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searching for CDK inhibitor 49 found (61 total)

CDKN1B (5,152 words) [view diff] no match in snippet view article find links to article

protein which belongs to the Cip/Kip family of cyclin dependent kinase (Cdk) inhibitor proteins. The encoded protein binds to and prevents the activation of

Sic1 (2,608 words) [view diff] case mismatch in snippet view article find links to article

the nucleus to the cytoplasm and avoids further transcription of the cdk inhibitor. Cdc28-Clb also phosphorylates any Sic1 molecules still available and

CDKN2D (1,227 words) [view diff] exact match in snippet view article find links to article

Zeslawski W, et al. (2002). "Protein folding and stability of human CDK inhibitor p19(INK4d)". J. Mol. Biol. 315 (3): 447–57. doi:10.1006/jmbi.2001.5242

Ovarian follicle activation (4,011 words) [view diff] no match in snippet view article find links to article

Ovarian follicle activation can be defined as primordial follicles in the ovary moving from a quiescent (inactive) to a growing phase. The primordial follicle

Cyclin-dependent kinase inhibitor 1C (2,000 words) [view diff] case mismatch in snippet view article find links to article

(Mar 1995). "p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene". Genes & Development.

CIP/KIP (2,181 words) [view diff] case mismatch in snippet view article find links to article

SJ (1995). "p57kip2, a structureally distinct member of the p21 cip1 cdk inhibitor family, is a candidate tumor suppressor gene". Genes & Development.

Cyclin-dependent kinase 3 (771 words) [view diff] case mismatch in snippet view article find links to article

family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6):

Nicolas H. Thomä (1,658 words) [view diff] exact match in snippet view article find links to article

S.; Thomä, Nicolas H.; Ebert, Benjamin L. (10 September 2020). "The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K". Nature

Cyclin-dependent kinase 10 (729 words) [view diff] case mismatch in snippet view article find links to article

family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6):

Fuzzy complex (1,914 words) [view diff] case mismatch in snippet view article find links to article

"Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21". Nature Chemical Biology. 7 (4): 214–21. doi:10.1038/nchembio.536

Pho4 (859 words) [view diff] exact match in snippet view article find links to article

cyclin dependent inhibitor PHO81. In low concentrations of phosphate the CDK inhibitor PHO80-PHO85 is able to inhibit PHO80-PHO85 from phosphorylating PHO4

Fasudil (1,191 words) [view diff] no match in snippet view article find links to article

degradation rate of p27Kip1. p27Kip1 is a cyclin-dependent kinase (CDK) inhibitor which down-regulates cell cycle by binding cyclin-CDK complex. Human

CDK-activating kinase (1,140 words) [view diff] case mismatch in snippet view article find links to article

located in the Cdk activation segment. Since Cdks need to be free of Cdk inhibitor proteins (CKIs) and associated with cyclins in order to be activated

Cyclin A1 (1,435 words) [view diff] no match in snippet view article find links to article

family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins. Cyclin-A1 interacts with: CDC20, Cyclin-dependent kinase 2

CDKN2B (1,386 words) [view diff] exact match in snippet view article find links to article

Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15". Nature. 387 (6631): 417–22. Bibcode:1997Natur.387..417L. doi:10

P27 cis-regulatory element (384 words) [view diff] case mismatch in snippet view article find links to article

Polyak K, Kato JY, Solomon MJ, et al. (January 1994). "p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell

INK4 (1,459 words) [view diff] exact match in snippet view article find links to article

Coffield VM, Xiong Y, Su L (September 2001). "An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation"

Tony Pawson (biochemist) (1,275 words) [view diff] exact match in snippet view article

F.; Pawson, T.; Tyers, M. (2001). "Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication". Nature. 414 (6863):

OGFr (1,564 words) [view diff] no match in snippet view article find links to article

increase in the synthesis of the selective cyclin-dependent kinase (CDK) inhibitor proteins, p12 and p16. Retinoblastoma protein becomes inactivated through

Ornithine decarboxylase (2,082 words) [view diff] no match in snippet view article find links to article

et al. (2000), which demonstrated that the cyclin-dependent kinase (Cdk) inhibitor p21Cip1 is also degraded by the proteasome in a ubiquitin-independent

Cyclin A (1,753 words) [view diff] exact match in snippet view article find links to article

the p53-pRb pathway. Activated p53 turns on genes for p21. P21 is a CDK inhibitor that binds to several cyclin/CDK complexes, including cyclin A-CDK2/1

Cyclin D (4,605 words) [view diff] case mismatch in snippet view article find links to article

Other than Rb, viral cyclin D-Cdk6 complex also targets p27Kip, a Cdk inhibitor of cyclin E and A. In addition, viral cyclin D-Cdk6 is resistant to

Charles Swanton (857 words) [view diff] exact match in snippet view article find links to article

Nic (1997). "Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins". Nature. 390 (6656): 184–187. Bibcode:1997Natur.390..184S

MYC (1,136 words) [view diff] exact match in snippet view article find links to article

with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)". Mol. Cell. 9 (1): 133–43. doi:10.1016/s1097-2765(01)00430-0

CD80 (2,435 words) [view diff] exact match in snippet view article find links to article

Coffield VM, Xiong Y, Su L (September 2001). "An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation"

ATM serine/threonine kinase (5,684 words) [view diff] exact match in snippet view article find links to article

and subsequent transcription of numerous p53 target genes including CDK inhibitor p21 which lead to long-term cell-cycle arrest or even apoptosis. The

Mir-26 microRNA precursor family (3,054 words) [view diff] exact match in snippet view article find links to article

E2, and cyclin-dependent kinases CDK4 and CDK6. p14ARF and p21CIPI CDK inhibitor expression are conversely enhanced, mediated chiefly by EZH2 expression

RUNX2 (2,246 words) [view diff] exact match in snippet view article find links to article

Furthermore, Runx2 controls the gene expression of cyclin D2, D3, and the CDK inhibitor p21(cip1) in hematopoietic cells. It has been shown that on a molecular

Cyclin-dependent kinase 1 (2,896 words) [view diff] case mismatch in snippet view article find links to article

Pom1. Cdk1-cyclin complexes are also governed by direct binding of Cdk inhibitor proteins (CKIs). One such protein, already discussed, is Sic1. Sic1

Mothers against decapentaplegic homolog 2 (1,925 words) [view diff] exact match in snippet view article find links to article

with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)". Mol. Cell. 9 (1): 133–43. doi:10.1016/S1097-2765(01)00430-0

Cell division (4,735 words) [view diff] exact match in snippet view article find links to article

E2) CDK 1 2 3 4 5 6 7 8 9 10 11A 11B 12 13 14 CDK-activating kinase CDK inhibitor INK4a/ARF (p14arf/p16, p15, p18, p19) cip/kip (p21, p27, p57) P53 p63

Glial scar (2,962 words) [view diff] no match in snippet view article find links to article

recovery. Olomoucine, a purine derivative, is a cyclin-dependent kinase (CDK) inhibitor. CDK is a cell-cycle promoting protein, which along with other pro-growth

P16 (4,271 words) [view diff] exact match in snippet view article find links to article

of p53. In spite of their structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory

Cellularization (1,935 words) [view diff] exact match in snippet view article find links to article

Saitoh (2010). "The syncytium-specific expression of the Orysa;KRP3 CDK inhibitor: implication of its involvement in the cell cycle control in the rice

Transcription factor Jun (5,452 words) [view diff] exact match in snippet view article find links to article

of c-jun, the expression of p53 (cell cycle arrest inducer) and p21 (CDK inhibitor and p53 target gene) is increased, and those cells exhibit cell cycle

CDC20 (3,307 words) [view diff] case mismatch in snippet view article find links to article

immediately be reactivated. Multiple different mechanisms inhibit Cdks in G1: Cdk inhibitor proteins are expressed, and cyclin gene expression is down-regulated

Mouse model of colorectal and intestinal cancer (2,530 words) [view diff] case mismatch in snippet view article find links to article

D, Carroll RE, Tyner AL (2004). "Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon". Oncogene. 23 (49): 8128–34. doi:10.1038/sj

Raymond J. Deshaies (2,482 words) [view diff] case mismatch in snippet view article find links to article

Skp1, and Cdc53/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1. Cell 91, 221-230 Petroski, M.D. and Deshaies, R. J. (2005). Function

Myc (6,672 words) [view diff] exact match in snippet view article find links to article

with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)". Molecular Cell. 9 (1): 133–43. doi:10.1016/s1097-2765(01)00430-0

Cyclin D1 (5,694 words) [view diff] exact match in snippet view article find links to article

motif; cyclin box domain for cyclin-dependent kinase (CDK) binding and CDK inhibitor binding; LxxLL binding motif for co-activator recruitment; PEST sequence

Cell cycle (9,093 words) [view diff] case mismatch in snippet view article find links to article

rise and fall in parallel with cyclin levels, although in some cases Cdk inhibitor proteins or phosphorylation introduce a delay between the formation

Cellular senescence (6,427 words) [view diff] no match in snippet view article find links to article

escape a senescent fate. The p16 protein is a cyclin dependent kinase (CDK) inhibitor and it activates Rb tumor suppressor. p16 binds to CDK 4/6 to inhibit

CUL4B (2,948 words) [view diff] exact match in snippet view article find links to article

Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T (Oct 2008). "CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2

SKP2 (3,999 words) [view diff] exact match in snippet view article find links to article

1999). "SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27". Nature Cell Biology. 1 (4): 193–9. doi:10.1038/12013. PMID 10559916

CUL4A (4,418 words) [view diff] exact match in snippet view article find links to article

Shiomi Y, Iida H, Michishita M, Takami T, Tsurimoto T (Oct 2008). "CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2

DNA damage (naturally occurring) (10,128 words) [view diff] exact match in snippet view article

transcription factors for both bax, a proapoptotic protein as well as p21, a CDK inhibitor. CDK Inhibitors result in cell cycle arrest. Arresting the cell provides

Induced cell cycle arrest (3,275 words) [view diff] case mismatch in snippet view article find links to article

growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells". Oncology Reports. 28 (6):

Molecular glue (4,143 words) [view diff] exact match in snippet view article find links to article

Petzold G, Li YD, Manojkumar M, Bunker RD, et al. (September 2020). "The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K". Nature

CSNK1D (14,740 words) [view diff] exact match in snippet view article find links to article

treatment of cells with the PKC-specific inhibitor Gö-6983 or the pan-CDK inhibitor dinaciclib. These findings indicate, that site-specific phosphorylation