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searching for CYP2C9 33 found (208 total)

alternate case: cYP2C9

Tienilic acid (614 words) [view diff] exact match in snippet view article find links to article

had liver failure after taking this drug contained antibodies recognizing CYP2C9 able to hydroxylate the drug and to give covalent binding. The above explanation
Tecarfarin (520 words) [view diff] exact match in snippet view article find links to article
warfarin patients (pint=0.16); among patients who had both a CYP2C9 variant allele and taking a CYP2C9 interacting drug, TTR was 76.5% and 69.5% for the tecarfarin
Gliclazide (1,440 words) [view diff] exact match in snippet view article find links to article
in human beings, mainly methylhydroxygliclazide and carboxygliclazide. CYP2C9 is involved in the formation of hydroxygliclazide in human liver microsomes
Coronaric acid (1,139 words) [view diff] exact match in snippet view article find links to article
linoleic acid by cytochrome P450 (CYP) epoxygenase enzymes. These CYPs (CYP2C9 and probably other CYPs that metabolize polyunsaturated fatty acids to epoxides)
Lobeglitazone (582 words) [view diff] exact match in snippet view article find links to article
South Korea Pharmacokinetic data Protein binding >99% Metabolism liver (CYP2C9, 2C19, and 1A2) Elimination half-life 7.8–9.8 hours Identifiers IUPAC name
Aconitine (3,598 words) [view diff] exact match in snippet view article find links to article
16-O-Demethyl-aconitine CYP3A4, CYP3A5, CYP2D6, CYP2C9 M3 N-deethyl-aconitine CYP3A4, CYP3A5, CYP2D6, CYP2C9 M4 O-didemethyl-aconitine CYP3A5, CYP2D6 M5
Flavones (968 words) [view diff] exact match in snippet view article find links to article
PMID 17073577. Si D, Wang Y, Zhou YH, et al. (March 2009). "Mechanism of CYP2C9 inhibition by flavones and flavonols". Drug Metab. Dispos. 37 (3): 629–34
Umbralisib (1,275 words) [view diff] exact match in snippet view article find links to article
status Legal status US: ℞-only / withdrawn Pharmacokinetic data Metabolism CYP2C9, CYP3A4, and CYP1A2 Elimination half-life 91 h Excretion Feces, urine Identifiers
Robert J. Desnick (3,726 words) [view diff] exact match in snippet view article find links to article
PMID 17533632 Scott, SA, Edelmann, L, Kornreich, R, Erazo, M and Desnick, RJ: CYP2C9, CYP2C19, and CYP2D6 allele frequencies in the Ashkenazi Jewish population
Macrolide (2,798 words) [view diff] exact match in snippet view article find links to article
Another option is to use fluvastatin, a statin that is metabolized by CYP2C9, an enzyme that is not inhibited by clarithromycin. Macrolides, including
Piroxicam (830 words) [view diff] exact match in snippet view article find links to article
Rheumatology. 4 (4): 393–404. PMID 342691. Dean L (2019). "Piroxicam Therapy and CYP2C9 Genotype". In Pratt VM, McLeod HL, Rubinstein WS, et al. (eds.). Medical
Rifapentine (961 words) [view diff] exact match in snippet view article find links to article
rifampicin and rifabutin. Rifapentine induces metabolism by CYP3A4, CYP2C8 and CYP2C9 enzymes. It may be necessary to adjust the dosage of drugs metabolized by
Butabarbital (1,576 words) [view diff] exact match in snippet view article find links to article
Half-Life: ~100 hr Duration: 6-8 hr Onset: 45-60 min Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4 Excretion: Urine The mechanism of action by which barbiturates
Prasugrel (2,035 words) [view diff] exact match in snippet view article find links to article
which is then converted by CYP3A4 and CYP2B6, and to a minor extent by CYP2C9 and CYP2C19, to a pharmacologically active metabolite (R-138727). R-138727
ALDH1A1 (1,510 words) [view diff] exact match in snippet view article find links to article
2008). "Influence of polymorphisms of drug metabolizing enzymes (CYP2B6, CYP2C9, CYP2C19, CYP3A4, CYP3A5, GSTA1, GSTP1, ALDH1A1 and ALDH3A1) on the pharmacokinetics
Bromazolam (2,056 words) [view diff] exact match in snippet view article find links to article
bromazolam, were formed by CYP2B6, CYP2C19, CYP3A4, and CYP3A5. Additionally, CYP2C9 was found to catalyse the formation of α-hydroxy bromazolam as well. α-4-dihydroxy
Constitutive androstane receptor (2,272 words) [view diff] exact match in snippet view article find links to article
LeCluyse EL, Negishi M, Goldstein JA (Sep 2002). "Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding
Cooperstown cocktail (339 words) [view diff] exact match in snippet view article find links to article
Warfarin (actually the S-warfarin enantiomer) is a specific probe for CYP2C9. The '+ 1' refers to the vitamin K that is given together with the warfarin
Asciminib (1,212 words) [view diff] exact match in snippet view article find links to article
a substrate of the CYP3A4 enzyme. Asciminib is an inhibitor of CYP3A4, CYP2C9, and P-glycoprotein. Asciminib reaches steady state in 3 days. The volume
Lacosamide (3,809 words) [view diff] exact match in snippet view article find links to article
is eliminated in the feces. The major metabolic pathway of lacosamide is CYP2C9, CY2C19, and CYP3A4-mediated demethylation. The dose-response curve for
Abrocitinib (2,608 words) [view diff] exact match in snippet view article find links to article
abrocitinib is metabolized mainly by cytochrome P450 (CYP450) in liver such as CYP2C9, CYP2C19, CYP3A4 and CYP2B6. The major metabolites of abrocitinib are pyrrolidinone
Discovery and development of cyclooxygenase 2 inhibitors (4,463 words) [view diff] exact match in snippet view article find links to article
oral doses, between 100 and 800 mg. Celecoxib is metabolized primarily by CYP2C9 isoenzyme to carboxylic acid and also by non-CYP-dependent glucuronidation
Moxifloxacin (3,376 words) [view diff] exact match in snippet view article find links to article
enzymes indicate that moxifloxacin does not inhibit 80 CYP3A4, CYP2D6, CYP2C9, CYP2C19, or CYP1A2, suggesting that moxifloxacin is unlikely to alter the
Ritonavir (3,407 words) [view diff] exact match in snippet view article find links to article
"Lopinavir/ritonavir induces the hepatic activity of cytochrome P450 enzymes CYP2C9, CYP2C19, and CYP1A2 but inhibits the hepatic and intestinal activity of
Medical cannabis (9,525 words) [view diff] exact match in snippet view article find links to article
rather than by urine. After delta-9-THC is hydroxylated into 11-OH-THC via CYP2C9, CYP2C19, and CYP3A4, it undergoes phase II metabolism into more than 30
Ketamine (11,397 words) [view diff] exact match in snippet view article find links to article
Hijazi Y, Boulieu R (July 2002). "Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes". Drug
Personalized medicine (9,832 words) [view diff] exact match in snippet view article find links to article
prescribed drugs. However, with the discovery of polymorphic variants in CYP2C9 and VKORC1 genotypes, two genes that encode the individual anticoagulant
Eicosanoid (9,476 words) [view diff] exact match in snippet view article find links to article
The human cytochrome P450 (CYP) epoxygenases, CYP1A1, CYP1A2, CYP2C8, CYP2C9, CYP2C18, CYP2C19, CYP2E1, CYP2J2, and CYP2S1 metabolize arachidonic acid
Jonathan L. Halperin (1,773 words) [view diff] exact match in snippet view article find links to article
Kornreich, Ruth; Halperin, Jonathan L; Desnick, Robert J (August 2009). "CYP2C9*8 is prevalent among African-Americans: implications for pharmacogenetic
Elagolix (6,216 words) [view diff] exact match in snippet view article find links to article
fluconazole (a strong inhibitor of CYP2C19 and a moderate inhibitor of CYP2C9 and CYP3A4). Elagolix is a substrate of the hepatic OATP1B1 transporter
Cornelia Ulrich (1,119 words) [view diff] exact match in snippet view article find links to article
Robert S.; McKeown-Eyssen, Gail E.; Ulrich, Cornelia M. (August 29, 2015). "CYP2C9 Variants Increase Risk of Colorectal Adenoma Recurrence and Modify Associations
Jorge H. Capdevila (2,441 words) [view diff] exact match in snippet view article find links to article
NSCLC in carriers of two known reduction of function variants of the human CYP2C9 Epoxygenase gene. In summary, Capdevila and collaborators contributed to
Hugo Zeberg (1,612 words) [view diff] exact match in snippet view article find links to article
Svante; Zeberg, Hugo (July 30, 2022). "The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals". The Pharmacogenomics Journal