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searching for BRCA1 217 found (515 total)

alternate case: bRCA1

DUSP3 (1,339 words) [view diff] exact match in snippet view article find links to article

by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although
Oophorectomy (3,591 words) [view diff] exact match in snippet view article find links to article
Specifically, RRSO provides BRCA1 mutation carriers with no prior breast cancer a 70% reduction of ovarian cancer risk. BRCA1 mutation carriers with prior
In the Family (2008 film) (358 words) [view diff] exact match in snippet view article
supporting a lawsuit made by the ACLU challenging the patent ownership of the BRCA1 and BRCA2 genes - the genes responsible for ovarian and breast cancer. Because
NBR1 (864 words) [view diff] exact match in snippet view article find links to article
Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was originally identified as
Ovary (3,426 words) [view diff] exact match in snippet view article find links to article
genetic factors. Women with an inherited mutation in the DNA repair gene BRCA1 undergo menopause prematurely, suggesting that naturally occurring DNA damages
BABAM1 (1,056 words) [view diff] exact match in snippet view article find links to article
BRCA1-A complex subunit MERIT40 is a protein that in humans is encoded by the BABAM1 gene. BABAM1 has been shown to interact with BRE. MERIT40, the protein
Nijmegen breakage syndrome (1,002 words) [view diff] exact match in snippet view article find links to article
errors in the cell DNA (2) to interact with FANCD2 that can activate the BRCA1/BRCA2 pathway of DNA repair. This explains why mutations in the NBS1 gene
PSME3 (1,142 words) [view diff] exact match in snippet view article find links to article
Slijepcevic P, Carlson M (Dec 1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat Genet. 7 (4): 472–9. doi:10.1038/ng0894-472
CTBP1 (2,351 words) [view diff] exact match in snippet view article find links to article
binds to the BRCT repeats within the breast cancer gene BRCA1 and enables CtBP to influence BRCA1 activity. Both proteins can also interact with a polycomb
Primary peritoneal carcinoma (454 words) [view diff] exact match in snippet view article find links to article
are not known, a link with certain variants of BRCA1/2 has been described. Furthermore, women with BRCA1/2 mutation have a 5% risk of developing primary
EZH1 (691 words) [view diff] exact match in snippet view article find links to article
"Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID 8921387. "Entrez
60S ribosomal protein L27 (566 words) [view diff] exact match in snippet view article find links to article
strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. Bibcode:1994Sci...266...66M. doi:10.1126/science
MEOX1 (481 words) [view diff] exact match in snippet view article find links to article
Barrett JC (Jan 1995). "Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture". Hum Mol Genet. 3 (8): 1359–64
IFI35 (682 words) [view diff] exact match in snippet view article find links to article
cloning, and identification of genes within a 500-kb region containing BRCA1". Proceedings of the National Academy of Sciences of the United States of
7-Methylguanine (342 words) [view diff] exact match in snippet view article find links to article
was demonstrated that 7-methylguanine could accelerate apoptotic death of BRCA1-deficient breast cancer cells induced by cisplatin and doxorubicin. Craddock
Breast MRI (367 words) [view diff] exact match in snippet view article find links to article
lifetime risk of breast cancer (especially those with high risk genes such as BRCA1 and BRCA2), evaluate breast implants for rupture, screening the opposite
VAT1 (536 words) [view diff] exact match in snippet view article find links to article
genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1". Genome Res. 6 (11): 1029–49. doi:10.1101/gr.6.11.1029. PMID 8938427. "Entrez
Basal-like carcinoma (1,820 words) [view diff] exact match in snippet view article find links to article
BLBC and familial BRCA1-associated breast cancer has been discussed in recent years. Several studies have demonstrated that BRCA1-associated breast cancer
Clinomics (201 words) [view diff] exact match in snippet view article find links to article
putative best form of treatment. Already we know that certain genes such as BRCA1 are associated with a higher probability of developing breast cancer. Clinomics
BRCA1P1 (41 words) [view diff] exact match in snippet view article find links to article
BRCA1 pseudogene 1 is a protein that in humans is encoded by the BRCA1P1 gene. "Human PubMed Reference:". National Center for Biotechnology Information
Cyclin A1 (1,405 words) [view diff] exact match in snippet view article find links to article
PMID 8565853. Wang H, Shao N, Ding QM, Cui J, Reddy ES, Rao VN (1997). "BRCA1 proteins are transported to the nucleus in the absence of serum and splice
GTF2H4 (988 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
GTF2F1 (1,487 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
UBE2D3 (1,253 words) [view diff] exact match in snippet view article find links to article
Kleiman FE, Manley JL, Ouchi T, Pan ZQ (Jun 2002). "Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase". The Journal of Biological Chemistry. 277 (24):
Maurice Blackburn (law firm) (408 words) [view diff] exact match in snippet view article
2010 and later acted on his behalf in a defamation matter; The Gene Patent BRCA1 Case - a ruling that saw the High Court rule that a mutated gene that causes
Jennifer Byrne (research scientist) (1,129 words) [view diff] exact match in snippet view article
LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity (2002) Sum, E., Peng, B, Yu, X., Chen, J, Byrne, J. et
TOPBP1 (1,458 words) [view diff] exact match in snippet view article find links to article
(Sep 1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA". Oncogene. 18 (37): 5194–203. doi:10
BRAP (gene) (540 words) [view diff] exact match in snippet view article
BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene. The protein encoded by this gene was identified by its ability to bind
SCGB3A1 (898 words) [view diff] exact match in snippet view article find links to article
Lindblom A, Polyak K (May 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Research. 63 (9): 2024–7. PMID 12727813
60S ribosomal protein L34 (643 words) [view diff] exact match in snippet view article find links to article
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091
60S ribosomal protein L34 (643 words) [view diff] exact match in snippet view article find links to article
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091
Thomas Kolb (412 words) [view diff] exact match in snippet view article find links to article
publication "Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2" published in the journal Science in 2003 detailing the clinical
Lori J. Pierce (1,256 words) [view diff] exact match in snippet view article find links to article
of women treated with radiation for breast cancer who are carriers of a BRCA1/2 breast cancer susceptibility gene. In 2019, Pierce was elected a member
OTUD4 (646 words) [view diff] exact match in snippet view article find links to article
Lindblom A, Polyak K (May 2003). "Lack of HIN-1 methylation in BRCA1-linked and "BRCA1-like" breast tumors". Cancer Res. 63 (9): 2024–7. PMID 12727813
Beth Karlan (1,612 words) [view diff] exact match in snippet view article find links to article
research focuses on inherited cancer risk, specifically cancers related to BRCA1/2 mutations. Her research has identified subtype-specific biomarkers for
LDB1 (1,068 words) [view diff] exact match in snippet view article find links to article
Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1): 155–8
UBE2L3 (2,124 words) [view diff] exact match in snippet view article find links to article
Bartek J, Tarsounas M, Ganesan S, Jonkers J (June 2010). "53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast
60S ribosomal protein L21 (834 words) [view diff] exact match in snippet view article find links to article
SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472
Conditional gene knockout (1,292 words) [view diff] exact match in snippet view article find links to article
known that mutations in the BRCA1 gene are linked to breast cancer. Scientists used conditional gene knockout to delete the BRCA1 allele in mammary gland
Karen H. Antman (1,054 words) [view diff] exact match in snippet view article find links to article
Cummings S, Garber J, Bernhardt B, Antman K, et al. Sequence analysis of BRCA1 and BRCA2: Correlation of mutations with family history and ovarian cancer
CSTF1 (689 words) [view diff] exact match in snippet view article find links to article
50kDa". Kleiman FE, Manley JL (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433):
BTAF1 (1,081 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
BTAF1 (1,081 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
Karen H. Antman (1,054 words) [view diff] exact match in snippet view article find links to article
Cummings S, Garber J, Bernhardt B, Antman K, et al. Sequence analysis of BRCA1 and BRCA2: Correlation of mutations with family history and ovarian cancer
CTDP1 (1,175 words) [view diff] exact match in snippet view article find links to article
Chao D M; Wei W; Ye L; Young R A; Livingston D M; Parvin J D (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
PCTK1 (908 words) [view diff] exact match in snippet view article find links to article
Bowcock AM, Aronheim A, Baer R (1998). "The C-terminal (BRCT) domains of BRCA1 interact in vivo with CtIP, a protein implicated in the CtBP pathway of
ARL4D (1,159 words) [view diff] exact match in snippet view article find links to article
strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954
TAF11 (1,524 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
Outline of biochemistry (702 words) [view diff] exact match in snippet view article find links to article
identification of risk by testing for mutations in two genes—Breast Cancer-1 gene (BRCA1) and the Breast Cancer-2 gene (BRCA2)—allow a woman to schedule increased
MLX (gene) (969 words) [view diff] exact match in snippet view article
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091
G6PC (1,032 words) [view diff] exact match in snippet view article find links to article
et al. (Jul 1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5
KIF1B (1,032 words) [view diff] exact match in snippet view article find links to article
X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10
MDC1 (3,021 words) [view diff] exact match in snippet view article find links to article
facilitates the recruitment of other DDR factors such as RNF168, 53BP1, and BRCA1. TQXF is important for proper passage through the G2/M checkpoint, however
Bonita Friedericy (307 words) [view diff] exact match in snippet view article find links to article
Episode: "Dick and Harry Fall Down a Hole" 2000 Strong Medicine Episode: "BRCA1" 2000 The Stepdaughter Nurse Calista Davis Video 2001 Spin City Edith Connelly
Kelly Metcalfe (956 words) [view diff] exact match in snippet view article find links to article
Metcalfe became interested in cancer research after the discovery of the BRCA1 (BReast CAncer one) and BRCA2 genes. As such, she accepted a research nurse
Frameshift mutation (4,433 words) [view diff] exact match in snippet view article find links to article
seem to play a role in the development of breast and ovarian cancer in the BRCA1 gene, many of which are frameshift. Crohn's disease has an association with
ACACA (1,216 words) [view diff] exact match in snippet view article find links to article
Vincent A, Dalla Venezia N (January 2009). "Cell cycle regulation of the BRCA1/acetyl-CoA-carboxylase complex". Biochemical and Biophysical Research Communications
CENPC1 (931 words) [view diff] exact match in snippet view article find links to article
X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10
ETV4 (1,069 words) [view diff] exact match in snippet view article find links to article
Dowd P, Lee MK, Rowell SE, Boyd J, King MC (Dec 1994). "The search for BRCA1". Cancer Research. 54 (24): 6374–82. PMID 7987831. Higashino F, Yoshida
LRRC37A (83 words) [view diff] exact match in snippet view article find links to article
Morris JR, Solomon E, Roberts RG (Dec 2004). "Structural evolution of the BRCA1 genomic region in primates". Genomics. 84 (6): 1071–82. doi:10.1016/j.ygeno
BACH1 (1,150 words) [view diff] exact match in snippet view article find links to article
(Apr 2001). "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function". Cell. 105 (1): 149–60. doi:10
LMO2 (1,843 words) [view diff] exact match in snippet view article find links to article
LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". The Journal of Biological Chemistry. 277 (10): 7849–56
Olufunmilayo Olopade (1,146 words) [view diff] exact match in snippet view article find links to article
Foundation and has performed extensive clinical work surrounding the role of the BRCA1 and BRCA2 genes in the incidence of breast cancer in women of African descent
Breast self-examination (1,541 words) [view diff] exact match in snippet view article find links to article
Spiegel TN, Hill KA, Warner E (July 2009). "The attitudes of women with BRCA1 and BRCA2 mutations toward clinical breast examinations and breast self-examinations"
Microcephalin (2,281 words) [view diff] exact match in snippet view article find links to article
"Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1". The Journal of Biological Chemistry. 279 (33): 34091–4. doi:10.1074/jbc
RNF8 (2,316 words) [view diff] exact match in snippet view article find links to article
molecules at DNA lesions. In particular, RNF8 activity is required to recruit BRCA1 for homologous recombination repair. Ku protein is a dimeric protein complex
NFYA (1,406 words) [view diff] exact match in snippet view article find links to article
Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q (March 2002). "BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs"
RNF8 (2,316 words) [view diff] exact match in snippet view article find links to article
molecules at DNA lesions. In particular, RNF8 activity is required to recruit BRCA1 for homologous recombination repair. Ku protein is a dimeric protein complex
PTP4A2 (977 words) [view diff] exact match in snippet view article find links to article
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091
Cyclin-dependent kinase 9 (1,447 words) [view diff] exact match in snippet view article find links to article
755. PMC 316581. PMID 9499409. Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase
NFYA (1,406 words) [view diff] exact match in snippet view article find links to article
Zhao H, Fan F, Antinore MJ, Rajasekaran B, Wu M, Zhan Q (March 2002). "BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs"
E2F4 (1,278 words) [view diff] exact match in snippet view article find links to article
5095. PMC 24637. PMID 9144196. Wang H, Shao N, Ding QM, et al. (1997). "BRCA1 proteins are transported to the nucleus in the absence of serum and splice
WNT2B (548 words) [view diff] exact match in snippet view article find links to article
Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10
UBE2D2 (1,289 words) [view diff] exact match in snippet view article find links to article
Xia Y, Pao GM, Chen HW, Verma IM, Hunter T (Feb 2003). "Enhancement of BRCA1 E3 ubiquitin ligase activity through direct interaction with the BARD1 protein"
Piet Borst (3,506 words) [view diff] exact match in snippet view article find links to article
Cranston A, O'Connor MJ, Martin NMB, Borst P, Jonkers J. High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination
Personalized medicine (6,873 words) [view diff] exact match in snippet view article find links to article
instance, many women are already being genotyped for certain mutations in the BRCA1 and BRCA2 gene if they are predisposed because of a family history of breast
Sex reassignment surgery (female-to-male) (1,961 words) [view diff] exact match in snippet view article
with high-risk of endometrial cancer, including patients with germ-line BRCA1/2 mutations, Lynch Syndrome and family history. Hysterectomy can also be
RRM2 (1,046 words) [view diff] exact match in snippet view article find links to article
Boukovinas I, Papadaki C, Mendez P, et al. (2008). Ramqvist T (ed.). "Tumor BRCA1, RRM1 and RRM2 mRNA Expression Levels and Clinical Response to First-Line
C22orf15 (1,081 words) [view diff] exact match in snippet view article find links to article
also significantly more prevalent in basal-like BRCA1-mutated tumors compared to nonmutated wild-type BRCA1 tumors. Additionally, C22orf15 is highly differentially
Auranofin (1,279 words) [view diff] exact match in snippet view article find links to article
2579. PMC 4151813. PMID 25096914. Oommen D, Yiannakis D, Jha AN (2016). "BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin"
Sylvia Plevritis (686 words) [view diff] exact match in snippet view article find links to article
demonstrate the cost-effectiveness of adding MRI to mammography for screening BRCA1/2 mutation carriers. In 2000, Plevritis led the NCI Cancer Intervention
Dictyate (520 words) [view diff] exact match in snippet view article find links to article
Dickler M, Robson M, Moy F, Goswami S, Oktay K (2013). "Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and
Shapiro–Senapathy algorithm (8,760 words) [view diff] exact match in snippet view article find links to article
in different splice sites in various genes causing breast cancer (e.g., BRCA1, PALB2), ovarian cancer (e.g.,  SLC9A3R1, COL7A1, HSD17B7), colon cancer
Chromosome 7 (2,872 words) [view diff] exact match in snippet view article find links to article
BCC6: encoding protein basal cell carcinoma, susceptibility to, 6 BRAT1: BRCA1-associated ATM activator 1 C7orf25: protein UPF0415 C7orf31: chromosome
RAB5C (468 words) [view diff] exact match in snippet view article find links to article
SA, Mazoyer S, et al. (1994). "A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat. Genet. 7 (4): 472–9. doi:10.1038/ng0894-472
Neutrophil cytosolic factor 1 (1,236 words) [view diff] exact match in snippet view article find links to article
strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954
RFC1 (2,249 words) [view diff] exact match in snippet view article find links to article
Yazdi P, Neff N, Elledge SJ, Qin J (April 2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA
Komen Brinker Award for Scientific Distinction (598 words) [view diff] exact match in snippet view article find links to article
Henry T. Lynch (1998) Mary-Claire King (1999), whose research isolated the BRCA1 and BRCA2 gene mutations associated with genetic forms of breast cancer
Nucleolar and spindle associated protein 1 (573 words) [view diff] exact match in snippet view article find links to article
JD (May 2014). "NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels". Cancer Biol. Ther. 15 (5): 533–43. doi:10.4161/cbt.28019
DIRAS3 (gene) (1,741 words) [view diff] exact match in snippet view article
For example, decreased expression of BRCA1 in cancerous tissue has been linked with hypermethylation of the "BRCA1" promoter. Indeed, hypermethylation
Cyclin-dependent kinase 8 (2,555 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proceedings of the
RAD51C (2,918 words) [view diff] exact match in snippet view article find links to article
"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway". Molecular and Cellular
Poly (ADP-ribose) polymerase (3,041 words) [view diff] exact match in snippet view article
inhibitors in HRR-defective cancer. HRR defects are classically associated with BRCA1 and 2 mutations associated with familial breast and ovarian cancer, but
Cyclin-dependent kinase 8 (2,555 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proceedings of the
RAD51C (2,918 words) [view diff] exact match in snippet view article find links to article
"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway". Molecular and Cellular
PAX8 (2,314 words) [view diff] exact match in snippet view article find links to article
Some whole-genome sequencing studies have shown that PAX8 also targets BRCA1 (carcinogenesis), MAPK pathways (thyroid malignancies), and Ccnb1 and Ccnb2
TUBG1 (513 words) [view diff] exact match in snippet view article find links to article
PMID 11163258. S2CID 15923472. Hsu LC, White RL (October 1998). "BRCA1 is associated with the centrosome during mitosis". Proceedings of the National
Micronucleus (1,957 words) [view diff] exact match in snippet view article find links to article
defects in genes related to homologous recombinational repair (ex: ATM, BRCA1, BRCA2, and RAD51) result in a dysfunctional error-free homologous recombinational
CTBP2 (1,894 words) [view diff] exact match in snippet view article find links to article
cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199
XRCC3 (1,745 words) [view diff] exact match in snippet view article find links to article
"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway". Mol. Cell. Biol. 33 (2):
ADP-ribosylation (3,429 words) [view diff] exact match in snippet view article find links to article
on the cancerous DNA by disallowing the reparative function of PARP1 in BRCA1/2 deficient individuals . PARP14 is another ADP-ribosylating enzyme that
Fiona Gilbert (1,457 words) [view diff] exact match in snippet view article find links to article
Kingdom Magnetic Resonance Imaging in Breast Screening Study, Cancers in BRCA1 and BRCA2 carriers and in women at high risk for breast cancer: MR imaging
Spencer Trask & Co. (2,169 words) [view diff] exact match in snippet view article find links to article
gene, BRCA1. Myriad then established the first clinical laboratory to commercialize genomic testing. By informing millions of women about their BRCA1/2 risk
MED13 (629 words) [view diff] exact match in snippet view article find links to article
PMID 15989967. Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220"
Ashok Venkitaraman (1,451 words) [view diff] exact match in snippet view article find links to article
Venkitaraman, A. R. (January 2002). "Cancer Susceptibility and the Functions of BRCA1 and BRCA2". Cell. 108 (2): 171–182. doi:10.1016/s0092-8674(02)00615-3. PMID 11832208
ID4 (3,026 words) [view diff] exact match in snippet view article find links to article
Barber JR, Wong-Staal F (2001). "Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach"
SMARCD2 (596 words) [view diff] exact match in snippet view article find links to article
1139/gen-42-3-545. PMID 10382302. Bochar DA, Wang L, Beniya H, et al. (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling
FANCM (1,747 words) [view diff] exact match in snippet view article find links to article
WC, Sethi L, Madireddy A, Schildkraut CL, Zhang D (July 2017). "FANCM, BRCA1, and BLM cooperatively resolve the replication stress at the ALT telomeres"
CTCFL (740 words) [view diff] exact match in snippet view article find links to article
X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10
CDS1 (gene) (518 words) [view diff] exact match in snippet view article
2011-07-11. Liu Y, Virshup DM, White RL, Hsu LC (November 2002). "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha". Cancer
DNAJA3 (1,941 words) [view diff] exact match in snippet view article find links to article
X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10
Lasker Award (1,478 words) [view diff] exact match in snippet view article find links to article
contributions to medical science and human rights – she discovered the BRCA1 gene locus that causes hereditary breast cancer and deployed DNA strategies
Retinoic acid receptor alpha (2,539 words) [view diff] exact match in snippet view article find links to article
Bowcock A, King MC (September 1993). "High-density genetic map of the BRCA1 region of chromosome 17q12-q21". Genomics. 17 (3): 618–23. doi:10.1006/geno
ATPase, H+ transporting, lysosomal V0 subunit a1 (699 words) [view diff] exact match in snippet view article find links to article
et al. (Jul 1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5
FAM134C (480 words) [view diff] exact match in snippet view article find links to article
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091
Founder effect (3,412 words) [view diff] exact match in snippet view article find links to article
2017-01-12. Ossa, C. A.; Torres, D. (2016). "Founder and Recurrent Mutations in BRCA1 and BRCA2 Genes in Latin American Countries: State of the Art and Literature
TOMM40 (890 words) [view diff] exact match in snippet view article find links to article
breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36
Cowden syndrome (2,114 words) [view diff] exact match in snippet view article find links to article
Kleibeuker JH, Schaapveld M, de Vries EG (April 2002). "Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility". Journal of Medical
UBA1 (2,373 words) [view diff] exact match in snippet view article find links to article
II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1". Molecular Cell. 28 (3): 386–97. doi:10.1016/j.molcel.2007.10.008. PMID 17996703
Cyclin T1 (1,335 words) [view diff] exact match in snippet view article find links to article
2003. PMC 151712. PMID 12588988. Cabart P, Chew HK, Murphy S (July 2004). "BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase
Menopause (12,395 words) [view diff] exact match in snippet view article find links to article
that are necessary for homologous recombinational repair during meiosis (BRCA1, MRE11, Rad51, and ATM) decline with age in oocytes. This age-related decline
SMUG1 (2,211 words) [view diff] exact match in snippet view article find links to article
phenotype in breast cancer. Low SMUG1 expression is also associated with BRCA1, ATM, XRCC1, implying genomic instability in SMUG1 low tumors. Preclinical
Joni L. Rutter (819 words) [view diff] exact match in snippet view article find links to article
2003). "Gynecologic Surgeries and Risk of Ovarian Cancer in Women With BRCA1 and BRCA2 Ashkenazi Founder Mutations: An Israeli Population-Based Case-Control
Nuclear receptor coactivator 3 (2,372 words) [view diff] exact match in snippet view article find links to article
"CBP/p300 interact with and function as transcriptional coactivators of BRCA1". Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1020–5. Bibcode:2000PNAS...97.1020P
TATA-binding protein (3,215 words) [view diff] exact match in snippet view article find links to article
Chao DM, Wei W, Ye L, Young RA, Livingston DM, Parvin JD (May 1997). "BRCA1 is a component of the RNA polymerase II holoenzyme". Proc. Natl. Acad. Sci
Medical genetics (5,111 words) [view diff] exact match in snippet view article find links to article
cystic fibrosis, Duchenne muscular dystrophy, hereditary breast cancer (BRCA1/2), Huntington disease, Marfan syndrome, Noonan syndrome, and Rett syndrome
DDX5 (1,548 words) [view diff] exact match in snippet view article find links to article
LH, et al. (1995). "Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17". Genomics. 25 (1): 238–47. doi:10.1016/0888-7543(95)80131-5
RFC2 (1,570 words) [view diff] exact match in snippet view article find links to article
Yazdi P, Neff N, Elledge SJ, Qin J (Apr 2000). "BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA
CRSP3 (1,241 words) [view diff] exact match in snippet view article find links to article
PMID 15175163. Wada O, Oishi H, Takada I, Yanagisawa J, Yano T, Kato S (Aug 2004). "BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220"
Proline rich 13 (219 words) [view diff] exact match in snippet view article find links to article
Stathopoulos E, Georgoulias V, Souglakos J (January 2011). "Correlation of BRCA1, TXR1 and TSP1 mRNA expression with treatment outcome to docetaxel-based
Folliculogenesis (2,934 words) [view diff] exact match in snippet view article find links to article
Dickler, M; Robson, M; Moy, F; Goswami, S; Oktay, K (2013). "Impairment of BRCA1-related DNA double-strand break repair leads to ovarian aging in mice and
The Cancer Genome Atlas (7,337 words) [view diff] exact match in snippet view article find links to article
lower frequency were found in a handful of other genes, including NF1, BRCA1, BRCA2, RB1 and CDK12. TCGA researchers were also able to identify gene
Klotho (biology) (3,757 words) [view diff] exact match in snippet view article
2010). "Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin". Oncogene. 29 (1): 26–33. doi:10
TH1L (1,028 words) [view diff] exact match in snippet view article find links to article
different N-termini. TH1L has been shown to interact with: ARAF, Cofactor of BRCA1, and RDBP. GRCh38: Ensembl release 89: ENSG00000101158 - Ensembl, May 2017
FANCF (2,433 words) [view diff] exact match in snippet view article find links to article
monoubiquitination of FANCD2 and this modified form of FANCD2 colocalizes with BRCA1, RAD51 and PCNA in foci that also contain other DNA repair proteins. All
Splice site mutation (1,528 words) [view diff] exact match in snippet view article find links to article
2017-10-07. "The Human Splicing Finder". Friedman, Lori (1994). "Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in
SMARCE1 (1,187 words) [view diff] exact match in snippet view article find links to article
mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter". The Journal of Biological Chemistry. 278 (20): 17876–84. doi:10
MTA1 (3,869 words) [view diff] exact match in snippet view article find links to article
Lee SW, Kumar R (Mar 2008). "MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene". Oncogene. 27 (14): 1971–80. doi:10.1038/sj.onc.1210839
Ageing (17,168 words) [view diff] exact match in snippet view article find links to article
young increase cancer risk in the old. Such variants occur in genes p53 and BRCA1. The reproductive-cell cycle theory argues that ageing is regulated specifically
SMARCC2 (1,348 words) [view diff] exact match in snippet view article find links to article
H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling
Prognosis marker (1,219 words) [view diff] exact match in snippet view article find links to article
cancer TP53, WT1, Ki67, Topo-II, BRCA1, BRCA2 Cervical cancer Ki67, MYC, p16INK4a, PTEN, Bm-3a Breast cancer BRCA1, BRCA2, HER-2, TP53, EGFR Prostate
ACOT13 (1,356 words) [view diff] exact match in snippet view article find links to article
breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36
SMARCC1 (1,346 words) [view diff] exact match in snippet view article find links to article
H, Kinev A, Xue Y, Lane WS, Wang W, Kashanchi F, Shiekhattar R (2000). "BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling
Simon N. Powell (1,364 words) [view diff] exact match in snippet view article find links to article
Weaver, DT; Chung, JH; Powell, SN; Xia, F (2004). "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair". Molecular and Cellular Biology
Hysterectomy (7,661 words) [view diff] exact match in snippet view article find links to article
reproductive system cancers (especially breast cancer in conjunction with BRCA1 or BRCA2 mutation), or as part of recovery from such cancers. Gynecologic
XRCC2 (1,841 words) [view diff] exact match in snippet view article find links to article
"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway". Mol. Cell. Biol. 33 (2):
BECN1 (1,426 words) [view diff] exact match in snippet view article find links to article
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21". Genomics. 28 (3): 530–42. doi:10.1006/geno.1995.1185. PMID 7490091
HDAC8 (1,531 words) [view diff] exact match in snippet view article find links to article
X, Chen J, Songyang Z (2004). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10
Mothers against decapentaplegic homolog 3 (4,219 words) [view diff] exact match in snippet view article find links to article
breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36
Prognosis marker (1,219 words) [view diff] exact match in snippet view article find links to article
cancer TP53, WT1, Ki67, Topo-II, BRCA1, BRCA2 Cervical cancer Ki67, MYC, p16INK4a, PTEN, Bm-3a Breast cancer BRCA1, BRCA2, HER-2, TP53, EGFR Prostate
H2AFY (1,259 words) [view diff] exact match in snippet view article find links to article
Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM (Nov 2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome". Cell. 111
Simon N. Powell (1,364 words) [view diff] exact match in snippet view article find links to article
Weaver, DT; Chung, JH; Powell, SN; Xia, F (2004). "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair". Molecular and Cellular Biology
RDBP (1,192 words) [view diff] exact match in snippet view article find links to article
region on chromosome 6. RDBP has been shown to interact with: Cofactor of BRCA1, TH1L, and WHSC2. ENSG00000206357, ENSG00000231044, ENSG00000204356, ENSG00000206268
HIST2H2AB (636 words) [view diff] exact match in snippet view article find links to article
Chen A, Kleiman FE, Manley JL, et al. (2002). "Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase". J. Biol. Chem. 277 (24): 22085–92. doi:10
BCCIP (981 words) [view diff] exact match in snippet view article find links to article
Machackova E, Damborsky J, Valik D, Foretova L (2002). "Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the
Cosegregation (2,258 words) [view diff] exact match in snippet view article find links to article
co-segregation analysis to evaluate the pathogenicity of unclassified variants; BRCA1 and BRCA2 as an example". BMC Cancer. 9: 211. doi:10.1186/1471-2407-9-211
Clinicogenomics (829 words) [view diff] exact match in snippet view article find links to article
certain conditions. For example, if a woman knows she has mutation in the BRCA1 gene, she can be more proactive about mammograms, Pap smears and other preventative
MRNA display (2,207 words) [view diff] exact match in snippet view article find links to article
"Peptide Library Approach to Uncover Phosphomimetic Inhibitors of the BRCA1 C-Terminal Domain". ACS Chemical Biology. 10 (5): 1198–1208. doi:10.1021/cb500757u
Proximity ligation assay (1,142 words) [view diff] exact match in snippet view article find links to article
Vincent A, Berthel E, Dacheux E, Magnard C, Venezia NL (April 2016). "BRCA1 affects protein phosphatase 6 signalling through its interaction with ANKRD28"
Andrew Jess Dannenberg (1,023 words) [view diff] exact match in snippet view article find links to article
aromatase expression in human adipocytes and breast cancer cells: Evidence of a BRCA1 and p300 exchange. Kotha Subbaramaiah, Clifford Hudis, Sung-Hee Chang, Timothy
Talazoparib (580 words) [view diff] exact match in snippet view article find links to article
polymerase (PARP) which aids in single strand DNA repair. Cells that have BRCA1/2 mutations are susceptible to the cytotoxic effects of PARP inhibitors
HIP2 (977 words) [view diff] exact match in snippet view article find links to article
19385. PMID 8702625. Christensen DE, Brzovic PS, Klevit RE (Oct 2007). "E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain
Ductal carcinoma in situ (2,660 words) [view diff] exact match in snippet view article find links to article
therapy (HRT) for more than five years after menopause, genetic mutations (BRCA1 or BRCA2 genes), atypical hyperplasia, as well as radiation exposure or
DDB2 (2,047 words) [view diff] exact match in snippet view article find links to article
PMID 28035050. El-Deiry WS (2003). "Transactivation of repair genes by BRCA1". Cancer Biology & Therapy. 1 (5): 490–1. doi:10.4161/cbt.1.5.162. PMID 12496474
Gretchen Gierach (694 words) [view diff] exact match in snippet view article find links to article
and computer-extracted mammographic texture pattern features differ by BRCA1/2 mutation status. In addition to addressing how molecular epidemiologic
Gail Jarvik (574 words) [view diff] exact match in snippet view article find links to article
(PMID 22361898) Murray ML, Cerrato F, Bennett RL, Jarvik GP. Follow-up of carriers of BRCA1 and BRCA2 variants of unknown significance: Variant reclassification and
HIST2H3C (1,133 words) [view diff] exact match in snippet view article find links to article
A, Marrese C, Marahrens Y, Deng CX, Feunteun J, Livingston DM (2002). "BRCA1 supports XIST RNA concentration on the inactive X chromosome". Cell. 111
PSMC3 (2,422 words) [view diff] exact match in snippet view article find links to article
"Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene". Gene. 248 (1–2): 99–107. doi:10.1016/S0378-1119(00)00141-4
CpG site (5,426 words) [view diff] exact match in snippet view article find links to article
hypermethylated promoters; these genes are XRCC1, MLH3, PMS1, RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN, SETMAR, HUS1, and PER1. About seventeen
Michael Stratton (2,684 words) [view diff] exact match in snippet view article find links to article
susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations". Nature Genetics. 31 (1): 55–9. doi:10.1038/ng879. PMID 11967536
NDFIP1 (573 words) [view diff] exact match in snippet view article find links to article
protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol
Gedatolisib (920 words) [view diff] exact match in snippet view article find links to article
NCT03911973 for "Gedatolisib Plus Talazoparib in Advanced Triple Negative or BRCA1/2 Positive, HER2 Negative Breast Cancers" at ClinicalTrials.gov Clinical
Human genome (11,531 words) [view diff] exact match in snippet view article find links to article
Breast/Ovarian cancer (susceptibility) ~5% of cases of these cancer types BRCA1, BRCA2 FAP (hereditary nonpolyposis coli) 1:3500 APC Lynch syndrome 5–10%
SETX (1,816 words) [view diff] exact match in snippet view article find links to article
damage repair, SETX co-localizes with many other DDR factors. For example, BRCA1 was also shown to recruit SETX to remove R-loops, which prevents DNA mutations
Alice S. Whittemore (885 words) [view diff] exact match in snippet view article find links to article
S.; Gong, G.; Itnyre, J. (March 1997), "Prevalence and contribution of BRCA1 mutations in breast cancer and ovarian cancer: results from three U.S. population-based
KPNA6 (1,113 words) [view diff] exact match in snippet view article find links to article
Li S, Chen Y, et al. (1997). "The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport
Joan H. Marks (733 words) [view diff] exact match in snippet view article find links to article
Mandell. "Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2." Science 302.5645 (2003): 643-646. Ciarleglio, Leslie J., et
DHRS7B (1,178 words) [view diff] exact match in snippet view article find links to article
transcription of most RNA polymerase II dependent genes. BRE is a component of the BRCA1-A complex, which recognizes Lys-63 linked ubiquitinated histones H2A and
Leishmania (5,206 words) [view diff] exact match in snippet view article find links to article
appear to be rare in L. major and L. donovani. L. infantum produces proteins BRCA1 and RAD51 that interact with each other to promote homologous recombinational
Intrinsically disordered proteins (5,716 words) [view diff] exact match in snippet view article find links to article
suppressors have large intrinsically unstructured regions, for example p53 and BRCA1. These regions of the proteins are responsible for mediating many of their
Jan Schouten (geneticist) (809 words) [view diff] exact match in snippet view article
R, Menko FH, Kluijt I. Large genomic deletions and duplications in the BRCA1 gene identified by a novel quantitative method. Cancer research. 2003 Apr
HIST2H2AC (924 words) [view diff] exact match in snippet view article find links to article
Chen A, Kleiman FE, Manley JL, et al. (2002). "Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase". J. Biol. Chem. 277 (24): 22085–92. doi:10
Ku80 (2,608 words) [view diff] exact match in snippet view article find links to article
(2007). "Epigenetic inactivation of the chromosomal stability control genes BRCA1, BRCA2, and XRCC5 in non-small cell lung cancer". Clin. Cancer Res. 13 (3):
Bradley Monk (3,245 words) [view diff] exact match in snippet view article find links to article
increasing the risk of hereditary breast and ovarian cancer (HBOC) in a BRCA1 and BRCA2 negative population of patients with a personal history of breast
Genetic counseling (9,777 words) [view diff] exact match in snippet view article find links to article
2017). "Genetic Predisposition to Breast Cancer Due to Mutations Other Than BRCA1 and BRCA2 Founder Alleles Among Ashkenazi Jewish Women". JAMA Oncology.
XRCC1 (2,849 words) [view diff] exact match in snippet view article find links to article
Jheon S, Sung SW, Kim JH (2010). "The prognostic significance of ERCC1, BRCA1, XRCC1, and betaIII-tubulin expression in patients with non-small cell lung
RAD52 (2,982 words) [view diff] exact match in snippet view article find links to article
"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway". Mol. Cell. Biol. 33 (2):
PEG3 (863 words) [view diff] exact match in snippet view article find links to article
Yarden RI, Brody LC (2002). "Identification of proteins that interact with BRCA1 by Far-Western library screening". J. Cell. Biochem. 83 (4): 521–31. doi:10
Regulation of transcription in cancer (2,363 words) [view diff] exact match in snippet view article find links to article
hypermethylated promoters; these genes are XRCC1, MLH3, PMS1, RAD51B, XRCC3, RAD54B, BRCA1, SHFM1, GEN1, FANCE, FAAP20, SPRTN, SETMAR, HUS1, and PER1. About seventeen
Gynecologic cancer disparities in the United States (4,505 words) [view diff] exact match in snippet view article find links to article
Mandell. "Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2, Science, 302 (5645) (2003), pp. 643–646. Schmeler, K.M.; Lynch
RAD9A (2,653 words) [view diff] exact match in snippet view article find links to article
The Rad9 protein contains a carboxy-terminal tandem repeat of the BRCT (BRCA1 carboxyl terminus) motif, which is found in many proteins involved in DNA
EZH2 (4,909 words) [view diff] exact match in snippet view article find links to article
"Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–171. doi:10.1006/geno.1996.0537. PMID 8921387. Laible
Sephardic Bnei Anusim (8,612 words) [view diff] exact match in snippet view article find links to article
Sephardi Jews in particular, including Jewish-specific mutations of the BRCA1 and BRCA2 genes which increases the risk of breast cancer (found also among
High Resolution Melt (2,575 words) [view diff] exact match in snippet view article find links to article
for the detection of mutations in the breast cancer susceptibility genes BRCA1 and BRCA2. More than 400 mutations have been identified in these genes.
2015 in Australia (8,608 words) [view diff] exact match in snippet view article find links to article
software. The High Court of Australia rules that the breast cancer gene BRCA1 is not a patentable invention. 8 October – Brian Loughnane resigns as Liberal
National Magazine Awards (2,882 words) [view diff] exact match in snippet view article find links to article
Washington Bureau Chief James West, Producer 2014 Glamour "Confronting Cancer: BRCA1 and BRCA2 Gene Mutations," October 9 "Recovery: Meds. And Love," October
Genetic privacy (3,703 words) [view diff] exact match in snippet view article find links to article
have strong predictive effects in the occurrences of diseases, such as the BRCA1 and BRCA2 mutant genes in Breast Cancer and Ovarian Cancer, or PSEN1, PSEN2
List of Strong Medicine episodes (86 words) [view diff] exact match in snippet view article find links to article
soon discovers the guardian is the one taking the boy’s medication. 10 10 "BRCA1" Joe Napolitano Tammy Ader & Richard Alexander October 15, 2000 (2000-10-15)
Richard Pestell (2,463 words) [view diff] exact match in snippet view article find links to article
Pestell, R.G.; Yuan, F.; Auborn, K.J.; Goldberg, I.D.; Rosen, E.M. (1999). "BRCA1 inhibition of estrogen receptor signaling in transfected cells". Science
Apc, wnt signaling pathway regulator (615 words) [view diff] exact match in snippet view article find links to article
Friedlander M, Buckley MF (July 2001). "The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the
Living Beyond Breast Cancer (1,972 words) [view diff] exact match in snippet view article find links to article
Hispanic women, premenopausal women, and women who test positive for the BRCA1 gene mutation, also have a higher prevalence of TNBC diagnosis. The study
Spindle checkpoint (8,942 words) [view diff] exact match in snippet view article find links to article
CX (December 2004). "A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint". Proceedings of the National Academy of Sciences
Deficiency of RbAp48 protein and memory loss (2,436 words) [view diff] exact match in snippet view article find links to article
both transactivation domains 9aaTADs of transcription factor p53. SIN3 BRCA1 CREBBP Nicolas, E.; Ait-Si-Ali, S; Trouche, D (2001). "The histone deacetylase
In re Roslin Institute (Edinburgh) (1,590 words) [view diff] exact match in snippet view article
the Court held that claims on two naturally occurring, isolated genes (BRCA1 and BRCA2), which can be examined to determine whether a person is likely
Combined hormonal contraception (3,115 words) [view diff] exact match in snippet view article find links to article
oral contraceptives have been shown to reduce risk of endometrial cancer, BRCA1 and BRCA2 ovarian cancer, and a modest reduction in colon cancer. Combined
PLD3 (3,069 words) [view diff] exact match in snippet view article find links to article
breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36
MAP4K4 (3,285 words) [view diff] exact match in snippet view article find links to article
J, Songyang Z (December 2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". The Journal of Biological Chemistry. 278
Periannan Senapathy (4,078 words) [view diff] exact match in snippet view article find links to article
Engert, Stefanie; Weber, Ute (11 December 2012). "Analysis of 30 Putative BRCA1 Splicing Mutations in Hereditary Breast and Ovarian Cancer Families Identifies
Prevent Breast Cancer (1,515 words) [view diff] exact match in snippet view article find links to article
risk information to families specifically with the BRCA gene mutation. The BRCA1 and BRCA2 gene mutations are known to increase the risk of breast cancer
Valosin-containing protein (5,791 words) [view diff] exact match in snippet view article find links to article
ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells". DNA and Cell Biology. 19 (5): 253–63. doi:10
Eukaryotic DNA replication (14,426 words) [view diff] exact match in snippet view article find links to article
enables the two replicative proteins to bind to Dpb11. Dpb11 had two pairs of BRCA1 C Terminus (BRCT) domains which are known as a phosphopeptide-binding domains
Mouse models of breast cancer metastasis (5,951 words) [view diff] exact match in snippet view article find links to article
E.; Fetten, K; Michor, F; Polyak, K (2012). "Evolutionary pathways in BRCA1-associated breast tumors". Cancer Discovery. 2 (6): 503–11. doi:10.1158/2159-8290
Surveyor nuclease assay (3,170 words) [view diff] exact match in snippet view article find links to article
enzyme to detect a variety of mutations and polymorphisms in the human BRCA1 gene. While monitoring the purification of CEL I using polyacrylamide gel
DeCODE genetics (9,638 words) [view diff] exact match in snippet view article find links to article
whose family-based research in the early 1990s led to the discovery of the BRCA1 and BRCA2 breast cancer genes, predicted not long after deCODE's founding
Thymidine kinase in clinical chemistry (9,985 words) [view diff] exact match in snippet view article find links to article
Peretz T (2013). "Increased proliferative background in healthy women with BRCA1/2 haploinsufficiency is associated with high risk for breast cancer". Cancer
Stress granule (12,269 words) [view diff] exact match in snippet view article find links to article
Division 1 Like 1 BOLL BOULE Boule Homolog, RNA Binding Protein BRAT1 BRAT1 BRCA1-associated ATM activator 1 BRF1 BRF1 BRF1, RNA Polymerase III Transcription
C7orf50 (3,622 words) [view diff] exact match in snippet view article find links to article
enhancers, in which SR proteins can bind, at bp positions 45 (SRSF1 (IgM-BRCA1)), 246 (SRSF6), 703 (SRSF5), 1301 (SRSF1), and 1308 (SRSF2) Both the 5'