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Longer titles found: Aminoacyl-tRNA hydrolase (view)

searching for Aminoacyl-tRNA 170 found (212 total)

Peptidyl transferase center (682 words) [view diff] no match in snippet view article find links to article

alignment between the CCA ends of the ribosome-bound peptidyl tRNA and aminoacyl tRNA in the peptidyl transferase center contribute to peptide bond formation

Glutamine—tRNA ligase (775 words) [view diff] exact match in snippet view article find links to article

Glutamine—tRNA ligase or glutaminyl-tRNA synthetase (GlnRS) is an aminoacyl-tRNA synthetase (aaRS or ARS), also called tRNA-ligase. is an enzyme that attaches

Methionine—tRNA ligase (368 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is

Cysteine—tRNA ligase (190 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-cysteine:tRNACys

Leucine—tRNA ligase (292 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-leucine:tRNALeu

Tryptophan—tRNA ligase (290 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is

Aspartate—tRNA ligase (241 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-aspartate:tRNAAsp

Glutamate—tRNA ligase (225 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlu

Arginine—tRNA ligase (348 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-arginine:tRNAArg

Asparagine—tRNA ligase (192 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is

Phenylalanine—tRNA ligase (503 words) [view diff] exact match in snippet view article find links to article

and aminoacyl-tRNA biosynthesis. Phenylalanine-tRNA synthetase (PheRS) is known to be among the most complex enzymes of the aaRS (Aminoacyl-tRNA synthetase)

Valine—tRNA ligase (254 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-valine:tRNAVal

Alanine—tRNA ligase (255 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-alanine:tRNAAla

Serine—tRNA ligase (303 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-serine:tRNASer

Isoleucine—tRNA ligase (293 words) [view diff] exact match in snippet view article find links to article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is

List of EC numbers (EC 6) (2,811 words) [view diff] no match in snippet view article

This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the

Amino acid activation (1,608 words) [view diff] no match in snippet view article find links to article

occurs in the cell cytosol and consists of two steps: first, the enzyme aminoacyl tRNA synthetase catalyzes the binding of adenosine triphosphate (ATP) to

Proline—tRNA ligase (212 words) [view diff] exact match in snippet view article find links to article

and aminoacyl-trna biosynthesis. This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and

Aminoacyl tRNA synthetases, class I (585 words) [view diff] exact match in snippet view article find links to article

The aminoacyl-tRNA synthetases catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction. These

EPRS (1,158 words) [view diff] exact match in snippet view article find links to article

Bifunctional aminoacyl-tRNA synthetase is an enzyme that in humans is encoded by the EPRS gene. Alternative splicing has been observed for this gene, but

Histidine—tRNA ligase (152 words) [view diff] case mismatch in snippet view article find links to article

L-histidyl-tRNA(His). This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis. Histidine—tRNA ligase belongs to the family of ligase

Aminoacyl tRNA synthetases, class II (472 words) [view diff] exact match in snippet view article find links to article

Aminoacyl-tRNA synthetases, class II is a family of proteins. These proteins catalyse the attachment of an amino acid to its cognate transfer RNA molecule

Lysine—tRNA ligase (284 words) [view diff] case mismatch in snippet view article find links to article

This enzyme participates in 3 metabolic pathways: lysine biosynthesis, aminoacyl-trna biosynthesis, and amyotrophic lateral sclerosis (als). This enzyme belongs

IARS (757 words) [view diff] exact match in snippet view article find links to article

cytoplasmic is an enzyme that in humans is encoded by the IARS1 gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino

LARS2 (673 words) [view diff] exact match in snippet view article find links to article

This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the

YARS (1,096 words) [view diff] exact match in snippet view article find links to article

synthetase is the tRNA that adds tyrosine to the end of a growing protein. Aminoacyl-tRNA synthetases catalyze the aminoacylation of transfer RNA (tRNA) by their

RARS (gene) (1,090 words) [view diff] exact match in snippet view article

cytoplasmic is an enzyme that in humans is encoded by the RARS gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino

QARS (1,040 words) [view diff] exact match in snippet view article find links to article

synthetase is an enzyme that in humans is encoded by the QARS gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino

DARS (gene) (904 words) [view diff] exact match in snippet view article

Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with

Multisynthetase complex auxiliary component p38 (945 words) [view diff] no match in snippet view article find links to article

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 is an enzyme that in humans is encoded by the AIMP2 gene. The JTV1 gene is located

EF-Ts (1,097 words) [view diff] no match in snippet view article find links to article

triphosphate molecule, release EF-Ts, and go on to catalyze another aminoacyl tRNA addition. The protein Qβ-Replicase is a tetrameric protein, meaning

D-alanine—poly(phosphoribitol) ligase (305 words) [view diff] exact match in snippet view article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is

VARS (897 words) [view diff] exact match in snippet view article find links to article

synthetase is an enzyme that in humans is encoded by the VARS gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino

EEF1E1 (515 words) [view diff] exact match in snippet view article find links to article

Norcum MT (1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". J. Biol

TARS (gene) (760 words) [view diff] no match in snippet view article

cytoplasmic is an enzyme that in humans is encoded by the TARS gene. Aminoacyl tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino

Leucyl-tRNA synthetase (963 words) [view diff] exact match in snippet view article find links to article

encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation

Karin Musier-Forsyth (1,978 words) [view diff] no match in snippet view article find links to article

of the genetic code. Her work has provided key insights into how the aminoacyl tRNA synthetases, the large family of enzymes involved in protein synthesis

MARS (gene) (731 words) [view diff] exact match in snippet view article

cytoplasmic is an enzyme that in humans is encoded by the MARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate

HARS (1,088 words) [view diff] exact match in snippet view article find links to article

histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate

MARS (gene) (731 words) [view diff] exact match in snippet view article

cytoplasmic is an enzyme that in humans is encoded by the MARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate

Glycine—tRNA ligase (1,940 words) [view diff] exact match in snippet view article find links to article

the GARS1 gene. This gene encodes glycyl-tRNA synthetase, one of the aminoacyl-tRNA synthetases that charge tRNAs with their cognate amino acids. The encoded

Rajan Sankaranarayanan (1,143 words) [view diff] exact match in snippet view article find links to article

archaeal-derived chiral proofreader D-aminoacyl-tRNA deacylase 2 (DTD2) in removing N-ethyl adducts formed on D-aminoacyl-tRNA by acetaldehyde, an anaerobic fermentation

Glutamate—tRNA(Gln) ligase (212 words) [view diff] exact match in snippet view article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlx

Bacterial translation (2,920 words) [view diff] no match in snippet view article find links to article

E site. The A site is the point of entry for the aminoacyl tRNA (except for the first aminoacyl tRNA, which enters at the P site). The P site is where

SCYE1 (1,143 words) [view diff] no match in snippet view article find links to article

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 is a protein that in humans is encoded by the AIMP1 gene. The protein encoded by

AspS RNA motif (202 words) [view diff] no match in snippet view article find links to article

sequence, thus regulating the gene translationally. aspS genes encode aminoacyl tRNA synthetases. T-box leader RNAs detect low levels of various amino acids

Xiang-Lei Yang (2,698 words) [view diff] exact match in snippet view article find links to article

has contributed to the establishment of physiological importance of aminoacyl-tRNA synthetases beyond their classical role in supporting mRNA translation

NARS (gene) (597 words) [view diff] exact match in snippet view article

cytoplasmic is an enzyme that in humans is encoded by the NARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate

AARS2 (527 words) [view diff] exact match in snippet view article find links to article

Sissler M (March 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44

Wang Enduo (557 words) [view diff] exact match in snippet view article find links to article

Recognized for her research on interaction between transfer RNAs (tRNA) and aminoacyl-tRNA synthetases (aaRS), she has been elected an academician of the Chinese

Phage-assisted continuous evolution (1,432 words) [view diff] exact match in snippet view article find links to article

protease with a significantly different peptide substrate. Using PACE, aminoacyl-tRNA synthetases (aaRSs) were evolved for noncanonical amino acids as well

Lysine—tRNA(Pyl) ligase (165 words) [view diff] exact match in snippet view article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-lysine:tRNAPyl

Wobble base pair (1,455 words) [view diff] no match in snippet view article find links to article

information can be seen on aminoacyl tRNA synthetase and the genomes of E. coli tRNA at the External links, Information on Aminoacyl tRNA Synthetases and Genomic

WARS (gene) (1,042 words) [view diff] exact match in snippet view article

Tryptophanyl-tRNA synthetase, cytoplasmic is an aminoacyl-tRNA synthetase enzyme that attaches the amino acid tryptophan to its cognate tRNA. In humans

KARS (gene) (1,417 words) [view diff] exact match in snippet view article

synthetase is an enzyme that in humans is encoded by the KARS gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate

EEF1G (1,220 words) [view diff] exact match in snippet view article find links to article

assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. EEF1G has been shown to interact with: EEF1B2, EEF1D, HARS

FARSA (gene) (539 words) [view diff] exact match in snippet view article

alpha chain is an enzyme that in humans is encoded by the FARSA gene. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate

T-box leader (1,013 words) [view diff] exact match in snippet view article find links to article

aminoacylation state. This interaction controls expression of downstream aminoacyl-tRNA synthetase genes, amino acid biosynthesis, and uptake-related genes

Aspartate—tRNA(Asn) ligase (358 words) [view diff] exact match in snippet view article

family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is

D arm (206 words) [view diff] exact match in snippet view article find links to article

recognition. It is widely believed that it acts as a recognition site for aminoacyl-tRNA synthetase, an enzyme involved in the aminoacylation of the tRNA molecule

Kim Sung-hoon (biologist) (638 words) [view diff] exact match in snippet view article

University, U.S. Dr. Sunghoon Kim has been studying novel functions of human aminoacyl-tRNA synthetases (ARSs) and searching for their pathophysiological connections

Susan A. Martinis (2,168 words) [view diff] no match in snippet view article find links to article

scientific book chapters. Her expertise is in protein:RNA interactions and aminoacyl tRNA synthetases. As of 2019, she is the Vice Chancellor for Research and

Cloverleaf model of tRNA (296 words) [view diff] no match in snippet view article find links to article

acids and such reactions are often catalyzed by a specific enzymes, aminoacyl tRNA synthetase. For example, if the amino acid that attach to the end is

Dino Moras (1,341 words) [view diff] no match in snippet view article find links to article

1038/347203a0. PMID 2203971. S2CID 4324290. Ruff, M. (1991). "Class II aminoacyl tRNA-synthetases : crystal structure of yeast aspartyl-tRNA synthetase complexed

Expanded genetic code (9,132 words) [view diff] no match in snippet view article find links to article

Many tRNAs are compatible with several codons. An enzyme called an aminoacyl tRNA synthetase covalently attaches the amino acid to the appropriate tRNA

VARS2 (448 words) [view diff] exact match in snippet view article find links to article

humans is encoded by the VARS2 gene. This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for

WARS2 (543 words) [view diff] exact match in snippet view article find links to article

mitochondrial is an enzyme that in humans is encoded by the WARS2 gene. Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino

Alloprotein (657 words) [view diff] no match in snippet view article find links to article

codons and related tRNA (transfer RNA) and tRNA synthetase enzymes (aminoacyl tRNA synthetase). The usual mechanisms, which produce amino acids and combine

EEF1B2 (1,233 words) [view diff] exact match in snippet view article find links to article

Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical

YbaK protein domain (330 words) [view diff] exact match in snippet view article find links to article

general aminoacyl-tRNA deacylases that preferentially hydrolyze Cys-tRNAPro and Cys-tRNACy. Furthermore, YbaK-mediated hydrolysis of aminoacyl-tRNA has been

EEF1D (1,395 words) [view diff] exact match in snippet view article find links to article

Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical

Antisynthetase syndrome (5,502 words) [view diff] no match in snippet view article find links to article

combination of radiologic features, clinical criteria, and identification of aminoacyl tRNA synthetase antibodies. Immunosuppressive medications such as mycophenolate

Prokaryotic large ribosomal subunit (1,476 words) [view diff] exact match in snippet view article find links to article

transfer reaction and prevents peptidyl hydrolysis. The amino group of an aminoacyl-tRNA (binds to A site) attacks the carbon of a carbonyl group of a peptidyl-tRNA

WHEP-TRS protein domain (359 words) [view diff] exact match in snippet view article find links to article

to six times in several enzymes. There are three copies in mammalian aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase

FARS2 (1,264 words) [view diff] exact match in snippet view article find links to article

position 25.1 and has 15 exons. This gene encodes a member of the class-II aminoacyl-tRNA synthetase family. FARS2 is a phenylalanine-tRNA synthetase (PheRS)

Ribosomal L28e protein family (605 words) [view diff] exact match in snippet view article find links to article

chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated

Eukaryotic translation (1,859 words) [view diff] exact match in snippet view article find links to article

occupies the P site in the ribosome, and the A site is ready to receive an aminoacyl-tRNA. During chain elongation, each additional amino acid is added to the

Terri Goss Kinzy (1,307 words) [view diff] exact match in snippet view article find links to article

University. Her 1991 dissertation was titled Characterization of GTP and aminoacyl-tRNA binding to eukaryotic initiation factor 2 and elongation factor 1. Her

SARS (gene) (1,210 words) [view diff] exact match in snippet view article

evolution of seryl-tRNA synthetases: implications for the evolution of aminoacyl-tRNA synthetases and the genetic code". BMC Nephrology. 40 (5): 519–530.

TSFM (445 words) [view diff] exact match in snippet view article find links to article

(1996). "Interaction of mitochondrial elongation factors Tu.Ts with aminoacyl-tRNA". Nucleic Acids Symp. Ser. (33): 163–6. PMID 8643359. TSFM human gene

Metabolite channeling (960 words) [view diff] exact match in snippet view article find links to article

enzyme dihydrofolate reductase-thymidylate synthase. The channeling of aminoacyl-tRNA for protein synthesis in vivo has been also reported. Some authors have

ATyr Pharma (784 words) [view diff] no match in snippet view article find links to article

In 2005, aTyr was founded by Paul Schimmel, and Xiang-Lei Yang, two aminoacyl tRNA synthetase scientists at The Scripps Research Institute. In 2009, Bruce

EEF-1 (720 words) [view diff] exact match in snippet view article find links to article

Mirande M (March 2009). "Dissection of the structural organization of the aminoacyl-tRNA synthetase complex". The Journal of Biological Chemistry. 284 (10):

Lithium acetate (302 words) [view diff] exact match in snippet view article find links to article

MT (Aug 15, 1991). "Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents". The Journal

Pyrrolysine (2,273 words) [view diff] exact match in snippet view article find links to article

(tRNA) with a CUA anticodon, and the pylS gene, which encodes a class II aminoacyl-tRNA synthetase that charges the pylT-derived tRNA with pyrrolysine. This

Norvaline (391 words) [view diff] exact match in snippet view article find links to article

into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. In Miller–Urey experiments probing prebiotic synthesis of

Brian S. Hartley (1,151 words) [view diff] no match in snippet view article find links to article

common evolutionary origin. Hartley also studied other enzymes, such as aminoacyl tRNA synthetases (with Alan Fersht), xylose isomerase and glucose isomerase

Genetic code (8,048 words) [view diff] no match in snippet view article find links to article

creating a unique codon (recoding) and a corresponding transfer-RNA:aminoacyl – tRNA-synthetase pair to encode it with diverse physicochemical and biological

YqeY protein domain (236 words) [view diff] exact match in snippet view article find links to article

chimer between proteins from an ancient and the modern pathways of aminoacyl-tRNA formation". Nucleic Acids Res. 35 (5): 1421–31. doi:10.1093/nar/gkl1164

Aar small RNA (270 words) [view diff] exact match in snippet view article find links to article

1007/s00203-010-0592-6. PMID 20559624. S2CID 16709707. Schimmel, PR; Söll, D (1979). "Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs". Annual

SARS2 (441 words) [view diff] exact match in snippet view article find links to article

Gene ontology Molecular function aminoacyl-tRNA ligase activity nucleotide binding ligase activity ATP binding serine-tRNA ligase activity RNA binding

Megavirus (574 words) [view diff] no match in snippet view article find links to article

with 1,259,197 base pairs in length.[citation needed] It exhibits 7 aminoacyl tRNA synthetases (Table 2), the archetypes of enzymes previously thought

B3/B4 tRNA-binding domain (262 words) [view diff] exact match in snippet view article find links to article

synthetase beta subunits, as well as in some non-tRNA synthetase proteins. Aminoacyl-tRNA synthetases can catalyse editing reactions to correct errors produced

Mimivirus (2,382 words) [view diff] no match in snippet view article find links to article

TFII-like transcription factor were found. However, three distinct aminoacyl tRNA synthetase enzyme transcripts and four unknown mRNA molecules specific

Stephen J. Benkovic (3,256 words) [view diff] exact match in snippet view article find links to article

Cusack, S., and Alley, M. R. K. (2007) An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site, Science 316, 1759-1761

Norleucine (404 words) [view diff] exact match in snippet view article find links to article

into peptides reflects the imperfect selectivity of the associated aminoacyl-tRNA synthetase. In Miller–Urey experiments probing prebiotic synthesis of

Methanosarcinaceae (547 words) [view diff] exact match in snippet view article find links to article

is inserted instead of the release factor. They also have a unique aminoacyl-tRNA synthetase to specifically load this tRNA with pyrrolysine. This unique

Horizontal evolution (179 words) [view diff] exact match in snippet view article find links to article

L.; Grishin, Nick V.; Koonin, Eugene V. (1999-09-09). "Evolution of Aminoacyl-tRNA Synthetases—Analysis of Unique Domain Architectures and Phylogenetic

Tupanvirus (1,807 words) [view diff] no match in snippet view article find links to article

largest translational apparatus within the known virosphere, carrying 20 aminoacyl tRNA synthetase (aaRS) and 70 transfer RNAs (tRNA), while the rest are involved

Prokaryotic small ribosomal subunit (1,045 words) [view diff] exact match in snippet view article find links to article

Igarashi, Kazuei; Tanaka, Shigeaki; Kaji, Akira (1971-02-11). "On the aminoacyl-tRNA binding site of the 30-S ribosomal subunit and its relation to the chain

Pyrrolysine—tRNAPyl ligase (205 words) [view diff] exact match in snippet view article find links to article

Winbush SM, McCloskey JA, Crain PF, Wood JL, Söll D (August 2004). "An aminoacyl-tRNA synthetase that specifically activates pyrrolysine". Proceedings of

Thrombotic microangiopathy (1,202 words) [view diff] no match in snippet view article find links to article

The Shiga-toxin inhibits the binding of eEF-1-dependent binding of aminoacyl tRNA to the 60S subunit of the ribosome, thus inhibiting protein synthesis

23S ribosomal RNA (976 words) [view diff] exact match in snippet view article find links to article

plays role in the peptide bond configuration. Both peptidyl-tRNA and aminoacyl-tRNA are important for protein synthesis and transpeptidation response. However

Marcin Hoffmann (2,981 words) [view diff] exact match in snippet view article find links to article

Design of novel leulcyl-tRNA synthetase inhibitors based on self-made aminoacyl-tRNA synthase inhibitor database. Identification of novel pregnane X receptor

Carl Woese (3,853 words) [view diff] exact match in snippet view article find links to article

evolution. He worked on detailed analyses of the phylogenies of the aminoacyl-tRNA synthetases and on the effect of horizontal gene transfer on the distribution

2-Aminoisobutyric acid (454 words) [view diff] exact match in snippet view article find links to article

incorporation of backbone modified amino acids via an editing-deficient aminoacyl-tRNA synthetase". Organic & Biomolecular Chemistry. 16 (7): 1073–1078. doi:10

Amino acid (10,141 words) [view diff] exact match in snippet view article find links to article

ester bond. This aminoacyl-tRNA is produced in an ATP-dependent reaction carried out by an aminoacyl tRNA synthetase. This aminoacyl-tRNA is then a substrate

Paul Schimmel (1,143 words) [view diff] no match in snippet view article find links to article

textbook on biophysical chemistry. His research interests have focused on aminoacyl tRNA synthetases as fundamental interpreters of the genetic information.

Asparaginyl-tRNA synthase (glutamine-hydrolysing) (238 words) [view diff] exact match in snippet view article

1073/pnas.95.22.12838. PMC 23620. PMID 9789001. Ibba M, Soll D (2000). "Aminoacyl-tRNA synthesis". Annu. Rev. Biochem. 69 (1): 617–50. doi:10.1146/annurev

Trojan Horse effect (211 words) [view diff] exact match in snippet view article find links to article

Konstantin; Dubiley, Svetlana (2021). "Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases". RSC Chemical Biology. 2 (2): 468–485. doi:10.1039/d0cb00208a

Codon degeneracy (905 words) [view diff] no match in snippet view article find links to article

residues. These tendencies may result from the shared ancestry of the aminoacyl tRNA synthetases related to these codons. These variable codes for amino

Var1 protein domain (436 words) [view diff] exact match in snippet view article find links to article

chain, situated in the P site as peptidyl-tRNA, is then transferred to aminoacyl-tRNA and the new peptidyl-tRNA, extended by one residue, is translocated

Xenobiology (4,530 words) [view diff] exact match in snippet view article find links to article

transfer RNA (tRNA)/aminoacyl-tRNA synthetase pairs the codon specificity can be changed. Cells endowed with such aminoacyl-[tRNA synthetases] are thus

Demeclocycline (1,043 words) [view diff] no match in snippet view article find links to article

acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria. It is bacteriostatic (it

Elongation factor (791 words) [view diff] no match in snippet view article find links to article

Eukaryotic/Archaeal Function EF-Tu eEF-1A (α) mediates the entry of the aminoacyl tRNA into a free site of the ribosome. EF-Ts eEF-1B (βγ) serves as the guanine

Ribonuclease V1 (707 words) [view diff] exact match in snippet view article find links to article

Vassilenko SK, Ebel JP (February 1981). "Partial digestion of tRNA--aminoacyl-tRNA synthetase complexes with cobra venom ribonuclease". Biochemistry. 20

Index of biology articles (1,370 words) [view diff] no match in snippet view article find links to article

allosteric enzyme – allosteric site – allozyme – alpha helix – amino acid – aminoacyl tRNA synthetase – amino group – amniocentesis – amniote – amphipathic molecule

RNA motif (817 words) [view diff] exact match in snippet view article find links to article

around the T-box, which in 1993 was determined to be associated with aminoacyl-tRNA synthetase genes. The mechanism by which this RNA motif regulates genes

Computational Resource for Drug Discovery (2,294 words) [view diff] no match in snippet view article find links to article

of antibacterial peptides. icaars: Prediction and classification of aminoacyl tRNA synthetases using PROSITE domains. CBtope: Prediction of conformational

Parkin (protein) (5,731 words) [view diff] exact match in snippet view article

ubiquitinating other Lewy body constituents, such as the p38 subunit of aminoacyl-tRNA synthetase complex and far upstream element-binding protein 1 through

Peggy Lemaux (394 words) [view diff] exact match in snippet view article find links to article

ISSN 1543-5008. Lemaux, Peggy Goodenow (1977). Regulation of the synthesis of aminoacyl-tRNA synthetases in Escherichia coli B (Ph.D. dissertation). Ann Arbor, Michigan:

Adenosine triphosphate (5,447 words) [view diff] exact match in snippet view article find links to article

transcription also consume ATP. Aminoacyl-tRNA synthetase enzymes consume ATP in the attachment tRNA to amino acids, forming aminoacyl-tRNA complexes. Aminoacyl

Enzyme (9,819 words) [view diff] no match in snippet view article find links to article

1 Similar proofreading mechanisms are also found in RNA polymerase, aminoacyl tRNA synthetases and ribosomes. Conversely, some enzymes display enzyme promiscuity

Alice Cheung (684 words) [view diff] no match in snippet view article find links to article

doctoral research considered the genetic and biochemical regulation of aminoacyl tRNA synthetase. At a scientific conference, she heard Eugene Nester discussing

Steven A. Benner (3,897 words) [view diff] no match in snippet view article find links to article

codons, many of them synthetic codons. For these codons to be useful, Aminoacyl tRNA synthetase has been created such that tRNA can code for the possibly

Cell-free protein synthesis (1,701 words) [view diff] exact match in snippet view article find links to article

The remains are the necessary cell machinery including ribosomes, aminoacyl-tRNA synthetases, translation initiation and elongation factors, nucleases

N-Formylmethionine (1,188 words) [view diff] exact match in snippet view article find links to article

modification is done after methionine has been loaded onto tRNAfMet by aminoacyl-tRNA synthetase. Methionine itself can be loaded either onto tRNAfMet or

Arul Chinnaiyan (944 words) [view diff] no match in snippet view article find links to article

interrogation of androgen action in prostate cancer cells reveals roles of aminoacyl tRNA synthetases". PLOS ONE. 4 (9): e7075. Bibcode:2009PLoSO...4.7075V. doi:10

Enzyme promiscuity (3,442 words) [view diff] exact match in snippet view article find links to article

(November 2012). "Structural diversity and protein engineering of the aminoacyl-tRNA synthetases". Biochemistry. 51 (44): 8705–29. doi:10.1021/bi301180x

Nucleic acid quaternary structure (1,980 words) [view diff] exact match in snippet view article find links to article

Svergun D (January 2013). "Quaternary structure of the yeast Arc1p-aminoacyl-tRNA synthetase complex in solution and its compaction upon binding of tRNAs"

POLG2 (1,099 words) [view diff] exact match in snippet view article find links to article

Bogenhagen DF (March 2000). "Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor

Dermatomyositis (2,761 words) [view diff] exact match in snippet view article find links to article

people have myositis-specific autoantibodies which include antibodies to aminoacyl-tRNA synthetases (anti-synthetase antibodies), including antibodies against

Mnemiopsis (2,174 words) [view diff] no match in snippet view article find links to article

genes have been genuinely lost along with nuclear-encoded mitochondrial aminoacyl tRNA synthetases. The mitochondrial rRNA molecules possess little similarity

MAFK (2,536 words) [view diff] exact match in snippet view article find links to article

E, Siatecka M, Mirande M (Jan 1999). "Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization

Mupirocin (2,605 words) [view diff] exact match in snippet view article find links to article

inhibition of protein synthesis. The uncharged form of the tRNA binds to the aminoacyl-tRNA binding site of ribosomes, triggering the formation of (p)ppGpp, which

Evolution of cells (3,190 words) [view diff] exact match in snippet view article find links to article

Luthey-Schulten Z (December 2003). "On the evolution of structure in aminoacyl-tRNA synthetases". Microbiology and Molecular Biology Reviews. 67 (4): 550–573

Elizabeth Maywood (1,272 words) [view diff] exact match in snippet view article find links to article

feedback loops (TTFLs). To do this, the researchers used orthogonal aminoacyl-tRNA synthetase/tRNA brought to the SCN by an adeno-associated virus vector

Protein metabolism (2,828 words) [view diff] exact match in snippet view article find links to article

an amino acid to a tRNA is known as tRNA charging. Here, the enzyme aminoacyl-tRNA-synthetase catalyzes two reactions. In the first one, it attaches an

Protein (11,472 words) [view diff] no match in snippet view article find links to article

the amino acid corresponding to the codon it recognizes. The enzyme aminoacyl tRNA synthetase "charges" the tRNA molecules with the correct amino acids

HEAT repeat (3,022 words) [view diff] no match in snippet view article find links to article

Translational regulation Elongation factor eEF3 Initiation factor eIF4G Aminoacyl tRNA synthetase transfer protein Cex1p DNA repair DNA-PK (DNA-dependent protein

Olke C. Uhlenbeck (1,339 words) [view diff] no match in snippet view article find links to article

modified tRNA. One of their major focuses is the development of an aminoacyl tRNA synthetase, which allows the researchers to conduct their experiment

UBALD1 (1,174 words) [view diff] exact match in snippet view article find links to article

EEF1E1, both of which are known to interact and be involved in the aminoacyl-tRNA synthetase multienzyme complex. UBALD1 has been associated with various

MRNA display (2,214 words) [view diff] exact match in snippet view article find links to article

translation components are present. Some components, such as amino acids and aminoacyl-tRNA synthases (AARSs) can be omitted from the system. Instead, chemically

DNA unwinding element (2,303 words) [view diff] exact match in snippet view article find links to article

hydrolyze ATP In order to function. Also possess similar sequence to aminoacyl-tRNA synthetase, and were previously classified a such. DUE-Bs form homodimers

Charcot–Marie–Tooth disease (4,670 words) [view diff] exact match in snippet view article find links to article

glycyl-tRNA synthetase (GlyRS). Glycyl-tRNA synthetase is a class II aminoacyl-tRNA synthetase and acts as the catalyst for the synthesis of glycyl-tRNA

Conformational proofreading (1,702 words) [view diff] exact match in snippet view article find links to article

binding and codon recognition: a complex of elongation factor (EF-Tu) and aminoacyl-tRNA binds to the ribosome. Codon is recognized by pairing with the anticodon

Kinetic proofreading (1,832 words) [view diff] no match in snippet view article find links to article

respective amino-acids – the enzyme that charges the tRNA is called aminoacyl tRNA synthetase. This enzyme utilizes a high energy intermediate state to

ATP phosphoribosyltransferase (763 words) [view diff] exact match in snippet view article find links to article

Delorme C, Bond J, Ehrlich SD, Renault P, Francklyn C (August 1999). "An aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesis"

Universal stress protein (2,579 words) [view diff] no match in snippet view article find links to article

1021/bi9017522. PMID 20113006.. Aravind L, et al. (2002). "Monophyly of class I aminoacyl tRNA synthetase, USPA, ETFP, photolyase, and PP-ATPase nucleotide-binding

Attenuator (genetics) (2,242 words) [view diff] exact match in snippet view article

specific uncharged tRNAs and modulate the expression of corresponding aminoacyl-tRNA synthetase operons. High levels of uncharged tRNA promote the anti-terminator

Karelsulcia muelleri (2,279 words) [view diff] no match in snippet view article find links to article

homoserine and 2-ketovaline. "Ca. K. muelleri" lacks a full set of Aminoacyl tRNA synthetases; surprisingly, however, it possesses all of the genes necessary

David Horn (Israeli physicist) (1,976 words) [view diff] no match in snippet view article

(2013): e1003346. David Horn. Taxa counting using Specific Peptides of Aminoacyl tRNA Synthetases Encyclopedia of Metagenomics, Springer, 2013. Sagi Shporer

Ordered two-template relay (1,704 words) [view diff] exact match in snippet view article find links to article

; Brandl, C. J.; O'Donoghue, P. (2019). "Thematic series: tRNAs and aminoacyl-tRNA synthetases in human disease: Pathways to disease from natural variations

Glycine (3,717 words) [view diff] exact match in snippet view article find links to article

Stathopoulos C, et al. (February 2017). "The complex evolutionary history of aminoacyl-tRNA synthetases". Nucleic Acids Research. 45 (3): 1059–1068. doi:10.1093/nar/gkw1182

Last universal common ancestor (6,605 words) [view diff] exact match in snippet view article find links to article

W. F. (1995). "Root of the Universal Tree of Life Based on Ancient Aminoacyl-tRNA Synthetase Gene Duplications". PNAS. 92 (7): 2441–2445. Bibcode:1995PNAS

Rickettsia rickettsii (4,790 words) [view diff] exact match in snippet view article find links to article

block the exit site for peptides, while chloramphenicol blocks the aminoacyl-tRNA attachment site for transfer RNA. The first documented case of Rocky

Microphthalmia-associated transcription factor (4,822 words) [view diff] exact match in snippet view article find links to article

the multisynthetase complex. This complex consists of nine different aminoacyl-tRNA synthetases and three scaffold proteins and has been termed the "signalosome"

Ribosomal RNA (7,195 words) [view diff] exact match in snippet view article find links to article

the A, P and E sites: In general, the A (aminoacyl) site contains an aminoacyl-tRNA (a tRNA esterified to an amino acid on the 3' end). The P (peptidyl)

Antinuclear antibody (6,097 words) [view diff] exact match in snippet view article find links to article

antibodies to the cytoplasmic protein, Histidyl-tRNA synthetase – an aminoacyl-tRNA synthetase essential for the synthesis of histidine loaded tRNA. They

Albert Schatz (scientist) (4,616 words) [view diff] exact match in snippet view article

Konstantin; Dubiley, Svetlana (2021). "Natural Trojan horse inhibitors of aminoacyl-tRNA synthetases". RSC Chemical Biology. 2 (2): 468–485. doi:10.1039/D0CB00208A

Valina L. Dawson (3,374 words) [view diff] exact match in snippet view article find links to article

TM (31 August 2005). "Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death"

Boron (13,548 words) [view diff] no match in snippet view article find links to article

generally approved for the purpose. Tavaborole (marketed as Kerydin) is an Aminoacyl tRNA synthetase inhibitor which is used to treat toenail fungus. It gained

L-Photo-methionine (2,542 words) [view diff] no match in snippet view article find links to article

but did not need to use modified tRNAs (transfer RNA's) or AARS's (aminoacyl tRNA syntheses) which that allowed the specific cross-linking needed. This

Edward Trifonov (4,353 words) [view diff] exact match in snippet view article find links to article

would be associated with the older one of the two known classes of aminoacyl-tRNA synthetases. Later on, Trifonov collected even 101 criteria: 123 for

Archaea (16,538 words) [view diff] no match in snippet view article find links to article

pathway into novel operons, and large differences in tRNA genes and their aminoacyl tRNA synthetases. Transcription in archaea more closely resembles eukaryotic

Heat shock protein 90kDa alpha (cytosolic), member A1 (8,199 words) [view diff] exact match in snippet view article

shock protein 90 mediates protein-protein interactions between human aminoacyl-tRNA synthetases". The Journal of Biological Chemistry. 275 (41): 31682–8

Synthetic biology (18,524 words) [view diff] no match in snippet view article find links to article

Typically, these projects make use of re-coded nonsense suppressor tRNA-Aminoacyl tRNA synthetase pairs from other organisms, though in most cases substantial

Αr14 RNA (2,402 words) [view diff] exact match in snippet view article find links to article

(NC_011369) αr14 gene AGROH133_02958 R 108794 109252 YP_004277412.1 aminoacyl-tRNA ligase Agrobacterium sp. H13-3 chromosome (NC_015183) αr14 sRNA AH13r14C1

Alternative abiogenesis scenarios (9,031 words) [view diff] exact match in snippet view article find links to article

this is consistent with the enhanced stability of RNA phosphodiester, aminoacyl-tRNA bonds, and peptides in acidic conditions. Cycling between supercritical

Glossary of cellular and molecular biology (M–Z) (24,506 words) [view diff] exact match in snippet view article

of transcription factors, polymerases, ribosomes, transfer RNAs, and aminoacyl-tRNA synthetases with which to direct transcription and translation of their