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searching for Parkin (ligase) 38 found (68 total)

Parkin (protein) (5,731 words) [view diff] no match in snippet view article

Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in

ARIH1 (686 words) [view diff] no match in snippet view article find links to article

SA, Markham AF, Robinson PA (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating

MUL1 (1,339 words) [view diff] no match in snippet view article find links to article

Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the

UBE2L6 (870 words) [view diff] no match in snippet view article find links to article

Zhang Y, Gao J, Chung KK, et al. (2001). "Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic

DNAJA1 (943 words) [view diff] no match in snippet view article find links to article

(2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1):

UBE2G1 (687 words) [view diff] no match in snippet view article find links to article

or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme

PARC (gene) (541 words) [view diff] no match in snippet view article

Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241

CUL1 (1,072 words) [view diff] no match in snippet view article find links to article

an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell

Ted M. Dawson (2,746 words) [view diff] no match in snippet view article find links to article

disease. They showed that parkin is a ubiquitin E3 ligase that is inactivated in patients with genetic mutations in parkin and that it is also inactivated

SYVN1 (1,074 words) [view diff] no match in snippet view article find links to article

Nomura Y (December 2006). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin". Journal of Neurochemistry. 99 (6):

ZNF746 (136 words) [view diff] no match in snippet view article find links to article

Zinc finger protein 746 also known as Parkin-interacting substrate (PARIS) is a zinc finger protein that, in humans, is encoded by the ZNF746 gene and

S-phase kinase-associated protein 1 (2,137 words) [view diff] no match in snippet view article find links to article

Schulman B, Demireva E, Abeliovich A (March 2003). "Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate

SMURF1 (1,916 words) [view diff] no match in snippet view article find links to article

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene. The SMURF1 Gene encodes a protein with a size of 757 amino

PACRG (1,027 words) [view diff] no match in snippet view article find links to article

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene. This gene encodes a protein that is conserved across metazoans

Valina L. Dawson (3,374 words) [view diff] no match in snippet view article find links to article

these proteins. They discovered parkin was an E3 ligase that is inactive in patients with genetic mutations in parkin, and that it is also inactive in

HSPA1B (1,959 words) [view diff] no match in snippet view article find links to article

Barbi J, Bu S, Yang HY, Li Z, Gao Y, et al. (August 2013). "The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting

Chromosome 6 (2,422 words) [view diff] no match in snippet view article find links to article

Coenzyme A mutase (6p12.3) NHLRC1: NHL repeat containing E3 ubiquitin protein ligase 1 (6p22.3) NOL7: nucleolar protein 7 (6p23) NQO2: N-ribosyldihydronicotinamide:quinone

Pseudoenzyme (1,384 words) [view diff] no match in snippet view article find links to article

F, Arthur JS, Cohen P (April 2017). "Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling". Proceedings of the National Academy of Sciences

TUBG1 (513 words) [view diff] no match in snippet view article find links to article

"Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity". Human Molecular Genetics

HDAC6 (1,738 words) [view diff] no match in snippet view article find links to article

Pichler A, Gast A, Müller S, Miska E, et al. (June 2002). "The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase". The EMBO Journal

AMBRA1 (1,622 words) [view diff] no match in snippet view article find links to article

Parkinson's disease and in interacting with Parkin, an E3 ubiquitin ligase, there is inhibition of Parkin mitophagy. AMBRA1 is involved in the regulation

BAG5 (581 words) [view diff] no match in snippet view article find links to article

Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (Dec 2004). "BAG5 inhibits parkin and enhances dopaminergic neuron degeneration". Neuron. 44 (6): 931–45.

HK3 (1,868 words) [view diff] no match in snippet view article find links to article

2012). "Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase". Biochemical and Biophysical Research Communications. 428 (1):

Protein tyrosine phosphatase (2,314 words) [view diff] no match in snippet view article find links to article

Lombroso PJ, Nairn AC (Jan 2018). "STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease". Proceedings of the National

Parkinson's disease in South Asians (4,796 words) [view diff] no match in snippet view article find links to article

PD in Indian populations. Encoded by the PARK2 gene, the PARKIN protein is a ubiquitin ligase that is indicated in protein processing as well as degradation

CCT2 (gene) (835 words) [view diff] no match in snippet view article

Abe K, Takahashi R (Dec 2003). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell

C19orf47 (440 words) [view diff] no match in snippet view article find links to article

Full Name Additional Notes PARK2 Parkin RBR E3 Ubiquitin Protein Ligase Component of multiprotein E3 ubiquitin ligase complex. Mutations are known to cause

MFN2 (3,260 words) [view diff] no match in snippet view article find links to article

are significantly increased in AD. MFN2 is a key substrate of the PINK1/parkin couple, whose mutations are linked to the familial forms of Parkinson's

PTPN5 (2,299 words) [view diff] no match in snippet view article find links to article

Lombroso PJ, Nairn AC (Jan 2015). "STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease". Proceedings of the National

HK2 (2,505 words) [view diff] no match in snippet view article find links to article

2012). "Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase". Biochemical and Biophysical Research Communications. 428 (1):

S-Nitrosylation (2,239 words) [view diff] no match in snippet view article find links to article

linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity". Proceedings of the National Academy of Sciences

Gingerol (2,832 words) [view diff] no match in snippet view article find links to article

p-Coumaric acid (3) with use of cinnamate 4-hydroxylase (C4H). 4-coumarate:CoA ligase (4CL) is then used to get p-Coumaroyl-CoA (5). P-Coumaroyl shikimate transferase

Janelle Ayres (1,361 words) [view diff] no match in snippet view article find links to article

Schneider, D.S., Nakamura, K., Shiloh, M.U., Cox, J.S. The ubiquitin ligase parkin mediates resistance to intracellular pathogens. (2013) Nature. 501(7468):512-6

MROH9 (2,277 words) [view diff] no match in snippet view article find links to article

are both E3 Ubiquitin ligases, which are responsible for targeting proteins for degradation. GLO1, or lactoylglutathione ligase, is an enzyme catalyzing

Interferon (7,054 words) [view diff] no match in snippet view article find links to article

Zou QP, Jia PM, Tong JH (March 2013). "Rig-G negatively regulates SCF-E3 ligase activities by disrupting the assembly of COP9 signalosome complex". Biochemical

Genome instability (4,560 words) [view diff] no match in snippet view article find links to article

perfect copy of DNA. Mutations of proteins such as DNA polymerase or DNA ligase can lead to impairment of replication and lead to spontaneous chromosomal

Oncovirus (6,056 words) [view diff] no match in snippet view article find links to article

1993). "The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53". Cell. 75 (3): 495–505. doi:10.1016/0092-8674(93)90384-3

Memory (16,062 words) [view diff] no match in snippet view article find links to article

non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand breaks within about