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Chromosome 21 (human) is a redirect to Chromosome 21

searching for Chromosome 21 (human) 61 found (275 total)

Genetic architecture (1,485 words) [view diff] no match in snippet view article find links to article

Syndrome. Down Syndrome is a genetic disorder caused by trisomy of human chromosome 21. The current hypothesis regarding congenital heart defect phenotypes

Radiation hybrid mapping (268 words) [view diff] no match in snippet view article find links to article

region of human chromosome 21 spanning 20 megabase pairs. Radiation hybrid mapping was also used in constructing early physical maps of the human genome

Human artificial chromosome (1,264 words) [view diff] no match in snippet view article find links to article

In 2010, a refined human artificial chromosome called 21HAC was reported. 21HAC is based on a stripped copy of human chromosome 21, producing a chromosome

Gene dosage (783 words) [view diff] no match in snippet view article find links to article

Syndrome is caused by trisomy 21, which means having three copies of chromosome 21. Thus gene dosage is increased by 50% for the genes on that chromosome

Nondisjunction (2,847 words) [view diff] no match in snippet view article find links to article

diploid cells. Down syndrome, a trisomy of chromosome 21, is the most common anomaly of chromosome number in humans. The majority of cases result from nondisjunction

Mitochondrial ribosomal protein L10 (542 words) [view diff] no match in snippet view article find links to article

in neurons differentiated from mouse ES cells containing a single human chromosome 21". Biochem. Biophys. Res. Commun. 314 (2): 335–50. doi:10.1016/j.bbrc

TTC3P1 (143 words) [view diff] no match in snippet view article find links to article

Tetratricopeptide repeat domain 3 pseudogene 1 is a protein that in humans is encoded by the TTC3P1 gene. GeneCards Symbol: TTC3P1 2 Tetratricopeptide

ERF (gene) (733 words) [view diff] no match in snippet view article

Busciglio J, Kola I, Hertzog PJ (December 2003). "Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis". Neurobiology

SH3BGRL3 (949 words) [view diff] no match in snippet view article find links to article

5.0. SH3 binding glutamic acid-rich (SH3BGR) gene is located to human chromosome 21. Two homologous genes, SH3BGRL and SH3BGRL3 are located to chromosome

MEMO1 (358 words) [view diff] no match in snippet view article find links to article

PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map". Genomics. 78 (1–2): 46–54. doi:10.1006/geno.2001

SIM1 (1,379 words) [view diff] no match in snippet view article find links to article

of neurogenesis, it was proposed that the human SIM2 gene, which resides in a critical region of chromosome 21, is a candidate for involvement in certain

CFAP298 (1,247 words) [view diff] no match in snippet view article find links to article

intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728

Bacterial artificial chromosome (925 words) [view diff] no match in snippet view article find links to article

750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene". Genome Research

Meiosis (7,299 words) [view diff] no match in snippet view article find links to article

and trisomic human embryos are not viable, but some aneuploidies can be tolerated, such as trisomy for the smallest chromosome, chromosome 21. Phenotypes

NcRNA therapy (5,353 words) [view diff] no match in snippet view article find links to article

observe the inactivation of one of chromosome 21 in the form of a condensed heterochromatin and labeled it as a chromosome 21 barr body. Such experiments have

Developmental disability (8,203 words) [view diff] no match in snippet view article find links to article

a genetic condition in which people are born with an extra copy of chromosome 21. This extra copy affects the development of the body and brain, causing

Rudolph E. Tanzi (4,371 words) [view diff] no match in snippet view article find links to article

gene, SOD1, by providing the key genetic and physical mapping data for chromosome 21 used to find the gene defect. As the leader of the Cure Alzheimer's

Cytogenetics (2,921 words) [view diff] no match in snippet view article find links to article

Lejeune discovered patients with Down syndrome had an extra copy of chromosome 21. Down syndrome is also referred to as trisomy 21. Other numerical abnormalities

Genetic disorder (3,582 words) [view diff] no match in snippet view article find links to article

most common form of Down syndrome), in which there is an extra copy of chromosome 21 in all cells. Due to the wide range of genetic disorders that are known

Germline mutation (3,080 words) [view diff] no match in snippet view article find links to article

having 3 copies of chromosome 21. This chromosome duplication occurs during germ cell formation, when both copies of chromosome 21 end up in the same

MYL7 (2,346 words) [view diff] no match in snippet view article find links to article

Itoh M, Shirayoshi Y, Kurimasa A, Oshimura M (July 2002). "An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome" (PDF)

Endostatin (2,612 words) [view diff] no match in snippet view article find links to article

be protected from diabetic retinopathy due to an additional copy of chromosome 21, and elevated expression of endostatin. Folkman, J. (2006). "Antiangiogenesis

Human Protein Atlas (2,989 words) [view diff] no match in snippet view article find links to article

raised against recombinant human protein fragments was carried out for a chromosome-wide protein profiling of chromosome 21. Other projects were also carried

X-inactivation (5,683 words) [view diff] no match in snippet view article find links to article

example, Jiang et al. inserted a copy of the Xist gene into one copy of chromosome 21 in stem cells derived from an individual with trisomy 21 (Down syndrome)

Laminin, beta 1 (1,257 words) [view diff] no match in snippet view article find links to article

Sabatelli P, et al. (1999). "Decreased expression of laminin beta 1 in chromosome 21-linked Bethlem myopathy". Neuromuscul. Disord. 9 (5): 326–9. doi:10

Terry Elton (1,163 words) [view diff] no match in snippet view article find links to article

papers have been retracted. Chromosome 21-derived MicroRNAs Provide an Etiological Basis for Aberrant Protein Expression in Human Down Syndrome Brains This

Interferon (7,054 words) [view diff] no match in snippet view article find links to article

PMC 2139494. PMID 4346649. Tan YH (March 1976). "Chromosome 21 and the cell growth inhibitory effect of human interferon preparations". Nature. 260 (5547):

Uterine serpin (1,514 words) [view diff] no match in snippet view article find links to article

(domestic cow) Symbol SERPINA14 Entrez 286871 RefSeq (mRNA) NM_174797 RefSeq (Prot) NP_777222 UniProt P46201 Other data Chromosome 21: 59.39 - 59.4 Mb

Ploidy (5,943 words) [view diff] no match in snippet view article find links to article

(as in Down syndrome, where affected individuals have three copies of chromosome 21) or missing a chromosome (as in Turner syndrome, where affected individuals

POLR2C (1,287 words) [view diff] no match in snippet view article find links to article

subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. POLR2C has been shown to interact with: ATF4, CCHCR1, Myogenin, POLR2A

Purinosome (1,426 words) [view diff] no match in snippet view article find links to article

gene (glycinamide ribonucleotide transformylase) to human chromosome 21". American Journal of Human Genetics. 39 (2): 179–185. PMC 1683921. PMID 3529945

Ribosomal RNA (7,195 words) [view diff] no match in snippet view article find links to article

Lee HS, Koren S, Dudekula D, et al. (July 2018). "Variation in human chromosome 21 ribosomal RNA genes characterized by TAR cloning and long-read sequencing"

NDUFA6 (1,056 words) [view diff] no match in snippet view article find links to article

Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10

Eukaryotic translation termination factor 1 (5,515 words) [view diff] no match in snippet view article find links to article

Buckingham RH, Heurgué-Hamard V (July 2008). "HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1". FEBS Letters. 582

G protein-gated ion channel (3,706 words) [view diff] no match in snippet view article find links to article

heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21". Physiological Genomics. 33 (2): 230–9. doi:10.1152/physiolgenomics

Amyloid plaques (3,370 words) [view diff] no match in snippet view article find links to article

result from the excess production of Aβ because the APP gene is on chromosome 21, which exists as three copies in Down syndrome. Amyloid plaques naturally

Herpes (8,735 words) [view diff] no match in snippet view article find links to article

play a role in the frequency of cold sore outbreaks. An area of human chromosome 21 that includes six genes has been linked to frequent oral herpes outbreaks

Atrioventricular septal defect (1,694 words) [view diff] no match in snippet view article find links to article

create multiple disease manifestations, leading to broad syndromes. Chromosome 21 harbors important regulators for cilia, and trisomy 21 (Down syndrome)

YTHDF2 (672 words) [view diff] no match in snippet view article find links to article

be associated with human longevity. Also, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in

Cream gene (4,679 words) [view diff] no match in snippet view article find links to article

responsible for the palomino and buckskin coat colors, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

Early-onset Alzheimer's disease (3,621 words) [view diff] no match in snippet view article find links to article

amyloid beta A4 precursor protein (APP) located on the long arm of chromosome 21 (21q21.3) cause familial Alzheimer disease. Further research into molecules

Haplotype block (622 words) [view diff] no match in snippet view article find links to article

limited haplotype diversity revealed by high-resolution scanning of human chromosome 21". Science. 294 (5547): 1719–23. Bibcode:2001Sci...294.1719P. doi:10

Tsuneko Okazaki (1,229 words) [view diff] no match in snippet view article find links to article

that harbor a single copy of human artificial chromosome (HAC) carrying a limited number of genes from human chromosome 21". Transgenic Research. 23 (2):

End-sequence profiling (1,534 words) [view diff] no match in snippet view article find links to article

750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene". Genome Research

ZTTK syndrome (2,954 words) [view diff] no match in snippet view article find links to article

gene encodes a conserved DNA binding protein mapping to human chromosome 21". Annals of Human Genetics. 58 (1): 25–34. doi:10.1111/j.1469-1809.1994.tb00723

Alejandro Trejo (888 words) [view diff] no match in snippet view article find links to article

país en DD.HH" [Alejandro Trejo: TV Settled a Debt with the Country on Human Rights] (in Spanish). Radio Cooperativa. 8 May 2012. Retrieved 14 May 2018

PRR29 (1,499 words) [view diff] no match in snippet view article find links to article

Protein Abundance Database". pax-db.org. "C21orf58 chromosome 21 open reading frame 58 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved

Equine vision (2,796 words) [view diff] no match in snippet view article find links to article

responsible for the palomino and buckskin coat colors, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–343. doi:10.1046/j.1365-2052.2001.00806

Cell-free fetal DNA (5,952 words) [view diff] no match in snippet view article find links to article

procedure's positive predictive value is low. Trisomy 21 Fetal trisomy of chromosome 21 is the cause of Down's syndrome. This trisomy can be detected by analysis

Orphan gene (4,629 words) [view diff] no match in snippet view article find links to article

recently reported the existence of several young microRNA genes on human chromosome 21. The duplication and divergence model for orphan genes involves a

Sequenom (1,978 words) [view diff] no match in snippet view article find links to article

some DNA from the fetus. The proportions of DNA from sequences from chromosome 21, 18, or 13 can indicate whether the fetus has trisomy in that chromosome

Tiling array (2,036 words) [view diff] no match in snippet view article find links to article

produce a more precise picture of gene structure. Earlier studies on chromosome 21 and 22 showed the power of tiling arrays for identifying transcription

Experimental models of Alzheimer's disease (3,543 words) [view diff] no match in snippet view article find links to article

include: human embryonic kidney 293 (HEK293), human neuroblastoma (SH-SY5Y), human neuroglioma (H4), human embryonic mesencephalic (LUHMES), human neural

Gerald Crabtree (2,721 words) [view diff] no match in snippet view article find links to article

Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 441(7093): 595-600, 2006. PMID 16554754. Kuo CJ, Chung J, Fiorentino

Raymond Turpin (499 words) [view diff] no match in snippet view article find links to article

chromosome instead of the usual two (disomy). This chromosome was designated chromosome 21 in 1960. Turpin discovered, in 1959, the first structural chromosomal

Ann T. Bowling (3,547 words) [view diff] no match in snippet view article find links to article

responsible for the palomino and buckskin coat colours, maps to horse chromosome 21". Animal Genetics. 32 (6): 340–3. doi:10.1046/j.1365-2052.2001.00806

List of events in NHGRI history (5,167 words) [view diff] no match in snippet view article find links to article

the May 18 issue of Nature that they have unraveled the genome of human chromosome 21, already known to be involved with Down syndrome, Alzheimer's disease

List of New York Institute of Technology faculty (805 words) [view diff] no match in snippet view article find links to article

Retrieved 2016-02-14. Erondu, U. A.; Cymet, T. C. (Winter 2006). "Chromosome 21 abnormalities a review and report of a case of erondu-cymet syndrome"

Developmental bioelectricity (17,264 words) [view diff] no match in snippet view article find links to article

Misovicova, Nadezda; Vrbicka, Dita (2013). "Partial trisomy and tetrasomy of chromosome 21 without down syndrome phenotype and short overview of genotype-phenotype

List of French inventions and discoveries (10,613 words) [view diff] no match in snippet view article find links to article

Laborit (chlorpromazine). Discovery of the cause of Down syndrome (chromosome 21 trisomy) by Jérôme Lejeune in 1958-1959 (syndrome first described by

GATA2 deficiency (5,784 words) [view diff] no match in snippet view article find links to article

deficiency include chromosome 8 trisomy (8% of cases) and, rarely, chromosome 21 monosomy. GATA2 deficiency is also associated with somatic mutations