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searching for Pic50 11 found (11 total)

alternate case: pic50

IC50 (1,062 words) [view diff] case mismatch in snippet view article find links to article

the pIC50 scale. pIC50=−log10⁡(IC50){\displaystyle {\ce {pIC_{50}}}=-\log _{10}{\ce {(IC_{50})}}} Due to the minus sign, higher values of pIC50 indicate

Lipophilic efficiency (645 words) [view diff] case mismatch in snippet view article find links to article

is defined as the pIC50 (or pEC50) of interest minus the LogP of the compound. LiPE=pIC50−log⁡P{\displaystyle {\ce {LiPE}}={\ce {pIC50}}-\log P} In practice

Ligand efficiency (481 words) [view diff] case mismatch in snippet view article find links to article

kDa) BEI = (pKi, pKd, or pIC50) / (molecular weight, kDa) SEI = (pKi, pKd, or pIC50) / (PSA/100 Å) where pKi, pKd and pIC50 is defined as −log(Ki), −log(Kd)

Druglikeness (890 words) [view diff] case mismatch in snippet view article find links to article

instead. Potency at the biological target. High potency (high value of pIC50) is a desirable attribute in drug candidates, as it reduces the risk of

Belotecan (260 words) [view diff] case mismatch in snippet view article find links to article

Dang Pharmaceuticals since 2003. Belotecan blocks topoisomerase I with a pIC50 of 6.56, stabilizing the cleavable complex of topoisomerase I-DNA, which

List of benzodiazepines (3,088 words) [view diff] case mismatch in snippet view article find links to article

agonists (e.g. flumazenil). Low IC50 or high pIC50 values indicate tighter binding (pIC50 of 8.0 = IC50 of 10nM, pIC50 of 9.0 = IC50 of 1nM, etc.) These are

Synephrine (9,894 words) [view diff] case mismatch in snippet view article find links to article

preparation from rat cerebral cortex, l-synephrine had pIC50 = 3.35, and d-synephrine had pIC50 = 2.42 in competition against [3H]-prazosin (standard α1

Adenosine diphosphate receptor inhibitor (5,282 words) [view diff] case mismatch in snippet view article find links to article

Compound pIC50 R1 R2 R3 ATP 3.6 O C C-NH2 1A 3.5 C C-NH2 1B 8.6 C-NH2 1C 9.1 Cangrelor 9.4

Dezocine (1,803 words) [view diff] case mismatch in snippet view article find links to article

found to act as a serotonin–norepinephrine reuptake inhibitor (SNRI), with pIC50 values of 5.86 for the serotonin transporter (SERT) and 5.68 for the norepinephrine

Partition coefficient (6,301 words) [view diff] case mismatch in snippet view article find links to article

efficiency for a compound is defined as its potency, via measured values of pIC50 or pEC50, minus its value of log P. In the context of pharmacokinetics (how

Trimipramine (4,676 words) [view diff] case mismatch in snippet view article find links to article

2-Hydroxytrimipramine >30 μM 4.960 4.585 Trimipramine-N-oxide 5.445 4.930 5.027 Values are pIC50. The higher the value, the more strongly the drug binds to the site.