibited by clarithromycin. Macrolides, including

Piroxicam (830 words) [view diff] exact match in snippet view article find links to article

Rheumatology. 4 (4): 393–404. PMID 342691. Dean L (2019). "Piroxicam Therapy and CYP2C9 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical

Rifapentine (961 words) [view diff] exact match in snippet view article find links to article

rifampicin and rifabutin. Rifapentine induces metabolism by CYP3A4, CYP2C8 and CYP2C9 enzymes. It may be necessary to adjust the dosage of drugs metabolized by

Butabarbital (1,576 words) [view diff] exact match in snippet view article find links to article

Half-Life: ~100 hr Duration: 6-8 hr Onset: 45-60 min Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4 Excretion: Urine The mechanism of action by which barbiturates

Prasugrel (2,035 words) [view diff] exact match in snippet view article find links to article

which is then converted by CYP3A4 and CYP2B6, and to a minor extent by CYP2C9 and CYP2C19, to a pharmacologically active metabolite (R-138727). R-138727

ALDH1A1 (1,510 words) [view diff] exact match in snippet view article find links to article

2008). "Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics

Bromazolam (2,075 words) [view diff] exact match in snippet view article find links to article

bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally, CYP2C9 was found to catalyse the formation of α-hydroxy bromazolam as well. α-4-dihydroxy

Constitutive androstane receptor (2,272 words) [view diff] exact match in snippet view article find links to article

LeCluyse EL, Negishi M, Goldstein JA (Sep 2002). "Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding

Abrocitinib (2,608 words) [view diff] exact match in snippet view article find links to article

abrocitinib is metabolized mainly by cytochrome P450 (CYP450) in liver such as CYP2C9, CYP2C19, CYP3A4 and CYP2B6. The major metabolites of abrocitinib are pyrrolidinone

Lacosamide (3,809 words) [view diff] exact match in snippet view article find links to article

is eliminated in the feces. The major metabolic pathway of lacosamide is CYP2C9, CY2C19, and CYP3A4-mediated demethylation. The dose-response curve for

Asciminib (1,212 words) [view diff] exact match in snippet view article find links to article

a substrate of the CYP3A4 enzyme. Asciminib is an inhibitor of CYP3A4, CYP2C9, and P-glycoprotein. Asciminib reaches steady state in 3 days. The volume

Discovery and development of cyclooxygenase 2 inhibitors (4,463 words) [view diff] exact match in snippet view article find links to article

oral doses, between 100 and 800 mg. Celecoxib is metabolized primarily by CYP2C9 isoenzyme to carboxylic acid and also by non-CYP-dependent glucuronidation

Medical cannabis (9,930 words) [view diff] exact match in snippet view article find links to article

rather than by urine. After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30

Moxifloxacin (3,378 words) [view diff] exact match in snippet view article find links to article

enzymes indicate that moxifloxacin does not inhibit 80 CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2, suggesting that moxifloxacin is unlikely to alter the

Ritonavir (3,407 words) [view diff] exact match in snippet view article find links to article

"Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of

Ketamine (11,355 words) [view diff] exact match in snippet view article find links to article

Hijazi Y, Boulieu R (July 2002). "Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes". Drug

Personalized medicine (9,261 words) [view diff] exact match in snippet view article find links to article

prescribed drugs. However, with the discovery of polymorphic variants in CYP2C9 and VKORC1 genotypes, two genes that encode the individual anticoagulant

Eicosanoid (9,517 words) [view diff] exact match in snippet view article find links to article

The human cytochrome P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize arachidonic acid

Jonathan L. Halperin (1,773 words) [view diff] exact match in snippet view article find links to article

Kornreich, Ruth; Halperin, Jonathan L; Desnick, Robert J (August 2009). "CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic

Elagolix (6,216 words) [view diff] exact match in snippet view article find links to article

fluconazole (a strong inhibitor of CYP2C19 and a moderate inhibitor of CYP2C9 and CYP3A4). Elagolix is a substrate of the hepatic OATP1B1 transporter

Cornelia Ulrich (1,119 words) [view diff] exact match in snippet view article find links to article

Robert S.; McKeown-Eyssen, Gail E.; Ulrich, Cornelia M. (August 29, 2015). "CYP2C9 Variants Increase Risk of Colorectal Adenoma Recurrence and Modify Associations

Jorge H. Capdevila (2,441 words) [view diff] exact match in snippet view article find links to article

NSCLC in carriers of two known reduction of function variants of the human CYP2C9 Epoxygenase gene. In summary, Capdevila and collaborators contributed to

Hugo Zeberg (1,612 words) [view diff] exact match in snippet view article find links to article

Svante; Zeberg, Hugo (July 30, 2022). "The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals". The Pharmacogenomics Journal