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searching for Transactivation domain 81 found (89 total)

RNA-binding protein EWS (1,638 words) [view diff] exact match in snippet view article find links to article

specifically 22q12.2. This region of chromosome 22 encodes the N-terminal transactivation domain of the EWS protein and that region may become joined to one of several

E2F2 (1,237 words) [view diff] exact match in snippet view article find links to article

transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation

KMT2A (2,393 words) [view diff] exact match in snippet view article find links to article

protein belongs to the group of histone-modifying enzymes comprising transactivation domain 9aaTAD and is involved in the epigenetic maintenance of transcriptional

Nuclear receptor coactivator 1 (1,661 words) [view diff] exact match in snippet view article find links to article

Prasad R, Granner DK (Jul 2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid

E2F3 (1,216 words) [view diff] exact match in snippet view article find links to article

transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation

E2F5 (1,228 words) [view diff] exact match in snippet view article find links to article

transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation

GTF2F1 (1,471 words) [view diff] exact match in snippet view article find links to article

interaction of the c-Myc transactivation domain with the TATA binding protein: evidence for an induced fit model of transactivation domain folding". Biochemistry

CREB-binding protein (6,083 words) [view diff] exact match in snippet view article find links to article

Grabner M, Kovarik P, Piskacek M (June 2007). "Nine-amino-acid transactivation domain: establishment and prediction utilities". Genomics. 89 (6): 756–68

E2F4 (1,288 words) [view diff] exact match in snippet view article find links to article

differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids (Asp + Glu), and a tumor suppressor

EEM syndrome (516 words) [view diff] exact match in snippet view article find links to article

ectrodactyly caused by a heterozygous missense mutation in the transactivation domain of Tp63". Am J Med Genet A. 134 (1): 74–76. doi:10.1002/ajmg.a.30277

Mucoepidermoid carcinoma (920 words) [view diff] exact match in snippet view article find links to article

coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2. A possible association with papillomavirus

E2F1 (1,787 words) [view diff] exact match in snippet view article find links to article

transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation

RELA (6,454 words) [view diff] exact match in snippet view article find links to article

contains a N-terminal REL-homology domain (RHD), and also a C-terminal transactivation domain (TAD). RHD is involved in DNA binding, dimerization and NF-κB/REL

EP300 (4,232 words) [view diff] exact match in snippet view article find links to article

Grabner M, Kovarik P, Piskacek M (June 2007). "Nine-amino-acid transactivation domain: establishment and prediction utilities". Genomics. 89 (6): 756–68

MED15 (1,582 words) [view diff] exact match in snippet view article find links to article

yeast MED15. Most of these transcription factors share the same transactivation domain, 9aaTAD, which directly interacts with KIX domain of the MED15.

TAF9 (1,786 words) [view diff] exact match in snippet view article find links to article

ALL1/MLL1. Inside of these 17 amino acids, a unique Nine-amino-acid transactivation domain (9aaTAD) was identified for each reported transcription factor.

Nuclear receptor coactivator 2 (2,152 words) [view diff] exact match in snippet view article find links to article

Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol Cell

Androgen insensitivity syndrome (12,693 words) [view diff] exact match in snippet view article find links to article

receptors, the AR protein consists of several functional domains: the transactivation domain (also called the transcription-regulation domain or the amino /

Alveolar rhabdomyosarcoma (1,289 words) [view diff] exact match in snippet view article find links to article

composed of either the PAX3 or PAX7 DNA binding domains and the FOXO1 transactivation domain. This fusion causes a dysregulation of transcription and acts as

Mdm2 (4,311 words) [view diff] exact match in snippet view article find links to article

"Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain". Science. 274 (5289): 948–53. Bibcode:1996Sci...274..948K. doi:10

RNF25 (403 words) [view diff] exact match in snippet view article find links to article

supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc

HIF3A (823 words) [view diff] exact match in snippet view article find links to article

to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits

TCF3 (1,178 words) [view diff] exact match in snippet view article find links to article

specification and commitment Piskacek, S (2007). "Nine-amino-acid transactivation domain: Establishment and prediction utilities". Genomics. 89 (6): 756–768

PAX3 (4,306 words) [view diff] exact match in snippet view article find links to article

the N-terminal PAX3 DNA-binding domain and the C-terminal FOXO1 transactivation domain. A smaller subset of ARMS cases is associated with less common fusions

STAT protein (512 words) [view diff] exact match in snippet view article find links to article

coiled-coil, DNA-binding, linker, Src homology 2 (SH2), and a C-terminal transactivation domain. Much research has focused on elucidating the roles each of these

Desmoplastic small-round-cell tumor (1,497 words) [view diff] exact match in snippet view article find links to article

This transcript codes for a protein that includes the N-terminal transactivation domain of EWSR1 and the DNA-binding domain of WT1. The EWS/WT1 translocation

NRL (gene) (1,086 words) [view diff] exact match in snippet view article

Mitton KP, Weber CH, Hicks D, Swaroop A (Nov 2004). "The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts

NFE2 (1,091 words) [view diff] exact match in snippet view article find links to article

Bresnick EH (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains"

P300-CBP coactivator family (2,119 words) [view diff] exact match in snippet view article find links to article

Grabner M, Kovarik P, Piskacek M (Jun 2007). "Nine-amino-acid transactivation domain: establishment and prediction utilities". Genomics. 89 (6): 756–68

GABPA (1,291 words) [view diff] exact match in snippet view article find links to article

Keum YS, Han J, Gallo MA, Kong AN (May 2004). "Regulation of Nrf2 transactivation domain activity. The differential effects of mitogen-activated protein

KLF1 (1,157 words) [view diff] exact match in snippet view article find links to article

erythroid (red blood) cells. The molecule has two domains; the transactivation domain and the chromatin-remodeling domain. The carboxyl (C) terminal is

IRF3 (1,480 words) [view diff] exact match in snippet view article find links to article

implications 1qwt: Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain 1t2k: Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun

E2F (1,909 words) [view diff] exact match in snippet view article find links to article

In activators, E2F binding with pRB has been shown to mask the transactivation domain responsible for transcription activation. In repressors E2F4 and

Mef2 (1,567 words) [view diff] exact match in snippet view article find links to article

Mef2 domains, however their sequences diverge in their C-terminal transactivation domain (see figure to the right). The MADS-box serves as the minimal DNA-binding

IRF7 (1,413 words) [view diff] exact match in snippet view article find links to article

interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain". Molecular and Cellular Biology. 20 (23): 8803–14. doi:10.1128/MCB

CREB1 (1,246 words) [view diff] exact match in snippet view article find links to article

1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell.

MDC1 (3,021 words) [view diff] exact match in snippet view article find links to article

the n-terminus of p53 through its BRC1 domain which blocks p53 transactivation domain. MDC1 can also inactivate p53 by reducing the phosphorylation levels

STAT6 (1,454 words) [view diff] exact match in snippet view article find links to article

PMID 9584180. Litterst CM, Pfitzner E (Sep 2002). "An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1". The Journal of Biological

Hypoxia-inducible factor-asparagine dioxygenase (383 words) [view diff] exact match in snippet view article find links to article

Whitelaw ML (February 2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. Bibcode:2002Sci

MPP2 (519 words) [view diff] exact match in snippet view article find links to article

PMID 15489334. Wierstra I, Alves J (2006). "Despite its strong transactivation domain, transcription factor FOXM1c is kept almost inactive by two different

FLI1 (1,979 words) [view diff] exact match in snippet view article find links to article

sarcoma a chromosomal translocation generates a fusion of the 5’ transactivation domain of EWSR1 (also known as EWS) with the 3’ Ets domain of Fli-1. The

PATZ1 (1,004 words) [view diff] exact match in snippet view article find links to article

exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct

ETS1 (1,794 words) [view diff] exact match in snippet view article find links to article

is phosphorylated. Acetyltransferases CBP and p300 bind to the transactivation domain. AP1, STAT5 and VDR bind to C-terminal domain. Also, ETS1 has been

HIF1AN (807 words) [view diff] exact match in snippet view article find links to article

Gorman JJ, Whitelaw ML (2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. doi:10.1126/science

KLF15 (2,777 words) [view diff] exact match in snippet view article find links to article

cells through its regulation of PPAR gamma expression. The minimal transactivation domain of erythroid Krüppel-like factor EKLFTAD) has two functional subdomains

PTTG1 (1,376 words) [view diff] exact match in snippet view article find links to article

The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially

Proline (2,293 words) [view diff] case mismatch in snippet view article find links to article

H.; et al. (2017). "A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms". Molecular Cell. 66 (4): 447–457.e7

Activating transcription factor 2 (2,242 words) [view diff] case mismatch in snippet view article find links to article

v t e PDB gallery 1bhi: STRUCTURE OF TRANSACTIVATION DOMAIN OF CRE-BP1/ATF-2, NMR, 20 STRUCTURES 1t2k: Structure Of The DNA Binding Domains Of IRF3, ATF-2

WWP1 (1,402 words) [view diff] exact match in snippet view article find links to article

Bresnick EH (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains"

KLF2 (2,205 words) [view diff] exact match in snippet view article find links to article

N-terminus with a proline-rich region presumed to function as the transactivation domain. KLF2 was first discovered, and is highly expressed in, the adult

NFAT5 (2,099 words) [view diff] exact match in snippet view article find links to article

Williams CK, Persaud P, et al. (2002). "Activity of the TonEBP/OREBP transactivation domain varies directly with extracellular NaCl concentration". Proc. Natl

SOX9 (2,387 words) [view diff] exact match in snippet view article find links to article

Scherer G (June 1996). "Sex reversal by loss of the C-terminal transactivation domain of human SOX9". Nature Genetics. 13 (2): 230–2. doi:10.1038/ng0696-230

SRA1 (1,454 words) [view diff] exact match in snippet view article find links to article

Prasad R, Granner DK (July 2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid

HNF1A (2,631 words) [view diff] exact match in snippet view article find links to article

an atypical POU-homeodomain (residues 98–280), and a C-terminal transactivation domain (residues 281–631). There is also a flexible linker (residues 33–97)

Homeobox protein NANOG (2,607 words) [view diff] exact match in snippet view article find links to article

KY, Chung HM, Kim JH (June 2005). "Identification of a putative transactivation domain in human Nanog". Experimental & Molecular Medicine. 37 (3): 250–4

Nerve growth factor IB (2,333 words) [view diff] exact match in snippet view article find links to article

identified. The NR4A1 gene contains seven exons. An amino terminal transactivation domain is encoded in exon 2, a DNA-binding domain in exons 3 and 4, and

EPAS1 (2,675 words) [view diff] exact match in snippet view article find links to article

Whitelaw ML (February 2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. Bibcode:2002Sci

Extraskeletal myxoid chondrosarcoma (1,233 words) [view diff] exact match in snippet view article find links to article

often can be seen in chimeric transcripts including EWSR1, the transactivation domain of EWSR1 fused to the DNA-binding domain of NR4A3. Several types

Jean Thomas (biochemist) (1,603 words) [view diff] exact match in snippet view article

2012). "HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail". Structure. 20 (12):

NFE2L2 (3,072 words) [view diff] exact match in snippet view article find links to article

domain may play a role in NRF2 protein stability and may act as a transactivation domain, interacting with component of the transcriptional apparatus. The

TATA-binding protein (3,213 words) [view diff] exact match in snippet view article find links to article

M, Baeuerle PA (March 1995). "Interaction of the COOH-terminal transactivation domain of p65 NF-kappa B with TATA-binding protein, transcription factor

RUNX1 (3,137 words) [view diff] exact match in snippet view article find links to article

homology domain (RHD) or the runt domain (exons 2, 3 and 4), and the transactivation domain (TAD) (exon 6). These domains are necessary for RUNX1 to mediate

MAGEA11 (1,760 words) [view diff] exact match in snippet view article find links to article

protein-A11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators". The Journal of Biological Chemistry. 284

C-Fos (3,881 words) [view diff] exact match in snippet view article find links to article

basic leucine zipper region for dimerisation and DNA-binding and a transactivation domain at C-terminus, and, like Jun proteins, it can form homodimers. In

Victoria Cowling (795 words) [view diff] case mismatch in snippet view article find links to article

Cole, Michael D.; Cowling, Victoria H. (2007-03-15). "The Myc Transactivation Domain Promotes Global Phosphorylation of the RNA Polymerase II Carboxy-Terminal

Mild androgen insensitivity syndrome (3,918 words) [view diff] exact match in snippet view article find links to article

Wang Q, Ghadessy FJ, Yong EL (September 1998). "Analysis of the transactivation domain of the androgen receptor in patients with male infertility". Clin

Glucocorticoid receptor (3,831 words) [view diff] exact match in snippet view article find links to article

Prasad R, Granner DK (July 2002). "A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid

Hypoxia-inducible factor (4,591 words) [view diff] exact match in snippet view article find links to article

HIF-1 alpha C terminal transactivation domain Structure of hypoxia-inducible factor-1 alpha subunit. Identifiers Symbol HIF-1a_CTAD Pfam PF08778 InterPro

Prolactin-induced protein (2,139 words) [view diff] exact match in snippet view article find links to article

PU.1 through phosphorylation-mediated modifications within its transactivation domain". J. Biol. Chem. 276 (11): 8460–8. doi:10.1074/jbc.M007482200. PMID 11133986

Signal transduction (7,502 words) [view diff] exact match in snippet view article find links to article

the other hand, may be repressive on gene expression when their transactivation domain is hidden. Receptor activity can be enhanced by phosphorylation

Aryl hydrocarbon receptor (5,304 words) [view diff] exact match in snippet view article find links to article

(November 2001). "The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity". The Journal

HIF1A (6,200 words) [view diff] exact match in snippet view article find links to article

Whitelaw ML (February 2002). "Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch". Science. 295 (5556): 858–61. Bibcode:2002Sci

Transcription factor (7,625 words) [view diff] exact match in snippet view article find links to article

sites are frequently referred to as activation functions (AFs), Transactivation domain (TAD) or Trans-activating domain TAD but not mix with topologically

Papillomaviridae (7,061 words) [view diff] exact match in snippet view article find links to article

located primarily in the long control region. The protein has a transactivation domain linked by a relatively unstructured hinge region to a well-characterized

NF-κB (9,378 words) [view diff] exact match in snippet view article find links to article

subfamily of NF-κB proteins, including RelA, RelB, and c-Rel, have a transactivation domain in their C-termini. In contrast, the NF-κB1 and NF-κB2 proteins

BRCA2 (968 words) [view diff] exact match in snippet view article find links to article

(1999). "Structure and expression of variant BRCA2a lacking the transactivation domain". Oncology Reports. 6 (2): 437–40. doi:10.3892/or.6.2.437. PMID 10023017

Retinoblastoma protein (9,401 words) [view diff] exact match in snippet view article find links to article

(December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes & Development. 16

Dioxins and dioxin-like compounds (10,084 words) [view diff] exact match in snippet view article find links to article

tumour promotion). The reason may be different requirements of the transactivation domain structure of the AH receptor for different genes. Some of these

Deficiency of RbAp48 protein and memory loss (2,419 words) [view diff] exact match in snippet view article find links to article

Martin; Kovarik, Pavel; Piskacek, Martin (2007). "Nine-amino-acid transactivation domain: Establishment and prediction utilities". Genomics. 89 (6): 756–68

Beta-catenin (11,854 words) [view diff] exact match in snippet view article find links to article

PMID 33085215. Vleminckx K, Kemler R, Hecht A (March 1999). "The C-terminal transactivation domain of beta-catenin is necessary and sufficient for signaling by the

CSNK1D (14,666 words) [view diff] exact match in snippet view article find links to article

"A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection". The Journal of Biological