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Longer titles found: Granzyme A (view), Granzyme B (view)

searching for Granzyme 47 found (108 total)

alternate case: granzyme

GZMM (543 words) [view diff] exact match in snippet view article find links to article

collectively termed granzymes and include 4 distinct gene products: granzyme A, granzyme B, granzyme H, and Met-ase, also known as granzyme M. GRCh38: Ensembl
SERPINB9 (1,045 words) [view diff] exact match in snippet view article find links to article
"Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction"
GZMH (698 words) [view diff] exact match in snippet view article find links to article
Granzyme H is a protein that in humans is encoded by the GZMH gene. GRCh38: Ensembl release 89: ENSG00000100450 - Ensembl, May 2017 GRCm38: Ensembl release
Protein SET (1,277 words) [view diff] exact match in snippet view article find links to article
assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/mcb.22
Heparan sulfate (4,149 words) [view diff] exact match in snippet view article find links to article
angiogenesis, blood coagulation, abolishing detachment activity by GrB (Granzyme B), and tumour metastasis. HS has also been shown to serve as cellular
Lymphomatoid papulosis (352 words) [view diff] exact match in snippet view article find links to article
and CD30+ lymphocytes that often stain with cytotoxic markers (TIA-1, granzyme, perforin). E Angioinvasive with small to large angiocentric CD30+ atypical
HMGB2 (1,190 words) [view diff] exact match in snippet view article find links to article
assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Molecular and Cellular Biology. 22 (8): 2810–20. doi:10.1128/MCB.22
Acidic leucine-rich nuclear phosphoprotein 32 family member A (989 words) [view diff] exact match in snippet view article find links to article
assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002
ELISpot (1,980 words) [view diff] exact match in snippet view article find links to article
cytokine responses, antibody specific secreting cells, tumor antigens, granzyme B and Perforin release by T cells, vaccine efficacy, epitope mapping, cytotoxic
XCL1 (1,213 words) [view diff] exact match in snippet view article find links to article
chemotaxis positive regulation of GTPase activity positive regulation of granzyme A production positive regulation of immunoglobulin production in mucosal
TREX1 (1,270 words) [view diff] exact match in snippet view article find links to article
SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres
LILRA4 (548 words) [view diff] exact match in snippet view article find links to article
hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood
TGFBR3 (1,632 words) [view diff] exact match in snippet view article find links to article
due to the proteolytic activity of the pro-apoptotic serine protease - granzyme B. Plasmin - a serine protease present in the blood, activated as part
UBE4B (825 words) [view diff] exact match in snippet view article find links to article
the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587
Caspase-9 (4,330 words) [view diff] exact match in snippet view article find links to article
the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B". The Journal of Biological Chemistry. 271 (28): 16720–4. doi:10.1074/jbc
Nucleolin (1,936 words) [view diff] exact match in snippet view article find links to article
Pasternack MS, Bleier KJ, McInerney TN (Aug 1991). "Granzyme A binding to target cell proteins. Granzyme A binds to and cleaves nucleolin in vitro". The Journal
Interleukin 28 (721 words) [view diff] exact match in snippet view article find links to article
Lewis MG, Talbott K, et al. (September 2010). "IL-28B/IFN-lambda 3 drives granzyme B loading and significantly increases CTL killing activity in macaques"
ANP32C (449 words) [view diff] exact match in snippet view article find links to article
"Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A". Nature Immunology. 4 (2): 145–53. doi:10.1038/ni885. PMID 12524539
Type 1 regulatory T cell (1,883 words) [view diff] exact match in snippet view article find links to article
production in vitro. Cytolitic activity: Tr1 cells can both express Granzyme A and granzyme B. It was shown recently, that Tr1 cells, in vitro and also ex
CD244 (1,912 words) [view diff] exact match in snippet view article find links to article
membrane Biological process innate immune response positive regulation of granzyme B production immune system process leukocyte migration adaptive immune
Cathepsin C (1,845 words) [view diff] exact match in snippet view article find links to article
with Papillon-Lefevre syndrome reveals a requirement for cathepsin C in granzyme B activation and NK cell cytolytic activity". Blood. 107 (9): 3665–8. doi:10
Eomesodermin (1,910 words) [view diff] exact match in snippet view article find links to article
expression of effector molecules (eomesodermin and its targets: perforin and granzyme B)". Journal of Immunology. 180 (12): 8102–8. doi:10.4049/jimmunol.180
Toxic epidermal necrolysis (2,598 words) [view diff] exact match in snippet view article find links to article
cell death through release of a number of molecules, including perforin, granzyme B, and granulysin. Other agents, including tumor necrosis factor alpha
GRIA3 (2,077 words) [view diff] exact match in snippet view article find links to article
PMC 1369911. PMID 10688364. Gahring L, Carlson NG, Meyer EL, Rogers SW (2001). "Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen
LAMP1 (2,161 words) [view diff] exact match in snippet view article find links to article
organelle positive regulation of natural killer cell mediated cytotoxicity granzyme-mediated apoptotic signaling pathway autophagic cell death neutrophil degranulation
UBE4A (550 words) [view diff] exact match in snippet view article find links to article
the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587
PD-L1 (2,846 words) [view diff] exact match in snippet view article find links to article
Blockade reduced TNFα and nitric oxide production by macrophages, reduced granzyme B production by NK cells, and decreased proliferation of L. monocytogenes
NDUFS3 (1,704 words) [view diff] exact match in snippet view article find links to article
ajhg.2009.04.020. PMC 2694978. PMID 19463981. Lieberman J (May 2010). "Granzyme A activates another way to die". Immunological Reviews. 235 (1): 93–104
Memory T cell (3,781 words) [view diff] exact match in snippet view article find links to article
present. One mechanism used by TRM to restrict pathogens is the secretion of granzyme B. Stem cell-like memory T cells (TSCM): Those lymphocytes are capable
Signaling lymphocytic activation molecule (1,117 words) [view diff] exact match in snippet view article find links to article
of multiple myeloma patients. Elotuzumab stimulates NK cells to release granzyme through blocking SLAMF7, through triggering antibody-dependent cellular
Nuclear mitotic apparatus protein 1 (1,112 words) [view diff] exact match in snippet view article find links to article
PMID 9288109. S2CID 21975861. Andrade F, Roy S, Nicholson D, et al. (1998). "Granzyme B directly and efficiently cleaves several downstream caspase substrates:
Fucosyltransferase 4 (537 words) [view diff] exact match in snippet view article find links to article
expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis". Biol. Pharm. Bull. 30 (4): 655–60. doi:10
Interleukin 10 (4,858 words) [view diff] exact match in snippet view article find links to article
been shown to enhance CD8+ T cell secretion of the cytotoxic molecules Granzyme B and Perforin and potentiate T cell receptor dependent IFNγ secretion
CMA1 (939 words) [view diff] exact match in snippet view article find links to article
"The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression". Genomics. 15 (3): 614–20
T helper cell 22 (646 words) [view diff] exact match in snippet view article find links to article
dermal DCs. Th22 cells are known to secrete IL-22, IL-13, IL-26, TNF-α, and granzyme B. Th22 cells express the chemokine receptors CCR4, CCR6, and CCR10 which
DFFA (1,405 words) [view diff] exact match in snippet view article find links to article
(June 2001). "Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation". The EMBO
Bacterial therapy (1,430 words) [view diff] exact match in snippet view article find links to article
subunit of the bacterial flagellum) via TLR5 activation. The perforin and granzyme proteins secreted by activated CD8+ T cells efficiently kill tumor cells
Living medicine (950 words) [view diff] exact match in snippet view article find links to article
subunit of the bacterial flagellum) via TLR5 activation. The perforin and granzyme proteins secreted by activated CD8+ T cells efficiently kill tumor cells
Nancy Thornberry (1,706 words) [view diff] exact match in snippet view article find links to article
Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B". Journal of Biological Chemistry. 272 (29): 17907–17911. doi:10.1074/jbc
Glypican 3 (2,625 words) [view diff] exact match in snippet view article find links to article
cells can eliminate GPC3-positive cancer cells, by inducing perforin- and granzyme-mediated cell death and reducing Wnt signaling in tumor cells. CAR (hYP7)
Lichen planus (6,325 words) [view diff] exact match in snippet view article find links to article
mechanisms such as secretion of tumor necrosis factor (TNF)-alpha, secretion of granzyme B, or Fas-Fas ligand interactions. Chemokines are produced by activated
Rheumatoid arthritis (17,100 words) [view diff] exact match in snippet view article find links to article
JH, McDavid A, Wei K, Rao DA, Raychaudhuri S, Brenner MB (June 2022). "Granzyme K+ CD8 T cells form a core population in inflamed human tissue". Science
Caspase-activated DNase (3,043 words) [view diff] exact match in snippet view article find links to article
(June 2001). "Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation". The EMBO
Veto cell (2,148 words) [view diff] exact match in snippet view article find links to article
cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7". Blood. 120 (8): 1647–57. doi:10.1182/blood-2012-02-410803
BNIP3 (2,672 words) [view diff] exact match in snippet view article find links to article
metabolic process viral process negative regulation of mitochondrial fusion granzyme-mediated apoptotic signaling pathway mitochondrial outer membrane permeabilization
2014 in science (25,345 words) [view diff] exact match in snippet view article find links to article
Intelligence" (AI100). By blocking the activity of an enzyme known as Granzyme b, researchers have slowed aging in the skin of mice. 17 December – A Colorado
Artificial white blood cells (2,231 words) [view diff] exact match in snippet view article find links to article
innate immune system, and they kill pathogens via release of perforin and granzyme to directly destroy cell membranes, release of cytokines such as TNF-α