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searching for hsp90 inhibitor 14 found (19 total)

Chaperome (733 words) [view diff] exact match in snippet view article find links to article

adapting to stress including hypoxia and heat. The small molecule Hsp90 inhibitor, PU-H71, has been found to have a preferential binding to Hsp90 when

Radicicol (269 words) [view diff] case mismatch in snippet view article find links to article

"Functional Characterization of the Biosynthesis of Radicicol, an Hsp90 Inhibitor Resorcylic Acid Lactone from Chaetomium chiversii". Chemistry & Biology

LYN (3,807 words) [view diff] case mismatch in snippet view article find links to article

rheostat that modulates signaling rather than as a binary on-off switch. HSP90 inhibitor NVP-BEP800 has been described to affect stability of LYN kinase and

Proto-oncogene tyrosine-protein kinase Src (2,795 words) [view diff] case mismatch in snippet view article find links to article

bosutinib, bafetinib, Saracatinib(AZD-0530), XLl-999, KX01 and XL228. HSP90 inhibitor NVP-BEP800 has been described to affect stability of Src tyrosine kinase

Paul Workman (scientist) (955 words) [view diff] exact match in snippet view article

cells, in particular, molecular chaperones such as Hsp90. The leading Hsp90 inhibitor was discovered by Workman's team at ICR in collaboration with Vernalis

Tyrosin-protein kinase Lck (4,466 words) [view diff] case mismatch in snippet view article find links to article

have some impact on its therapeutic effects in canine mastocytoma. HSP90 inhibitor NVP-BEP800 has been described to affect stability of the LCK kinase

Vernalis Research (1,160 words) [view diff] exact match in snippet view article find links to article

July 2015. Additionally, luminespib (AUY922) is a novel intravenous Hsp90 inhibitor with the potential to target a range of cancers, which arose from a

FNIP1 (707 words) [view diff] exact match in snippet view article find links to article

Trepel JB, Whitesell L, Picard D (July 2018). "Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches

Clusterin (2,433 words) [view diff] no match in snippet view article find links to article

that blocks the CLU mRNA transcript, enhanced heat-shock protein 90 (HSP90) inhibitor activity by suppressing the heat-shock response in castrate-resistant

Lutetium (177Lu) chloride (678 words) [view diff] case mismatch in snippet view article

Lundsten S, Spiegelberg D, Stenerlöw B, Nestor M (December 2019). "The HSP90 inhibitor onalespib potentiates 177Lu‑DOTATATE therapy in neuroendocrine tumor

List of pharmaceutical compound number prefixes (1,656 words) [view diff] case mismatch in snippet view article find links to article

Archived from the original on 2012-04-16. Retrieved 2012-04-17. "Exelixis HSP90 inhibitor XL888". Archived from the original on 2016-09-18. Retrieved 2016-09-16

Heat shock protein (5,525 words) [view diff] exact match in snippet view article find links to article

HSPs, especially Hsp90 show promise as anticancer agents. The potent Hsp90 inhibitor 17-AAG was in clinical trials for the treatment of several types of

Hsp70 (5,631 words) [view diff] exact match in snippet view article find links to article

et al. (June 2018). "Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art". Biomedicine & Pharmacotherapy

Heat shock protein 90kDa alpha (cytosolic), member A1 (8,175 words) [view diff] exact match in snippet view article

most amenable to inhibitor generation. To date, there are 23 active Hsp90 inhibitor oncology trials, and 13 HSP90 inhibitors are currently undergoing clinical