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searching for Anti-VEGF 68 found (82 total)

alternate case: anti-VEGF

Polypoidal choroidal vasculopathy (708 words) [view diff] exact match in snippet view article find links to article

observation, photodynamic therapy, thermal laser, intravitreal injection of anti-VEGF therapy, or combination therapy. PCV is an ocular disease characterised

Intravitreal administration (2,323 words) [view diff] exact match in snippet view article find links to article

performed. This doubled to 2 million just 3 years later in 2011 when another anti-VEGF intravitreal injection aflibercept became available for the treatment

ALK inhibitor (1,951 words) [view diff] exact match in snippet view article find links to article

only inhibits EGFR). Several trials are investigating the combination of anti-VEGF antibody bevacizumab with ALK inhibitors such as alectinib and brigatinib

Corneal neovascularization (1,530 words) [view diff] exact match in snippet view article find links to article

activity by competing the binding of VEGF with specific neutralizing anti-VEGF antibody. VEGF inhibitors include pegaptanib sodium, ranibizumab, and

Napoleone Ferrara (472 words) [view diff] exact match in snippet view article find links to article

diabetic retinopathy. At Genentech, he discovered VEGF—and made the first anti-VEGF antibody—which suppresses growth of a variety of tumors. These findings

Retinopathy (2,059 words) [view diff] exact match in snippet view article find links to article

(VEGF) seems to play a vital role in promoting neovascularization. Using anti-VEGF drugs (antibodies to sequester the growth factor), research have shown

Central retinal vein occlusion (389 words) [view diff] exact match in snippet view article find links to article

thrombosis) in patients with retinal vascular occlusion. Treatment consists of Anti-VEGF drugs like Lucentis or intravitreal steroid implant (Ozurdex) and Pan-Retinal

Choroidal neovascularization (833 words) [view diff] exact match in snippet view article find links to article

with intravitreal injections of angiogenesis inhibitors (also known as "anti-VEGF" drugs) to control neovascularization and reduce the area of fluid below

Conbercept (1,699 words) [view diff] exact match in snippet view article find links to article

age-related macular degeneration (AMD) and diabetic macular edema (DME). The anti-VEGF was approved for the treatment of neovascular AMD by the China State FDA

Punctate inner choroiditis (1,058 words) [view diff] exact match in snippet view article find links to article

intravitreal anti VEGF agents namely bevacizumab and ranibizumab have been described recently. The current evidence supporting the use of anti-VEGF agents is

Macular edema (1,554 words) [view diff] exact match in snippet view article find links to article

BRVO. A 2014 Cochrane Systematic Review studied the effectiveness of two anti-VEGF treatments, ranibizumab and pegaptanib, on patients with macular edema

Rubeosis iridis (409 words) [view diff] exact match in snippet view article find links to article

reversed with prompt panretinal photocoagulation (PRP), or injection of anti-VEGF medications with subsequent PRP. The injection blocks the direct effect

Bevacizumab (6,455 words) [view diff] exact match in snippet view article find links to article

inhibiting vascular endothelial growth factor A (VEGF-A), in other words anti–VEGF therapy. Bevacizumab was approved for medical use in the United States

Sickle cell retinopathy (2,209 words) [view diff] exact match in snippet view article find links to article

fan lesions which are types of neovascularization. Bevacizumab is an anti-VEGF drug used in intravitreal injection that is known to cause reversal of

Fuchs spot (236 words) [view diff] exact match in snippet view article find links to article

the actual cause. Photothermal laser ablation, photodynamic therapy, anti-VEGF therapy, or a combination of these are the treatment options of choroidal

Branch retinal vein occlusion (1,296 words) [view diff] exact match in snippet view article find links to article

improved visual and anatomic outcomes with these agents. Intravitreal anti-VEGF drugs have a low incidence of adverse side effects compared with intravitreal

Thrombotic microangiopathy (1,202 words) [view diff] exact match in snippet view article find links to article

targeted agents, such as targeted cancer therapies, immunotoxins, and anti-VEGF therapy. Bacterial toxins are the primary cause of one category of thrombotic

Angiogenesis inhibitor (3,229 words) [view diff] exact match in snippet view article find links to article

complications. [citation needed] While the mechanisms of bleeding induced by anti-VEGF agents are complicated and not yet totally understood, the most accepted

Oncolytic virus (8,636 words) [view diff] exact match in snippet view article find links to article

several cancer chemotherapies. The anti-angiogenesis drug bevacizumab (anti-VEGF antibody) has been shown to reduce the inflammatory response to oncolytic

Faricimab (1,566 words) [view diff] exact match in snippet view article find links to article

González DP, Loewenstein A, Zur D (February 2022). "Next-generation anti-VEGF agents for diabetic macular oedema". Eye. 36 (2): 273–277. doi:10

Pachychoroid disorders of the macula (1,020 words) [view diff] exact match in snippet view article find links to article

massive reduction in vision due to bleeding and scarring of the macula. Anti-VEGF therapy, which is injected directly into the eye (intravitreally), has

Pericorneal plexus (88 words) [view diff] exact match in snippet view article find links to article

Jain, Sandeep; Azar, Dimitri T. (2012). "Corneal Neovascularization: An Anti-VEGF Therapy Review". Survey of Ophthalmology. 57 (5): 415–429. doi:10.1016/j

Electroretinography (1,249 words) [view diff] exact match in snippet view article find links to article

Retinal Vein Occlusion: Clinical Characteristics, Prognosis, and Effects of Anti-VEGF Agent". Investigative Ophthalmology & Visual Science. 59 (15): 5854–5861

Triamcinolone acetonide (1,220 words) [view diff] exact match in snippet view article find links to article

reducing macular edema. Drug trials have found it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a two-year period. A systematic

Glaucoma (10,066 words) [view diff] exact match in snippet view article find links to article

that anti-VEGF medications are effective either for short-term or for longer-term treatment. The short, medium, and long-term safety of anti-VEGF treatment

Preferential hyperacuity perimetry (635 words) [view diff] exact match in snippet view article find links to article

patients, leads to early treatment (such as intravitreal injection of anti-VEGF factors, e.g. bevacizumab or ranibizumab) and prevents loss of vision

Radiation retinopathy (407 words) [view diff] exact match in snippet view article find links to article

PMID 15923510. Finger, PT; Mukkamala, SK (Jul–Aug 2011). "Intravitreal anti-VEGF bevacizumab (Avastin) for external beam related radiation retinopathy"

Follicle-stimulating hormone (2,261 words) [view diff] exact match in snippet view article find links to article

antagonists as an anti-tumor angiogenesis therapy (cf. avastin for current anti-VEGF approaches). EFSH, a follicle-stimulating hormone obtained from equine

Frank A. Sloan (424 words) [view diff] exact match in snippet view article find links to article

Managed Care. Greenwood Publishing Group. pp. 69–. ISBN 978-0-86569-263-3. "Anti-VEGF Treats Wet Macular Degeneration". Today's Geriatric Medicine, By Jennifer

Intraretinal microvascular abnormalities (299 words) [view diff] exact match in snippet view article find links to article

"Morphological changes in intraretinal microvascular abnormalities after anti-VEGF therapy visualized on optical coherence tomography angiography". Eye and

Hereditary hemorrhagic telangiectasia (5,921 words) [view diff] exact match in snippet view article find links to article

in conjunction with therapies listed above. Intravenously administered anti-VEGF substances such as bevacizumab (brand name Avastin), pazopinab, and thalidomide

Aflibercept (2,769 words) [view diff] exact match in snippet view article find links to article

from frequent injections. A 2017 review update studying the effects of anti-VEGF drugs on diabetic macular edema found that while all three studied treatments

RO4929097 (385 words) [view diff] exact match in snippet view article find links to article

ovarian cancer, renal cell carcinoma in patients that were unsuccessful on anti-VEGF treatments, metastatic pancreatic cancer, advanced brain tumors, and relapsed

Genentech (2,865 words) [view diff] exact match in snippet view article find links to article

progressive multifocal leukoencephalopathy. 2004: Avastin (bevacizumab): Anti-VEGF monoclonal antibody for the treatment of metastatic cancer of the colon

Ixoberogene soroparvovec (159 words) [view diff] exact match in snippet view article find links to article

(2021-04-01). "Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular

Interleukin-17A (6,247 words) [view diff] exact match in snippet view article find links to article

cells and it has been shown that IL-17A also mediates tumor resistance to anti-VEGF therapy through the recruitment of MDSCs. However IL-17A KO mice were

HOHMS (999 words) [view diff] exact match in snippet view article find links to article

carcinoma (cisplatinum/gemcitabine) Squamous cell carcinoma (no bevacizumab/anti-VEGF in cavitary or in near large vessels Vincent MD (August 2009). "Optimizing

Lasker Award (1,590 words) [view diff] exact match in snippet view article find links to article

a major mediator of angiogenesis and the development of an effective anti-VEGF therapy for wet macular degeneration, a leading cause of blindness in

Lasker Award (1,590 words) [view diff] exact match in snippet view article find links to article

a major mediator of angiogenesis and the development of an effective anti-VEGF therapy for wet macular degeneration, a leading cause of blindness in

Aptamer (6,724 words) [view diff] exact match in snippet view article find links to article

Cunningham ET, Guyer DR, Adamis AP (February 2006). "Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease". Nature Reviews. Drug Discovery.

Host response to cancer therapy (2,573 words) [view diff] exact match in snippet view article find links to article

Hans-Peter; Ferrara, Napoleone (29 July 2007). "Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells". Nature Biotechnology

Onyx Pharmaceuticals (1,081 words) [view diff] exact match in snippet view article find links to article

fluoropyrimidine-, oxaliplatin, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if KRAS wild-type, an anti-EGFR therapy. On February 25

Retinopathy of prematurity (3,695 words) [view diff] exact match in snippet view article find links to article

children treated for ROP are followed yearly. Follow-up after laser or anti-VEGF treatment is individualized. Follow-up of premature children (with or

Fruquintinib (600 words) [view diff] exact match in snippet view article find links to article

fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically appropriate, an anti-EGFR

Ranibizumab (2,761 words) [view diff] exact match in snippet view article find links to article

degeneration: a meta-analysis of dose effects and comparison with no anti-VEGF treatment and bevacizumab". Journal of Clinical Pharmacy and Therapeutics

Interleukin 33 (3,015 words) [view diff] exact match in snippet view article find links to article

and thus impaired vision. Current treatment includes administration of anti-VEGF but is not sufficient. Retinal pigment epithelial cells can express IL-33

Neuropilin 1 (1,812 words) [view diff] exact match in snippet view article find links to article

Soluble NRP1 has the opposite effect of membrane bound NRP1 and has anti-VEGF activity. In vivo mouse studies have shown that injections of sNRP-1 inhibits

Vascular endothelial growth factor A (3,053 words) [view diff] no match in snippet view article find links to article

and NRP1, Vascular endothelial growth factor Bevacizumab (or Avastin) anti VEGF-A human antibody drug. GRCh38: Ensembl release 89: ENSG00000112715 – Ensembl

Vascular endothelial growth factor (4,578 words) [view diff] exact match in snippet view article find links to article

Hence, VEGF is a potential target for the treatment of cancer. The first anti-VEGF drug, a monoclonal antibody named bevacizumab, was approved in 2004. Approximately

Gholam A. Peyman (2,006 words) [view diff] exact match in snippet view article find links to article

Intravitreal slow-release Rock inhibitors alone or in combination with Anti-VEGF Artificial Retina Stimulation Semiconductor photodiode stimulation of

Angiogenesis (5,887 words) [view diff] exact match in snippet view article find links to article

PMID 15501967. Bagri A, Kouros-Mehr H, Leong KG, Plowman GD (March 2010). "Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale". Trends in Molecular

Stacey Finley (780 words) [view diff] exact match in snippet view article find links to article

(2013-06-05). "Effect of Tumor Microenvironment on Tumor VEGF During Anti-VEGF Treatment: Systems Biology Predictions". JNCI: Journal of the National

Micropsia (2,860 words) [view diff] exact match in snippet view article find links to article

You've Never Heard Of[permanent dead link‍] Ozkiris A (January 2010). "Anti-VEGF agents for age-related macular degeneration". Expert Opinion on Therapeutic

Endothelial stem cell (3,444 words) [view diff] exact match in snippet view article find links to article

secreting factors such as VEGF and by reducing the amount of PGK, an anti-VEGF enzyme. The result is an uncontrolled production of beta-catenin, which

Large-cell lung carcinoma with rhabdoid phenotype (3,858 words) [view diff] exact match in snippet view article find links to article

extreme caution if contemplating the therapeutic use of bevacizumab, other anti-VEGF compounds, or anti-angiogenesis agents in general, which have been associated

Retina (9,299 words) [view diff] exact match in snippet view article find links to article

modalities of management for retinal disease: Intravitreal medication, such as anti-VEGF or corticosteroid agents Vitreoretinal surgery Use of nutritional supplements

Cancer (20,066 words) [view diff] exact match in snippet view article find links to article

PMID 19360048. Bagri A, Kouros-Mehr H, Leong KG, Plowman GD (March 2010). "Use of anti-VEGF adjuvant therapy in cancer: challenges and rationale". Trends in Molecular

Vestibular schwannoma (6,712 words) [view diff] exact match in snippet view article find links to article

endothelial growth factor) that initiates proliferation was discovered. An anti-VEGF drug named bevacizumab (Avastin) was developed and showed promise in stopping

National Eye Institute (5,859 words) [view diff] exact match in snippet view article find links to article

no effect on the risk, onset, progression, or severity of retinopathy. Anti-VEGF therapy for diabetic retinopathy: This two-year, NEI-supported study,

Novartis (12,146 words) [view diff] exact match in snippet view article find links to article

anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments) outside the U.S. for up to $1 billion. Novartis acquired exclusive

Yihai Cao (1,267 words) [view diff] exact match in snippet view article find links to article

Jones, Bernt; Wu, Yan; Zhu, Zhenping; Pytowski, Bronislaw (2008-11-25). "Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated

TMEM230 (1,744 words) [view diff] exact match in snippet view article find links to article

associated angiogenesis research and may represent an alternative to anti-VEGF for tumor treatment. In normal vertebrate embryo development, TMEM230

Osteopontin (8,300 words) [view diff] exact match in snippet view article find links to article

inhibited metastasis in an in vivo study and also when hybridized with the anti-VEGF antibody bevacizumab . At least one clinical trial is exploring the use

Choroidal nevus (2,688 words) [view diff] exact match in snippet view article find links to article

vascular tissue as a result of the development of nevi can be treated using anti-VEGF agents, injected through the veins. These drugs inactivate the growth

Epithelioid sarcoma (5,913 words) [view diff] exact match in snippet view article find links to article

vessels, which provide necessary elements to the tumor for tumor survival. Anti-VEGF agents such as pazopanib are approved for use in carcinomas and in soft

List of Italian inventions and discoveries (25,879 words) [view diff] exact match in snippet view article find links to article

working at Genentech. He is credited with developing a whole new class of anti-VEGF drugs for cancer treatment. He had a leading role in the development of

VEGFR-2 inhibitor (4,735 words) [view diff] exact match in snippet view article find links to article

Kamba, T; McDonald, D M (22 May 2007). "Mechanisms of adverse effects of anti-VEGF therapy for cancer". British Journal of Cancer. 96 (12): 1788–1795. doi:10

Ovarian squamous cell carcinoma (3,019 words) [view diff] exact match in snippet view article find links to article

Nonetheless, evidence indicates that combining chemotherapy with the humanized anti-VEGF monoclonal antibody, bevacizumab, in the treatment of recurrent, persistent