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searching for RNA-dependent RNA polymerase 102 found (254 total)

alternate case: rNA-dependent RNA polymerase

Valopicitabine (251 words) [view diff] exact match in snippet view article find links to article

progressed as far as Phase III clinical trials. It acts as an RNA-dependent RNA polymerase inhibitor. It is a prodrug which is converted inside the body
Tombusvirus 3′ UTR region IV (245 words) [view diff] exact match in snippet view article find links to article
RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions
4-Hydroxy-TEMPO (377 words) [view diff] exact match in snippet view article find links to article
styrene. It is a promising model substance to inhibit SARS-CoV-2 RNA-dependent RNA polymerase. pH neutral aqueous organic flow batteries Zakrzewski, Jerzy;
DCL3 (174 words) [view diff] exact match in snippet view article find links to article
45 nucleotides in length, which are converted into dsRNA by RNA-dependent RNA polymerase 2. Once cleaved by DCL3, the 24-nt siRNA strand is loaded into
Tombusvirus 5′ UTR (418 words) [view diff] exact match in snippet view article find links to article
RNA intermediate. In addition to viral proteins p33 and the RNA-dependent RNA polymerase p92, and unknown host factors, conserved and structural regions
Potato virus X (434 words) [view diff] case mismatch in snippet view article find links to article
five open reading frames (ORFs) encoding five proteins: the RNA-dependent RNA Polymerase (RdRP), the movement proteins encoded by three overlapping ORFs
Orsay virus (340 words) [view diff] exact match in snippet view article find links to article
segments, termed RNA1 and RNA2. The RNA1 segment encodes an RNA-dependent RNA polymerase (RdRP) of 982 amino acids. The RNA2 segment has two open reading
Cap snatching (1,642 words) [view diff] exact match in snippet view article find links to article
initiate the synthesis of the nascent viral mRNA. The viral RNA-dependent RNA polymerase (RdRp) can then proceed to replicate the negative-sense genome
Bwamba orthobunyavirus (795 words) [view diff] no match in snippet view article find links to article
non structural membrane polypeptide and the L RNA encodes an RNA dependent RNA polymerase. The segmented RNAs are surrounded by nucleocapsid proteins that
Barnaviridae (217 words) [view diff] no match in snippet view article find links to article
possibly auto-cleaved by the ORF2 viral protease. ORF3 encodes the RNA dependent RNA polymerase and may be translated by ribosomal frameshifting as an ORF2-ORF3
Bat mumps orthorubulavirus (1,846 words) [view diff] exact match in snippet view article find links to article
undergo generic reassortment, so no antigenic shift can occur. RNA-dependent RNA polymerase does not have a function to be able to check for errors in coding
Phenuiviridae (439 words) [view diff] exact match in snippet view article find links to article
Its genome is segmented into three pieces: L segment (encoding RNA-dependent RNA polymerase), M segment, and S segment. Some members of the family have ambisense
Hepatitis C virus nonstructural protein 3 (250 words) [view diff] case mismatch in snippet view article find links to article
(NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase / J. Virol. July 2005 vol. 79 no. 14 8687-8697 Schregel, V; Jacobi
Nodamura virus (770 words) [view diff] no match in snippet view article find links to article
responsible for encoding protein A, which is the RNA dependent RNA polymerase. RNA dependent RNA polymerase is necessary for replication of the nodamura virus
Viral replication (1,486 words) [view diff] exact match in snippet view article find links to article
transcription from the negative-stranded genome by the viral RNA-dependent RNA polymerase to yield monocistronic mRNAs that code for the various viral
Deepak T. Nair (3,799 words) [view diff] no match in snippet view article find links to article
2012:285481). His laboratory has shown how GTP binding to the viral RNA-dependent-RNA polymerase ensures accurate initiation of replication of the viral genome
CMX521 (175 words) [view diff] case mismatch in snippet view article find links to article
Shapi M (December 2020). "Discovery of Potential Inhibitors for RNA-Dependent RNA Polymerase of Norovirus: Virtual Screening, and Molecular Dynamics". International
Retrotransposon silencing (896 words) [view diff] exact match in snippet view article find links to article
(Darricarrere et al 2013). Though the mechanism is as of yet unclear, RNA-dependent RNA polymerase RrpC has been shown to post-transcriptionally silence retrotransposons
Strawberry crinkle cytorhabdovirus (2,036 words) [view diff] exact match in snippet view article find links to article
indicating that the virus needs to bring their own enzyme, RNA-dependent RNA polymerase, in order to copy the negative strand into mRNA. This allows
Deformed wing virus (1,896 words) [view diff] exact match in snippet view article find links to article
proteins: an RNA helicase, a chymotrypsin-like 3C protease and an RNA-dependent RNA polymerase. VP1 is encoded between codons 486 to 880 and VP3 lies between
Kupe orthonairovirus (297 words) [view diff] exact match in snippet view article find links to article
This open reading frame encodes several modules including a RNA-dependent RNA polymerase. It is probably post translationally cleaved into several proteins
UPSK RNA (303 words) [view diff] exact match in snippet view article find links to article
yellow mosaic virus RNA in minus-strand synthesis by the viral RNA-dependent RNA polymerase". J Virol. 71 (8): 5990–5996. doi:10.1128/JVI.71.8.5990-5996
Tombusviridae (1,050 words) [view diff] exact match in snippet view article find links to article
strand synthesis. This mechanism is thought to be recognised by RNA-dependent RNA polymerase, found encoded within the genome. Viruses in Tombusviridae have
IDX-184 (363 words) [view diff] no match in snippet view article find links to article
Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study". Life Sciences. 253: 117592
Filibuvir (311 words) [view diff] exact match in snippet view article find links to article
PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase". Antimicrobial Agents and Chemotherapy. 53 (6): 2544–52. doi:10
Cilevirus (377 words) [view diff] no match in snippet view article find links to article
conserved domains: methyltransferase, protease, helicase and an RNA dependent RNA polymerase. RNA 2 encodes four ORFs which correspond to 15, 61, 32 and 24
Kakugo virus (313 words) [view diff] exact match in snippet view article find links to article
that correspond to the virion protein, helicase, protease, and RNA-dependent RNA polymerase domains of various picorna-like virus polyproteins. The increased
Schmallenberg orthobunyavirus (1,400 words) [view diff] exact match in snippet view article find links to article
(S), Medium (M) and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins
Bunyamwera orthobunyavirus (592 words) [view diff] exact match in snippet view article find links to article
(S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins
Bunyamwera orthobunyavirus (592 words) [view diff] exact match in snippet view article find links to article
(S), Middle (M), and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins
Riccardo Cortese (2,833 words) [view diff] exact match in snippet view article find links to article
S. E.; et al. (1996). "Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus". The EMBO Journal. 15 (1): 12–22. doi:10
Phytoreovirus (503 words) [view diff] exact match in snippet view article find links to article
each virus. Like all other reoviruses, they contain their own RNA-dependent RNA polymerase, allowing for endogenous synthesis of viral mRNA within the virus
Hepatitis C virus nonstructural protein 5A (1,179 words) [view diff] exact match in snippet view article find links to article
has been shown to modulate the polymerase activity of NS5B, an RNA-dependent RNA polymerase (RdRp). Intriguingly, NS5A may be a RNA binding protein because
ERDRP-0519 (197 words) [view diff] exact match in snippet view article find links to article
et al. (July 2007). "Nonnucleoside inhibitor of measles virus RNA-dependent RNA polymerase complex activity". Antimicrobial Agents and Chemotherapy. 51
Negevirus (294 words) [view diff] no match in snippet view article find links to article
This polyprotein has methyl transferase, viral helicase and RNA dependent RNA polymerase domains. There are untranslated regions at the 5' and 3' ends
Drosophila X virus (1,868 words) [view diff] exact match in snippet view article find links to article
translated. This polypeptide has been characterized to be the RNA-dependent RNA polymerase (RdRp) and the VpG. This polypeptide is 977 amino acids in length
West Caucasian bat lyssavirus (1,897 words) [view diff] exact match in snippet view article find links to article
glycoprotein, and L encodes for the polymerase. WCBL must encode for an RNA-dependent RNA polymerase (RdRp) in its genome in order for viral replication and synthesis
Mir-390 microRNA precursor family (1,387 words) [view diff] exact match in snippet view article find links to article
2006). "Identification of trans-acting siRNAs in moss and an RNA-dependent RNA polymerase required for their biogenesis". The Plant Journal. 48 (4): 511–21
Chandipura vesiculovirus (827 words) [view diff] no match in snippet view article find links to article
cellular RNAse function. L and P protein together forms viral RNA dependent RNA polymerase; where catalytic functions for RNA polymerization, capping and
Hazara orthonairovirus (842 words) [view diff] exact match in snippet view article find links to article
(S), Middle (M) and Large (L). The L RNA segment encodes an RNA-dependent RNA polymerase (L protein), the M RNA segment encodes two surface glycoproteins
Trans-acting siRNA (1,153 words) [view diff] exact match in snippet view article find links to article
2006). "Identification of trans-acting siRNAs in moss and an RNA-dependent RNA polymerase required for their biogenesis". Plant J. 48 (4): 511–21. doi:10
EF-Ts (1,097 words) [view diff] no match in snippet view article find links to article
factors, EF-Tu & EF-Ts, the ribosomal protein subunit S1, and the RNA dependent RNA polymerase β-subunit. The two elongation factors form a heterodimer structure
Stockholm format (1,600 words) [view diff] exact match in snippet view article find links to article
yellow mosaic virus RNA in minus-strand synthesis by the viral RNA-dependent RNA polymerase". Journal of Virology. 71 (8): 5990–5996. doi:10.1128/JVI.71
Lymphocytic choriomeningitis (6,308 words) [view diff] exact match in snippet view article find links to article
polypeptide Z with unknown function and a ring finger motif. The viral RNA-dependent RNA polymerase is encoded by the L protein which contains conserved characteristic
Punta Toro phlebovirus (542 words) [view diff] exact match in snippet view article find links to article
transcription takes place in the host cell cytoplasm with the use of an RNA-dependent RNA polymerase, and enters replication after enough nucleoprotein has built
RevCen (454 words) [view diff] exact match in snippet view article find links to article
Sugiyama T, Cam H, Verdel A, Moazed D, Grewal SI (January 2005). "RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin
Orthoreovirus (3,685 words) [view diff] exact match in snippet view article find links to article
point. The core also contains within it twelve copies of λ3, the RNA-dependent RNA polymerase. One λ3 protein is found slightly offset from each of the twelve
David Bartel (840 words) [view diff] exact match in snippet view article find links to article
Institute, he further evolved this ribozyme to function as a RNA-dependent RNA polymerase to extend primers on external RNA templates, bolstering the "RNA
High Plains wheat mosaic emaravirus (582 words) [view diff] exact match in snippet view article find links to article
segments, the most in a known negative-sense RNA plant virus. The RNA-dependent RNA polymerase, glycoprotein precursor, nucleocapsid, and P4 proteins of WMoV
Orthobunyavirus (1,679 words) [view diff] no match in snippet view article find links to article
protease into Gn, NSm and Gc proteins. The L RNA encodes the viral RNA dependent RNA Polymerase or L Protein The primary vectors of Orthobunyaviruses are hematophagous
Ghanaian bat henipavirus (2,732 words) [view diff] no match in snippet view article find links to article
can occur. As a negative-strand RNA virus, GhV brings its own RNA-dependent RNA-polymerase with it into the cell. Three proteins are essential for GhV replication:
Antheraea paphia (847 words) [view diff] no match in snippet view article find links to article
(2010). Molecular characterization of genome segment 2 encoding RNA dependent RNA polymerase of Antheraea mylitta cytoplasmic polyhedrosis virus. Virology
UBQLN1 (1,428 words) [view diff] exact match in snippet view article find links to article
enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase". Journal of Virology. 77 (7): 4149–59. doi:10.1128/JVI.77.7
Tilapia tilapinevirus (2,180 words) [view diff] no match in snippet view article find links to article
fusion is complete, the viral genome, accessory proteins, and RNA dependent RNA polymerase are released into the host cell cytoplasm. Through in situ hybridization
Jamestown Canyon encephalitis (1,657 words) [view diff] exact match in snippet view article find links to article
three segments. The L segment encodes the L endonuclease (an RNA-dependent RNA polymerase enzyme) for genome replication and mRNA synthesis. The M segment
Richard A. Collins (1,240 words) [view diff] exact match in snippet view article find links to article
PMID 12646228. Chen X, Feng Q, Wu Z, et al. (September 2003). "RNA-dependent RNA polymerase gene sequence from foot-and-mouth disease virus in Hong Kong"
Batai orthobunyavirus (2,288 words) [view diff] exact match in snippet view article find links to article
precursor in the open reading frame. The L segment encodes for an RNA-dependent RNA polymerase. Batai virus is geographically spread throughout Asia and Europe
Cucumber mosaic virus (1,907 words) [view diff] exact match in snippet view article find links to article
replication of a eukaryotic virus RNA in vitro by a purified RNA-dependent RNA polymerase". Cell. 63 (2): 363–368. doi:10.1016/0092-8674(90)90169-f. Bujarski
Dengue virus (6,366 words) [view diff] exact match in snippet view article find links to article
methyltransferase domain at its N-terminal end (residues 1–296) and a RNA-dependent RNA polymerase (RdRp) at its C-terminal end (residues 320–900). The methyltransferase
Henry I. Miller (1,505 words) [view diff] exact match in snippet view article find links to article
articles Penhoet, E.; Miller, H.I.; Doyle, M.; Blatti, S. (1971). "RNA-dependent RNA polymerase in influenza virions". Proceedings of the National Academy of
Ervin Fodor (1,062 words) [view diff] exact match in snippet view article find links to article
; Fodor, Ervin (26 October 2015). "Crystal structure of the RNA-dependent RNA polymerase from influenza C virus". Nature. 527 (7576): 114–117. Bibcode:2015Natur
Viperin (1,413 words) [view diff] no match in snippet view article find links to article
ddhCTP (3ʹ-deoxy-3′,4ʹdidehydro-CTP), which inhibits the viral RNA dependent RNA polymerase (RdRp). ddhCTP also appears to abolish metabolism of amino acids
Coxsackie B4 virus (1,706 words) [view diff] exact match in snippet view article find links to article
cleavage of the polyprotein encoded for by the genome. 3D is the RNA-dependent RNA polymerase (RdRP). 2B, 2C, and 3A are core viral proteins. The genome also
Tomato chlorosis virus (647 words) [view diff] exact match in snippet view article find links to article
methyl transferase, PRO denotes proteinase, and RdRp indicates RNA-dependent RNA polymerase. Similar to other members of the crinivirus genus, ToCV is transmitted
Obeldesivir (529 words) [view diff] exact match in snippet view article find links to article
(2020). "Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high
Cassava brown streak virus (1,725 words) [view diff] no match in snippet view article find links to article
which then can be processed by the viral proteases to produce RNA dependent RNA polymerase (RdRp) and other structural proteins. The viral replication happens
Viral vector vaccine (3,317 words) [view diff] exact match in snippet view article find links to article
for nucleocapsid, phosphoprotein, matrix, glycoprotein, and an RNA-dependent RNA polymerase proteins. The rVSV-ZEBOV vaccine, known as Ervebo, was approved
Prune dwarf virus (1,588 words) [view diff] exact match in snippet view article find links to article
RNA replication process The P2 protein encoded by ORF2 is the RNA-dependent RNA polymerase (RdRp) part of the replicase enzyme. Most likely, the P1 and
Sapovirus (2,058 words) [view diff] exact match in snippet view article find links to article
have been designed in order to specifically target and amplify RNA-dependent RNA polymerase. This can be used to "partially characterize the Sapovirus and
Andes orthohantavirus (2,343 words) [view diff] exact match in snippet view article find links to article
nucleocapsids enter the cytoplasm. The virus genome contains its own RNA-dependent RNA polymerase (RdRp) which directs both transcription and replication of the
Lassa mammarenavirus (2,461 words) [view diff] exact match in snippet view article find links to article
and L proteins. The L protein most likely represents the viral RNA-dependent RNA polymerase. When the cell is infected by the virus, L polymerase is associated
Brome mosaic virus (1,607 words) [view diff] exact match in snippet view article find links to article
capping. RNA2 (2.9 kb) encodes the 2a protein (94 kDa), the RNA-dependent RNA polymerase, responsible for replication of the viral genome. The dicistronic
Australian bat lyssavirus (2,576 words) [view diff] no match in snippet view article find links to article
Utilized for host cell entry with receptor-mediated endocytosis L RNA dependent RNA polymerase Enzyme for transcription (produce mRNA from genome) and viral
Bluetongue disease (3,041 words) [view diff] exact match in snippet view article find links to article
The viral genome is replicated via structural protein VP1, an RNA-dependent RNA polymerase. The lack of proof-reading abilities results in high levels of
Phlebovirus (2,895 words) [view diff] exact match in snippet view article find links to article
components. The product of the largest segment (L) is the viral RNA-dependent RNA polymerase. The Phlebovirus replicates in a 7 step process. First, the cellular
Suramin (2,025 words) [view diff] exact match in snippet view article find links to article
inhibitor of sirtuins, purified topoisomerase II and SARS-CoV-2 RNA-dependent RNA polymerase (RdRp). "Suramin Injection Advanced Patient Information". Drugs
Human parainfluenza viruses (2,835 words) [view diff] exact match in snippet view article find links to article
Subsequently, genomic transcription occurs using the viruses own 'viral RNA-dependent RNA polymerase' (L protein). The cell's own ribosomes are then tasked with translation
David Baulcombe (1,931 words) [view diff] exact match in snippet view article find links to article
Hamilton, A.; Rudd, S.; Angell, S.; Baulcombe, D. (2000). "An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene
Lucy Shapiro (2,883 words) [view diff] exact match in snippet view article find links to article
DNA-dependent RNA polymerase. Shapiro was given the task of looking for RNA-dependent RNA polymerase using F2 RNA phage from Norton Zinder. She was successful in
William Paul Duprex (2,008 words) [view diff] case mismatch in snippet view article find links to article
Challenge-Protective Vaccine Concept by Modification of the Viral RNA-Dependent RNA Polymerase of Canine Distemper Virus". Journal of Virology. 81 (24): 13649–13658
Adenosine (3,346 words) [view diff] exact match in snippet view article find links to article
NITD008 has been reported to directly inhibit the recombinant RNA-dependent RNA polymerase of the dengue virus by terminating its RNA chain synthesis. This
Cowpea chlorotic mottle virus (2,239 words) [view diff] no match in snippet view article find links to article
The viral RNA is replicated into a dsRNA genome utilizing an RNA dependent-RNA polymerase. The newly synthesized dsRNA is used to both transcribe more
Rabies virus (4,260 words) [view diff] exact match in snippet view article find links to article
of 242 k-Da and interacts with the phosphoprotein to form the RNA-dependent RNA polymerase complex. L and P bind to each other and according to current
Murine respirovirus (31,225 words) [view diff] exact match in snippet view article find links to article
phosphoproteins (P), which is an essential subunit of the viral of RNA-dependent RNA polymerase (RDRP), and the large protein (L) that is a catalytic subunit
Simeprevir (2,541 words) [view diff] exact match in snippet view article find links to article
SARS-CoV-2, simeprevir acts by inhibiting Main protease (Mpro) and RNA-dependent RNA polymerase, a non-structural protein, essential for viral RNA synthesis
Arenavirus (4,050 words) [view diff] no match in snippet view article find links to article
L-segment RNA is approximately 7.2 kb, and encodes the viral RNA-dependent RNA-polymerase (L) and a small RING-domain containing protein (Z). The Z protein
AtSCE1 (1,718 words) [view diff] case mismatch in snippet view article find links to article
SUMO-Conjugating Enzyme in Plants That Interacts with NIb, the RNA-Dependent RNA Polymerase of Turnip Mosaic Virus, Is Required for Viral Infection". Journal
Potato mop-top virus (2,296 words) [view diff] no match in snippet view article find links to article
tripartite genome. The longest segment of PMTV, RNA-rep encodes RNA dependent RNA polymerase and replicase subunits. The second segment, RNA-CP codes for
Norovirus (6,274 words) [view diff] case mismatch in snippet view article find links to article
Kimura, Hirokazu (2018). "Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase Region in Norovirus Genogroup II". Frontiers in Microbiology
Sepik virus (2,022 words) [view diff] no match in snippet view article find links to article
enzymatic activity as a helicase and protease, while NS5 is an RNA dependent RNA polymerase, allowing the virus to replicate a new (+)RNA genome by creating
Pestivirus (3,931 words) [view diff] exact match in snippet view article find links to article
NS5B (p75), which features a functional motif typical of viral RNA-dependent RNA polymerase, is roughly 77 kDa in size (RdRp). It primarily participates
ZFP62 (1,655 words) [view diff] exact match in snippet view article find links to article
to target ZFP62 is named Artenimol, which would inhibit the RNA-dependent RNA polymerase activity of ZFP62, which is known to be an effective mechanism
Infectious pancreatic necrosis virus (4,954 words) [view diff] exact match in snippet view article find links to article
factors. Segment B contains genetic information for creating an RNA-dependent RNA polymerase enzyme made of VP1. The composition of the surface of virus particles
Baltimore classification (5,685 words) [view diff] exact match in snippet view article find links to article
is transcribed to mRNA from the negative strand by the viral RNA-dependent RNA polymerase (RdRp). The mRNA may be used for translation or replication.
Hepatitis D (5,940 words) [view diff] exact match in snippet view article find links to article
Brueckner F, Cramer P (November 2007). "Molecular basis of RNA-dependent RNA polymerase II activity". Nature. 450 (7168): 445–9. Bibcode:2007Natur.450
Chloroquine (5,892 words) [view diff] exact match in snippet view article find links to article
allows extracellular zinc to enter the cell and inhibit viral RNA-dependent RNA polymerase. Chloroquine inhibits thiamine uptake. It acts specifically on
RNA editing (7,300 words) [view diff] exact match in snippet view article find links to article
protein variants. Viral RNAs are transcribed by a virus-encoded RNA-dependent RNA polymerase, which is prone to pausing and "stuttering" at certain nucleotide
David Baltimore (8,304 words) [view diff] exact match in snippet view article find links to article
Martha Stampfer discovered that VSV replication involved an RNA-dependent RNA polymerase within the virus particle, and used a novel strategy to replicate
Transgenerational epigenetic inheritance (10,351 words) [view diff] exact match in snippet view article find links to article
Seshadri V, Dorweiler JE, White J, et al. (July 2006). "An RNA-dependent RNA polymerase is required for paramutation in maize". Nature. 442 (7100): 295–298
CRISPR (16,244 words) [view diff] no match in snippet view article find links to article
RNA-guided RNase VI-A Cas13a (C2c2) VI-B Cas13b VI-C Cas13c VI-D Cas13d VI-X Cas13x.1 RNA dependent RNA polymerase, Prophylactic RNA-virus inhibition VI-Y
Lily mottle virus (3,417 words) [view diff] exact match in snippet view article find links to article
protein at the ribosomes, as at least one copy of the viral RNA-dependent RNA polymerase is required for the replication of the RNA. After this has synthesized
Japanese scientific misconduct allegations (4,895 words) [view diff] exact match in snippet view article find links to article
hepatitis C virus NS5B is critical for catalytic activity of RNA-dependent RNA polymerase". Journal of Biological Chemistry. 290 (36): 22310. doi:10.1074/jbc