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searching for Cellular senescence 152 found (208 total)

alternate case: cellular senescence

Senotherapy (1,380 words) [view diff] exact match in snippet view article find links to article

possible therapeutic agents and strategies to specifically target cellular senescence, an altered cell state associated with ageing and age-related diseases
P16 (4,114 words) [view diff] exact match in snippet view article find links to article
protects against cancer while increasing the risks associated with cellular senescence. p16 is an inhibitor of cyclin-dependent kinases (CDK). It slows
Sierra Sciences (738 words) [view diff] exact match in snippet view article find links to article
1999 in Reno, Nevada with the goal of preventing and/or reversing cellular senescence, and ultimately curing diseases associated with human aging, including
Epigenetic clock (7,351 words) [view diff] exact match in snippet view article find links to article
senescent cells. It is unclear whether the three major types of cellular senescence, namely replicative senescence, oncogene-induced senescence and DNA
Cycloastragenol (607 words) [view diff] exact match in snippet view article find links to article
moderately increase telomerase activity and inhibit the onset of cellular senescence. Cycloastragenol was studied by Geron Corporation and sold to T.A
Genetics of aging (1,920 words) [view diff] exact match in snippet view article find links to article
mother cell during cell division, and are believed to result in cellular senescence by titrating away (competing for) essential nuclear factors. ERCs
Gerontogens (136 words) [view diff] exact match in snippet view article find links to article
accelerates cell destruction. Gerontogens can also accelerate the rate of cellular senescence, where normal diploid cells cease to divide. This can be measured
Progenitor cell (1,306 words) [view diff] exact match in snippet view article find links to article
medicine has focused on progenitor cells, and stem cells, because their cellular senescence contributes largely to the process of aging. Research on cancer biology
Mir-598 microRNA precursor family (287 words) [view diff] exact match in snippet view article find links to article
usually observed with increased STR1 levels. miR-598 acts to modulate cellular senescence. More specifically, its overexpression induces senescence in early-passage
CGAS–STING cytosolic DNA sensing pathway (2,736 words) [view diff] exact match in snippet view article find links to article
Wang H, Ren J, Chen Q, Chen ZJ (June 2017). "cGAS is essential for cellular senescence". Proceedings of the National Academy of Sciences of the United States
Alexis Carrel (4,539 words) [view diff] no match in snippet view article find links to article
Alexis Carrel (French: [alɛksi kaʁɛl]; 28 June 1873 – 5 November 1944) was a French surgeon and biologist who was awarded the Nobel Prize in Physiology
EEF1E1 (481 words) [view diff] exact match in snippet view article find links to article
protein translation • protein biosynthesis • positive regulation of cellular senescence • negative regulation of cell proliferation • glutathione metabolic
Mitochondrial ROS (1,119 words) [view diff] exact match in snippet view article find links to article
to treat patients with coronavirus. Mitochondrial ROS can promote cellular senescence and aging phenotypes in the skin of mice. Ordinarily mitochondrial
Mir-542 microRNA precursor family (705 words) [view diff] exact match in snippet view article find links to article
Santoro M, Cimino F (April 2012). "A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts". Cell Death and Differentiation
SOD2 (2,965 words) [view diff] exact match in snippet view article find links to article
mitochondrial oxidative stress caused by SOD2 deficiency promoted cellular senescence and aging phenotypes in the skin including an increase in DNA double-strand
Promyelocytic leukemia protein (4,007 words) [view diff] exact match in snippet view article find links to article
Caspase-8. Beyond apoptosis, other studies have implicated PML-NBs in cellular senescence, particularly its induction. It has been shown to be involved with
GNG11 (585 words) [view diff] exact match in snippet view article find links to article
Ayusawa D (2007). "G-protein gamma subunit GNG11 strongly regulates cellular senescence". Biochem. Biophys. Res. Commun. 351 (3): 645–50. doi:10.1016/j.bbrc
MARCH5 (1,074 words) [view diff] exact match in snippet view article find links to article
standard mitochondria morphology, and deficiencies in it promote cellular senescence. Considering that both Drp1 and MAP1B are substrates for MITOL, MITOL
Biological immortality (3,266 words) [view diff] case mismatch in snippet view article find links to article
Biological Immortality Slide show by Michael R. Rose Cellular Senescence and Apoptosis in Aging Cellular Senescence Information Center Geron Announces Launch of
HMGA2 (2,892 words) [view diff] exact match in snippet view article find links to article
end joining • chondrocyte proliferation • positive regulation of cellular senescence • positive regulation of response to DNA damage stimulus • epithelial
Sirtuin 1 (4,398 words) [view diff] exact match in snippet view article find links to article
2002). "Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence". The EMBO Journal. 21 (10): 2383–96. doi:10.1093/emboj/21.10.2383
Germinal center B-cell like diffuse large B-cell lymphoma (2,423 words) [view diff] exact match in snippet view article find links to article
cell-cycle inhibitor (p27KIP1). BCL-6 is also an inhibitor of cellular senescence. Cellular senescence is a programmed response that prevents a cell from dividing
John Scott Medal (410 words) [view diff] exact match in snippet view article find links to article
Susan Band Horwitz cancer therapeutics Leonard Hayflick discovery of cellular senescence and innovations in microscopy Paul S. Moorhead 2013 P. Leslie Dutton
NINJ1 (435 words) [view diff] exact match in snippet view article find links to article
et al. (2005). "Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells". J. Hepatol. 41 (4): 637–43. doi:10.1016/j
SKP2 (3,885 words) [view diff] exact match in snippet view article find links to article
profoundly restricts cancer development by triggering a massive cellular senescence and/or apoptosis response that is surprisingly observed only in oncogenic
Hepatic stellate cell (844 words) [view diff] exact match in snippet view article find links to article
staining, as well as p53 accumulation and activation of Rb–hallmarks of cellular senescence. Senescent hepatic stellate cells have been demonstrated to limit
Anne Dejean-Assémat (1,210 words) [view diff] exact match in snippet view article find links to article
oncoprotein E7 targets the promyelocytic leukemia protein and circumvents cellular senescence via the Rb and p53 tumor suppressor pathways"". pubpeer.com. Retrieved
KIR2DL4 (1,219 words) [view diff] exact match in snippet view article find links to article
cytokine production • negative regulation of natural killer cell mediated cytotoxicity • positive regulation of cellular senescence Sources:Amigo / QuickGO
CDKN2B (1,250 words) [view diff] exact match in snippet view article find links to article
of cell proliferation • negative regulation of cyclin-dependent protein serine/threonine kinase activity • cellular senescence Sources:Amigo / QuickGO
MB21D1 (93 words) [view diff] exact match in snippet view article find links to article
interferon production • paracrine signaling • positive regulation of cellular senescence • positive regulation of cGMP-mediated signaling • positive regulation
FIS1 (1,699 words) [view diff] exact match in snippet view article find links to article
2006). "Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1"
NUAK1 (774 words) [view diff] exact match in snippet view article find links to article
cell adhesion • regulation of cell proliferation • regulation of cellular senescence • regulation of myosin-light-chain-phosphatase activity • regulation
VASH1 (438 words) [view diff] exact match in snippet view article find links to article
Biological process • negative regulation of angiogenesis • regulation of cellular senescence • cell cycle • negative regulation of lymphangiogenesis • response
SMC6 (976 words) [view diff] exact match in snippet view article find links to article
to DNA damage stimulus • telomere maintenance via recombination • cellular senescence • positive regulation of chromosome segregation • double-strand break
HSPA9 (1,126 words) [view diff] exact match in snippet view article find links to article
T, Aida S, Kaul SC, Wadhwa R (2007). "Involvement of mortalin in cellular senescence from the perspective of its mitochondrial import, chaperone, and
ABL (gene) (3,242 words) [view diff] exact match in snippet view article
autophosphorylation • alpha-beta T cell differentiation • regulation of cellular senescence • negative regulation of protein serine/threonine kinase activity
Optic nerve glioma (673 words) [view diff] exact match in snippet view article find links to article
museum to molecular evaluation suggests possibe interventions in the cellular senescence and microglial pathways (an American Ophthalmological Society thesis)"
GeroScience (339 words) [view diff] exact match in snippet view article find links to article
GeroScience covers topics like chronic low-grade inflammation, cellular senescence, macromolecular damage, oxidative-nitrative stress, maladaptation
DUSP6 (1,167 words) [view diff] exact match in snippet view article find links to article
phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence". The Journal of Biological Chemistry. 278 (39): 37497–510. doi:10
SMC5 (906 words) [view diff] exact match in snippet view article find links to article
stimulus • cell division • telomere maintenance via recombination • cellular senescence • positive regulation of chromosome segregation • double-strand break
ZNF277P (422 words) [view diff] exact match in snippet view article find links to article
Cellular component • cell nucleus Biological process • regulation of cellular senescence • regulation of transcription, DNA-templated • transcription, DNA-templated
AKT3 (1,180 words) [view diff] exact match in snippet view article find links to article
vascular endothelial cell proliferation • positive regulation of artery morphogenesis • negative regulation of cellular senescence Sources:Amigo / QuickGO
Caloric restriction mimetic (2,688 words) [view diff] exact match in snippet view article find links to article
NAD+/NADH ratio has been proposed carbohydrate metabolism-controlled cellular senescence mechanism. Because of its parallel effects on these pathways, oxaloacetate
1-Methylcyclopropene (783 words) [view diff] exact match in snippet view article find links to article
Sisler, E.C.; Borochov, A. (1995). "Inhibition of ethylene-induced cellular senescence symptoms by 1-methylcyclopropene, a new inhibitor of ethylene action"
EHF (gene) (846 words) [view diff] exact match in snippet view article
"ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence". Cancer Sci. 98 (9): 1468–75. doi:10.1111/j.1349-7006.2007.00543
PRKCD (1,087 words) [view diff] exact match in snippet view article find links to article
endodeoxyribonuclease activity • platelet activation • protein phosphorylation • cellular senescence • negative regulation of insulin receptor signaling pathway • positive
ING2 (934 words) [view diff] exact match in snippet view article find links to article
organization • positive regulation of histone deacetylation • regulation of apoptotic process • regulation of cellular senescence Sources:Amigo / QuickGO
Cytolethal distending toxin (1,899 words) [view diff] exact match in snippet view article find links to article
restore its normal size. Aside from classical apoptosis, signs of cellular senescence has also been observed in normal and cancer cell lines (fibroblasts
ABI3BP (394 words) [view diff] exact match in snippet view article find links to article
Ishigami A, Shimada J, Maruyama M (2009). "Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression". Biochem. Biophys. Res
RSL1D1 (619 words) [view diff] exact match in snippet view article find links to article
Biological process • regulation of apoptotic process • regulation of cellular senescence • osteoblast differentiation • regulation of protein localization
TBX3 (4,617 words) [view diff] exact match in snippet view article find links to article
contributes to several hallmarks of cancer. Indeed, TBX3 can bypass cellular senescence, apoptosis and anoikis as well as promote uncontrolled cell proliferation
Collagen loss (2,667 words) [view diff] exact match in snippet view article find links to article
to explain skin aging on a molecular basis such as the theory of cellular senescence, the reduction in the cell's DNA repair capacity, and the loss of
Tetrahymena (1,917 words) [view diff] exact match in snippet view article find links to article
enzyme, the templating role of telomerase RNA and their roles in cellular senescence and chromosome healing (for which a Nobel Prize was won). Nobel Prize–winning
PRMT6 (587 words) [view diff] exact match in snippet view article find links to article
transcription, DNA-templated • cellular response to DNA damage stimulus • cellular senescence • methylation • peptidyl-arginine methylation, to asymmetrical-dimethyl
Keratinocyte (2,498 words) [view diff] exact match in snippet view article find links to article
ROS. Loss of SOD2 in mouse epidermal cells was observed to cause cellular senescence that irreversibly arrested proliferation in a fraction of keratinocytes
Jun dimerization protein (4,280 words) [view diff] exact match in snippet view article find links to article
JDP2 has been shown to play an important role in the regulation of cellular senescence. JDP2-deficient mouse embryonic fibroblasts are resistant to replicative
HMGA1 (1,484 words) [view diff] exact match in snippet view article find links to article
transcription from RNA polymerase II promoter • positive regulation of cellular senescence • senescence-associated heterochromatin focus assembly • negative
IFI16 (1,274 words) [view diff] exact match in snippet view article find links to article
interferon-inducible p200-protein family, in prostate epithelial cellular senescence". Oncogene. 22 (31): 4831–40. doi:10.1038/sj.onc.1206754. PMID 12894224
PHB2 (840 words) [view diff] exact match in snippet view article find links to article
prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Exp Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID 11302691
ARG2 (643 words) [view diff] exact match in snippet view article find links to article
regulation of interleukin-13 secretion • positive regulation of cellular senescence • adaptive immune response • immune system process • innate immune
SIX1 (1,327 words) [view diff] exact match in snippet view article find links to article
Menéndez C, Abad M, Palmero I (2015). "The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes"
ID2 (1,238 words) [view diff] exact match in snippet view article find links to article
regulation of cell cycle arrest • cellular response to lithium ion • cellular senescence • negative regulation of neural precursor cell proliferation • neuron
MAP2K1 (1,470 words) [view diff] exact match in snippet view article find links to article
positive regulation of protein serine/threonine kinase activity • cellular senescence • face development • cerebellar cortex formation • negative regulation
MAP3K3 (1,806 words) [view diff] exact match in snippet view article find links to article
migration involved in sprouting angiogenesis • negative regulation of cellular senescence • signal transduction by protein phosphorylation Sources:Amigo /
Andrea Ablasser (694 words) [view diff] exact match in snippet view article find links to article
understanding of the molecular connections between innate immunity and cellular senescence with the goal to exploit this knowledge for novel therapeutic strategies
Costello syndrome (1,309 words) [view diff] exact match in snippet view article find links to article
"Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells". Disease Models & Mechanisms. 2 (1–2):
Sphingolipid (2,590 words) [view diff] exact match in snippet view article find links to article
MJ, Bielawska A, Obeid LM (December 1995). "Role of ceramide in cellular senescence". The Journal of Biological Chemistry. 270 (51): 30701–8. doi:10
BCL6 (1,384 words) [view diff] exact match in snippet view article find links to article
signaling pathway • erythrocyte development • negative regulation of cellular senescence • regulation of apoptotic process • negative regulation of mitotic
Serum response factor (1,458 words) [view diff] exact match in snippet view article find links to article
platelet activation • cardiac myofibril assembly • heart looping • cellular senescence • face development • regulation of cell adhesion • long term synaptic
Retinoic acid receptor beta (1,230 words) [view diff] exact match in snippet view article find links to article
PMID 3014347. Si SP, Tsou HC, Lee X, Peacocke M (Jul 1995). "Effect of cellular senescence and retinoic acid on the expression of cellular retinoic acid binding
Edith Heard (899 words) [view diff] case mismatch in snippet view article find links to article
Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence". Cell. 113 (6): 703–16. doi:10.1016/S0092-8674(03)00401-X. PMID 12809602
DNA damage theory of aging (9,969 words) [view diff] exact match in snippet view article find links to article
contribute to aging either indirectly (by increasing apoptosis or cellular senescence) or directly (by increasing cell dysfunction). Several review articles
DUSP3 (1,320 words) [view diff] exact match in snippet view article find links to article
phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence" (PDF). J. Biol. Chem. 278 (39): 37497–510. doi:10.1074/jbc.M211739200
GNL3 (992 words) [view diff] exact match in snippet view article find links to article
PMID 17000083. Zhu Q, Yasumoto H, Tsai RY (2006). "Nucleostemin delays cellular senescence and negatively regulates TRF1 protein stability". Mol. Cell. Biol
TERF2 (3,311 words) [view diff] exact match in snippet view article find links to article
activity • protein localization to chromosome, telomeric region • cellular senescence • negative regulation of telomere capping • positive regulation of
HRAS (1,314 words) [view diff] exact match in snippet view article find links to article
apoptotic process • small GTPase mediated signal transduction • cellular senescence • response to isolation stress • cellular response to gamma radiation
MAGEA2 (671 words) [view diff] exact match in snippet view article find links to article
Biological process • signal transduction by p53 class mediator • cellular senescence • negative regulation of protein sumoylation • regulation of transcription
Elastin (2,303 words) [view diff] exact match in snippet view article find links to article
0b013e3181c4b0fe. PMC 6748032. PMID 20051886. Bertram C, Hass R (Oct 2009). "Cellular senescence of human mammary epithelial cells (HMEC) is associated with an altered
Beta-galactosidase (2,550 words) [view diff] exact match in snippet view article find links to article
Itahana K, Campisi J, Dimri GP (2007). Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol
ID1 (1,858 words) [view diff] exact match in snippet view article find links to article
"Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence". Nature. 409 (6823): 1067–70. doi:10.1038/35059131. PMID 11234019
FBXO5 (1,083 words) [view diff] exact match in snippet view article find links to article
regulation of mesenchymal stem cell migration • negative regulation of cellular senescence • negative regulation of response to DNA damage stimulus • protein
Retinoblastoma-like protein 1 (1,936 words) [view diff] exact match in snippet view article find links to article
expression • transcription, DNA-templated • negative regulation of cellular senescence • chromatin organization • regulation of mitotic cell cycle • cell
NOL12 (766 words) [view diff] case mismatch in snippet view article find links to article
PS (June 2019). "NOL12 Repression Induces Nucleolar Stress-Driven Cellular Senescence and Is Associated with Normative Aging". Molecular and Cellular Biology
KAT6A (958 words) [view diff] exact match in snippet view article find links to article
DNA-templated • positive regulation of transcription, DNA-templated • cellular senescence • histone H3 acetylation • negative regulation of transcription,
ELAV-like protein 1 (953 words) [view diff] exact match in snippet view article find links to article
"Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function". J. Biol. Chem. 278 (29): 27016–27023
GATA4 (2,239 words) [view diff] exact match in snippet view article find links to article
regulated through the autophagy-lysosome pathway in eukaryotic cells. In cellular senescence, ATM and ATR inhibit p62, an autophagy adaptor responsible for selective
Telomerase RNA component (2,497 words) [view diff] exact match in snippet view article find links to article
sequence acts as the template. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting
TGFB1I1 (1,652 words) [view diff] exact match in snippet view article find links to article
putative novel zinc finger protein and its possible involvement in cellular senescence". The Journal of Biological Chemistry. 269 (43): 26767–74. PMID 7929412
Telomerase reverse transcriptase (5,271 words) [view diff] exact match in snippet view article find links to article
template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells, resulting
Intervertebral disc (1,610 words) [view diff] exact match in snippet view article find links to article
itself. Herniated discs are also found to have a higher degree of cellular senescence than non-herniated discs. In addition to scoliosis, which is the
BCL2L12 (678 words) [view diff] exact match in snippet view article find links to article
activity involved in apoptotic process • negative regulation of cellular senescence • apoptotic process • regulation of apoptotic process Sources:Amigo
Bryant Villeponteau (1,949 words) [view diff] exact match in snippet view article find links to article
Since telomere length tends to shorten with age in humans leading to cellular senescence, telomerase was a potential key factor in promoting human aging from
Lina M. Obeid (855 words) [view diff] exact match in snippet view article find links to article
Smyth, Alicja Bielawska, and Lina M. Obeid "Role of ceramide in cellular senescence" J. Biol. Chem., vol. 270, issue 51, 1995, p. 30701-30708. Accessed
BMPR1A (1,460 words) [view diff] exact match in snippet view article find links to article
morphogenesis • mesendoderm development • immune response • regulation of cellular senescence • neural plate mediolateral regionalization • dorsal/ventral pattern
Prohibitin (2,239 words) [view diff] exact match in snippet view article find links to article
prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Experimental Cell Research. 265 (2): 262–73. doi:10.1006/excr.2001
TP63 (1,811 words) [view diff] exact match in snippet view article find links to article
regulation of transcription, DNA-templated • negative regulation of cellular senescence • intrinsic apoptotic signaling pathway in response to DNA damage
George Truskey (792 words) [view diff] exact match in snippet view article find links to article
Ganatra; Erica Peters; George Truskey (December 1, 2012). "Effect of cellular senescence on the albumin permeability of blood-derived endothelial cells".
Twist transcription factor (2,233 words) [view diff] exact match in snippet view article find links to article
transcription from RNA polymerase II promoter • negative regulation of cellular senescence • embryonic hindlimb morphogenesis • negative regulation of transcription
Augurin (538 words) [view diff] exact match in snippet view article find links to article
plasma membrane • cell membrane • membrane Biological process • cellular senescence • G1 to G0 transition • anaphase-promoting complex-dependent catabolic
TBX2 (2,470 words) [view diff] exact match in snippet view article find links to article
• heart looping • muscle cell fate determination • cell aging • cellular senescence • developmental growth involved in morphogenesis • regulation of
Dynamin-like 120 kDa protein (1,906 words) [view diff] exact match in snippet view article find links to article
mitochondrion organization • positive regulation of dendrite development • cellular senescence • axonal transport of mitochondrion • positive regulation of mitochondrial
PAWR (1,331 words) [view diff] exact match in snippet view article find links to article
transcription from RNA polymerase II promoter • positive regulation of cellular senescence • positive regulation of gene expression • negative regulation of
Ursodeoxycholic acid (1,854 words) [view diff] exact match in snippet view article find links to article
chemopreventive, perhaps by inducing cellular differentiation and/or cellular senescence in colon epithelial cells. The term is from the Latin noun ursus
Calreticulin (2,397 words) [view diff] exact match in snippet view article find links to article
receptor-mediated endocytosis • response to organic substance • cellular senescence • spermatogenesis • positive regulation of dendritic cell chemotaxis
CD9 (3,131 words) [view diff] exact match in snippet view article find links to article
PMID 9295027. Cho, J.H., Kim, E., Son, Y. et al. (2020). CD9 induces cellular senescence and aggravates atherosclerotic plaque formation. Cell Death & Differentiation
NEK6 (1,147 words) [view diff] exact match in snippet view article find links to article
kinase/NF-kappaB signaling • autophosphorylation • regulation of cellular senescence • cell cycle • apoptotic process • signal transduction Sources:Amigo
LMNA (2,663 words) [view diff] exact match in snippet view article find links to article
(2006). "Dysfunction of lamin A triggers a DNA damage response and cellular senescence". DNA Repair (Amst.). 5 (2): 286–9. doi:10.1016/j.dnarep.2005.10
Geron Corporation (1,941 words) [view diff] exact match in snippet view article find links to article
possible applications of activating the enzyme in normal cells to delay cellular senescence. The company is in the early stages of developing a telomerase based
Homeobox protein NANOG (2,722 words) [view diff] exact match in snippet view article find links to article
differentiation potential that is lost due to organismal aging or cellular senescence. NANOG is highly expressed in cancer stem cells and may thus function
HLA-G (1,838 words) [view diff] exact match in snippet view article find links to article
regulation of endothelial cell apoptotic process • positive regulation of cellular senescence • antigen processing and presentation of endogenous peptide antigen
Syncytin-1 (2,016 words) [view diff] exact match in snippet view article find links to article
(November 2013). "Cell fusion induced by ERVWE1 or measles virus causes cellular senescence". Genes & Development. 27 (21): 2356–66. doi:10.1101/gad.227512.113
PTEN (gene) (3,333 words) [view diff] exact match in snippet view article
Cordon-Cardo C, Pandolfi PP (August 2005). "Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis". Nature. 436 (7051):
KDM4A (1,559 words) [view diff] case mismatch in snippet view article find links to article
15, 2012). "JMJD2A Promotes Cellular Transformation by Blocking Cellular Senescence through Transcriptional Repression of the Tumor Suppressor CHD5"
Stuart A. Aaronson (1,497 words) [view diff] exact match in snippet view article find links to article
E, Qiao R, Wang X, Kim S, Manfredi J, Lee S, Aaronson S (2009). "Cellular senescence and organismal ageing in the absence of p21 CIP1/WAF1 in ku80-/-mice"
Solute carrier family 30 member 10 (589 words) [view diff] exact match in snippet view article find links to article
regulation of cellular response to manganese ion • negative regulation of cellular senescence • cation transmembrane transport Sources:Amigo / QuickGO
Shelterin (2,109 words) [view diff] exact match in snippet view article find links to article
Haendeler J, Böhm M, Laufs U (2009). "Physical exercise prevents cellular senescence in circulating leukocytes and in the vessel wall". Circulation. 120
Glyceraldehyde 3-phosphate dehydrogenase (3,078 words) [view diff] exact match in snippet view article find links to article
Krynetskaia N, Mishra A, Krynetskiy E (July 2011). "Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells". Biochemical
Ethics of cloning (2,362 words) [view diff] exact match in snippet view article find links to article
of the considered options to repair the cell depletion related to cellular senescence is to grow replacement tissues from stem cells harvested from a cloned
P21 (3,883 words) [view diff] exact match in snippet view article find links to article
regulation of cell cycle • intrinsic apoptotic signaling pathway • cellular senescence • positive regulation of reactive oxygen species metabolic process
Carol W. Greider (2,796 words) [view diff] exact match in snippet view article find links to article
worked with Calvin Harley to show that telomere shortening underlies cellular senescence (1990). To further test this idea mouse and human telomerase were
Inhibitor of DNA-binding protein (1,138 words) [view diff] exact match in snippet view article find links to article
Hara E (December 2001). "Id proteins in cell cycle control and cellular senescence". Oncogene. 20 (58): 8317–25. doi:10.1038/sj.onc.1205092. PMID 11840324
Fanconi anemia (3,271 words) [view diff] exact match in snippet view article find links to article
between hyperoxic blood and hypoxic marrow tissues, leads to premature cellular senescence and therefore inhibition of haemopoietic function. Senescence, together
Rhoda Erdmann (1,381 words) [view diff] exact match in snippet view article find links to article
the survival of Paramecium cultures led to important insights on cellular senescence and methods of genetic transmission Her work at Yale and Princeton
DNA repair (13,632 words) [view diff] exact match in snippet view article find links to article
CAN-05-4006. PMID 16540631. Lynch MD (February 2006). "How does cellular senescence prevent cancer?". DNA and Cell Biology. 25 (2): 69–78. doi:10.1089/dna
KRAS (4,099 words) [view diff] exact match in snippet view article find links to article
ERBB2 signaling pathway • liver development • positive regulation of cellular senescence • female pregnancy • response to isolation stress Sources:Amigo /
Insulin-like growth factor 1 (3,013 words) [view diff] exact match in snippet view article find links to article
role-playing inducer in modulating the metabolic effects of IGF-1 for cellular senescence and survival. At a localized target cell, IGF-1R elicits the mediation
H2AFX (2,628 words) [view diff] exact match in snippet view article find links to article
regulation of DNA repair • cellular response to DNA damage stimulus • cellular senescence • GO:0007126 meiotic cell cycle • cellular response to gamma radiation
Cyclin-dependent kinase 6 (4,169 words) [view diff] exact match in snippet view article find links to article
regulation of myeloid cell differentiation • negative regulation of cellular senescence • gliogenesis • negative regulation of cell proliferation • negative
ARNTL (4,963 words) [view diff] exact match in snippet view article find links to article
regulation of glucocorticoid receptor signaling pathway • regulation of cellular senescence • positive regulation of skeletal muscle cell differentiation • positive
DNA-PKcs (3,152 words) [view diff] exact match in snippet view article find links to article
transcription from RNA polymerase II promoter • negative regulation of cellular senescence • immunoglobulin production • double-strand break repair • DNA repair
Nicotinamide phosphoribosyltransferase (2,416 words) [view diff] exact match in snippet view article find links to article
oxygen-glucose deprivation • cellular response to amyloid-beta • response to D-galactose • negative regulation of cellular senescence Sources:Amigo / QuickGO
MRN complex (3,018 words) [view diff] exact match in snippet view article find links to article
p16INK4a tumor suppressor protein, which is capable of inducing cellular senescence and subsequently halting tumor cell proliferation. This is thought
Protein inhibitor of activated STAT (3,194 words) [view diff] exact match in snippet view article find links to article
Dejean A (June 2006). "The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis". Molecular Cell. 22 (6): 783–94. doi:10.1016/j.molcel
PINX1 (2,559 words) [view diff] exact match in snippet view article find links to article
and PINX1 without G-patch motif induce apoptosis, G1 arrest, and cellular senescence Truncated PINX1 does not affect telomerase Cervical Regulated by
Reactive oxygen species (7,506 words) [view diff] exact match in snippet view article find links to article
signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence". Nature Cell Biology. 8 (11): 1291–7. doi:10.1038/ncb1491. PMID 17028578
GADD45G (3,052 words) [view diff] exact match in snippet view article find links to article
kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinoma". Hepatology. 59 (1): 178–89
Polyploidy (7,923 words) [view diff] exact match in snippet view article find links to article
; Knöfler, M.; Pollheimer, J. (2018). "Genome amplification and cellular senescence are hallmarks of human placenta development". PLOS Genetics. 14 (10):
Embryomics (2,159 words) [view diff] exact match in snippet view article find links to article
indefinitely, without undergoing either differentiation or cellular aging (cellular senescence). The first differentiation of the hESCs that form the embryo proper
Eduardo Arzt (1,724 words) [view diff] exact match in snippet view article find links to article
GK, Melmed S (March 2009). "Pituitary adenoma growth: a model for cellular senescence and cytokine action". Cell Cycle. 8 (5): 677–8. doi:10.4161/cc.8
Lipid signaling (5,570 words) [view diff] exact match in snippet view article find links to article
M. J.; Bielawska, A.; Obeid, L. M. (1995). "Role of ceramide in cellular senescence". J. Biol. Chem. 270 (51): 30701–30708. doi:10.1074/jbc.270.51.30701
Darwinian puzzle (2,008 words) [view diff] exact match in snippet view article find links to article
while the two male geese continue through their lives together. (1) Cellular senescence Monarch butterfly: The monarch butterfly is a species that has an
Caretaker gene (2,593 words) [view diff] exact match in snippet view article find links to article
activities of products encoded by p53) but a faster rate of aging. Cellular senescence, also encoded by a gatekeeper gene, is arrest of the cell cycle in
C16orf71 (1,791 words) [view diff] exact match in snippet view article find links to article
Cartilage development Negative regulation of gene expression and cellular senescence T-cell and stem cell differentiation Positive regulation of transcription
Retinoblastoma protein (9,322 words) [view diff] exact match in snippet view article find links to article
cells, increases chromosomal instability, prevents induction of cellular senescence, promotes angiogenesis, and increases metastatic potential. In vivo
Pathogenic Escherichia coli (5,500 words) [view diff] exact match in snippet view article find links to article
colonized with E. coli that harbor the pks island. Colibactin can cause cellular senescence or cancer by damaging DNA. However, the mucosal barrier prevents
Marrow adipose tissue (3,872 words) [view diff] exact match in snippet view article find links to article
Lustgarten J, Scrable H, et al. (October 2010). "Fat tissue, aging, and cellular senescence". Aging Cell. 9 (5): 667–84. doi:10.1111/j.1474-9726.2010.00608.x
AGR2 (2,858 words) [view diff] exact match in snippet view article find links to article
Li Z, Tian K, Young CY, Yuan H (2012). "Knockdown of AGR2 induces cellular senescence in prostate cancer cells". Carcinogenesis. 33 (6): 1178–86. doi:10
POLD1 (8,463 words) [view diff] exact match in snippet view article find links to article
instability and checkpoint activation, ultimately leading to cell death or cellular senescence. Alternatively, Polδ is associated with lamins and the nuclear envelope
DNA repair protein XRCC4 (5,667 words) [view diff] exact match in snippet view article find links to article
the age related decline in expression of XRCC4 may contribute to cellular senescence. Based on the findings that (1) several polypeptides in the NHEJ
Stem cell marker (5,605 words) [view diff] exact match in snippet view article find links to article
PMID 16818453. Youn SW, Kim DS, Cho HJ, et al. (August 2004). "Cellular senescence induced loss of stem cell proportion in the skin in vitro". Journal
Telomeric repeat–containing RNA (4,625 words) [view diff] exact match in snippet view article find links to article
pathway. It is proposed that TERRA may work to delay the onset of cellular senescence in these cells and instead promote mechanisms of homologous recombination
British Society for Research on Ageing (8,532 words) [view diff] exact match in snippet view article find links to article
a particular focus on preventing or ameliorating the effects of cellular senescence. Drosphila melanogaster as a tool for the chemical analysis of ageing