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searching for Non-homologous end joining 48 found (233 total)

alternate case: non-homologous end joining

Desiccation (835 words) [view diff] exact match in snippet view article find links to article

deficient in the ability to repair double-strand breaks by the non-homologous end joining (NHEJ) pathway are more sensitive to prolonged desiccation during

Caulimoviridae (885 words) [view diff] no match in snippet view article find links to article

family Caulimoviridae. Integration is thought to occur through non-homologous end-joining (illegitimate recombination) during DNA repair mechanisms. Most

Cernunnos deficiency (513 words) [view diff] no match in snippet view article find links to article

pathophysiology of Cernunnos deficiency begins with normal function of Non-homologous end-joining factor 1 gene. NHEJ1 encodes a protein which helps repair of breaks

Simon Boulton (1,928 words) [view diff] exact match in snippet view article find links to article

defects of Fanconi Anemia cells can be suppressed by blocking non-homologous end joining. He has also demonstrated that a newly identified helicase, RTEL1

Genetic variability (1,091 words) [view diff] exact match in snippet view article find links to article

significant source of mutation is an inaccurate DNA repair process, non-homologous end joining, that is often employed in repair of DNA double-strand breaks

Knockout rat (3,268 words) [view diff] exact match in snippet view article find links to article

namely homologous recombination and non-homologous end joining. When the cell uses the non-homologous end joining pathway to repair the double-strand

Leptotene stage (581 words) [view diff] exact match in snippet view article find links to article

mid-pachytene to diplotene, the predominant repair pathway shifts to non-homologous end joining. Leptotene is followed by the zygotene stage, where synapsis between

Gene knockdown (1,611 words) [view diff] exact match in snippet view article find links to article

cleavage of the target DNA sequence by the TALEN, the cell uses non-homologous end joining as a DNA repair mechanism to correct the cleavage. The cell's

XRCC1 (2,856 words) [view diff] exact match in snippet view article find links to article

excision repair), aprataxin (active in single-strand DNA repair and non-homologous end joining) and a third protein designated aprataxin- and PNKP-like factor

TFIP11 (682 words) [view diff] exact match in snippet view article find links to article

extracellular matrix Biological process RNA processing protection from non-homologous end joining at telomere negative regulation of protein-containing complex

Clastogen (1,295 words) [view diff] exact match in snippet view article find links to article

Lopezcolorado FW, Tsai LJ, Stark JM (January 2020). "The canonical non-homologous end joining factor XLF promotes chromosomal deletion rearrangements in human

SiDNA (939 words) [view diff] exact match in snippet view article find links to article

genome, the cell most commonly repairs the damaged segment via non-homologous end joining (NHEJ). NHEJ involves the ligation of the damaged segments without

DCLRE1A (757 words) [view diff] exact match in snippet view article find links to article

nonhomologous end joining interstrand cross-link repair protection from non-homologous end joining at telomere cell division nucleic acid phosphodiester bond hydrolysis

Histone methylation (2,866 words) [view diff] exact match in snippet view article find links to article

53BP1 involved in the repair of double-stranded DNA breaks by non-homologous end joining. H4K20me3 is observed to be concentrated in heterochromatin and

Micronucleus (1,955 words) [view diff] no match in snippet view article find links to article

repair pathway and causes the cell to resort to the error-prone non-homologous end-joining (NHEJ) repair pathway, increasing the likelihood of incorrect

TERF2IP (1,161 words) [view diff] exact match in snippet view article find links to article

telomere telomere maintenance via telomerase protection from non-homologous end joining at telomere regulation of double-strand break repair via homologous

ACD (gene) (1,485 words) [view diff] exact match in snippet view article

regulation of single-stranded telomeric DNA binding protection from non-homologous end joining at telomere protein localization to chromosome, telomeric region

Cell damage (2,829 words) [view diff] no match in snippet view article find links to article

nucleotide excision repair, base excision repair, mismatch repair, non-homologous end-joining and homologous recombinational repair (HRR) (see chart in DNA

Field cancerization (1,850 words) [view diff] exact match in snippet view article find links to article

expression of 3 different DNA repair enzymes: Ku86 (active in the non-homologous end joining pathway), ERCC1 (active in the nucleotide excision DNA repair

ADP-ribosylation (3,535 words) [view diff] exact match in snippet view article find links to article

stranded DNA. PARP1 may function as a synapsis factor in alternative non-homologous end joining. Additionally, it has been proposed that PARP1 is required to

Artemis (protein) (1,840 words) [view diff] exact match in snippet view article

immune response interstrand cross-link repair protection from non-homologous end joining at telomere immune system process chromosome organization cellular

Restriction modification system (2,623 words) [view diff] no match in snippet view article find links to article

appear to mimic the action of RM-systems in bacteria, and the non-homologous end-joining (NHEJ) that follows the use of ZFN without a repair template.

Telomere (4,840 words) [view diff] exact match in snippet view article find links to article

recognized as breakpoints by the DNA repair machinery. Should non-homologous end joining occur at the telomeric ends, chromosomal fusion would result.

PNKP (1,881 words) [view diff] exact match in snippet view article find links to article

human polynucleotide kinase in double-strand break repair by non-homologous end joining". EMBO J. 21 (11): 2827–32. doi:10.1093/emboj/21.11.2827. PMC 126026

PNKP (1,881 words) [view diff] exact match in snippet view article find links to article

human polynucleotide kinase in double-strand break repair by non-homologous end joining". EMBO J. 21 (11): 2827–32. doi:10.1093/emboj/21.11.2827. PMC 126026

Autoimmune regulator (3,095 words) [view diff] exact match in snippet view article find links to article

polymerase (PARP1) which are involved in DNA break and repair through non-homologous end joining. The AIRE gene is mutated in the rare autoimmune syndrome autoimmune

Intron (5,770 words) [view diff] exact match in snippet view article find links to article

coding sequence of the gene. Double-stranded break repair via non-homologous end joining was recently identified as a source of intron gain when researchers

DNA-deoxyinosine glycosylase (1,301 words) [view diff] exact match in snippet view article find links to article

(NER), mismatch repair (MMR), homologous recombination (HR), and non-homologous end joining (NHEJ). While hypoxanthine, or inosine when attached to a ribose

Isogenic human disease models (2,046 words) [view diff] exact match in snippet view article find links to article

Hendrickson EA (February 2010). Pearson CE (ed.). "Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic

Chromatin (5,949 words) [view diff] exact match in snippet view article find links to article

maintain genomic integrity, “homologous recombination and classical non-homologous end joining process” has been followed by DNA to be repaired. The packaging

Restriction enzyme (5,855 words) [view diff] no match in snippet view article find links to article

appear to mimic the action of RM-systems in bacteria, and the non-homologous end-joining (NHEJ) that follows the use of ZFN without a repair template.

Recombinant AAV mediated genome engineering (2,673 words) [view diff] exact match in snippet view article find links to article

Lichter N, Hendrickson EA (February 2010). "Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic

Chromosome instability (3,401 words) [view diff] exact match in snippet view article find links to article

where parts of non-homologous chromosomes are joined together. Non-homologous end joining can also join two different chromosomes together that had broken

Protein inhibitor of activated STAT (3,226 words) [view diff] exact match in snippet view article find links to article

(October 2013). "PIAS3 promotes homology-directed repair and distal non-homologous end joining". Oncology Letters. 6 (4): 1045–1048. doi:10.3892/ol.2013.1472

Reptin (1,889 words) [view diff] exact match in snippet view article find links to article

directly participate in both the homologous recombination and the non-homologous end joining processes for fixing double stranded breaks. In addition, it removes

MDC1 (3,123 words) [view diff] exact match in snippet view article find links to article

a role in DNA repair by both homologous recombination and by Non-homologous end joining, however the mechanism through which it facilitates repair of

Helitron (biology) (3,784 words) [view diff] case mismatch in snippet view article

Helitrons during their transposition. Low-fidelity repair of DSB by Non-Homologous End Joining is more frequent in plants and mammals than repair through homologous

Anindya Dutta (2,387 words) [view diff] case mismatch in snippet view article find links to article

Im, JS; Shibata, E; Dutta, A (5 October 2017). "ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand

Ligation (molecular biology) (4,862 words) [view diff] exact match in snippet view article

mediates bacterial chromosome DSBs repair as single component non-homologous end joining". Synthetic and Systems Biotechnology. 4 (2): 107–112. doi:10

IFFO1 (1,758 words) [view diff] exact match in snippet view article find links to article

DNA-dependent protein kinase in DNA repair of double-stranded breaks by non-homologous end joining Another protein interaction with ubiquitin C was found from affinity

DNA shuffling (2,913 words) [view diff] exact match in snippet view article find links to article

0402202101. PMC 406457. PMID 15118093. Zhu S, Peng A (June 2016). "Non-homologous end joining repair in Xenopus egg extract". Scientific Reports. 6 (1): 27797

Human genetic enhancement (10,464 words) [view diff] exact match in snippet view article find links to article

help with single-base exchanges, homology-directed repair, and non-homologous end joining. The primary application is targeted gene knockouts, involving

Retinoblastoma protein (9,499 words) [view diff] exact match in snippet view article find links to article

to sites of DNA breaks during the repair process and assist in non-homologous end joining and homologous recombination through complexing with E2F1. Once

LIG3 (3,805 words) [view diff] exact match in snippet view article find links to article

double strand breaks are repaired by DNA ligase IV-dependent non-homologous end joining (NHEJ). DNA ligase III-alpha participates in a minor alternative

Surveyor nuclease assay (3,176 words) [view diff] no match in snippet view article find links to article

of a double strand DNA break, followed by repair through the non-homologous end-joining (NHEJ) or homology-directed repair (HDR) pathways. While HDR is

Gene therapy (17,769 words) [view diff] exact match in snippet view article find links to article

introduces a DNA double strand break, which is then followed by gene modification via homologous recombination (HDR) or non-homologous end joining (NHEJ).

Actin (17,979 words) [view diff] no match in snippet view article find links to article

polymer of actin (F-actin) acts both in the DNA repair pathway of non homologous end joining and in the pathway of homologous recombinational repair. Due to

Biochemistry of Alzheimer's disease (7,749 words) [view diff] exact match in snippet view article find links to article

predominant mechanism for repairing DNA double-strand breaks is non-homologous end joining (NHEJ), a mechanism that utilizes the DNA-dependent protein kinase