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searching for Antibody-drug conjugate 27 found (105 total)

Glypican 2 (865 words) [view diff] exact match in snippet view article find links to article

immunohistochemistry, and immunofluorescence. A GPC2 specific antibody-drug conjugate (ADC) can inhibit neuroblastoma and small-cell lung cancer cell

Index of biotechnology articles (363 words) [view diff] no match in snippet view article find links to article

Category:Alcoholic beverages -- Algal fuel -- Amgen -- Antibiotic -- Antibody drug conjugate -- Antisense RNA -- Aptamer -- Assisted reproductive technology

Nectin (837 words) [view diff] no match in snippet view article find links to article

vedotin-ejfv was approved by the FDA in 2019; it is a Nectin-4-directed antibody drug conjugate that has shown clinical activity in metastatic urothelial cancer

SN-38 (225 words) [view diff] exact match in snippet view article find links to article

NK012, a nanodevice formulation of SN-38 Sacituzumab govitecan, an antibody-drug conjugate that uses SN-38 as the cytotoxic drug. "CAMPTOSAR- irinotecan hydrochloride

Telisotuzumab vedotin (407 words) [view diff] case mismatch in snippet view article find links to article

Dose-Escalation and -Expansion Study of Telisotuzumab Vedotin, an Antibody–Drug Conjugate Targeting c-Met, in Patients With Advanced Solid Tumors". Journal

Triple-negative breast cancer (3,411 words) [view diff] exact match in snippet view article find links to article

clinical trials, including the PARP inhibitor BSI 201, NK012. A novel antibody-drug conjugate known as glembatumumab vedotin (CDX-011), which targets the protein

Jane Osbourn (2,277 words) [view diff] case mismatch in snippet view article find links to article

antibody discovery and development: A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible

DLL3 (879 words) [view diff] exact match in snippet view article find links to article

Rudin CM, Stull RA, Dylla SJ (August 2015). "A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating

ROR1 (1,200 words) [view diff] exact match in snippet view article find links to article

be targeted for anti-CSC therapy. Zilovertamab vedotin (ZV), an antibody–drug conjugate comprising a monoclonal antibody recognizing extracellular ROR1

CD46 (1,159 words) [view diff] exact match in snippet view article find links to article

affinity for prostate cancer tissue. YS5 has been developed into an antibody-drug conjugate, FOR46, which is currently in a phase I clinical trial (NCT03575819)

CEACAM5 (1,486 words) [view diff] exact match in snippet view article find links to article

immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)". Journal of Clinical Oncology

Zinc transporter SLC39A7 (1,712 words) [view diff] case mismatch in snippet view article find links to article

ZIP7-targeted antibodies, in combination with a secondary anti-rabbit Antibody-Drug Conjugate (ADC), selectively induced cell death in TNBC cells over NBE cells

FXYD5 (1,216 words) [view diff] no match in snippet view article find links to article

subunit interactions. Dysadherin is a target for an extracellular antibody drug conjugate where the antibody to dysadherin is attached to a cardiac glycoside

Taofeek Owonikoko (561 words) [view diff] exact match in snippet view article find links to article

"First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70". Cancer Chemotherapy and Pharmacology. 77 (1):

Takeda Oncology (1,243 words) [view diff] exact match in snippet view article find links to article

cases. March 2009 N/A ADCETRIS brentuximab vedotin Adcetris is an antibody-drug conjugate approved to treat anaplastic large cell lymphoma (ALCL) and Hodgkin

WuXi Biologics (1,965 words) [view diff] no match in snippet view article find links to article

MFG5. and the Wuxi New Area site contains labs dedicated to the antibody drug conjugate development and production. With 30,000 liters of capacity, MFG2

Genentech (3,362 words) [view diff] exact match in snippet view article find links to article

2013: Kadcyla (ado-trastuzumab emtansine): The first Genentech antibody-drug conjugate (ADC) to receive FDA approval. It consists of trastuzumab (Herceptin)

Glypican 1 (1,777 words) [view diff] exact match in snippet view article find links to article

S, Matsuzaki S, Ueda Y, et al. (March 2018). "Anti-glypican-1 antibody-drug conjugate exhibits potent preclinical antitumor activity against glypican-1

Non-Hodgkin lymphoma (3,184 words) [view diff] exact match in snippet view article find links to article

prednisone) plus rituximab. R-CHP with polatuzumab vedotin, an antibody-drug conjugate, was included as a category 1 preferred regimen for first-line

Glypican (2,445 words) [view diff] exact match in snippet view article find links to article

tumors in a metastatic neuroblastoma mouse model. A GPC2-directed antibody-drug conjugate (ADC) is capable of killing GPC2-expressing neuroblastoma cells

PI3K/AKT/mTOR pathway (4,322 words) [view diff] exact match in snippet view article find links to article

development for the treatment of TNBC, in combination with PTK7 antibody–drug conjugate. Apitolisib (GDC-0980) is a PI3K inhibitor (subunits α, δ, and

Gilead Sciences (7,528 words) [view diff] exact match in snippet view article find links to article

Trodelvy (Sacituzumab govitecan-hziy) – a first-in-class Trop-2 antibody-drug conjugate. In December, the business announced it would acquire German biotech

AstraZeneca (7,811 words) [view diff] no match in snippet view article find links to article

Daiichi Sankyo, centred around the development of DS-1062, an antibody drug conjugate. The deal could potentially be worth up to US$6 billion for Daiichi

Hodgkin lymphoma (8,577 words) [view diff] exact match in snippet view article find links to article

M, DeRemer D (2013-04-01). "Brentuximab vedotin: An anti-CD30 antibody–drug conjugate". American Journal of Health-System Pharmacy. 70 (7): 589–597.

PLAC1 (3,873 words) [view diff] exact match in snippet view article find links to article

R. 2017 Placenta-specific1 (PLAC1) is a potential target for antibody-drug conjugate-based prostate cancer immunotherapy. Sci Rep. Oct 17;7(1):13373

Stimuli-responsive drug delivery systems (2,367 words) [view diff] no match in snippet view article find links to article

Stimulus Carrier Therapeutic Target Status Reference Redox-Responsive Antibody drug conjugate Docetaxel Metastatic breast cancer Approved by FDA in 2013 Micelles

Cora Sternberg (3,310 words) [view diff] exact match in snippet view article find links to article

Sacituzumab govitecan (anti-Trop-2-SN-38 ADC), a first-in-class antibody-drug conjugate. Their findings have recently been published in the JCO. She has