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searching for B cell 275 found (1740 total)

alternate case: b cell

Non-Hodgkin lymphoma (2,752 words) [view diff] no match in snippet view article find links to article

splenic marginal zone lymphoma, lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma HIV infection Some chemicals, like polychlorinated biphenyls (PCBs)
Acute lymphoblastic leukemia (7,397 words) [view diff] no match in snippet view article find links to article
less than 10% of adults and less than 5% of children, particularly mature B-cell ALL (Burkitt leukemia) at presentation. The signs and symptoms of ALL are
B-cell CLL/lymphoma (53 words) [view diff] no match in snippet view article find links to article
B-cell CLL/lymphoma refers to a family of genes associated with certain types of lymphoma and leukemia. Although named for B-cell chronic lymphocytic
Helicobacter pylori (14,341 words) [view diff] no match in snippet view article find links to article
extranodal marginal zone B-cell lymphoma of the cited organ), and of lymphoid tissue in the stomach (termed diffuse large B-cell lymphoma). H. pylori infection
B-cell maturation antigen (1,504 words) [view diff] no match in snippet view article find links to article
B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is
GPR183 (579 words) [view diff] exact match in snippet view article find links to article
lymphocytes. EBI2 helps B cell homing within a lymph node. EBI2 expression increases during B cell activation, after B cell receptor and CD40 stimulation;
VPREB1 (1,010 words) [view diff] exact match in snippet view article find links to article
apparent MW of 16-18 kDa. It is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. CD179a has an Ig V domain-like
Beta cell (3,510 words) [view diff] no match in snippet view article find links to article
Rorsman P (February 1990). "ATP-sensitive K+ channels: a link between B-cell metabolism and insulin secretion". Biochemical Society Transactions. 18
Alpha-taxilin (1,022 words) [view diff] no match in snippet view article find links to article
Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA
IGLL1 (1,112 words) [view diff] exact match in snippet view article find links to article
gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which
CD180 (772 words) [view diff] exact match in snippet view article find links to article
receptors (TLR). CD180/MD-1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent
Artificial pancreas (2,543 words) [view diff] no match in snippet view article find links to article
The artificial pancreas is a technology in development to help people with diabetes, primarily type 1, automatically and continuously control their blood
BCL11A (1,504 words) [view diff] no match in snippet view article find links to article
B-cell lymphoma/leukemia 11A is a protein that in humans is encoded by the BCL11A gene. The BCL11A gene encodes for a regulatory C2H2 type zinc-finger
Roseola (1,910 words) [view diff] no match in snippet view article find links to article
Roseola, also known as sixth disease, is an infectious disease caused by certain types of virus. Most infections occur before the age of three. Symptoms
PBX1 (1,468 words) [view diff] no match in snippet view article find links to article
Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene. PBX1 has been shown to interact with: HOXB1, HOXB7
SLAMF1 (1,190 words) [view diff] exact match in snippet view article find links to article
family. The interaction of SLAMF1 promoter and enhancers with the Early B-cell factor 1 (EBF1) is required for the expression of SLAMF1 gene in B cells
Toralizumab (184 words) [view diff] no match in snippet view article find links to article
pancreatic islet cell transplantation, and corneal transplantation), and B-cell malignancies such as CLL/small lymphocytic lymphoma, follicular cell lymphoma
BST1 (1,173 words) [view diff] no match in snippet view article find links to article
line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38
Nodal marginal zone B cell lymphoma (193 words) [view diff] exact match in snippet view article find links to article
Nodal marginal zone B cell lymphoma (NMZL) is an uncommon form of marginal-zone lymphoma that can produce colonization of the follicles in the lymph node
International Classification of Diseases for Oncology (9,855 words) [view diff] no match in snippet view article find links to article
rich large B-cell lymphoma Histiocyte-rich large B-cell lymphoma Anaplastic large B-cell lymphoma M9684/3 Malignant lymphoma, large B-cell, diffuse, immunoblastic
PBX2 (839 words) [view diff] no match in snippet view article find links to article
Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene. This gene encodes a ubiquitously expressed member of
Denintuzumab mafodotin (344 words) [view diff] no match in snippet view article find links to article
designed for the treatment of CD19-positive acute lymphoblastic leukemia and B-cell non-Hodgkin lymphoma. It consists of an anti-CD19 mAb linked to monomethyl
Camidanlumab tesirine (513 words) [view diff] no match in snippet view article find links to article
trials for the treatment of B-cell Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma (NHL), and for the treatment of B-cell acute lymphoblastic leukemia
AIDS-related lymphoma (520 words) [view diff] no match in snippet view article find links to article
three different varieties of AIDS-related lymphoma: Diffuse large B-cell lymphoma, B-cell immunoblastic lymphoma, and Burkitt's lymphoma (small non-cleaved
Cladribine (3,112 words) [view diff] no match in snippet view article find links to article
used to treat hairy cell leukemia (HCL, leukemic reticuloendotheliosis), B-cell chronic lymphocytic leukemia and Relapsing-remitting Multiple Sclerosis
PBX3 (529 words) [view diff] no match in snippet view article find links to article
Pre-B-cell leukemia transcription factor 3 is a protein that in humans is encoded by the PBX3 gene. GRCh38: Ensembl release 89: ENSG00000167081 - Ensembl
Primary cutaneous immunocytoma (103 words) [view diff] no match in snippet view article find links to article
immunocytoma is a skin condition that represents a low grade B-cell lymphoma related to marginal zone B-cell lymphoma but with a predominance of cells having plasmacytic
12-O-Tetradecanoylphorbol-13-acetate (637 words) [view diff] no match in snippet view article find links to article
cancer[citation needed] TPA has a specific use in cancer diagnostics as a B-cell specific mitogen in cytogenetic testing. To view the chromosomes, a cytogenetic
Primary cutaneous follicle center lymphoma (522 words) [view diff] no match in snippet view article find links to article
B-cell lymphomas (PCBCL); primary cutaneous marginal zone lymphoma and diffuse large B-cell cell lymphoma, leg type are the other primary cutaneous B-cell
CD37 (1,502 words) [view diff] exact match in snippet view article find links to article
responses. CD37-deficiency in mice leads to spontaneous development on B cell lymphoma, and patients with CD37-negative lymphomas have a worse clinical
Mir-127 (1,079 words) [view diff] no match in snippet view article find links to article
caused a downregulation of B-cell lymphoma 6 protein, a proto-oncogene which is usually hypermutated in diffuse large B-cell lymphoma (DLCL). Moreover
CD320 (521 words) [view diff] case mismatch in snippet view article find links to article
Human Follicular Dendritic Cell Molecule That Stimulates Germinal Center B Cell Growth". J. Exp. Med. 191 (6): 1077–84. doi:10.1084/jem.191.6.1077. PMC 2193124
PTPRC (1,644 words) [view diff] no match in snippet view article find links to article
plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction
Galiximab (57 words) [view diff] no match in snippet view article find links to article
Galiximab is a monoclonal antibody designed for the treatment of B-cell lymphoma. As of September 2009[update], it is undergoing Phase III clinical trials
Polatuzumab vedotin (517 words) [view diff] no match in snippet view article find links to article
approved polatuzumab vedotin in June 2019 for treatment of diffuse large B-cell lymphoma when used in combination with bendamustine and rituximab. The drug
Primary cutaneous marginal zone lymphoma (99 words) [view diff] no match in snippet view article find links to article
cutaneous immunocytoma Marginal zone B-cell lymphoma Mucosa-associated lymphoid tissue lymphoma Cutaneous B-cell lymphoma Skin lesion James, William D
FOXP1 (1,497 words) [view diff] no match in snippet view article find links to article
strongly associated with inferior survival in patients with diffuse large B-cell lymphoma". Clin. Cancer Res. 11 (3): 1065–72. PMID 15709173. Brown P, Marafioti
Nodular lymphocyte predominant Hodgkin lymphoma (1,766 words) [view diff] exact match in snippet view article find links to article
lymphoma), and that (unlike classic HL) NLPHL may progress to diffuse large B cell lymphoma. There are small but clear differences in prognosis between the
Mantle cell lymphoma (3,534 words) [view diff] no match in snippet view article find links to article
mantle cell lymphoma. MCL is a subtype of B-cell lymphoma, due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds
TCF3 (1,178 words) [view diff] no match in snippet view article find links to article
translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1 and t(17;19), with HLF)
IFNB1 (812 words) [view diff] no match in snippet view article find links to article
stimulatory effects of IFN-alpha, -beta, and -gamma on human B-cell proliferation induced by various B-cell mitogens". Clin. Immunol. Immunopathol. 48 (3): 297–306
Activation-induced cytidine deaminase (2,313 words) [view diff] exact match in snippet view article find links to article
that produce antibody diversity, but that same mutation process leads to B cell lymphoma. This gene encodes a DNA-editing deaminase that is a member of
Co-stimulation (789 words) [view diff] exact match in snippet view article find links to article
which binds to CD40 on the B cell, thus the Th2 cell can co-stimulate the B cell. Without this co-stimulation the B cell cannot proliferate further.
MEF2C (1,870 words) [view diff] no match in snippet view article find links to article
Binding Site for MEF2C Resulting in Reduced CXCR5 Promoter Activity in B-Cell Lymphoblastic Cell Lines". Front. Immunol. 7 (515): 515. doi:10.3389/fimmu
Proliferating angioendotheliomatosis (218 words) [view diff] no match in snippet view article find links to article
an intravascular lymphoma, usually of the diffuse B-cell type, known as intravascular large B-cell lymphoma. It progresses rapidly through involvement
IRF4 (1,579 words) [view diff] no match in snippet view article find links to article
Organization (2016) provisionally defined large B-cell lymphoma with IRF4 rearrangement as a rare indolent large B-cell lymphoma of children and adolescents. This
Thyroid lymphoma (394 words) [view diff] no match in snippet view article find links to article
non–Hodgkin's B-cell lymphomas; a minority exhibit properties of T-cell lymphomas . Diffuse large B-cell lymphoma with marginal zone Diffuse large B-cell lymphoma
Tau-protein kinase (398 words) [view diff] exact match in snippet view article find links to article
signaling pathway, hedgehog signaling pathway, axon guidance, focal adhesion, b cell receptor signaling pathway, insulin signaling pathway, melanogenesis, alzheimer's
Immunomics (3,819 words) [view diff] no match in snippet view article find links to article
smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system
Rheumatology (1,241 words) [view diff] exact match in snippet view article find links to article
moderate to severe rheumatoid arthritis. The biologic agent rituximab (anti-B cell therapy) is now licensed for use in refractory rheumatoid arthritis.Physiotherapy
Mir-19 microRNA precursor family (3,151 words) [view diff] no match in snippet view article find links to article
miR-19 family can be expressed from: * T-cell acute lymphoblastic leukemia * B-cell lymphomas * Cell lines * Cerebellum * Purkinje cells * HeLa cells Finally
IKZF3 (1,200 words) [view diff] exact match in snippet view article find links to article
Pillai S, Morgan BA, Georgopoulos K (October 1998). "Aiolos regulates B cell activation and maturation to effector state". Immunity. 9 (4): 543–53. doi:10
Primary mediastinal B-cell lymphoma (427 words) [view diff] no match in snippet view article find links to article
Primary mediastinal B-cell lymphoma, abbreviated PMBL, is a rare type of lymphoma that forms in the mediastinum (the space in between the lungs) and predominantly
PTPRJ (1,268 words) [view diff] no match in snippet view article find links to article
tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage". Blood. 95 (3): 965–72. PMID 10648410. Kovalenko
FCRL5 (648 words) [view diff] exact match in snippet view article find links to article
"Altered gene expression upon BCR cross-linking in Burkitt's lymphoma B cell line". Biochem Biophys Res Commun. 277 (1): 124–7. doi:10.1006/bbrc.2000
Tyrosine-protein kinase BLK (800 words) [view diff] exact match in snippet view article find links to article
PMID 7592787. Saouaf SJ, Kut SA, Fargnoli J, et al. (1995). "Reconstitution of the B cell antigen receptor signaling components in COS cells". J. Biol. Chem. 270
Mir-16 microRNA precursor family (3,990 words) [view diff] no match in snippet view article find links to article
colleagues. Karyotyping of chromosome structures from individuals with B-cell chronic lymphocytic leukaemias (B-CLL) found that more than half have alterations
Belantamab mafodotin (700 words) [view diff] no match in snippet view article find links to article
Belantamab mafodotin is a humanized IgG1κ monoclonal antibody against the B-cell maturation antigen (BCMA) conjugated with a cytotoxic agent, maleimidocaproyl
Venetoclax (2,312 words) [view diff] exact match in snippet view article find links to article
deletion or TP53 mutation in adults who are unsuitable for or have failed a B cell receptor pathway inhibitor and for the treatment of CLL in the absence of
Urelumab (195 words) [view diff] no match in snippet view article find links to article
nivolumab (NCT02253992) for metastatic solid tumors, NSCLC, melanoma, B-cell non-Hodgkin lymphoma, colorectal cancer, and multiple myeloma. A biomarker
PTPN6 (2,253 words) [view diff] exact match in snippet view article find links to article
PMID 9890995. Otipoby KL, Draves KE, Clark EA (November 2001). "CD22 regulates B cell receptor-mediated signals via two domains that independently recruit Grb2
Zinc transporter ZIP10 (218 words) [view diff] exact match in snippet view article find links to article
positive regulation of B cell proliferation • transmembrane transport • cellular zinc ion homeostasis • positive regulation of B cell receptor signaling pathway
Richter's transformation (588 words) [view diff] exact match in snippet view article find links to article
is a transformation of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia into a fast-growing diffuse large B cell lymphoma, a variety of
BTLA (848 words) [view diff] exact match in snippet view article find links to article
WD, Persin C, Cambier JC (February 1997). "Molecular targets of CD45 in B cell antigen receptor signal transduction". Journal of Immunology. 158 (3): 1116–24
Dermatitis herpetiformis (3,510 words) [view diff] exact match in snippet view article find links to article
Thus, the B cell presents the foreign peptide (modified gliadin) but produces antibodies specific for the self-antigen (tTG). Once the B cell becomes activated
Large-cell lymphoma (283 words) [view diff] no match in snippet view article find links to article
system lymphomas, which are often diffuse large-B-cell lymphomas Activated B-Cell Diffuse Large B-Cell Lymphoma, or ABC-DLBCL, is believed to be caused
Antigenicity (135 words) [view diff] exact match in snippet view article find links to article
products that have adaptive immunity: T cell receptors or antibodies (a.k.a. B cell receptors). Antigenicity was more commonly used in the past to refer to
Antigen processing (1,719 words) [view diff] exact match in snippet view article find links to article
complementary TCRs) bind this B cell and secrete lymphokines that: Stimulate the B cell to enter the cell cycle The B cell undergoes repeated mitotic cell
PTPN22 (1,597 words) [view diff] exact match in snippet view article find links to article
expressed in different forms. PTPN22 affects the responsiveness of T and B cell receptors, and mutations are associated with increases or decreases in risks
RhoH (1,015 words) [view diff] no match in snippet view article find links to article
and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin". Leukemia. 21 (8): 1821–4. doi:10.1038/sj.leu
Antibody-drug conjugate (2,112 words) [view diff] no match in snippet view article find links to article
monotherapy for the treatment of adults with relapsed or refractory CD22-positive B-cell precursor acute lymphoblastic leukemia (ALL) on June 30, 2017 under the
Mir-15 microRNA precursor family (1,238 words) [view diff] no match in snippet view article find links to article
cells, therefore hinting at an important role of miR-15/16 in normal CD5+ B-cell homeostasis. The CHEK1 (checkpoint kinase 1) gene, located at chromosome
Oblimersen (340 words) [view diff] no match in snippet view article find links to article
treatment for several types of cancer, including chronic lymphocytic leukemia, B-cell lymphoma, and breast cancer. It may kill cancer cells by blocking the production
Heavy chain disease (931 words) [view diff] exact match in snippet view article find links to article
the heavy chain disease protein leads to aggregation and signaling of the B cell receptor, presumably due to the loss of the anti-aggregating properties
DNA polymerase mu (697 words) [view diff] no match in snippet view article find links to article
nucleotides to DNA ends during V(D)J recombination, the process by which B-cell and T-cell receptor diversity is generated in the vertebrate immune system
PRKD3 (1,053 words) [view diff] no match in snippet view article find links to article
in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C
IFNA6 (361 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
Bcl-xL (850 words) [view diff] no match in snippet view article find links to article
B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a member of the Bcl-2 family
IFNA14 (450 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
IFNA5 (384 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
MEF2B (1,153 words) [view diff] no match in snippet view article find links to article
diffuse large B-cell lymphoma. In its mutated form, MEF2B can lead to deregulation of the proto-oncogene BCL6 expression in diffuse large B-cell lymphomas
ID4 (3,026 words) [view diff] no match in snippet view article find links to article
in the differentiation of fallopian tubes, uterus, cervix and vagina. In B-Cell (B lymphocyte) acute lymphoblastic leukaemia (B-ALL), ID4 is overexpressed
Anaplastic large-cell lymphoma (2,273 words) [view diff] no match in snippet view article find links to article
B) cell type. These lymphomas show immunopositivity for ALK protein in 70% of cases. They are also typically positive for EMA. In contrast to many B-cell
Epitope mapping (2,522 words) [view diff] no match in snippet view article find links to article
incorporated into robust algorithms to facilitate in silico prediction of B-cell epitopes based on sequence and/or structural data. Epitopes are generally
IFNA21 (394 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
Lipid raft (6,336 words) [view diff] exact match in snippet view article find links to article
such as Immunoglobulin E signalling, T cell antigen receptor signalling, B cell antigen receptor signalling, EGF receptor signalling, insulin receptor signalling
Small cleaved cells (271 words) [view diff] no match in snippet view article find links to article
(C83.1) . The "small cleaved cells" are usually centrocytes that express B-cell markers such as CD20. The disease is strongly correlated with the genetic
CD99 (2,205 words) [view diff] no match in snippet view article find links to article
CD99 than women. In patients with diffuse large B-cell lymphoma (DLBCL) with the germinal center B-cell (GCB, classified according to the Muris algorithm)
Intraocular lymphoma (705 words) [view diff] no match in snippet view article find links to article
system lymphoma (PCNSL). PCNSL (and PIOL) are most commonly a diffuse large B-cell immunohistologic subtype of non-Hodgkin's lymphoma according to the World
IFNA17 (528 words) [view diff] exact match in snippet view article find links to article
activation involved in immune response • B cell differentiation • defense response • response to virus • B cell proliferation • blood coagulation • positive
List of cancer types (1,000 words) [view diff] exact match in snippet view article find links to article
granulomatosis Mantle cell lymphoma Marginal zone B-cell lymphoma Mast cell leukemia Mediastinal large B cell lymphoma Multiple myeloma/plasma cell neoplasm
IFNA4 (502 words) [view diff] exact match in snippet view article find links to article
immune response • B cell proliferation • humoral immune response • defense response to virus • type I interferon signaling pathway • B cell differentiation
IFNA10 (443 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
IFNA8 (434 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
Daratumumab (1,477 words) [view diff] exact match in snippet view article find links to article
It was awarded orphan drug status for multiple myeloma, diffuse large B cell lymphoma, follicular lymphoma, and mantle cell lymphoma. In November 2015
ARID domain (609 words) [view diff] no match in snippet view article find links to article
biology, the ARID domain (AT-rich interaction domain; also known as BRIGHT (B-cell Regulator of Ig Heavy chain Transcription) domain)) is a protein domain
Richard Ramirez (4,903 words) [view diff] no match in snippet view article find links to article
viciousness beyond any human understanding". Ramirez died of complications from B-cell lymphoma while awaiting execution on California's death row. Ramirez was
Seattle Genetics (2,780 words) [view diff] no match in snippet view article find links to article
Dazcetuzumab (also known as SGN-40 or huS2C6) for the treatment of diffuse Large B-cell lymphoma 16 November: initiation of phase I clinical trial for SGN-75 (INN:
IFNW1 (559 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • response to virus • positive regulation
CD70 (228 words) [view diff] no match in snippet view article find links to article
CD70 protein is expressed on highly activated lymphocytes (like in T- and B-cell lymphomas). It is therefore suggested that anti-CD70 antibodies might be
BCL10 (1,817 words) [view diff] no match in snippet view article find links to article
B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance
Orbital lymphoma (1,326 words) [view diff] exact match in snippet view article find links to article
is still debated. Follicular lymphoma, diffuse large B cell lymphoma, mantle cell lymphoma, B-cell chronic lymphocytic leukemia, peripheral T-cell lymphoma
CD300A (571 words) [view diff] exact match in snippet view article find links to article
• negative regulation of NK T cell activation • negative regulation of B cell receptor signaling pathway • negative regulation of activation of Janus
CDH17 (749 words) [view diff] exact match in snippet view article find links to article
catenin complex Biological process • spleen development • marginal zone B cell differentiation • integrin-mediated signaling pathway • positive regulation
Zinc transporter ZIP9 (2,400 words) [view diff] no match in snippet view article find links to article
23 cases of patients with circulation related cancers such as B-cell lymphoma and B-cell chronic lymphocytic leukaemia (CLL). Chimeric genes are a result
Aggressive NK-cell leukemia (1,213 words) [view diff] exact match in snippet view article find links to article
to the NK lineage, clonal rearrangements of lymphoid (T cell receptor; B cell receptor) genes are not seen. The genome of the Epstein Barr virus (EBV)
IFNA7 (839 words) [view diff] exact match in snippet view article find links to article
immune response • B cell proliferation • humoral immune response • defense response to virus • type I interferon signaling pathway • B cell differentiation
BCL3 (1,408 words) [view diff] no match in snippet view article find links to article
B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene. This gene is a proto-oncogene candidate. It is identified by
Bcl-2-associated X protein (2,108 words) [view diff] exact match in snippet view article find links to article
substance • B cell negative selection • mitochondrial fusion • neuron apoptotic process • male gonad development • positive regulation of B cell apoptotic
Mediastinal tumors (873 words) [view diff] exact match in snippet view article find links to article
diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphoma"
ELF2 (479 words) [view diff] exact match in snippet view article find links to article
AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". J. Biol. Chem. 279 (19): 19512–22. doi:10.1074/jbc.M309074200
Prolymphocytic leukemia (34 words) [view diff] no match in snippet view article find links to article
leukemia is divided into two types according to the kind of cell involved: B-cell prolymphocytic leukemia and T-cell prolymphocytic leukemia. It is usually
BCL9 (1,263 words) [view diff] no match in snippet view article find links to article
B-cell CLL/lymphoma 9 protein is a protein that in humans is encoded by the BCL9 gene. BCL9, together with its paralogue gene BCL9L (BCL9 like or BCL9
Immunological memory (890 words) [view diff] exact match in snippet view article find links to article
immune response is similar to primary immune response. After the memory B cell recognizes the antigen it presents the peptide: MHC II complex to nearby
Protein kinase N1 (1,725 words) [view diff] exact match in snippet view article find links to article
• activation of JUN kinase activity • histone H3-T11 phosphorylation • B cell apoptotic process • negative regulation of protein kinase activity • phosphorylation
GPR97 (850 words) [view diff] no match in snippet view article find links to article
cells. Gene-deficient mice revealed that Gpr97 is crucial for maintaining B-cell population via constitutive CREB and NF-κB activities. Human lymphatic endothelial
Monoclonal antibody therapy (3,726 words) [view diff] no match in snippet view article find links to article
alemtuzumab Campath, Lemtrada Genzyme 5/7/2001 intravenous humanized CD52 B-cell chronic lymphocytic leukemia 103948 Link alirocumab Praluent Sanofi Aventis
TLR10 (652 words) [view diff] exact match in snippet view article find links to article
control cells. TLR10 engagement also has long-term effects on monocyte and B cell activation/differentiation by suppressing the transcription of activation
Interleukin 21 (2,923 words) [view diff] exact match in snippet view article find links to article
2007). "Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration". Journal of Immunology
Veltuzumab (277 words) [view diff] no match in snippet view article find links to article
interferon-alpha, a novel and potent immunocytokine for the therapy of B-cell lymphomas". Blood. 114 (18): 3864–71. doi:10.1182/blood-2009-06-228890.
ABL (gene) (3,242 words) [view diff] exact match in snippet view article
Biological process • positive regulation of protein phosphorylation • B-1 B cell homeostasis • regulation of axon extension • neuromuscular process controlling
MNDA (776 words) [view diff] exact match in snippet view article find links to article
process • B cell receptor signaling pathway • cellular defense response • regulation of transcription, DNA-templated • negative regulation of B cell proliferation
EBF1 (1,182 words) [view diff] exact match in snippet view article find links to article
EBF1 gene. EBF1 stands for Early B-Cell Factor 1. EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction
IFNK (747 words) [view diff] exact match in snippet view article find links to article
involved in immune response • B cell differentiation • defense response • response to virus • natural killer cell activation • B cell proliferation • regulation
Follicular cell (43 words) [view diff] exact match in snippet view article find links to article
oocytes Follicular dendritic cell, found in the follicles of lymphoid tissue Follicular B cell, found in the follicles of lymphoid tissue Follicle (anatomy)
P2RY8 (465 words) [view diff] no match in snippet view article find links to article
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. P2Y receptor GRCh38: Ensembl release 89: ENSG00000182162 - Ensembl
Integrin alpha 4 (1,105 words) [view diff] exact match in snippet view article find links to article
fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY". J. Biol. Chem. 267 (12): 8366–70. PMID 1373725. Fernández-Ruiz
IFNA13 (829 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
Multiple myeloma (9,942 words) [view diff] exact match in snippet view article find links to article
associated with MM cells is generally taken to be either an activated memory B cell or the precursor to plasma cells, the plasmablast. The immune system keeps
IFNA16 (874 words) [view diff] exact match in snippet view article find links to article
killer cell activation involved in immune response • B cell differentiation • defense response • B cell proliferation • blood coagulation • positive regulation
Adenosine deaminase (2,858 words) [view diff] exact match in snippet view article find links to article
process • in utero embryonic development • negative regulation of mature B cell apoptotic process • nucleotide metabolic process • response to vitamin E
List of histologic stains that aid in diagnosis of cutaneous conditions (254 words) [view diff] no match in snippet view article find links to article
Basal cell carcinoma Primary cutaneous marginal zone lymphoma Diffuse large B-cell lymphoma leg type Bcl-6 Primary cutaneous follicular lymphoma BerEp4 Desmoplastic
Amplicon (1,374 words) [view diff] exact match in snippet view article find links to article
implicated in several forms of human cancer including primary mediastinal B cell lymphoma and Hodgkin's lymphoma. In this context the term amplicon can refer
Humanized antibody (1,556 words) [view diff] no match in snippet view article find links to article
into a human antibody framework. Alemtuzumab is approved for treatment of B-cell chronic lymphocytic leukemia and is currently in clinical trials for a variety
KMT2D (3,510 words) [view diff] no match in snippet view article find links to article
development. Knockout studies in mice also show that KMT2D is required for proper B-cell development. KMT2D is partially functionally redundant with KMT2C and is
Kite Pharma (3,710 words) [view diff] no match in snippet view article find links to article
FDA for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy. MIT Technology Review
Phosphoinositide 3-kinase inhibitor (2,686 words) [view diff] no match in snippet view article find links to article
p110β, p110γ, and p110δ) and a weaker inhibitor of mTOR. In trial for B-cell lymphomas, e.g. CLL and follicular lymphoma. With phase I results announced :
Transforming growth factor beta (6,808 words) [view diff] exact match in snippet view article find links to article
lymphocytes. TGF-β inhibits B cell proliferation. The exact mechanism is unknown, but there is evidence that TGF-β inhibits B cell proliferation by inducing
Brentuximab vedotin (1,871 words) [view diff] no match in snippet view article find links to article
brentuximab vedotin in relapsed or refractory CD30-positive NHL, including B-cell neoplasms. These results demonstrated that single-agent brentuximab vedotin
Cationic amino acid transporter 4 (491 words) [view diff] no match in snippet view article find links to article
"Comparative analysis of ZAP-70 expression and Ig VH mutational status in B-cell chronic lymphocytic leukemia". Cytometry Part B. 72 (2): 96–102. doi:10
LAIR1 (1,032 words) [view diff] exact match in snippet view article find links to article
receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". European Journal of Immunology
PLCG2 (1,356 words) [view diff] exact match in snippet view article find links to article
Garcia-Lloret M, Wahl MI, Rawlings DJ (August 2000). "Engagement of the human pre-B cell receptor generates a lipid raft-dependent calcium signaling complex". Immunity
Abexinostat (435 words) [view diff] no match in snippet view article find links to article
Pharmacyclics and licensed to Xynomic. and is in Phase II clinical trials for B-cell lymphoma. Pre-clinical study suggests the potential for treatment of different
CD43 (1,253 words) [view diff] no match in snippet view article find links to article
CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell lymphoblastic lymphoma, since the malignant cells in this condition are
Ruxolitinib (944 words) [view diff] no match in snippet view article find links to article
investigated for plaque psoriasis, alopecia areata, relapsed diffuse large B-cell lymphoma, and peripheral T-cell lymphoma. In Feb 2016, a phase III trial
John Kanzius (1,203 words) [view diff] no match in snippet view article find links to article
undergoing chemotherapy for treatment of non-Hodgkin's lymphoma. He died of B-cell leukemia with complications from pneumonia without seeing FDA approval and
Cutaneous lymphoma (97 words) [view diff] no match in snippet view article find links to article
of lymphomas that affect the skin: Cutaneous T-cell lymphoma Cutaneous B-cell lymphoma Paller, Amy S.; Mancini, Anthony J. (2015). Hurwitz Clinical Pediatric
Philadelphia chromosome (3,322 words) [view diff] no match in snippet view article find links to article
are the p190, p210, and p230 isoforms. p190 is generally associated with B-cell acute lymphoblastic leukemia (ALL), while p210 is generally associated with
TLR9 (2,437 words) [view diff] exact match in snippet view article find links to article
regulation of B cell proliferation • regulation of toll-like receptor 9 signaling pathway • positive regulation of MAPK cascade • regulation of B cell differentiation
Asymptomatic (669 words) [view diff] no match in snippet view article find links to article
diverticulum Microvenular hemangioma Mitral valve prolapse Monkeypox Monoclonal B-cell lymphocytosis Myelolipoma Optic disc pit Osteoporosis Pertussis (whooping
Membrane glycoproteins (39 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Small modular immunopharmaceutical (477 words) [view diff] no match in snippet view article find links to article
B-cell malignancies". Current Opinion in Investigational Drugs. 10 (12): 1383–1390. PMID 19943209. TruEmergent: TRU-016 for the Treatment of B-Cell Malignancies
Macrophage (7,880 words) [view diff] no match in snippet view article find links to article
B-cell. T cells that express the T cell receptor which recognizes the antigen-MHCII complex (with co-stimulatory factors- CD40 and CD40L) cause the B-cell
Hashimoto's thyroiditis (3,046 words) [view diff] no match in snippet view article find links to article
T-lymphocytes. A rare but serious complication is thyroid lymphoma, generally the B-cell type, non-Hodgkin lymphoma. The strong genetic component is borne out in
HLA-DR (2,225 words) [view diff] no match in snippet view article find links to article
These cells then bind to antigens on the surface of B-cells stimulating B-cell proliferation. The primary function of HLA-DR is to present peptide antigens
Human T-lymphotropic virus 2 (1,254 words) [view diff] exact match in snippet view article find links to article
lymphoproliferative disease that was described as having characteristics similar to the B cell disorder, hairy cell leukemia. HTLV-2 was identified in a second patient
Supported Integration Training and Employment (SITE) (257 words) [view diff] case mismatch in snippet view article
which they have identified as appropriate to their needs is the Listed B Cell Block adjacent to the Centre for Sensory Impairment in Partick, Glasgow
BCAP31 (1,030 words) [view diff] no match in snippet view article find links to article
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene. BCAP31 has been shown to interact with: APP, BCL2L1, BCL2
AURKC (1,993 words) [view diff] no match in snippet view article find links to article
"Aurora-C kinase supports mitotic progression in the absence of Aurora-B". Cell Cycle. 8 (18): 2984–94. doi:10.4161/cc.8.18.9591. PMID 19713763. "Aurora
Immunological synapse (1,765 words) [view diff] exact match in snippet view article find links to article
an antigen-presenting cell or target cell and a lymphocyte such as a T/B cell or Natural Killer cell. The interface was originally named after the neuronal
NFATC2 (1,374 words) [view diff] exact match in snippet view article find links to article
• nuclear chromatin • cytosol • ribonucleoprotein Biological process • B cell receptor signaling pathway • regulation of transcription, DNA-templated
BACH2 (1,427 words) [view diff] exact match in snippet view article find links to article
Igarashi K, Yokoyama M (August 2000). "Cloning and expression of human B cell-specific transcription factor BACH2 mapped to chromosome 6q15". Oncogene
Homing (hematopoietic) (255 words) [view diff] exact match in snippet view article
2004). "Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin
IGHM (869 words) [view diff] exact match in snippet view article find links to article
PMC 329453. PMID 1904154. Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form
Blue Gender (2,230 words) [view diff] no match in snippet view article find links to article
the Blue, which are alien insectoid creatures containing a newly-evolved B-cell that recently appeared in several humans, including the main protagonist
Gray zone lymphoma (70 words) [view diff] no match in snippet view article find links to article
B-cell lymphomas. Traverse-Glehen A, Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell
GroEL (2,073 words) [view diff] exact match in snippet view article find links to article
isotype switching to IgG isotypes • B cell activation • B cell cytokine production • response to unfolded protein • B cell proliferation • protein folding
Milatuzumab (743 words) [view diff] no match in snippet view article find links to article
published or announced. CD74: a new candidate target for the immunotherapy of B-cell neoplasms. R. Stein, M.J. Mattes, T.M. Cardillo, H.J. Hansen, C.H. Chang
IGHV@ (593 words) [view diff] no match in snippet view article find links to article
gene. IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated
Timeline of lymphoma (645 words) [view diff] no match in snippet view article find links to article
Morgan EA, Nascimento AF (2012). "Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma". Adv Hematol. 2012: 1–6
List of therapeutic monoclonal antibodies (1,741 words) [view diff] no match in snippet view article find links to article
D; Lindhofer, H; Kolb, HJ; et al. (2008). "Immunotherapy of recurrent Bcell malignancies after allo SCT with Bi20 (FBTA05), a trifunctional anti-CD3
Chemoimmunotherapy (988 words) [view diff] no match in snippet view article find links to article
chemoimmunotherapy regimen is CHOP combined with rituximab (CHOP-R) for B-cell non-Hodgkin lymphomas. NCI Dictionary of Cancer Terms - Definition of chemoimmunotherapy
Proteoglycan (738 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Ketan J. Patel (1,357 words) [view diff] exact match in snippet view article find links to article
PMID 15327776. Patel, K.J.; Neuberger, M.S. (1993). "Antigen presentation by the B cell antigen receptor is driven by the αβ sheath and occurs independently of
SWAP70 (679 words) [view diff] exact match in snippet view article find links to article
Herndier B, Wabl M, Ferrick D (Apr 2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc Natl Acad Sci U S A. 97 (5): 2180–4. doi:10
Dedicator of cytokinesis protein 10 (621 words) [view diff] no match in snippet view article find links to article
response to the cytokine IL-4. This suggests that Dock10 may have a role in B-cell activation and proliferation. Another study identified Dock10 as a protein
GNA13 (2,022 words) [view diff] no match in snippet view article find links to article
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. G12/G13 alpha subunits G protein-coupled receptor Heterotrimeric
Cell culture (6,008 words) [view diff] exact match in snippet view article find links to article
of an immunised animal are combined with an immortal myeloma cell line (B cell lineage) to produce a hybridoma which has the antibody specificity of the
BTG1 (1,769 words) [view diff] no match in snippet view article find links to article
be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative
Agnatha (2,147 words) [view diff] exact match in snippet view article find links to article
vertebrates diversify their repertoire of immunoglobulin domain-based T and B cell antigen receptors mainly through the rearrangement of V(D)J gene segments
Plasmacytosis (126 words) [view diff] no match in snippet view article find links to article
tuberculosis, abscess) whereas multiple myeloma is rarely found. Cutaneous B-cell lymphoma Multiple myeloma Plasmacytoma Skin lesion James, William D.; Berger
HVCN1 (1,384 words) [view diff] exact match in snippet view article find links to article
Yamasaki S, et al. (2007). "Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function". Eur
Interleukin-6 receptor (1,385 words) [view diff] exact match in snippet view article find links to article
Pahwa S (1993). "HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6". J. Immunol. 150 (6):
Cirmtuzumab (121 words) [view diff] no match in snippet view article find links to article
NCT03420183 for "A Study of Cirmtuzumab and Ibrutinib in Patients With B-Cell Lymphoid Malignancies" at ClinicalTrials.gov "1st Mantle Cell Lymphoma Patient
PRDM1 (1,387 words) [view diff] exact match in snippet view article find links to article
"Modular nature of Blimp-1 in the regulation of gene expression during B cell maturation". Journal of Immunology. 172 (9): 5427–40. doi:10.4049/jimmunol
Mucoprotein (64 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Acute monocytic leukemia (292 words) [view diff] no match in snippet view article find links to article
CD33) and monocytic (CD11b, CD11c) markers. Cells may aberrantly express B-cell marker CD20 and the NK marker CD56. Monoblasts may be positive for CD34
CKAP2 (794 words) [view diff] no match in snippet view article find links to article
head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia
Alemtuzumab (1,786 words) [view diff] no match in snippet view article find links to article
Lemtrada aimed at multiple sclerosis. Alemtuzumab is used for the treatment of B-cell chronic lymphocytic leukemia (B-CLL) in people who have been treated with
Asialoglycoprotein (52 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Tingible body macrophage (185 words) [view diff] no match in snippet view article find links to article
germinal center reaction by the release of prostaglandins and hence a reduced B-cell induction of IL-2. Macrophages that contain debris from ingested lymphocytes
BCL6B (335 words) [view diff] no match in snippet view article find links to article
B-cell CLL/lymphoma 6 member B protein is a protein that in humans is encoded by the BCL6B gene. GRCh38: Ensembl release 89: ENSG00000161940 - Ensembl
Salivary gland tumour (1,676 words) [view diff] exact match in snippet view article find links to article
Hematolymphoid tumors Hodgkin lymphoma Diffuse large B-cell lymphoma Extranodal marginal zone B cell lymphoma Secondary tumors (i.e. a tumor which has metastasized
Hematologic disease (535 words) [view diff] no match in snippet view article find links to article
Chronic myelogenous leukemia (CML) T-cell prolymphocytic leukemia (T-PLL) B-cell prolymphocytic leukemia (B-PLL) Chronic neutrophilic leukemia (CNL) Hairy
Indolent lymphoma (2,940 words) [view diff] exact match in snippet view article find links to article
Except for a few exceptions, indolent lymphomas are almost entirely of B cell origin. They are classified based on pathological and cytological features
CD47 (3,984 words) [view diff] no match in snippet view article find links to article
extracellular domain. Similarly, CD47 ligation rapidly induces apoptosis in B-cell chronic lymphocytic leukemia (CLL) cells. Treatment with a disulfide-linked
Infectious causes of cancer (4,747 words) [view diff] no match in snippet view article find links to article
Epstein–Barr virus-positive diffuse large B-cell lymphomas, not otherwise specified, diffuse large B-cell lymphomas associated with chronic inflammation
Thyroxine-binding proteins (42 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
The great imitator (467 words) [view diff] no match in snippet view article find links to article
referred to with this name include: Various cancers Intravascular large B-cell lymphoma Mycosis Fungoides Beriberi Various rheumatic conditions, including:
Minimal change disease (1,756 words) [view diff] exact match in snippet view article find links to article
T cells, increased markers for B cell activation during a relapse of minimal change disease, and alterations in B cell sub-classes during minimal change
CHRNB2 (1,047 words) [view diff] exact match in snippet view article find links to article
behavioral response to nicotine • regulation of dendrite morphogenesis • B cell activation • neuromuscular synaptic transmission • synaptic transmission
FCRL3 (871 words) [view diff] exact match in snippet view article find links to article
"Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS
Serum B-cell maturation antigen (4,562 words) [view diff] no match in snippet view article find links to article
Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the serum of normal patients and
ROR1 (1,071 words) [view diff] no match in snippet view article find links to article
"Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia". Clinical Cancer Research. 14 (2): 396–404
MorphoSys (1,057 words) [view diff] no match in snippet view article find links to article
with lenalidomide for the treatment of relapsed/refractory diffuse large B-cell lymphoma. The submission was accepted for filing in February 2020, and a
WHO Disease Staging System for HIV Infection and Disease in Children (442 words) [view diff] exact match in snippet view article find links to article
herpes simplex infection Acquired HIV associated rectal fistula Cerebral or B cell non-Hodgkin lymphoma Progressive multifocal leukoencephalopathy (PML) HIV-associated
CIITA (1,026 words) [view diff] exact match in snippet view article find links to article
involved in the pathogenesis of Hodgkin lymphoma and primary mediastinal B cell lymphoma. CIITA mRNA can only be detected in human leukocyte antigen (HLA)
Oncology (5,430 words) [view diff] exact match in snippet view article find links to article
therapy (IFRT). Non-Hodgkin lymphoma (NHL) Chemo-immunotherapy (R-CHOP) for B cell lymphomas, and chemotherapy (CHOP) for T cell lymphomas. Includes acute
Selinexor (1,759 words) [view diff] no match in snippet view article find links to article
action. The most common adverse reactions in people with diffuse large B-cell lymphoma (DLBCL), excluding laboratory abnormalities, were fatigue, nausea
ETS1 (1,844 words) [view diff] exact match in snippet view article find links to article
partial defects in bone marrow B cell development with reduced cellularity and inefficient transition from pro-B to pre-B cell stages. Meta-analyses of multiple
Beta-actin (966 words) [view diff] no match in snippet view article find links to article
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma. Beta actin is usually used as a loading control, for among others
Serum B-cell maturation antigen (4,562 words) [view diff] no match in snippet view article find links to article
Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the serum of normal patients and
BTG4 (425 words) [view diff] no match in snippet view article find links to article
family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4). BTG4 has anti-proliferative properties and can induce
Effector cell (887 words) [view diff] exact match in snippet view article find links to article
at the terminal end of an efferent nerve fiber Plasma cell, an effector B cell in the immune system Effector T cells, T cells that actively respond to
CARD11 (1,132 words) [view diff] exact match in snippet view article find links to article
activity • GDP metabolic process • immunoglobulin production • B cell differentiation • B cell proliferation • T cell activation • lymphocyte activation •
Clone (484 words) [view diff] no match in snippet view article find links to article
Clones, County Fermanagh Clones, County Monaghan, a town in Ireland Clone (B-cell), a lymphocyte clone, the massive presence of which may indicate a pathological
Quilizumab (331 words) [view diff] exact match in snippet view article find links to article
Matthews JG, O'Byrne PM (July 2014). "Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production"
Hydroa vacciniforme (591 words) [view diff] exact match in snippet view article find links to article
lymphoproliferative disease such as T cell lymphoma, T cell leukemia, B cell lymphoma, and B cell leukemia. In many children hydroa vacciniforme (HV) regresses
PBX (64 words) [view diff] no match in snippet view article find links to article
Susuhunan of Surakarta in Java, Indonesia Polymer-bonded explosive Pre-B-cell leukemia homeobox Private branch exchange, a telephone exchange that serves
Ovomucin (140 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Cyclin-dependent kinase inhibitor 1C (1,580 words) [view diff] no match in snippet view article find links to article
2001). "Novel expression of cyclin-dependent kinase inhibitors in human B-cell precursors". Experimental Hematology. 29 (4): 490–8. doi:10.1016/S0301-472X(01)00619-1
DLEU2 (642 words) [view diff] no match in snippet view article find links to article
potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia. Long non-coding RNA "Human PubMed Reference:"
CXCR4 (2,623 words) [view diff] no match in snippet view article find links to article
recently identified in patients with Waldenström's macroglobulinemia, a B-cell malignancy. The presence of CXCR4 WHIM mutations has been associated with
HEADstrong Foundation (226 words) [view diff] no match in snippet view article find links to article
was founded in 2006 by Nicholas "Head" Colleluori, who was diagnosed with B-cell Non-Hodgkin's lymphoma during his sophomore year of college. Colleluori
Clonal selection algorithm (345 words) [view diff] no match in snippet view article find links to article
selection ALGorithm AIRS: The Artificial Immune Recognition System BCA: The B-Cell Algorithm Artificial immune system Biologically inspired computing Computational
VCAM-1 (677 words) [view diff] exact match in snippet view article find links to article
of immune response • leukocyte tethering or rolling • cell chemotaxis • B cell differentiation • cellular response to vascular endothelial growth factor
4-1BB ligand (68 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Protein A (1,840 words) [view diff] exact match in snippet view article find links to article
CS, Silverman GJ (May 2003). "Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal Toxin". The
CD 205 (539 words) [view diff] exact match in snippet view article find links to article
molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor
CD74 (2,119 words) [view diff] exact match in snippet view article find links to article
regulation of peptidyl-tyrosine phosphorylation • negative regulation of mature B cell apoptotic process • regulation of macrophage activation • negative regulation
ETV6 (4,615 words) [view diff] exact match in snippet view article find links to article
hematological (e.g. chronic myelomonocytic leukemia, acute myelocytic leukemia, B cell acute lymphoblastic leukemia, mixed phenotype acute leukemia, Myelodysplastic
MALT1 (2,564 words) [view diff] no match in snippet view article find links to article
two central immunoglobulin-like domains involved in the binding to the B-cell lymphoma 10 (Bcl10) protein and a caspase-like domain. The death domain
Sialoglycoprotein (94 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
BCAP29 (587 words) [view diff] no match in snippet view article find links to article
B-cell receptor-associated protein 29 is a protein that in humans is encoded by the BCAP29 gene. ENSG00000075790 GRCh38: Ensembl release 89: ENSG00000283852
Mucin 5B (113 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Peptidoglycan (1,322 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
CD1 (672 words) [view diff] exact match in snippet view article find links to article
conditions that may show CD1 positivity include myeloid leukaemia and some B cell lymphomas. Mice lack the group 1 CD1 molecules, and instead have 2 copies
Mucin 6 (73 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
BCAP29 (587 words) [view diff] no match in snippet view article find links to article
B-cell receptor-associated protein 29 is a protein that in humans is encoded by the BCAP29 gene. ENSG00000075790 GRCh38: Ensembl release 89: ENSG00000283852
Pixantrone (1,927 words) [view diff] no match in snippet view article find links to article
Adult Patients with Multiply Relapsed or Refractory Aggressive Non-Hodgkin B-Cell Lymphomas. Pixantrone is as potent as mitoxantrone in animal models of multiple
DHAP (chemotherapy) (125 words) [view diff] no match in snippet view article
[R]-DHAP regimen consists of: Rituximab, a monoclonal antibody, directed at B-cell surface antigen CD20 (D)examethasone, a glucocorticoid hormone (H)igh-dose
Forodesine (637 words) [view diff] no match in snippet view article find links to article
patients with T-cell acute lymphoblastic leukemia (T-ALL) and for treatment of B-cell acute lymphocytic leukemia (B-ALL). Forodesine was originally discovered
Aggrecan (1,784 words) [view diff] exact match in snippet view article find links to article
Schwartz-Albiez R (1997). "Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation
PTK2B (1,847 words) [view diff] exact match in snippet view article find links to article
regulation of JNK cascade • regulation of angiogenesis • marginal zone B cell differentiation • negative regulation of muscle cell apoptotic process •
IGL@ (923 words) [view diff] exact match in snippet view article find links to article
locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment
CTLA-4 (3,296 words) [view diff] exact match in snippet view article find links to article
membrane Biological process • B cell receptor signaling pathway • T cell costimulation • negative regulation of B cell proliferation • adaptive immune
Mir-339 microRNA precursor family (626 words) [view diff] no match in snippet view article find links to article
Shen B (January 2009). "Differential microRNA expression in childhood B-cell precursor acute lymphoblastic leukemia". Pediatric Hematology and Oncology
Death receptor 6 (1,038 words) [view diff] exact match in snippet view article find links to article
apoptotic process • oligodendrocyte apoptotic process • negative regulation of B cell proliferation • neuron apoptotic process • humoral immune response • myelination
DAPP1 (701 words) [view diff] exact match in snippet view article find links to article
Mecklenbräuker I, et al. (2003). "Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival". Immunity. 19 (4):
Barton Haynes (1,090 words) [view diff] no match in snippet view article find links to article
and Infectious Diseases (NIAID) in 2012. In addition, Haynes directs the B-cell Lineage Envelope Design Study, the Centralized Envelope Phase I Study, and
CSPG4 (1,478 words) [view diff] exact match in snippet view article find links to article
R (February 1997). "Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation
Mucin 3A (159 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
Lipoprotein lipase (3,907 words) [view diff] no match in snippet view article find links to article
Jäger U (July 2005). "High expression of lipoprotein lipase in poor risk B-cell chronic lymphocytic leukemia". Leukemia. 19 (7): 1216–23. doi:10.1038/sj
Tasuku Honjo (1,403 words) [view diff] no match in snippet view article find links to article
of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II". Nature. Springer Nature. 324 (6092): 70–73. Bibcode:1986Natur
MicroRNA (15,750 words) [view diff] exact match in snippet view article find links to article
miRNAs participate in pathways fundamental to B cell development like B-cell receptor (BCR) signalling, B-cell migration/adhesion, cell-cell interactions
SLAMF8 (265 words) [view diff] exact match in snippet view article find links to article
studies of a similar protein in mouse suggest that it may function during B cell lineage commitment. The gene is found in a region of chromosome 1 containing
David Flavell (577 words) [view diff] exact match in snippet view article find links to article
immunotoxins in adult patients with B-cell non-Hodgkin’s lymphoma (B-NHL), multiple myeloma and in children with pre-B cell acute lymphoblastic leukaemia (ALL)
Conidium (1,010 words) [view diff] no match in snippet view article find links to article
leukemia patients on induction chemotherapy, AIDS patients with superimposed B-cell lymphoma, bone marrow transplantation patients, or major organ transplant
Phosphoinositide phospholipase C (2,228 words) [view diff] exact match in snippet view article find links to article
pathways necessary for antigen mediated B cell activation are necessary for B cell development from CLPs. In B cell signaling, PI 3-kinase is recruited to
Fas receptor (2,320 words) [view diff] exact match in snippet view article find links to article
differentiation • protein homooligomerization • response to toxic substance • B cell mediated immunity • neuron apoptotic process • positive regulation of protein
Mir-153 microRNA precursor family (749 words) [view diff] no match in snippet view article find links to article
PMID 20106983. Xu J, Liao X, Wong C (February 2010). "Downregulations of B-cell lymphoma 2 and myeloid cell leukemia sequence 1 by microRNA 153 induce apoptosis
Cernunnos deficiency (484 words) [view diff] no match in snippet view article find links to article
Cernunnos deficiency is a form of combined immunodeficiency characterized by microcephaly, due to mutations in the NHEJ1 gene, it is inherited via autosomal
KIDINS220 (744 words) [view diff] no match in snippet view article find links to article
shown to have important roles in the immune system by interacting with the B-cell and T-cell receptor. The gene is located on the short arm of chromosome
IFNA2 (2,572 words) [view diff] exact match in snippet view article find links to article
receptor signaling pathway • B cell proliferation • humoral immune response • type I interferon signaling pathway • B cell differentiation • positive regulation
Lenalidomide (2,161 words) [view diff] no match in snippet view article find links to article
increased risk of developing cancers such as acute myelogenous leukemia and B-cell lymphoma, though it did not advise patients to discontinue treatment with
Glycoconjugate (224 words) [view diff] no match in snippet view article find links to article
Alpha 1-antichymotrypsin Apolipoprotein H CD70 Asialoglycoprotein Avidin B-cell activating factor 4-1BB ligand Cholesterylester transfer protein Clusterin
T-cell lymphoma (210 words) [view diff] no match in snippet view article find links to article
2% are precursor T lymphoblastic and 2% are cutaneous T cell lymphomas. B-cell lymphoma "The Lymphomas" (PDF). The Leukemia & Lymphoma Society. May 2006
Locus suicide recombination (165 words) [view diff] no match in snippet view article find links to article
It thus terminates immunoglobulin and B-cell receptor (BCR) expression in B-lymphocytes and results in B-cell death since survival of such cells requires
Clodoveo Ferri (781 words) [view diff] no match in snippet view article find links to article
(cryoglobulinemic vasculitis) and in a significant percentage of patients with B-cell non-Hodgkin's lymphoma. Ferri is a member of the SIR (Italian Society of
ATM serine/threonine kinase (4,920 words) [view diff] exact match in snippet view article find links to article
leukemias and lymphomas, including mantle cell lymphoma, T-ALL, atypical B cell chronic lymphocytic leukemia, and T-PLL are also associated with ATM defects
ELF4 (594 words) [view diff] exact match in snippet view article find links to article
AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene". The Journal of Biological Chemistry. 279 (19): 19512–22
Wandering cell (921 words) [view diff] exact match in snippet view article find links to article
organisms or substances that the body identifies as foreign. Every individual B cell makes only one particular type of antibody, specific to only one type of
MAP4K1 (548 words) [view diff] no match in snippet view article find links to article
play a role in JNK activation. MAP4K1 has been shown to interact with: B-cell linker, CRK, CRKL, Drebrin-like, GRAP2, Grb2, Linker of activated T cells
ADCY4 (670 words) [view diff] exact match in snippet view article find links to article
TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression". J. Allergy Clin
LYL1 (627 words) [view diff] exact match in snippet view article find links to article
Biological process • positive regulation of transcription, DNA-templated • B cell differentiation • definitive hemopoiesis • regulation of transcription,