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searching for CTLA-4 51 found (127 total)

alternate case: cTLA-4

Hashimoto's thyroiditis (6,042 words) [view diff] exact match in snippet view article find links to article

CTLA-4 gene polymorphisms may contribute to the reduced inhibition of T-cell proliferation and increase susceptibility to autoimmune response. CTLA-4
T helper 3 cell (1,239 words) [view diff] exact match in snippet view article find links to article
4 (CTLA-4), which is constitutively expressed on naturally arising Treg cells, it is possible that TGF-β production from Treg cells through CTLA-4− mediated
Anti-topoisomerase antibodies (858 words) [view diff] exact match in snippet view article find links to article
PMID 16525896. Sato S, Fujimoto M, Hasegawa M, et al. (2004). "Serum soluble CTLA-4 levels are increased in diffuse cutaneous systemic sclerosis". Rheumatology
KLRG1 (1,599 words) [view diff] exact match in snippet view article find links to article
widespread interest (e.g., CTLA-4, PD-1, and its ligand PD-L1). Unlike the obvious enhanced immune activation present in CTLA-4 and PD-1 gene knockout mice
Immunologic checkpoint (385 words) [view diff] exact match in snippet view article find links to article
autoimmunity. Examples of such a molecule are cytotoxic T-lymphocyte antigen 4 (CTLA-4 or CD152), which is an inhibitory receptor found on immune cells and programmed
Craig B. Thompson (2,338 words) [view diff] exact match in snippet view article find links to article
Thompson identified the evolutionary duplication of CD28 into CD28 and CTLA-4 and demonstrated that CTLA4 had an inhibitory effect on immune activation
Peter Fecci (2,110 words) [view diff] exact match in snippet view article find links to article
immunotherapeutic strategy in brain tumor models: “Systemic blockade of CTLA-4 ameliorates glioma-induced changes to the CD4 T-cell compartment without
VISTA (protein) (1,098 words) [view diff] exact match in snippet view article
Library of Medicine. Le Mercier I, Lines JL, Noelle RJ (August 2015). "Beyond CTLA-4 and PD-1, the Generation Z of Negative Checkpoint Regulators". Frontiers
Alloimmunity (2,380 words) [view diff] exact match in snippet view article find links to article
T-lymphocytes that cause inhibition of T-cell activation (for instance CD152/CTLA-4 receptor which binds CD80 and CD86 as well). If T-lymphocyte does not receive
TXK (gene) (715 words) [view diff] exact match in snippet view article
phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4". Biochem. Biophys. Res. Commun. 252 (1): 14–9. doi:10.1006/bbrc.1998.9559
Treatment of cancer (7,256 words) [view diff] exact match in snippet view article find links to article
two "checkpoint" proteins, cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4) and programmed death 1 (PD-1). Under normal conditions, the immune system
HLA-DR53 (704 words) [view diff] exact match in snippet view article find links to article
Fukazawa T, Maruyama H, Saruta T (2003). "Interactions of HLA-DRB4 and CTLA-4 genes influence thyroid function in Hashimoto's thyroiditis in Japanese
MedImmune (798 words) [view diff] exact match in snippet view article find links to article
Major phase III trials include: durvalumab (anti-PD-L1) tremelimumab (anti-CTLA-4) moxetumomab pasudotox (anti-CD22) benralizumab (anti-IL-5R) tralokinumab
Non-small-cell lung carcinoma (4,602 words) [view diff] exact match in snippet view article find links to article
monoclonal antibody that targets Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on the surface of T cells. Bevacizumab is a monoclonal antibody that targets
Interleukin 35 (1,663 words) [view diff] exact match in snippet view article find links to article
prostate tumor antigen-specific CD8+ regulatory T cells are inhibited by CTLA-4 or IL-35 blockade". Journal of Immunology. 189 (12): 5590–601. doi:10.4049/jimmunol
Thymoglobulin (834 words) [view diff] exact match in snippet view article find links to article
a number of regulatory cell markers in vitro, including CD25, GITR, and CTLA-4 (aka CD152, functions as immune checkpoint, downregulates immune response)
Epigenetics of autoimmune disorders (5,683 words) [view diff] exact match in snippet view article find links to article
significantly higher levels of methylation in the CTLA-4 region is observed in MG patients compared to controls. CTLA-4 gene expression serves as a negative regulator
LRRC23 (771 words) [view diff] exact match in snippet view article find links to article
PMID 11830501. Chang TT, Kuchroo VK, Sharpe AH (Feb 2002). "Role of the B7-CD28/CTLA-4 pathway in autoimmune disease". Signal Transduction Pathways in Autoimmunity
Trastuzumab deruxtecan (1,563 words) [view diff] exact match in snippet view article find links to article
deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model". PLOS ONE. 14 (10): e0222280. Bibcode:2019PLoSO
Adaptor complexes medium subunit domain (339 words) [view diff] case mismatch in snippet view article find links to article
mu2 adaptin subunit (ap50) of ap2 adaptor (second domain), complexed with ctla-4 internalization peptide ttgvyvkmppt Identifiers Symbol Adap_comp_sub Pfam
VTCN1 (1,019 words) [view diff] exact match in snippet view article find links to article
(July 2003). "BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1". Nature Immunology. 4 (7): 670–9. doi:10.1038/ni944. PMID 12796776
Abscopal effect (1,079 words) [view diff] exact match in snippet view article find links to article
“Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res. 2005;11:728‐734
GPLD1 (968 words) [view diff] exact match in snippet view article find links to article
Manzotti CN, Perry LC, Liu MK, Burke F, et al. (April 2005). "Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated
Epigenetics of neurodegenerative diseases (13,393 words) [view diff] exact match in snippet view article find links to article
has not been widely researched. Research in China has identified the gene CTLA-4 (cytotoxic T lymphocyte antigen-4) as being highly methylated in myasthenia
TNFRSF18 (2,147 words) [view diff] exact match in snippet view article find links to article
agonistic antibodies is enhanced in combination with anti-PD-1 or anti-CTLA-4 therapies. GITR-/- mice in pancreatitis model have reduced IkBα and decreased
Tang Prize (1,114 words) [view diff] exact match in snippet view article find links to article
Biopharmaceutical Science James P. Allison  United States "for the discoveries of CTLA-4 and PD-1 as immune inhibitory molecules that led to their applications in
Vijay Kuchroo (2,114 words) [view diff] exact match in snippet view article find links to article
autoimmunity and cancer. Similar to other checkpoint inhibitors such as PD-1 and CTLA-4, TIM-3 has been successfully targeted to treat several solid and hematogenous
Oncology (5,619 words) [view diff] no match in snippet view article find links to article
surgery, radiation, targeted therapy (BRAF & MEK inhibitors), Immunotherapy (CTLA 4 & PD 1 inhibitors, and chemotherapy. Kidney cancer Treatment options include
Agenus (991 words) [view diff] exact match in snippet view article find links to article
cancer. Agenus has programs targeting the checkpoint modulators GITR, OX40, CTLA-4, LAG-3, TIM-3 and PD-1. The company is expanding that portfolio by using
Harvey Prize (3,102 words) [view diff] exact match in snippet view article find links to article
co-stimulatory molecule CD28 and the discovery of a critical T-cell inhibitor CTLA-4." 2014 – Reinhard Genzel, Germany – "in recognition of developing many novel
Nivolumab (4,159 words) [view diff] exact match in snippet view article find links to article
Paclitaxel in Advanced Melanoma Patients That Have Progressed Following Anti-CTLA-4 Therapy (CheckMate 037)" at ClinicalTrials.gov Clinical trial number NCT01721772
Atezolizumab (3,851 words) [view diff] exact match in snippet view article find links to article
monoclonal antibody that targets Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on the surface of T cells. Bevacizumab is a monoclonal antibody that targets
Adjuvant therapy (3,995 words) [view diff] exact match in snippet view article find links to article
April 2013). "Immune-Mediated Adverse Events Associated with Ipilimumab CTLA-4 Blockade Therapy: The Underlying Mechanisms and Clinical Management". Scientifica
Granulomatous–lymphocytic interstitial lung disease (904 words) [view diff] exact match in snippet view article find links to article
also been associated with specific genetic mutations in CVID, including CTLA-4 deficiency. The diagnosis is usually suspected following a CT scan. Typical
Fascin (1,554 words) [view diff] exact match in snippet view article find links to article
suppression of antigen presenting cells is a multi-step process. In addition to CTLA-4 CD80/CD86 interaction fascin dependent polarization of cytoskeleton towards
Immunotransplant (1,435 words) [view diff] exact match in snippet view article find links to article
been considered to amplify T cell mediated immune responses(e.g. IL-2, CTLA-4, IL-7, CD137), and some of these have shown clinical efficacy in eliminating
Trogocytosis (2,125 words) [view diff] exact match in snippet view article find links to article
of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4". Science. 332 (6029): 600–603. Bibcode:2011Sci...332..600Q. doi:10.1126/science
PTPN22 (3,896 words) [view diff] exact match in snippet view article find links to article
PMID 15790351. S2CID 30275010. Brand O, Gough S, Heward J (October 2005). "HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?". Expert Reviews
Type 1 regulatory T cell (1,883 words) [view diff] exact match in snippet view article find links to article
Cell to cell contact: Type 1 regulatory T cells poses inhibitory receptor CTLA-4 through which they exert suppressor function. Metabolic disruption: Tr1
Macrophage (8,196 words) [view diff] exact match in snippet view article find links to article
J, Allison JP (May 2019). "TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion". Proceedings of the
Yang Liu (immunologist) (737 words) [view diff] exact match in snippet view article
Immunol. 2009;30(12):557-61. [5] Du X, Tang F, Liu M, et al. A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy. Cell Res. 2018;28(4):416-432
Photoimmunotherapy (1,001 words) [view diff] exact match in snippet view article find links to article
by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis". Adv Mater. 26 (48): 8154–62. doi:10
Gamma delta T cell (4,444 words) [view diff] exact match in snippet view article find links to article
in the TME expression of transcription factors (FoxP3, Helios) and CD86-CTLA-4 interaction between APCs and γδ T cells. They also impair effector immune
HAVCR2 (2,866 words) [view diff] exact match in snippet view article find links to article
autoimmunity and cancer. Similar to other checkpoint inhibitors such as PD-1 and CTLA-4, TIM-3 has been successfully targeted to treat several solid and hematogenous
Photodynamic therapy (10,211 words) [view diff] exact match in snippet view article find links to article
by photothermal therapy with carbon nanotubes in combination with anti-CTLA-4 therapy to inhibit cancer metastasis". Adv Mater. 26 (48): 8154–62. doi:10
MiR-155 (10,406 words) [view diff] exact match in snippet view article find links to article
the proliferative response of T(H) cells through the downregulation of CTLA-4. In Autoimmune disorders such as rheumatoid arthritis, miR-155 showed higher
Tolerogenic dendritic cell (2,762 words) [view diff] exact match in snippet view article find links to article
dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4" (PDF). Nature Immunology. 6 (3): 280–6. doi:10.1038/ni1165. PMID 15685176
List of autoimmune diseases (3,389 words) [view diff] exact match in snippet view article find links to article
antibodies. Thyroid gland Autoimmune thyroiditis Strong, A IV 245.8 HLADR5, CTLA-4. Autoantibodies: Antibodies against thyroid peroxidase and/or thyroglobulin
Carla V. Rothlin (2,718 words) [view diff] exact match in snippet view article find links to article
immune system, blocking the cellular breaking system on T cells (such as CTLA-4 and PD-1 inhibitors) to enhance immunogenicity of the tumor microenvironment
Treatment of lung cancer (6,175 words) [view diff] exact match in snippet view article find links to article
monoclonal antibody that targets Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) on the surface of T cells. Bevacizumab is a monoclonal antibody that targets
Tumor antigens recognized by T lymphocytes (2,553 words) [view diff] exact match in snippet view article find links to article
Wolchok J. D., Chan T. A. 2014. " Genetic basis for clinical response to CTLA-4 blockade in melanoma ". The New England Journal of Medicine. 371(23): 2189-2199