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searching for Granzyme B 35 found (70 total)

alternate case: granzyme B

GZMB (305 words) [view diff] exact match in snippet view article find links to article

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer

SERPINB9 (1,045 words) [view diff] exact match in snippet view article find links to article

"Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction"

Perforin-1 (1,410 words) [view diff] exact match in snippet view article find links to article

between the pore-forming protein, perforin, and the serine protease, granzyme B". Australian and New Zealand Journal of Medicine. 25 (6): 793–9. doi:10

GZMM (543 words) [view diff] exact match in snippet view article find links to article

collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M. GRCh38: Ensembl release

Heparan sulfate (4,149 words) [view diff] exact match in snippet view article find links to article

angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B), and tumour metastasis. HS has also been shown to serve as cellular receptor

GZMH (698 words) [view diff] exact match in snippet view article find links to article

Waterhouse NJ, Trapani JA (2007). "H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells". Trends Immunol. 28 (9): 373–5. doi:10

Serglycin (1,130 words) [view diff] exact match in snippet view article find links to article

2002). "Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation"

ELISpot (1,980 words) [view diff] exact match in snippet view article find links to article

cytokine responses, antibody specific secreting cells, tumor antigens, granzyme B and Perforin release by T cells, vaccine efficacy, epitope mapping, cytotoxic

Degranulation (635 words) [view diff] exact match in snippet view article find links to article

K, Motyka B, Frantz C, Shostak I, Sawchuk T, Bleackley R (2004). "The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis"

LILRA4 (548 words) [view diff] exact match in snippet view article find links to article

hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood

TGFBR3 (1,632 words) [view diff] exact match in snippet view article find links to article

due to the proteolytic activity of the pro-apoptotic serine protease - granzyme B. Plasmin - a serine protease present in the blood, activated as part of

Caspase-9 (4,330 words) [view diff] exact match in snippet view article find links to article

ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B". The Journal of Biological Chemistry. 271 (28): 16720–4. doi:10.1074/jbc

Interleukin 28 (721 words) [view diff] exact match in snippet view article find links to article

Lewis MG, Talbott K, et al. (September 2010). "IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques"

Cathepsin C (1,845 words) [view diff] exact match in snippet view article find links to article

with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity". Blood. 107 (9): 3665–8. doi:10

Eomesodermin (1,910 words) [view diff] exact match in snippet view article find links to article

expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)". Journal of Immunology. 180 (12): 8102–8. doi:10.4049/jimmunol.180.12

CD244 (1,912 words) [view diff] exact match in snippet view article find links to article

membrane Biological process innate immune response positive regulation of granzyme B production immune system process leukocyte migration adaptive immune response

UBE4A (550 words) [view diff] exact match in snippet view article find links to article

the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587

XCL1 (1,213 words) [view diff] exact match in snippet view article find links to article

negative regulation of T-helper 1 cell activation positive regulation of granzyme B production signal transduction antimicrobial humoral immune response mediated

GRIA3 (2,077 words) [view diff] exact match in snippet view article find links to article

PMC 1369911. PMID 10688364. Gahring L, Carlson NG, Meyer EL, Rogers SW (2001). "Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen

Toxic epidermal necrolysis (2,598 words) [view diff] exact match in snippet view article find links to article

cell death through release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha and

UBE4B (825 words) [view diff] exact match in snippet view article find links to article

the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587

PD-L1 (2,846 words) [view diff] exact match in snippet view article find links to article

Blockade reduced TNFα and nitric oxide production by macrophages, reduced granzyme B production by NK cells, and decreased proliferation of L. monocytogenes

Nuclear mitotic apparatus protein 1 (1,140 words) [view diff] exact match in snippet view article find links to article

Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L (1998). "Granzyme B directly and efficiently cleaves several downstream caspase substrates:

Fucosyltransferase 4 (537 words) [view diff] exact match in snippet view article find links to article

expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis". Biol. Pharm. Bull. 30 (4): 655–60. doi:10

Cathepsin G (2,860 words) [view diff] exact match in snippet view article find links to article

Bangalore N, Travis J (January 1991). "Human lysosomal cathepsin G and granzyme B share a functionally conserved broad spectrum antibacterial peptide".

T helper cell 22 (646 words) [view diff] exact match in snippet view article find links to article

DCs. Th22 cells are known to secrete IL-22, IL-13, IL-26, TNF-α, and granzyme B. Th22 cells express the chemokine receptors CCR4, CCR6, and CCR10 which

Memory T cell (3,781 words) [view diff] exact match in snippet view article find links to article

One mechanism used by TRM to restrict pathogens is the secretion of granzyme B. Stem cell-like memory T cells (TSCM): Those lymphocytes are capable of

DFFA (1,405 words) [view diff] exact match in snippet view article find links to article

(June 2001). "Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation". The EMBO

Type 1 regulatory T cell (1,883 words) [view diff] exact match in snippet view article find links to article

vitro. Cytolitic activity: Tr1 cells can both express Granzyme A and granzyme B. It was shown recently, that Tr1 cells, in vitro and also ex vivo, specifically

Interleukin 10 (4,858 words) [view diff] exact match in snippet view article find links to article

been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion.

Nancy Thornberry (1,706 words) [view diff] exact match in snippet view article find links to article

Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B". Journal of Biological Chemistry. 272 (29): 17907–17911. doi:10.1074/jbc

GNLY (2,318 words) [view diff] exact match in snippet view article find links to article

Yalman N, et al. (January 2003). "Sequence analysis of the granulysin and granzyme B genes in familial hemophagocytic lymphohistiocytosis". Human Genetics

Caspase-activated DNase (3,043 words) [view diff] exact match in snippet view article find links to article

(June 2001). "Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation". The EMBO

Lichen planus (6,325 words) [view diff] exact match in snippet view article find links to article

such as secretion of tumor necrosis factor (TNF)-alpha, secretion of granzyme B, or Fas-Fas ligand interactions. Chemokines are produced by activated

2014 in science (25,345 words) [view diff] case mismatch in snippet view article find links to article

Intelligence" (AI100). By blocking the activity of an enzyme known as Granzyme b, researchers have slowed aging in the skin of mice. 17 December – A Colorado