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searching for Diphtheria toxin 44 found (247 total)

Alwin Max Pappenheimer Jr. (351 words) [view diff] exact match in snippet view article find links to article

analysis of the diphtheria toxin for which he received Eli Lilly Award in 1941. He performed ultracentrifugation-based analysis of diphtheria toxin-antitoxin

DPH5 (629 words) [view diff] exact match in snippet view article find links to article

It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The

Gaston Ramon (220 words) [view diff] exact match in snippet view article find links to article

tetanus. In particular, he developed a method for inactivating the diphtheria toxin and the tetanus toxin using formaldehyde which, in its essentials,

W. Ian McDonald (365 words) [view diff] exact match in snippet view article find links to article

thesis work dealt with experimental neuropathy in cats induced by diphtheria toxin. It was conducted at the Department of Physiology under the supervision

Schick test (376 words) [view diff] exact match in snippet view article find links to article

a simple procedure. A small amount (0.1 ml) of diluted (1/50 MLD) diphtheria toxin is injected intradermally into one arm of the person and a heat inactivated

Corynebacterium ulcerans (588 words) [view diff] exact match in snippet view article find links to article

ulcerans has been found to carry the same gene that codes for the diphtheria toxin. After swabbing lesions on a 53-year-old woman in Germany who experienced

Saporin (901 words) [view diff] exact match in snippet view article find links to article

the enzymatic chain of Pseudomonas exotoxin, the enzymatic chain of diphtheria toxin have also been used, again with variations in success. Immunotoxins

Suicide gene (2,163 words) [view diff] exact match in snippet view article find links to article

instance, the most researched immunotoxin for cancer therapy is the diphtheria toxin as it inhibits protein synthesis by inactivating elongation factor

Synthetic vaccine (415 words) [view diff] exact match in snippet view article find links to article

pandemic. The world's first synthetic vaccine was created in 1796 from diphtheria toxin by Louis Chedid (scientist) from the Pasteur Institute and Michael

Biopharmaceutical (2,798 words) [view diff] exact match in snippet view article find links to article

Ontak cutaneous T-cell lymphoma (CTCL) Diphtheria toxin engineered protein combining Interleukin-2 and Diphtheria toxin Interleukin-2 receptor binder golimumab

CD9 (3,140 words) [view diff] exact match in snippet view article find links to article

inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor". The Journal

Interleukin-3 receptor (206 words) [view diff] exact match in snippet view article find links to article

subtypes, including leukemic stem cells. Tagraxofusp, human IL-3 fused to diphtheria toxin, is an approved treatment for BPDCN. An experimental antibody-drug

Pathogenicity island (877 words) [view diff] exact match in snippet view article find links to article

specific bacteriophages. Phage encoded Cholera toxin of Vibrio cholerae, Diphtheria toxin of Corynebacterium diphtheriae, Neurotoxins of Clostridium botulinum

Olga Povitzky (1,257 words) [view diff] exact match in snippet view article find links to article

Methods for the Isolation and Later Cultivation of B. Pertussis" (1923) "Diphtheria toxin-antitoxin titration by Ramon method for practical application" (1924

Selman A. Waksman Award in Microbiology (762 words) [view diff] exact match in snippet view article find links to article

of bacterial pathogenesis by the elucidation of the action of the diphtheria toxin. Carl R. Woese (1997) For discovering a kingdom of life, the Archaea—using

1890 in science (1,010 words) [view diff] exact match in snippet view article find links to article

immunizing people against diphtheria can be prepared by injecting diphtheria toxin into animals. Curt Schimmelbusch invents the Schimmelbusch mask for

William Hallock Park (627 words) [view diff] exact match in snippet view article find links to article

Corynebacterium diphtheriae most widely used for the production of diphtheria toxin was discovered by Anna Williams, who worked with Park. Highlights of

1888 in science (1,245 words) [view diff] exact match in snippet view article find links to article

known as Martinotti cells. Emile Roux and Alexandre Yersin isolate diphtheria toxin. Heinrich Wilhelm Gottfried von Waldeyer-Hartz names the chromosome

Rino Rappuoli (1,020 words) [view diff] exact match in snippet view article find links to article

characteristics of cross-reacting material 197 (CRM197), a non-toxic mutant of diphtheria toxin: Use as a conjugation protein in vaccines and other potential clinical

Claus W. Jungeblut (292 words) [view diff] case mismatch in snippet view article find links to article

in Experimental Poliomyelitis (1939) Studies on the Inactivation of Diphtheria Toxin by Vitamin C (I-Ascorbic Acid) (1941) American Men of Medicine, Volume

Cell ablation (617 words) [view diff] exact match in snippet view article find links to article

treatment for small tumors. Michiko, Saito; et al. (1 August 2001). "Diphtheria toxin receptor mediated conditional and targeted cell ablation in transgenic

Alexander Glenny (318 words) [view diff] exact match in snippet view article find links to article

Alexander Thomas; Südmerson, H.J. (1921). "Notes on the immunity to diphtheria toxin". Journal of Hygiene. 20 (2): 179–220. doi:10.1017/s0022172400033945

Modeccin (2,553 words) [view diff] exact match in snippet view article find links to article

cell-permeable ceramide analogs against modeccin, ricin, Pseudomonas toxin, and diphtheria toxin". Experimental Cell Research. 221 (1): 1–10. doi:10.1006/excr.1995

Niels Kaj Jerne (1,234 words) [view diff] case mismatch in snippet view article find links to article

for his thesis, A Study of Avidity Based on Rabbit Skin Responses to Diphtheria Toxin-Antitoxin Mixtures. From 1943 to 1956 Jerne was a research worker at

Émile Roux (1,738 words) [view diff] exact match in snippet view article find links to article

diphtheria. Roux had been nominated in 1888 for the isolation of the diphtheria toxin, but didn't win the prize in 1901 because his discovery was deemed

Mary Locke Petermann (1,081 words) [view diff] exact match in snippet view article find links to article

analysis of antibody-antigen interactions, in particular those between diphtheria toxin and antitoxin. Using ultracentrifugation, they showed that about 2/3

Chronobiology (3,417 words) [view diff] exact match in snippet view article find links to article

photoentrainment. In 2008, Hattar and his research team transplanted diphtheria toxin genes into the mouse melanopsin gene locus to create mutant mice that

Maud Menten (2,147 words) [view diff] exact match in snippet view article find links to article

ML. (1935). "The influence of vitamin C level upon resistance to diphtheria toxin I. Changes in body weight and duration of life". Journal of Nutrition

Edith M. Taylor (933 words) [view diff] exact match in snippet view article find links to article

to the culturing process of diphtheria toxoid, a non-toxic form of diphtheria toxin safe for vaccination. Connaught had been producing tetanus toxoid since

List of antineoplastic agents (708 words) [view diff] exact match in snippet view article find links to article

Interleukin 2 combined with diphtheria toxin which binds to the interleukin receptor on immune cells and introduces the diphtheria toxin into the cell. Cutaneous

Structural gene (2,197 words) [view diff] exact match in snippet view article find links to article

A. (1983-11-01). "Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta". Proceedings of the National Academy

CSL Limited (2,888 words) [view diff] exact match in snippet view article find links to article

was drawn into a serious public health disaster when a batch of its diphtheria toxin-antitoxin was implicated in the deaths of twelve children in what became

Mark Pallen (1,750 words) [view diff] exact match in snippet view article find links to article

microbiologysociety.org. Pallen, Mark John (1993). Detection and characterisation of diphtheria toxin genes and insertion sequences by PCR and other molecular techniques

Pneumococcal conjugate vaccine (4,208 words) [view diff] exact match in snippet view article find links to article

through reductive amination to CRM197, a nontoxic recombinant variant of diphtheria toxin. CRM197 is derived from the C7 strain of Corynebacterium diphtheriae

Pasteur Institute (5,703 words) [view diff] exact match in snippet view article find links to article

by the toxin.: 74 Some German researchers had also discovered the diphtheria toxin and were trying to immunize some guinea pigs through the use of a vaccine:

Paul Uhlenhuth (1,408 words) [view diff] exact match in snippet view article find links to article

significant discovery by Emil von Behring that animals inoculated with diphtheria toxin formed defensive substances in their blood serum. These defensive substances

Telomerase reverse transcriptase (5,301 words) [view diff] exact match in snippet view article find links to article

be a toxin, an apoptotic factor, or a viral protein. Toxins such as diphtheria toxin interfere with cellular processes and eventually induce apoptosis.

Charles Kellaway (2,931 words) [view diff] exact match in snippet view article find links to article

Bundaberg tragedy, in which 12 children died following inoculation with diphtheria toxin-antitoxin. The rigour of this inquiry was lauded by the medical profession

History of animal testing (4,144 words) [view diff] exact match in snippet view article find links to article

stress levels. In the 1880s and 1890s, Emil von Behring isolated the diphtheria toxin and demonstrated its effects in guinea pigs. He went on to demonstrate

Model organism (8,690 words) [view diff] exact match in snippet view article find links to article

centuries. In the late 19th century, Emil von Behring isolated the diphtheria toxin and demonstrated its effects in guinea pigs. He went on to develop

Protein nanoparticles (2,945 words) [view diff] exact match in snippet view article find links to article

second FDA-approved PNP is Ontak, a protein conjugate carrying L-2 and Diphtheria toxin used for cutaneous T-cell lymphoma. The two approved formulations are

Ana Domingos (2,568 words) [view diff] exact match in snippet view article find links to article

Miguel López, Gonçalo J L Bernardes, Ana I Domingos. A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Commun

Connaught Laboratories (8,679 words) [view diff] exact match in snippet view article find links to article

with Gaston Ramon, who had recently discovered that treating a potent diphtheria toxin with formaldehyde and heat could make it non-toxic (resulting in a

Development of Jehovah's Witnesses doctrine (13,064 words) [view diff] exact match in snippet view article find links to article

September 15, 1958. Q: Are we to consider the injection of serums such as diphtheria toxin antitoxin and blood fractions such as gamma globulin into the blood