Cepheid variable

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pages: 492 words: 149,259

Big Bang by Simon Singh

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Albert Einstein, Albert Michelson, All science is either physics or stamp collecting, Andrew Wiles, anthropic principle, Arthur Eddington, Astronomia nova, Brownian motion, carbon-based life, Cepheid variable, Chance favours the prepared mind, Commentariolus, Copley Medal, cosmic abundance, cosmic microwave background, cosmological constant, cosmological principle, dark matter, Dava Sobel, Defenestration of Prague, discovery of penicillin, Dmitri Mendeleev, Edmond Halley, Edward Charles Pickering, Eratosthenes, Ernest Rutherford, Erwin Freundlich, Fellow of the Royal Society, fudge factor, Hans Lippershey, Harlow Shapley and Heber Curtis, Harvard Computers: women astronomers, Henri Poincaré, horn antenna, if you see hoof prints, think horses—not zebras, Index librorum prohibitorum, invention of the telescope, Isaac Newton, John von Neumann, Karl Jansky, Louis Daguerre, Louis Pasteur, luminiferous ether, Magellanic Cloud, Murray Gell-Mann, music of the spheres, Olbers’ paradox, On the Revolutions of the Heavenly Spheres, Paul Erdős, retrograde motion, Richard Feynman, Richard Feynman, scientific mainstream, Simon Singh, Solar eclipse in 1919, Stephen Hawking, the scientific method, Thomas Kuhn: the structure of scientific revolutions, unbiased observer, V2 rocket, Wilhelm Olbers, William of Occam

They could prove that one Cepheid was, say, 12 times farther away than another, but that was all. If only the distance to just one Cepheid variable star could be found, then it would be possible to anchor Leavitt’s measurement scale and gauge the distance to every single Cepheid. The decisive observations that made this possible and thereby calibrated the Cepheid distance scale were achieved thanks to a team effort by astronomers who included Harlow Shapley and Denmark’s Ejnar Hertzsprung. Together they used a combination of techniques, including parallax, to measure the distance to one Cepheid variable, which then transformed Leavitt’s research into the ultimate distance guide for the cosmos. Cepheid variables could act as a yardstick for the universe. In summary, an astronomer could now measure the distance to any Cepheid by a simple three-step process.

This pattern cannot be explained by any sort of eclipse effect, so the two young men assumed that there must be something intrinsic to the two stars that was causing the variation. They decided that Eta Aquilae and Delta Cephei belonged to a new class of variable star, which we now call Cepheid variables, or simply Cepheids. Some Cepheids are very subtle, such as Polaris, the North Star, which is our closest Cepheid. William Shakespeare was completely unaware of the star’s variable nature, and in Julius Caesar he has Caesar proclaim: ‘But I am constant as the Northern Star.’ Although this star is constant inasmuch as it always indicates north, its luminosity varies and it grows slightly brighter and dimmer roughly every four nights. Today we know what goes on inside a Cepheid variable star, what causes its asymmetric variability and what makes it different from other stars. Most stars are in a state of stable equilibrium, which essentially means that the huge mass of a star wants to collapse in on itself under the force of gravity, but this is counteracted by the outward pressure caused by the intense heat of the material within the star.

Leavitt made the most of this burgeoning technology and would discover more than 2,400 variable stars, about half of the total known in her day. Professor Charles Young of Princeton University was so impressed that he called her ‘a variable-star fiend’. Of the various types of variable star, Leavitt developed a particular passion for Cepheids. After months spent measuring and cataloguing Cepheid variables, she yearned to gain some understanding of what determined the rhythm of their fluctuations. In an effort to solve the mystery she turned her attention to the only two firm pieces of information available for any Cepheid variable: its period of variation and its brightness. Ideally, she wanted to see whether there was any relationship between period and brightness – perhaps brighter stars might prove to have a longer period of variation than dimmer stars, or vice versa. Unfortunately, it seemed virtually impossible to make any sense of the brightness data.


pages: 442 words: 110,704

The Glass Universe: How the Ladies of the Harvard Observatory Took the Measure of the Stars by Dava Sobel

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Albert Einstein, card file, Cepheid variable, crowdsourcing, dark matter, Dava Sobel, Edmond Halley, Edward Charles Pickering, Ernest Rutherford, Harlow Shapley and Heber Curtis, Harvard Computers: women astronomers, index card, invention of the telescope, Isaac Newton, John Harrison: Longitude, luminiferous ether, Magellanic Cloud, pattern recognition, QWERTY keyboard, Ralph Waldo Emerson, Solar eclipse in 1919, V2 rocket

There was no telling how far into space astronomers might penetrate by the light of Miss Leavitt’s stars. Having limned the extent of the Milky Way on a foundation of Cepheids, Shapley recognized the need to refine Miss Leavitt’s magnitude measurements, to make sure they were strong enough to support his conclusions. In a letter to Pickering on July 20, 1918, Shapley stated, “I believe the most important photometric work that can be done on Cepheid variables at the present time is a study of the Harvard plates of the Magellanic clouds. Probably Miss Leavitt’s many other problems have interrupted and delayed her work on the variables of the clouds for the interval of six or seven years since her preliminary work was published.” No doubt her illness, which had been diagnosed as cancer, figured chief among Miss Leavitt’s problems, though her many other scientific assignments had effectively barred her from further pursuit of her Cepheid discoveries.

No doubt her illness, which had been diagnosed as cancer, figured chief among Miss Leavitt’s problems, though her many other scientific assignments had effectively barred her from further pursuit of her Cepheid discoveries. Shapley closed his letter with a prediction: “The theory of stellar variation, the laws of stellar luminosities, the arrangement of objects throughout the whole galactic system, the structure of the clouds—all these problems will benefit directly or indirectly from a further knowledge of the Cepheid variables.” • • • THE MEMBERS OF THE AAVSO, those devoted observers of the long-period variables, met in November 1918 at the Harvard College Observatory. They had been accustomed to getting together in Connecticut or New Jersey at the homes of the association’s officers, but now that Leon Campbell had returned from Peru and resumed close communication with the volunteers, the observatory served as the new unofficial headquarters.

And I walked back to my room in the dormitory in a dream. My feet did not seem to touch the ground . . . it was almost like flying. I had not wanted to tell him that I was quite a good typist myself.” Miss Payne happened to be in Shapley’s office the day he received a letter, dated February 19, 1924, from Edwin Hubble, a former colleague of his at Mount Wilson. “Dear Shapley,” it began. “You will be interested to hear that I have found a Cepheid variable in the Andromeda Nebula.” Few announcements could have rattled Shapley more than this one. The Andromeda Nebula, dimly visible to the naked eye, was the largest, most closely observed of all the spirals. A nova had erupted at its heart in August 1885, but was never captured on glass, given the primitive state of celestial photography at that early date. Since then the Andromeda Nebula had borne no evidence of individual stars, either at its center or anywhere along its spiral arms.


pages: 661 words: 169,298

Coming of Age in the Milky Way by Timothy Ferris

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Albert Einstein, Albert Michelson, Alfred Russel Wallace, anthropic principle, Arthur Eddington, Atahualpa, Cepheid variable, Chance favours the prepared mind, Commentariolus, cosmic abundance, cosmic microwave background, cosmological constant, cosmological principle, dark matter, delayed gratification, Edmond Halley, Eratosthenes, Ernest Rutherford, Gary Taubes, Harlow Shapley and Heber Curtis, Harvard Computers: women astronomers, Henri Poincaré, invention of writing, Isaac Newton, John Harrison: Longitude, Karl Jansky, Lao Tzu, Louis Pasteur, Magellanic Cloud, mandelbrot fractal, Menlo Park, Murray Gell-Mann, music of the spheres, planetary scale, retrograde motion, Richard Feynman, Richard Feynman, Search for Extraterrestrial Intelligence, Searching for Interstellar Communications, Solar eclipse in 1919, Stephen Hawking, Thomas Kuhn: the structure of scientific revolutions, Thomas Malthus, Wilhelm Olbers

Once the absolute magnitude of any star is known, it is a simple matter to compute its distance: All the astronomer has to do is measure its apparent magnitude and then apply the formula that brightness decreases by the square of the distance. If, for instance, we have two Cepheid variables with the same period, we may assume that they have about the same absolute magnitude. If the apparent magnitude of one is four times that of the other, we conclude (barring complications such as the interference of an intervening interstellar cloud) that the dimmer star is twice as far away. The relationship between the periodicity and the absolute magnitude of Cepheid variable stars was discovered in 1912 by Henrietta Swan Leavitt, one of a number of women hired at meager wages to work as “computers” in the Harvard College Observatory office in Cambridge, Massachusetts. Leavitt spent her days examining photographic plates taken through the twenty-four-inch refracting telescope at the Harvard station in Arequipa, Peru.

This means that any significant difference in the apparent magnitudes of stars in a Magellanic Cloud must result from genuine differences in their absolute magnitudes and not from the effect of differing distances. Thanks to this happy circumstance, Leavitt in studying Cepheid variable stars in the Magellanic Clouds was able to notice a correlation between their brightness and their period of variability—the brighter the Cepheid, the longer its cycle of variation. The period-luminosity function Leavitt discovered was to become the cornerstone of measuring distance in the Milky Way and beyond. Shapley, out to chart the Milky Way galaxy, seized on the Cepheids with great enthusiasm. Using the big sixty-inch Mount Wilson telescope, he photographed globular star clusters—spectacular assemblages of hundreds of thousands to millions of stars —identified Cepheid variable stars in each of them, then employed the Cepheids to calibrate the distances of the clusters. “The results are continual pleasure,” he wrote the astronomer Jacobus Kapteyn in 1917.

The diameter of the Milky Way galaxy previously had been reckoned—by various investigators, Shapley among them—at some fifteen to twenty thousand light-years. Now, with his Cepheid variable work in hand, Shapley concluded that the correct figure was three hundred thousand light-years—more than ten times larger than the dimensions entertained by his contemporaries, and three times the most generous estimates we have today.* Various errors contributed to Shapley’s inflated picture of the Milky Way galaxy. Like many of his contemporaries, he underestimated the extent to which clouds of interstellar gas and dust dim the images of distant stars, making them appear farther away than they really are. Moreover, he assumed that the Cepheid variable stars he observed in globular clusters were essentially identical to those Henrietta Leavitt had found in the Magellanic Clouds; actually, as Walter Baade and other astrophysicists were to find, the cluster variables are less massive and intrinsically less bright, and therefore by implication less distant, than a straightforward comparison of their periods with those of their younger cousins would imply.


pages: 412 words: 122,952

Day We Found the Universe by Marcia Bartusiak

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Albert Einstein, Albert Michelson, Arthur Eddington, California gold rush, Cepheid variable, Copley Medal, cosmic microwave background, cosmological constant, Edmond Halley, Edward Charles Pickering, Fellow of the Royal Society, fudge factor, Harlow Shapley and Heber Curtis, Harvard Computers: women astronomers, horn antenna, invention of the telescope, Isaac Newton, Louis Pasteur, Magellanic Cloud, Occam's razor, Pluto: dwarf planet, Solar eclipse in 1919, William of Occam

The variable star went through its complete cycle—from bright to dim and back to bright again—in a matter of 31.415 days. From the length of this period and the shape of the curve (sharp rise and slow decline), Hubble now comprehended that he had captured that elusive and rare celestial beast—a Cepheid variable, a star seven thousand times brighter than our Sun. But it appeared so dim—the barest smudge on his photographic plate—that Hubble knew it had to reside at a great distance. It was on average more than one hundred thousand times dimmer than the faintest stars visible to the unaided eye. The photographic plate of Andromeda (M31) on which Edwin Hubble identified a Cepheid variable star, mistaken at first for a nova, in a spiral nebula—the first step in Hubble's opening up the universe (Courtesy of the Observatories of the Carnegie Institution of Washington) At some point during these deliberations, Hubble went back to his logbook, page 157, and quickly scrawled an added note on the side of the page to amend the report of his October 5 observing run.

She dutifully reported her findings in the 1908 Annals of the Astronomical Observatory of Harvard College, with thirteen pages taken up with listing every new variable she had discovered, its exact position in the sky, as well as its minimum and maximum brightness. More intriguing was what she wrote at the end of this paper. Over the course of her painstaking examination of the Small Magellanic Cloud, she came to notice a special group of variable stars, sixteen in number. They were later identified as Cepheid variables, stars that are thousands of times more luminous than our Sun. Their name was derived from one of the first and brightest discovered, δ Cephei, located in the constellation Cepheus the King, a major landmark in the northern sky. These stars regularly vary their brightness in a matter of days or months. The shortest cycle Leavitt measured for these Magellanic variables was 1.2 days, the longest 127 days.

In its broad stroke, the arrow makes his excitement visible upon the page. For once Hubble dropped his guard and figuratively clicked his heels at this moment of discovery. Hubble couldn't help but notify his nemesis. On February 19 he wrote Harlow Shapley about his efforts over the previous months. Hubble didn't open with polite niceties or inquiries of health. He got straight to the point. “Dear Shapley:—You will be interested to hear that I have found a Cepheid variable in the Andromeda Nebula (M31). I have followed the nebula this season as closely as the weather permitted and in the last five months have netted nine novae and two variables.” His glee in communicating this news jumped off the page as he then provided Shapley with all the technical details on color index corrections and magnitude estimations. Shapley was, after all, the world's reigning Cepheid expert—not only in using them as standard candles but figuring out early on, soon after he arrived at Mount Wilson, that they were pulsating stars, their atmospheres repeatedly ballooning in and out.


pages: 240 words: 60,660

Models. Behaving. Badly.: Why Confusing Illusion With Reality Can Lead to Disaster, on Wall Street and in Life by Emanuel Derman

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Albert Einstein, Asian financial crisis, Augustin-Louis Cauchy, Black-Scholes formula, British Empire, Brownian motion, capital asset pricing model, Cepheid variable, crony capitalism, diversified portfolio, Douglas Hofstadter, Emanuel Derman, Eugene Fama: efficient market hypothesis, Henri Poincaré, Isaac Newton, law of one price, Mikhail Gorbachev, quantitative trading / quantitative finance, random walk, Richard Feynman, Richard Feynman, riskless arbitrage, savings glut, Schrödinger's Cat, Sharpe ratio, stochastic volatility, the scientific method, washing machines reduced drudgery, yield curve

We measure household distances with a ruler or tape measure, but how do you measure the distance to faraway galaxies that the science sections of newspapers so merrily quote as being 100 million light years away? You can’t lay out measuring sticks across the universe. The distance to a galaxy is also an unspoken kind of analytic continuation. One of the ways galactic distances are measured is by observing Cepheid variables, stars whose visible brightness varies. Their true luminosities (“luminosity” is the technical term for their light output, or brightness) have been found to pulsate in a predictably regular way, so that the frequency of their pulsation depends on their luminosity. By measuring the frequency, you can tell something about the true luminosity of these stars. I say “true” luminosities because I want to distinguish between true and apparent luminosities.

The true luminosity is the actual light emitted by the star; the apparent luminosity is how bright the star looks, as determined by the light that enters your eye. The farther away a star is, the less light from it reaches your eye. Because the light from a star a distance R away radiates out over a sphere of surface 4πR2 , the apparent luminosity decreases with distance inversely proportional to R2 . When you look at a Cepheid variable in a distant galaxy through a telescope, you see its apparent luminosity, but the frequency of the pulsation tells you its absolute luminosity. From the ratio of the true and apparent luminosities you can calculate the distance R to the star.8 What an indirect way this is of measuring something as apparently simple and intuitive as distance! The distance to a galaxy has been determined by making use of a regularity of these weird stars that links the quantity of light emitted to the frequency of their pulsation, a “law” that is believable because it can be explained by plausible models of stellar evolution.

See evil bailouts bare electrons Barfield, Owen Bedazzled (film) Begin, Menachem behavior, human: adequate knowledge and EMM as assumption about explanations for and humans as responsible for their actions and idolatry of models Law of One Price and laws of pragmamorphism and Ben-Gurion, David Bernoulli, Daniel Bernstein, Jeremy beta: CAPM and Betar (Brit Yosef Trumpeldor) binocular diplopia birds Black, Fischer Black-Scholes Model Merton and Blake, William Bnei Akiva (Sons of Akiva) Bnei Zion (Sons of Zion) body-mind relationship Bohr, Aage Bohr, Niels bonds: financial models and See also type of bond Boyle’s Law Brahe, Tycho brain Brave New World (Huxley) Brownian motion bundling of complex products cage: moth in perfect calibration Cape Flats Development Association (South Africa) Capital Asset Pricing Model (CAPM) capitalism caricatures: models as cash. See currency/cash Cauchy, Augustin-Louis causes Cepheid variable stars chalazion chaver (comrade) Chekhov, Anton chemistry: electromagnetic theory and Chesterton, G. K. Chinese choice chromatography Churchill, Winston Coetzee, J. M. coin tossing Coleridge, Samuel Taylor collateralized default obligations (CDOs) collective model, of nucleus Collie, Max commodities communism: in South Africa The Communist Manifesto (Marx and Engels) complex numbers, theory of computer programs consciousness Consolidated Edison stock contempt content: Goethe’s view about method and method and contradictions control: purpose of models and theories and self- and theory of controlling engineering devices Cornell, Joseph Cornford, Francis corporate bonds corporate welfare corporations: bailouts of cosmology Coulomb, Charles creative destruction credit crisis (2007) credit markets curls: electromagnetic theory and currency/cash darkness: Goethe’s view about light and light and Darwin, Charles de Klerk, F.


pages: 692 words: 127,032

Fool Me Twice: Fighting the Assault on Science in America by Shawn Lawrence Otto

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affirmative action, Albert Einstein, anthropic principle, Berlin Wall, Brownian motion, carbon footprint, Cepheid variable, clean water, Climategate, Climatic Research Unit, cognitive dissonance, Columbine, cosmological constant, crowdsourcing, cuban missile crisis, Dean Kamen, desegregation, double helix, energy security, Exxon Valdez, fudge factor, ghettoisation, Harlow Shapley and Heber Curtis, Harvard Computers: women astronomers, informal economy, invisible hand, Isaac Newton, Louis Pasteur, mutually assured destruction, Richard Feynman, Richard Feynman, Ronald Reagan, Saturday Night Live, shareholder value, sharing economy, smart grid, Solar eclipse in 1919, stem cell, the scientific method, The Wealth of Nations by Adam Smith, Thomas Kuhn: the structure of scientific revolutions, transaction costs, University of East Anglia, War on Poverty, white flight, Winter of Discontent, working poor

He arrived at the Carnegie Institution of Washington-funded Mount Wilson Observatory outside Pasadena, California, insisting on being called “Major Hubble.”24 Looking through the great Hooker telescope—at one hundred and one inches in diameter and weighing more than one hundred tons it was by far the largest and most powerful scientific instrument in the world—Hubble was able to view the universe with a light-gathering capacity of more than two hundred thousand human eyes. What he saw changed humanity’s view of the universe forever—and would further roil the controversy over science’s role in defining the origins of creation. A conservative Baconian observer, Hubble photographed a small blinking star in the Andromeda nebula that he identified as a Cepheid variable. This observation would become iconic in its power. Another astronomer, Harvard College Observatory’s Henrietta Leavitt, had in 1912 shown something remarkable about Cepheid variable stars: The longer their period, the brighter they appeared to be. This made sense. Stars were very faint, and to probe deeply, astronomers began to mount cameras to their telescopes and take very-long-exposure photographs on glass plates so they could capture light from stars that were too faint to see with the human eye.

She was paid a premium rate of thirty cents per hour, over the usual two bits, because of the high quality of her work.25 Danish astronomer Ejnar Hertzsprung seized upon Leavitt’s discovery to create a means of measuring intergalactic distances. Using inductive reasoning, Hertzsprung determined in 1913 that if two Cepheid variable stars had similar periods but one was dimmer than the other, it was probably farther away. He found Cepheids close enough to Earth to measure the distance to them using statistical parallax and was able to compare this with their apparent brightness (their brightness as observed from Earth). The resulting formula allowed scientists to measure the distances to all Cepheid variables. These blinking stars became “standard candles” for measuring distance throughout the heavens. This was an immense discovery, and in 1915 American astronomer Harlow Shapley, a liberal Democrat, used it and Mount Wilson’s sixty-inch telescope to map the Milky Way in three dimensions.

The debate ended in a draw because there wasn’t yet enough observational data to draw firm conclusions, but this was partly because Shapley, without realizing it, had stopped using Locke’s and Bacon’s inductive reasoning to build knowledge from observation and was instead trying to prove his point with a rhetorical argument—an a priori, top-down, Cartesian approach of first principles that had him arguing more like an attorney than a scientist. When his assistant Milton Humason showed Shapley a photographic plate that seemed to indicate the presence of a Cepheid variable in Andromeda, Shapley shook his head and said it wasn’t possible. Humason had unimpressive formal credentials—he had been elevated to assistant from a lowly mule driver and had but an eighth-grade education—but it was Shapley’s a priori idea that occluded his vision. He took out his handkerchief and wiped the glass plate clean of Humason’s grease pencil marks before handing it back.27 No one realized it at the time, but Shapley’s career as a major scientist ended at that moment.


pages: 233 words: 62,563

Zero: The Biography of a Dangerous Idea by Charles Seife

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Albert Einstein, Albert Michelson, Arthur Eddington, Cepheid variable, cosmological constant, dark matter, Edmond Halley, Georg Cantor, Isaac Newton, John Conway, place-making, probability theory / Blaise Pascal / Pierre de Fermat, retrograde motion, Richard Feynman, Richard Feynman, Solar eclipse in 1919, Stephen Hawking

In 1900 the Milky Way was the known universe. Astronomers had little idea that anything lay beyond our own dusty little disk of stars. Though astronomers had spotted some glowing, swirly clouds, there was little reason to believe that they were anything but glowing gas inside our galaxy. In the 1920s that all changed, thanks to an American astronomer named Edwin Hubble. A special type of star, called a Cepheid variable, had a property that allowed Hubble to measure the distance to faraway objects. Cepheid stars pulsate, getting brighter and dimmer in a very predictable way; the way they pulsate is closely related to how much light they put out. They are standard candles, objects of known brightness, and became a key tool for Hubble. They were like the headlights of a train. If you watch a train coming at you, you will see that its headlight gets brighter and brighter as it approaches.

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pages: 330 words: 99,226

Extraterrestrial Civilizations by Isaac Asimov

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Albert Einstein, Cepheid variable, Columbine, Edward Charles Pickering, Harvard Computers: women astronomers, invention of radio, invention of the telescope, invention of writing, Isaac Newton, Louis Pasteur, Magellanic Cloud, Search for Extraterrestrial Intelligence

They were not studied in detail until John Herschel observed them from the astronomic observatory at the Cape of Good Hope in 1834 (the expedition that fueled the Moon Hoax). Like the Milky Way, the Magellanic Clouds turned out to be assemblages of vast numbers of very dim stars, dim because of their distance. In the first decade of the twentieth century, the American astronomer Henrietta Swan Leavitt (1868–1921) studied certain variable stars in the Magellanic Clouds. By 1912, the use of these variable stars (called Cepheid variables because the first to be discovered was in the constellation Cepheus) made it possible to measure vast distances that could not be estimated in other ways. The Large Magellanic Cloud turned out to be 170,000 light-years away and the Small Magellanic Cloud 200,000 light-years away. Both are well outside the Galaxy. Each is a galaxy in its own right. They are not large, however. The Large Magellanic Cloud may include perhaps 10 billion stars and the Small Magellanic Cloud only about 2 billion.

Eventually, after a lapse of many generations, a particular free-world may approach a star. It would probably not be an accident that it does so. Undoubtedly, the free-world’s astronomers would study all stars within so many light-years’ distance and suggest an approach to one that is particularly interesting. They might in this way study white dwarfs, neutron stars, black holes, red giants, Cepheid variables, and so on—all from a careful, safe distance. They may also favor approaching stars that are Sunlike in order to investigate (with some nostalgia, perhaps) the chances of a civilization in existence there. It could well be that there will be no impulse whatever to land on an Earthlike planet and to subject themselves to the long forgotten and by now possibly repulsive way of life on the outside of a world.


pages: 465 words: 103,303

The Cancer Chronicles: Unlocking Medicine's Deepest Mystery by George Johnson

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Atul Gawande, Cepheid variable, Columbine, dark matter, discovery of DNA, double helix, Drosophila, epigenetics, Gary Taubes, Harvard Computers: women astronomers, Isaac Newton, Magellanic Cloud, meta analysis, meta-analysis, microbiome, mouse model, Murray Gell-Mann, phenotype, profit motive, stem cell

Using a device like Hillis’s, you could take their proteomic snapshots and lay one on top of the other and look for something that is different. Even if you don’t know what the pattern means, it might be used as a marker to identify which patients will most likely benefit from the drug. I was reminded of Henrietta Leavitt, the astronomer who had died of stomach cancer but not before discovering Cepheid variables, the pulsating stars cosmologists use to measure the universe. She would start with two images of the same patch of sky—glass photographic plates taken a few weeks apart. One would be a negative with the stars glowing in black. She would place that plate on top of the other and hold the glass sandwich to the light. Stars that had grown brighter would appear as larger white spots with smaller black centers.

Burkitt’s lymphoma, 3.1, 5.1, 7.1 CA-125, 2.1, 13.1 cachexia Canada, 1.1, 11.1 cancer ambiguities in, 2.1, 2.2, 2.3, 4.1, 12.1 anthropological perspective on in children, 3.1, 3.2, 3.3, 3.4, 5.1, 7.1, 7.2, 11.1, 12.1, 12.2, 13.1 classification scheme for complex and convoluted nature of, 10.1, 12.1 as contagious debate over screening for detection methods for, 2.1, 3.1, 12.1 as disease of genetic information, 5.1, 9.1 earliest evidence in genus Homo, 3.1 evolving historical insights on, 4.1, 10.1, 12.1 fear of, 11.1, 12.1 hallmarks of, 9.1, 9.2 historical vs. current rate of, 3.1, 7.1, 10.1 identifying characteristics of incidence rates of, 7.1, 9.1, 13.1, 13.2 as incurable, 4.1, 12.1, 12.2 long term development of, 2.1, 10.1 mechanics of metastatic, see metastasis mortality rates from, 7.1, 9.1 oldest known case of, 1.1, 1.2 paradoxes of, 3.1, 5.1 perceived as contagious, 4.1, 5.1 as phenomenon physiological safeguards against, 1.1, 1.2, 4.1, 5.1 politics and predictions of epidemic of, 7.1, 7.2 in primordial creation as a process questions and hypotheses about randomness of, 2.1, 2.2, 6.1, 7.1, 8.1, 11.1, epl.1, epl.2 rare types of, 1.1, 8.1, 8.2, 9.1, 10.1, 12.1, 12.2 recurrence of, 2.1, 7.1, 9.1, 10.1, 12.1, 12.2, epl.1 reducing the odds in, 8.1, 13.1, epl.1 risk factors for, see cancer risk factors search for prehistoric origins of selectiveness in incidence of, 1.1, 1.2 sources of survival rates for, 4.1, 12.1, 12.2, 12.3, epl.1 terminology of, 3.1, 6.1, 6.2, 9.1, 11.1, 12.1 testing for trivializing of, 12.1, 12.2 worldwide incidence of, 7.1, 11.1 see also Johnson, Joe; Maret, Nancy (author’s wife), cancer of; specific types of cancer cancer clusters, 2.1, 7.1 Cancer Genome Atlas “cancering,” “cancer juice,” cancer microenvironment cancer prevention dubious and contradictory information on lifestyle in, 7.1, 10.1 cancer research, 1.1, 2.1, 7.1 ambiguities in evolution of, 5.1, 9.1, 12.1, epl.1 monetary aspects of, 9.1, 12.1, 12.2, 12.3 Nancy’s personal neglected types in new perspectives on pharmaceutical companies in, 9.1, 12.1 public support and hype in, 12.1, 12.2 on radiation statistical, 12.1, 13.1 two factions in see also specific studies cancer risk factors, 7.1, epl.1 ambiguity about, 7.1, 10.1 demographic, 7.1, 7.2 endemic, 1.1, 1.2 environmental, 1.1, 1.2, 2.1, 3.1, 7.1 genetic, 2.1, 2.2, 3.1, 7.1, 7.2 of lifestyle, 1.1, 2.1, 7.1, 7.2 metabolic multiple and interconnected, 10.1, 12.1 overestimation of radiation as, 3.1, 3.2, 5.1, 7.1, 7.2, 11.1 research into, 7.1, 10.1 socioeconomic synergistic interactions in trauma and injury as see also carcinogens, carcinogenesis; specific risk factors cancer stem cell theory cancer treatments ethical issues in historical, 3.1, 10.1 Joe’s, see Johnson, Joe, treatment strategy for limited effectiveness of, 9.1, 12.1 Nancy’s, see Maret, Nancy (author’s wife), cancer of, treatment strategy for new perspectives on, 9.1, 13.1 predictions of cure in, 9.1, 9.2, 12.1, 13.1 shortcomings of, 2.1, 12.1 unnecessary, 2.1, 12.1 Cancer Ward (Solzhenitsyn), 12.1, 12.2, epl.1 canine transmissible venereal tumor carcinogens, carcinogenesis, 2.1, 2.2, 3.1, 5.1, 5.2, 10.1, 13.1, epl.1 artificially produced, 7.1, 7.2, 10.1 bans on carbon-based in chemotherapy, 8.1, 8.2 environmental, 7.1, 7.2, 10.1 inconclusive hypothesis on metabolic naturally occurring, 2.1, 5.1, 7.1, 11.1, 11.2 origin of term see also specific cancer risk factors carcinomas, 1.1, 2.1, 3.1, 3.2, 3.3, 3.4, 4.1, 5.1, epl.1 as most common cancer, 6.1, 6.2 Carnegie Museum of Natural History, 1.1, 1.2 Carson, Rachel castration cat scratch fever “Causes of Cancer, The” (Doll and Peto), 7.1, 7.2 celebrities celibacy Cell, cell adhesion molecules, 5.1, 6.1 “cell fate,” cell invasion cells aerobic and anaerobic aggressive multiplication of, 1.1, 1.2, 2.1, 3.1, 3.2, 5.1, 5.2, 5.3, 7.1, 12.1 collaboration among differentiation of, 4.1, 6.1, 6.2, 9.1 duplication errors in, 1.1, 1.2, 2.1, 2.2, 2.3, 3.1, 5.1, 5.2, 7.1, 7.2, 8.1, 13.1 electricity and evolving historical insights on in mechanics of cancer in metastasis polarization in precancerous, epl.1, epl.2 programmed death of, see apoptosis cellular phones, 13.1, 13.2 Cepheid variables, 13.1, 13.2 cerebellum cervical cancer, 5.1, 7.1, 7.2, 7.3, 10.1 cervix Chase, Martha Chemical Weapons Convention chemotherapy, 2.1, 5.1, 7.1, 8.1, 9.1, 9.2, 9.3, 12.1, 12.2, 12.3, 12.4, 13.1, 13.2 alternatives to Joe’s Nancy’s, 8.1, 11.1, 11.2 negative effects of, 4.1, 8.1, 8.2, 8.3, 8.4, 8.5, 11.1, 12.1, epl.1 process of, 8.1, 11.1 resistance to, 8.1, 8.2, 9.1, 12.1 Chernobyl nuclear plant, 11.1 chickens tumor research on childlessness cancer risk from, 2.1, 2.2, 2.3, 7.1, 7.2, 8.1, 10.1 of Nancy, 6.1, 11.1 children cancer in, 3.1, 3.2, 3.3, 3.4, 5.1, 7.1, 7.2, 11.1, 12.1, 13.1 deformities of, 6.1, 7.1 chimney sweeps, 5.1, 10.1, epl.1 chondroblastomas chondrosarcoma Christmas chromosomes, 5.1, 5.2, 5.3, 5.4, 7.1 cigarettes, see smoking circadian disruption cisplatin, 8.1, 8.2, 8.3, epl.1 Cleveland Museum of Natural History clinical equipose clones CM 72656 (dinosaur bone) coal tar, 5.1, 10.1, 10.2, epl.1 coffee, carcinogens in cohorts Cohort Study of Mobile Phone Use and Health (COSMOS) colon cancer, 2.1, 4.1, 5.1, 7.1, 7.2, 9.1, 10.1, 10.2, 10.3, 12.1 colonoscopy Colorado, 1.1, 1.2, 1.3 colorectal cancer, 2.1, 3.1, 3.2, 7.1 as common risk factors for colorectal polyps conifers “Contagious Cancer,” contraceptives cortisol cosmology creation theory, 6.1, 9.1, 9.2 Cretaceous period, 1.1, 1.2 Crick, Francis, 5.1, 9.1 Crookes, William crown gall CT scans, 2.1, 3.1, 3.2, 11.1, epl.1 Curie, Marie, 5.1, 11.1 Curie, Pierre, 5.1, 11.1 curies Curran, Tom cycads cyclopamine, 6.1, 12.1 Cyclopes cytokines dacarbazine Dana-Farber cancer center, 1.1, 12.1, 12.2 Darwinian evolution, 1.1, 4.1, 7.1, 9.1 cancer development and, 4.1, 7.1, 12.1, 13.1 David, A.


pages: 654 words: 204,260

A Short History of Nearly Everything by Bill Bryson

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Albert Einstein, Albert Michelson, Alfred Russel Wallace, All science is either physics or stamp collecting, Arthur Eddington, Barry Marshall: ulcers, Brownian motion, California gold rush, Cepheid variable, clean water, Copley Medal, cosmological constant, dark matter, Dava Sobel, David Attenborough, double helix, Drosophila, Edmond Halley, Ernest Rutherford, Fellow of the Royal Society, Harvard Computers: women astronomers, Isaac Newton, James Watt: steam engine, John Harrison: Longitude, Kevin Kelly, Kuiper Belt, Louis Pasteur, luminiferous ether, Magellanic Cloud, Menlo Park, Murray Gell-Mann, out of africa, Richard Feynman, Richard Feynman, Stephen Hawking, supervolcano, Thomas Malthus, Wilhelm Olbers

The system, however unfair, did have certain unexpected benefits: it meant that half the finest minds available were directed to work that would otherwise have attracted little reflective attention, and it ensured that women ended up with an appreciation of the fine structure of the cosmos that often eluded their male counterparts. One Harvard computer, Annie Jump Cannon, used her repetitive acquaintance with the stars to devise a system of stellar classifications so practical that it is still in use today. Leavitt's contribution was even more profound. She noticed that a type of star known as a Cepheid variable (after the constellation Cepheus, where it first was identified) pulsated with a regular rhythm—a kind of stellar heartbeat. Cepheids are quite rare, but at least one of them is well known to most of us. Polaris, the Pole Star, is a Cepheid. We now know that Cepheids throb as they do because they are elderly stars that have moved past their “main sequence phase,” in the parlance of astronomers, and become red giants.

Using his formula, Hubble calculated that the universe was about two billion years old, which was a little awkward because even by the late 1920s it was fairly obvious that many things within the universe—not least Earth itself—were probably older than that. Refining this figure has been an ongoing preoccupation of cosmology. Almost the only thing constant about the Hubble constant has been the amount of disagreement over what value to give it. In 1956, astronomers discovered that Cepheid variables were more variable than they had thought; they came in two varieties, not one. This allowed them to rework their calculations and come up with a new age for the universe of from 7 to 20 billion years—not terribly precise, but at least old enough, at last, to embrace the formation of the Earth. In the years that followed there erupted a long-running dispute between Allan Sandage, heir to Hubble at Mount Wilson, and Gérard de Vaucouleurs, a French-born astronomer based at the University of Texas.

Wireless by Stross, Charles

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anthropic principle, back-to-the-land, Benoit Mandelbrot, Buckminster Fuller, Cepheid variable, cognitive dissonance, colonial exploitation, cosmic microwave background, epigenetics, finite state, Georg Cantor, gravity well, hive mind, jitney, Khyber Pass, Magellanic Cloud, mandelbrot fractal, peak oil, phenotype, Pluto: dwarf planet, security theater, sensible shoes, Turing machine

Sagan smiles in a vaguely disconnected way. “We’re nowhere near our original galactic neighborhood and whoever moved us here, they didn’t bend the laws of physics far enough to violate the speed limit. It takes light about 160,000 years to cross the distance between where we used to live, and our new stellar neighborhood, the Lesser Magellanic Cloud. Which we have fixed, incidentally, by measuring the distance to known Cepheid variables, once we were able to take into account the measurable blue shift of infalling light and the fact that some of them were changing frequency slowly and seem to have changed rather a lot. Our best estimate is eight hundred thousand years, plus or minus two hundred thousand. That’s about four times as long as our species has existed, gentlemen. We’re fossils, an archaeology experiment or something.

Beggars in Spain by Nancy Kress

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Cepheid variable, double helix, gravity well, index card, indoor plumbing, job automation, phenotype, union organizing

She would not give in to the degradation of jealousy. She was better than that. Tony deserved better than that of his sister. Idealism. (Stoicism, Epicureanism “We are shaped and fashioned by what we love,” Tony’s butt pumping away in Christina . . . ) She would solve this problem her own way (darkness, fullness, the throbbing ache, gravitational pressure to ignite gases into thermonuclear reactions, cepheid variables . . . ). Miri washed her face and hands. She put on a clean pair of white shorts and tied a red ribbon in her dark hair. Her lips, despite their constant twitching, set together hard. She didn’t have to think whom to approach; she already knew, and knew that she knew, and knew all the implications of already knowing (darkness, fullness, lying on her belly on her lab floor or under the genemod soy plants that met in a concealing arc, her hands between her legs).