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Longer titles found: Autophagy-related protein 101 (view), Autophagy-related protein 13 (view), Autophagy (disambiguation) (view), Autophagy (journal) (view), Autophagy database (view), Myopathy, X-linked, with excessive autophagy (view), Chaperone-mediated autophagy (view), Chaperone-assisted selective autophagy (view), Microautophagy (view)

searching for Autophagy 251 found (893 total)

alternate case: autophagy

ATG7 (967 words) [view diff] exact match in snippet view article find links to article

Autophagy related 7 is a protein in humans encoded by ATG7 gene. Related to GSA7; APG7L; APG7-LIKE. ATG 7, present in both plant and animal genomes, acts
ATG3 (580 words) [view diff] exact match in snippet view article find links to article
In molecular biology, autophagy related 3 (Atg3) is the E2 enzyme for the LC3 lipidation process. It is essential for autophagocytosis. The super protein
Acute myeloblastic leukemia with maturation (3,102 words) [view diff] exact match in snippet view article find links to article
mediated by autophagy, but there is an observed pro-survival autophagy in the leukemic cells (Torgersen et al., 2013). Thus, an inhibition of autophagy would
P70-S6 Kinase 1 (2,108 words) [view diff] exact match in snippet view article find links to article
has been used as a hallmark of activation by mTOR and correlated with autophagy inhibition in various situations. However, several recent studies suggest
ATG5 (2,761 words) [view diff] exact match in snippet view article find links to article
Autophagy related 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on Chromosome 6. It is an E3 ubi autophagic cell death. ATG5
Arenobufagin (1,480 words) [view diff] exact match in snippet view article find links to article
completion), Atg9, Atg16L1 and p62/SQSTM1, all proteins which induce autophagy. Blockers of autophagy increase the cytotoxic effect of arenobufagin. Addition of
Heat shock response (2,086 words) [view diff] exact match in snippet view article find links to article
prevent incorrect folding, the protein may be degraded by the proteasome or autophagy to remove any potentially toxic aggregates. Misfolded proteins, if left
MAPK15 (1,078 words) [view diff] exact match in snippet view article find links to article
Chiariello M (Dec 2012). "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins". Autophagy. 8 (12): 1724–40. doi:10.4161/auto.21857.
PFKFB3 (3,698 words) [view diff] exact match in snippet view article find links to article
glycolysis, and thus increases autophagy. Likewise, inhibition of PFKFB3 has been found to induce autophagy. See summary image. Autophagy can prolong cellular survival
Leelamine (138 words) [view diff] exact match in snippet view article find links to article
lysosomes leading to disruption of intracellular cholesterol transport, autophagy and endocytosis followed by cell death. Abietic acid "Leelamine - Dehydroabietylamine
LRRK2 (1,874 words) [view diff] exact match in snippet view article find links to article
macroautophagy, and can be prevented by protein kinase A regulation of the autophagy protein LC3. The G2019S and R1441C mutations elicit post-synaptic calcium
Coibamide A (318 words) [view diff] exact match in snippet view article find links to article
cells lacking autophagy-related protein 5 (Atg5) that suggest coibamide A as a compound with characteristics that may utilize autophagy for pro-death
GATA4 (2,240 words) [view diff] exact match in snippet view article find links to article
regulated through the autophagy-lysosome pathway in eukaryotic cells. In cellular senescence, ATM and ATR inhibit p62, an autophagy adaptor responsible
Protein kinase B (3,517 words) [view diff] exact match in snippet view article find links to article
Akt promotes nuclear translocation of TFEB, lysosomal biogenesis and autophagy. Akt1 has also been implicated in angiogenesis and tumor development.
BNIP3 (2,663 words) [view diff] exact match in snippet view article find links to article
mitochondrial swelling and fission, and an increase in mitochondrial turnover via autophagy. Sequence similarity with Bcl-2 family members was not detected. Humans
ATG9A (453 words) [view diff] exact match in snippet view article find links to article
Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene. GRCh38: Ensembl release 89: ENSG00000198925 - Ensembl, May 2017
Dengue virus (5,816 words) [view diff] exact match in snippet view article find links to article
such as autophagy and ER stress response, not to mention apoptosis, are triggered depending on the infected cell type. The activation of autophagy and ER
ATG4B (1,277 words) [view diff] exact match in snippet view article find links to article
the ATG4B gene. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to
ATG4D (320 words) [view diff] exact match in snippet view article find links to article
The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase. Autophagy is the process by which endogenous proteins and damaged organelles
ATG10 (592 words) [view diff] exact match in snippet view article find links to article
Autophagy-related protein 10 is a protein that in humans is encoded by the ATG10 gene. GRCh38: Ensembl release 89: ENSG00000152348 - Ensembl, May 2017
NBR1 (855 words) [view diff] exact match in snippet view article find links to article
for this gene. One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy. NBR1 has been shown to interact with FEZ1
Akt/PKB signaling pathway (4,054 words) [view diff] exact match in snippet view article find links to article
Akt promotes nuclear translocation of TFEB, lysosomal biogenesis and autophagy. Akt promotes G1-S phase cell cycle progression by phosphorylating and
ATP13A2 (697 words) [view diff] exact match in snippet view article find links to article
homeostasis • cation transport • ion transmembrane transport • regulation of autophagy of mitochondrion • regulation of autophagosome size • regulation of endopeptidase
Cathepsin A (978 words) [view diff] exact match in snippet view article find links to article
glycosphingolipid metabolic process • proteolysis • regulation of chaperone-mediated autophagy • proteolysis involved in cellular protein catabolic process • intracellular
SOGA1 (410 words) [view diff] exact match in snippet view article find links to article
Protein SOGA1 also known as SOGA family member 1 or suppressor of glucose, autophagy-associated protein 1 (SOGA1) is a protein that in humans is encoded by
HMGB1 (2,731 words) [view diff] exact match in snippet view article find links to article
cells. Under such conditions, HMGB1 promotes cell survival by sustaining autophagy through interactions with beclin-1. It is largely considered as an antiapoptotic
XBP1 (1,401 words) [view diff] exact match in snippet view article find links to article
apoptotic signaling pathway • cell differentiation • positive regulation of autophagy • cellular response to laminar fluid shear stress • positive regulation
WIPI1 (389 words) [view diff] exact match in snippet view article find links to article
aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573
Enzyme activator (574 words) [view diff] exact match in snippet view article find links to article
2018). "Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma
TP53-inducible glycolysis and apoptosis regulator (3,415 words) [view diff] exact match in snippet view article find links to article
enhances the apoptosis rate. Autophagy is when a cell digests some of its own organelles by lysosomal degradation. Autophagy is employed to remove damaged
SOGA3 (74 words) [view diff] exact match in snippet view article find links to article
Protein SOGA3 also known as suppressor of glucose, autophagy associated 3 (SOGA3) is a protein in humans that is encoded by the SOGA3 gene. GRCh38: Ensembl
V-ATPase (4,344 words) [view diff] exact match in snippet view article find links to article
acidify the endolymph of the inner ear. X-linked myopathy with excessive autophagy is a rare genetic disease resulting from mutations in the VMA21 gene.
Vici syndrome (1,422 words) [view diff] exact match in snippet view article find links to article
615068), which encodes an important regulator of the autophagy pathway, the ectopic P-granules autophagy protein 5, involved in the formation of lysosomes
HDAC6 (1,433 words) [view diff] exact match in snippet view article find links to article
2007). "HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration". Autophagy. 3 (6): 643–5. doi:10.4161/auto.5050
RAB3GAP1 (929 words) [view diff] exact match in snippet view article find links to article
rapamycin-induced autophagy in human fibroblasts and C. elegans. Further, the RAB3GAP1 knockdown has shown to affect the autophagy and mineralization
Pawan Gupta (335 words) [view diff] exact match in snippet view article find links to article
Development" (PDF). Department of Biotechnology. 2016. Retrieved 20 November 2017. "Autophagy Labs". Autophagy India Network. 15 May 2018. Retrieved 15 May 2018.
SOGA2 (1,517 words) [view diff] exact match in snippet view article find links to article
SOGA2, also known as Suppressor of glucose autophagy associated 2 or CCDC165, is a protein that in humans is encoded by the SOGA2 gene. SOGA2 has two
Sirtuin 1 (4,398 words) [view diff] exact match in snippet view article find links to article
protein. SIRT1 also stimulates autophagy by preventing acetylation of proteins (via deacetylation) required for autophagy as demonstrated in cultured cells
Fayaz A. Malik (1,602 words) [view diff] exact match in snippet view article find links to article
Hasan; Malik, Fayaz (29 September 2016). "Interplay between cell cycle and autophagy induced by boswellic acid analog". Scientific Reports. 6 (1): 33146. Bibcode:2016NatSR
PRKAA2 (950 words) [view diff] exact match in snippet view article find links to article
transcription, DNA-templated • glucose homeostasis • positive regulation of autophagy • phosphorylation • rhythmic process • lipid metabolism • response to
PEA15 (1,210 words) [view diff] exact match in snippet view article find links to article
the central nervous system, particularly in astrocytes. PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner. PEA15 has been shown to interact
KIAA1012 (432 words) [view diff] exact match in snippet view article find links to article
localization to pre-autophagosomal structure • autophagy of peroxisome • protein localization by the Cvt pathway • autophagy of nucleus • ER to Golgi vesicle-mediated
Goldilocks principle (916 words) [view diff] exact match in snippet view article find links to article
Bears". Martin, S J (August 2011). "Oncogene-induced autophagy and the Goldilocks principle". Autophagy. 7 (8): 922–3. doi:10.4161/auto.7.8.15821. PMID 21552010
GABARAP (1,637 words) [view diff] exact match in snippet view article find links to article
Moreover, GABARAP has an important function in autophagosome mediated autophagy, since it is crucial for autophagosome formation and sequestration of
Protein aggregation (2,427 words) [view diff] exact match in snippet view article find links to article
deposition. There is evidence that the proteins here may be removed by autophagy. These two pathways work together in that the proteins tend to come to
Laforin (242 words) [view diff] exact match in snippet view article find links to article
been progress made in the study by Ortolano et al. Laforin regulates autophagy via Mammalian target of rapamycin, which is impaired in Lafora disease
Chromaffin cell (1,329 words) [view diff] exact match in snippet view article find links to article
Huber, Tobias B; Schütz, Günther; Unsicker, Klaus (2013). "Cell Loss and Autophagy in the Extra-Adrenal Chromaffin Organ of Zuckerkandl are Regulated by
Internalin (264 words) [view diff] exact match in snippet view article find links to article
recognition of cellular receptors to aid in pathogen entry to escape from autophagy. Listeria poses a particular threat to pregnant women because of its ability
TLR9 (2,437 words) [view diff] exact match in snippet view article find links to article
human mitochondrial DNA. Usually, damaged mitochondria are digested via autophagy in cardiomyocytes, and mitochondrial DNA is digested by the enzyme DNase
Granule (cell biology) (662 words) [view diff] exact match in snippet view article
C.; Ricci, R. (19 February 2015). "Insulin secretory granules control autophagy in pancreatic cells". Science. 347 (6224): 878–882. doi:10.1126/science
PIKFYVE (2,957 words) [view diff] exact match in snippet view article find links to article
inhibitors cause cell death also in A-375 melanoma cells, which depend on autophagy for growth and proliferation, due to impaired lysosome homeostasis. The
WDR45 (831 words) [view diff] exact match in snippet view article find links to article
aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573
Ashitaba (644 words) [view diff] exact match in snippet view article find links to article
natural flavonoid that promotes health through autophagy-dependent and-independent effects. Autophagy, 15(9), 1662-1664. PMID 31248332 PMC 6693465 doi:10
CISD2 (618 words) [view diff] exact match in snippet view article find links to article
Germain M, Shore GC (February 2010). "Antagonism of Beclin 1-dependent autophagy by BCL-2 at the endoplasmic reticulum requires NAF-1". EMBO J. 29 (3):
WDR45L (265 words) [view diff] exact match in snippet view article find links to article
aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573
DAPK1 (1,159 words) [view diff] exact match in snippet view article find links to article
endopeptidase activity involved in apoptotic process • regulation of autophagy • negative regulation of extrinsic apoptotic signaling pathway via death
MFN2 (1,027 words) [view diff] exact match in snippet view article find links to article
inhibit mitochondrial quality control mechanisms such as mitophagy and autophagy - leading to a defect in insulin secretion and eventual beta-cell failure
TP53INP1 (639 words) [view diff] exact match in snippet view article find links to article
DNA-templated • cellular response to ethanol • positive regulation of autophagy • cellular response to methyl methanesulfonate • cellular response to
IFI16 (1,329 words) [view diff] exact match in snippet view article find links to article
ionizing radiation • negative regulation of DNA binding • regulation of autophagy • myeloid cell differentiation • intrinsic apoptotic signaling pathway
Interleukin 27 (668 words) [view diff] exact match in snippet view article find links to article
Malhotra H, Majumdar S (October 2014). "IL-27 inhibits IFN-γ induced autophagy by concomitant induction of JAK/PI3 K/Akt/mTOR cascade and up-regulation
HIF1A (5,467 words) [view diff] exact match in snippet view article find links to article
hypoxia-inducible factor signaling via an autophagy-dependent mechanism in hepatocellular carcinoma". Autophagy. 10 (1): 111–22. doi:10.4161/auto.26838
Lewy body (1,337 words) [view diff] exact match in snippet view article find links to article
(April 2008). "Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease". Autophagy. 4 (3): 372–74. doi:10.4161/auto.5604. PMID 18216494
ATM serine/threonine kinase (4,666 words) [view diff] exact match in snippet view article find links to article
involved in mitochondrial homeostasis, as a regulator of mitochondrial autophagy (mitophagy) whereby old, dysfunctional mitochondria are removed. Increased
RB1CC1 (1,036 words) [view diff] exact match in snippet view article find links to article
development • macroautophagy • autophagy • positive regulation of JNK cascade • autophagy of mitochondrion • autophagy of peroxisome • reticulophagy •
Protein kinase, AMP-activated, alpha 1 (1,160 words) [view diff] exact match in snippet view article find links to article
transcription, DNA-templated • cellular response to prostaglandin E stimulus • autophagy • protein phosphorylation • negative regulation of TOR signaling • cold
Whi2 (251 words) [view diff] exact match in snippet view article find links to article
signals about nutrient availability on to stress responsive elements and autophagy/mitophagy mechanisms. It is encoded by a 1.46 kbp gene located on chromosome
GSK3A (478 words) [view diff] exact match in snippet view article find links to article
negative regulation of insulin receptor signaling pathway • regulation of autophagy of mitochondrion • negative regulation of glycogen (starch) synthase activity
EEF2K (1,629 words) [view diff] exact match in snippet view article find links to article
"Elongation factor-2 kinase: its role in protein synthesis and autophagy". Autophagy. 2 (4): 294–6. doi:10.4161/auto.2857. PMID 16921268. Beausoleil
PTPN22 (1,595 words) [view diff] exact match in snippet view article find links to article
receptor signaling pathway • cellular response to muramyl dipeptide • autophagy • response to lipopolysaccharide • T cell differentiation • positive regulation
List of abnormal behaviours in animals (2,084 words) [view diff] exact match in snippet view article find links to article
animal, often including cannibalistic infanticide. Self-cannibalism (Autophagy, Autosarcophagy); an animal eating itself. Self-injury; an animal injuring
Filamin (281 words) [view diff] exact match in snippet view article find links to article
M, Chen J, Yang M, Pu J (February 2018). "Filamin A (FLNA) regulates autophagy of bladder carcinoma cell and affects its proliferation, invasion and
MTORC2 (3,086 words) [view diff] exact match in snippet view article find links to article
activity has been implicated in the regulation of autophagy(macroautophagy and chaperone mediated autophagy). In addition, mTORC2 has tyrosine kinase activity
STK11 (2,114 words) [view diff] exact match in snippet view article find links to article
assembly • axonogenesis • glucose homeostasis • positive regulation of autophagy • phosphorylation • negative regulation of lipid biosynthetic process
GRID2 (2,037 words) [view diff] exact match in snippet view article find links to article
"A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5):
HMGB4 (223 words) [view diff] exact match in snippet view article find links to article
II promoter • regulation of receptor activity • positive regulation of autophagy • developmental process • positive regulation of interleukin-6 production
C9orf72 (3,166 words) [view diff] exact match in snippet view article find links to article
confirm this: C9ORF72 was found to regulate endosomal trafficking and autophagy in neuronal cells and primary neurons. This suggests that certain aspects
GABARAPL2 (1,098 words) [view diff] exact match in snippet view article find links to article
(2015-06-18). "Regulation of endoplasmic reticulum turnover by selective autophagy". Nature. 522 (7556): 354–358. doi:10.1038/nature14498. ISSN 0028-0836
FUNDC1 (441 words) [view diff] exact match in snippet view article find links to article
• mitochondrial outer membrane Biological process • autophagy • response to hypoxia • autophagy of mitochondrion • response to organonitrogen compound
STX17 (398 words) [view diff] exact match in snippet view article find links to article
organization • protein localization to pre-autophagosomal structure • autophagy • ER to Golgi vesicle-mediated transport • vesicle docking • autophagosome
ROCK1 (2,197 words) [view diff] exact match in snippet view article find links to article
pathway • aortic valve morphogenesis • regulation of autophagy • positive regulation of autophagy • positive regulation of cardiac muscle hypertrophy •
EEF1A2 (958 words) [view diff] exact match in snippet view article find links to article
positive regulation of apoptotic process • regulation of chaperone-mediated autophagy • translational elongation • positive regulation of lipid kinase activity
WDR24 (406 words) [view diff] exact match in snippet view article find links to article
process • cellular response to amino acid starvation • regulation of autophagyautophagy • positive regulation of TOR signaling Sources:Amigo / QuickGO
Ghanshyam Swarup (1,044 words) [view diff] exact match in snippet view article find links to article
involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy". PLoS ONE. 9 (4): e95758. doi:10.1371/journal.pone.0095758. PMC 3994150
RRAGA (605 words) [view diff] exact match in snippet view article find links to article
response to amino acid stimulus • viral process • negative regulation of autophagy • positive regulation of TOR signaling • apoptotic process • protein ubiquitination
60S ribosomal protein L28 (806 words) [view diff] exact match in snippet view article find links to article
SRP-dependent cotranslational protein targeting to membrane • regulation of autophagy of mitochondrion • translational initiation • nuclear-transcribed mRNA
USP13 (446 words) [view diff] exact match in snippet view article find links to article
process • positive regulation of ERAD pathway • proteolysis • autophagy • regulation of autophagy • protein K63-linked deubiquitination • maintenance of unfolded
RAB39B (452 words) [view diff] exact match in snippet view article find links to article
synapse organization • vesicle-mediated transport • regulation of autophagyautophagy • intracellular protein transport • Rab protein signal transduction
USP13 (446 words) [view diff] exact match in snippet view article find links to article
process • positive regulation of ERAD pathway • proteolysis • autophagy • regulation of autophagy • protein K63-linked deubiquitination • maintenance of unfolded
Transmembrane protein 150b (163 words) [view diff] exact match in snippet view article find links to article
the TMEM150B gene. The protein belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results
Tectonin beta-propeller repeat containing 1 (122 words) [view diff] exact match in snippet view article find links to article
by the TECPR1 gene. This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting
RAB8A (1,069 words) [view diff] exact match in snippet view article find links to article
neurotransmitter receptor transport to postsynaptic membrane • regulation of autophagyautophagy • post-translational modification • regulation of exocytosis • transport
Harmol (207 words) [view diff] exact match in snippet view article find links to article
by O-demethylation of harmine. Abe A, Kokuba H (2013). "Harmol induces autophagy and subsequent apoptosis in U251MG human glioma cells through the downregulation
TPCN2 (691 words) [view diff] exact match in snippet view article find links to article
homeostasis • ion transport • ion transmembrane transport • regulation of autophagy • calcium ion transmembrane transport • lysosome organization • calcium-mediated
TPCN1 (697 words) [view diff] exact match in snippet view article find links to article
membrane depolarization during action potential • positive regulation of autophagy • regulation of ion transmembrane transport • ion transport • ion transmembrane
EIF4G2 (1,104 words) [view diff] exact match in snippet view article find links to article
translation • regulation of translational initiation • negative regulation of autophagy • positive regulation of cell growth • cellular macromolecule biosynthetic
GRID1 (669 words) [view diff] exact match in snippet view article find links to article
"A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. 35 (5):
SH3GLB1 (736 words) [view diff] exact match in snippet view article find links to article
positive regulation of autophagosome assembly • positive regulation of autophagy • positive regulation of protein targeting to mitochondrion • cellular
WDFY3 (632 words) [view diff] exact match in snippet view article find links to article
some variants has not been defined. This protein appears to act as a autophagy scaffolding protein. Mutations in this gene have been associated with
CHMP4B (690 words) [view diff] exact match in snippet view article find links to article
negative regulation of cell death • regulation of mitotic spindle assembly • autophagy • endosomal transport • posttranslational protein targeting to endoplasmic
Markus Rüegg (583 words) [view diff] exact match in snippet view article find links to article
multi-protein complex mTORC1 is an important regulator of muscle growth and autophagy, a cellular self-cleaning process. These findings may help to counteract
RGS19 (1,557 words) [view diff] exact match in snippet view article find links to article
Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells". J. Biol. Chem. 275 (50): 39090–5. doi:10
FOXO1 (3,321 words) [view diff] exact match in snippet view article find links to article
protein catabolic process • glucose homeostasis • positive regulation of autophagy • cellular glucose homeostasis • cellular response to hyperoxia • regulation
EIF2AK4 (483 words) [view diff] exact match in snippet view article find links to article
response to endoplasmic reticulum stress • induction by virus of host autophagy • autophosphorylation • cell cycle • negative regulation by host of viral
PIK3C3 (861 words) [view diff] exact match in snippet view article find links to article
starvation • protein lipidation • autophagy • autophagosome assembly • protein phosphorylation • endocytosis • autophagy of peroxisome • phosphatidylinositol-mediated
Cyclin D (4,547 words) [view diff] exact match in snippet view article find links to article
increased cell survival, induction of chromosomal instability, restraint of autophagy and potentially non-canonical functions. Overexpression is induced as
FZD5 (788 words) [view diff] exact match in snippet view article find links to article
receptor signaling pathway • vasculature development • regulation of autophagy of mitochondrion • branching involved in labyrinthine layer morphogenesis
Fig4 (2,523 words) [view diff] exact match in snippet view article find links to article
juvenile lethality, hence the name pale tremor mouse (plt). Neuronal autophagy has been suggested as an important consequence of the knockout, however
EI24 (499 words) [view diff] exact match in snippet view article find links to article
Identifiers Aliases EI24, EPG4, PIG8, TP53I8, autophagy associated transmembrane protein, EI24 autophagy associated transmembrane protein External IDs
ACER2 (389 words) [view diff] exact match in snippet view article find links to article
by integrin • cellular response to DNA damage stimulus • regulation of autophagy • DNA damage response, signal transduction by p53 class mediator • regulation
EIF4G3 (1,067 words) [view diff] exact match in snippet view article find links to article
protein biosynthesis • regulation of translation • regulation of translational initiation • negative regulation of autophagy Sources:Amigo / QuickGO
CVT (253 words) [view diff] exact match in snippet view article find links to article
Coordinated Video Timings, specified by VESA Cytoplasm-to-vacuole targeting, a autophagy-related pathway in yeast Compound Value Type, a type within Freebase which
Protease inhibitor (pharmacology) (917 words) [view diff] exact match in snippet view article
Broad-Spectrum, Anticancer Agent that Induces Endoplasmic Reticulum Stress, Autophagy, and Apoptosis In vitro and In vivo". Clinical Cancer Research. 13 (17):
Kitten (3,647 words) [view diff] exact match in snippet view article find links to article
Maloy, K. J. (2016). The mucosal immune system and its regulation by autophagy. Frontiers in immunology, 7. Case, L. P., Daristotle, L., Hayek, M. G
PLK2 (737 words) [view diff] exact match in snippet view article find links to article
positive regulation of protein catabolic process • positive regulation of autophagy • phosphorylation • mitotic cell cycle checkpoint • G1 phase • mitotic
USP10 (990 words) [view diff] exact match in snippet view article find links to article
ubiquitin-dependent protein catabolic process • proteolysis • autophagy • regulation of autophagy • translesion synthesis • cellular response to interleukin-1
PLK2 (737 words) [view diff] exact match in snippet view article find links to article
positive regulation of protein catabolic process • positive regulation of autophagy • phosphorylation • mitotic cell cycle checkpoint • G1 phase • mitotic
CD84 (1,273 words) [view diff] exact match in snippet view article find links to article
activation • leukocyte migration • homophilic cell adhesion via plasma membrane adhesion molecules • immune system process • autophagy Sources:Amigo / QuickGO
PIK3CB (940 words) [view diff] exact match in snippet view article find links to article
signaling pathway • embryonic cleavage • endocytosis • positive regulation of autophagy • Fc-gamma receptor signaling pathway involved in phagocytosis • transmembrane
Coxiella burnetii (1,255 words) [view diff] exact match in snippet view article find links to article
burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis". PLoS Pathogens. 10 (7): e1004286. doi:10.1371/journal
Bupleurum chinense (426 words) [view diff] exact match in snippet view article find links to article
anticancer effects via autophagy induction. See linked article for reviews of the pharmacological findings for the roles of autophagy in the pharmacological
Farnesyltransferase inhibitor (1,079 words) [view diff] exact match in snippet view article find links to article
this represents a completely novel mechanism to evaluate in people. If autophagy mechanisms in humans are similar as those of mice, then there is much
Protein DEPP (391 words) [view diff] exact match in snippet view article find links to article
DEPP, FIG, Fseg, chromosome 10 open reading frame 10, autophagy regulator, C10orf10, DEPP1 autophagy regulator External IDs OMIM: 611309 MGI: 1918730 HomoloGene:
NUPR1 (851 words) [view diff] exact match in snippet view article find links to article
nucleic acid-templated transcription • regulation of autophagy • negative regulation of autophagy • negative regulation of cardiac muscle cell apoptotic
TRIB3 (1,088 words) [view diff] exact match in snippet view article find links to article
process • regulation of lipid metabolic process • negative regulation of protein kinase B signaling • regulation of autophagy Sources:Amigo / QuickGO
Senotherapy (1,380 words) [view diff] exact match in snippet view article find links to article
Nektarios; Minois, Nadege; Kroemer, Guido; Madeo, Frank (2009). "Induction of autophagy by spermidine promotes longevity". Nature Cell Biology. 11 (11): 1305–14
DAPK2 (683 words) [view diff] exact match in snippet view article find links to article
phosphorylation • positive regulation of eosinophil chemotaxis • regulation of autophagy • anoikis • positive regulation of neutrophil chemotaxis • autophosphorylation
Acetyl-coenzyme A transporter 1 (619 words) [view diff] exact match in snippet view article find links to article
Puglielli L (August 2012). "SLC33A1/AT-1 protein regulates the induction of autophagy downstream of IRE1/XBP1 pathway". The Journal of Biological Chemistry
DAPK3 (834 words) [view diff] exact match in snippet view article find links to article
extrinsic apoptotic signaling pathway in absence of ligand • regulation of autophagy • neuron differentiation • regulation of mitotic cell cycle • regulation
TMEM49 (498 words) [view diff] exact match in snippet view article find links to article
(2008). "The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells". J. Biol. Chem. 282 (51): 37124–33. doi:10.1074/jbc
HDAC10 (640 words) [view diff] exact match in snippet view article find links to article
deacetylation • spermidine deacetylation • DNA repair • DNA recombination • autophagy • cellular response to DNA damage stimulus Sources:Amigo / QuickGO
FOXK2 (609 words) [view diff] exact match in snippet view article find links to article
polymerase II promoter • cellular glucose homeostasis • negative regulation of autophagy • regulation of glucose metabolic process • response to starvation • negative
GOPC (1,190 words) [view diff] exact match in snippet view article find links to article
"A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice". Neuron. United States
Ullrich congenital muscular dystrophy (853 words) [view diff] exact match in snippet view article find links to article
Bonaldo, Paolo (2013-05-01). "Mitochondrial Dysfunction and Defective Autophagy in the Pathogenesis of Collagen VI Muscular Dystrophies". Cold Spring
Necrosis (2,867 words) [view diff] exact match in snippet view article find links to article
Thompson CB; Thompson (2004). "Death by design: apoptosis, necrosis and autophagy". Curr. Opin. Cell Biol. 16 (6): 663–9. doi:10.1016/j.ceb.2004.09.011
Integrin beta 4 (1,450 words) [view diff] exact match in snippet view article find links to article
nail development • cell motility • extracellular matrix organization • autophagy • cell communication • cell adhesion • response to wounding • mesodermal
Intracellular parasite (1,088 words) [view diff] exact match in snippet view article find links to article
Staphylococcus aureus Modulates Host Central Carbon Metabolism To Activate Autophagy". American Society for Microbiology. doi:10.1128/mSphere.00374-18. Sebghati
Folliculin (5,357 words) [view diff] exact match in snippet view article find links to article
(October 2014). "FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation". Autophagy. 10 (10): 1749–60. doi:10.4161/auto
Rosenstiel Award (921 words) [view diff] exact match in snippet view article find links to article
molecular pathways and biological functions of protein degradation by autophagy 2014 Frederick Alt, in recognition of his pioneering work in elucidating
Rifampicin (4,350 words) [view diff] exact match in snippet view article find links to article
inhibiting mycolate synthesis) and ambroxol (through host directed effects in autophagy and pharmacokinetics). Rifampicin inhibits bacterial DNA-dependent RNA
Rosenstiel Award (921 words) [view diff] exact match in snippet view article find links to article
molecular pathways and biological functions of protein degradation by autophagy 2014 Frederick Alt, in recognition of his pioneering work in elucidating
NLRP6 (314 words) [view diff] exact match in snippet view article find links to article
kinase/NF-kappaB signaling • negative regulation of immune response • regulation of autophagy • negative regulation of toll-like receptor signaling pathway • negative
Organ of Zuckerkandl (580 words) [view diff] exact match in snippet view article find links to article
Huber, Tobias B.; Schütz, Günther; Unsicker, Klaus (2013). "Cell Loss and Autophagy in the Extra-Adrenal Chromaffin Organ of Zuckerkandl are Regulated by
PLK3 (1,185 words) [view diff] exact match in snippet view article find links to article
transduction by p53 class mediator • positive regulation of chaperone-mediated autophagy • G1/S transition of mitotic cell cycle • mitotic cell cycle Sources:Amigo
SNAP29 (1,286 words) [view diff] exact match in snippet view article find links to article
vesicle fusion to presynaptic active zone membrane • Lipid bilayer fusion • autophagy • autophagosome maturation • cell projection organization • synaptic vesicle
MARK2 (1,112 words) [view diff] exact match in snippet view article find links to article
axonogenesis • multicellular organism development • protein phosphorylation • autophagy of mitochondrion • establishment or maintenance of epithelial cell apical/basal
TMEM59 (769 words) [view diff] exact match in snippet view article find links to article
extracellular exosome Biological process • positive regulation of autophagy • proteolysis • autophagy • negative regulation of protein glycosylation in Golgi •
GOLGA2 (1,636 words) [view diff] exact match in snippet view article find links to article
Chakravarty P, Judith D, Tooze SA (2015). "Activation of ULK Kinase and Autophagy by GABARAP Trafficking from the Centrosome Is Regulated by WAC and GM130"
Chromosome 19 (2,342 words) [view diff] exact match in snippet view article find links to article
protein Armadillo repeat-containing protein 6 ATG4D: encoding protein Autophagy related 4D, cysteine peptidase ATP5SL: encoding protein ATP synthase subunit
Butyric acid (4,397 words) [view diff] exact match in snippet view article find links to article
(colonocytes). Without butyric acid for energy, colon cells undergo upregulated autophagy (i.e., self-digestion). Butyrate produces different effects in healthy
ABL (gene) (3,249 words) [view diff] exact match in snippet view article
positive regulation of microtubule binding • cell adhesion • regulation of autophagy • peptidyl-tyrosine autophosphorylation • alpha-beta T cell differentiation
Optineurin (1,401 words) [view diff] exact match in snippet view article find links to article
death • negative regulation of I-kappaB kinase/NF-kappaB signaling • autophagy • cellular protein localization • G2/M transition of mitotic cell cycle
HADHB (1,784 words) [view diff] exact match in snippet view article find links to article
Sowa ME, Gygi SP, Harper JW (2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. doi:10.1038/nature09204. PMC 2901998
PIK3R4 (544 words) [view diff] exact match in snippet view article find links to article
Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages". Nat. Cell Biol. 11 (4): 385–96. doi:10.1038/ncb1846
Bcl-2 (4,605 words) [view diff] exact match in snippet view article find links to article
metanephros development • melanocyte differentiation • negative regulation of autophagy • positive regulation of neuron maturation • negative regulation of myeloid
VDAC1 (3,999 words) [view diff] exact match in snippet view article find links to article
(VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy". The Journal of Biological Chemistry. 287 (48): 40652–60. doi:10.1074/jbc
Protein kinase D1 (1,275 words) [view diff] exact match in snippet view article find links to article
RNA polymerase II promoter • apoptotic process • positive regulation of autophagy • cellular response to amino acid starvation • positive regulation of
ITPR1 (1,603 words) [view diff] exact match in snippet view article find links to article
signaling pathway in response to endoplasmic reticulum stress • regulation of autophagy • transmembrane transport • calcium ion transmembrane transport • negative
Endosome (2,436 words) [view diff] exact match in snippet view article find links to article
913. PMC 2133374. PMID 8922376. Fader CM, Colombo MI (January 2009). "Autophagy and multivesicular bodies: two closely related partners". Cell Death and
Sterol regulatory element-binding protein 2 (1,429 words) [view diff] exact match in snippet view article find links to article
polymerase II promoter • transcription, DNA-templated • regulation of autophagy of mitochondrion • negative regulation of cholesterol efflux • positive
Kiaa0226 like (331 words) [view diff] exact match in snippet view article find links to article
beclin 1 interacting protein like, PACER, rubicon like autophagy regulator, rubicon like autophagy enhancer External IDs MGI: 2685590 HomoloGene: 57021
Gaba type a receptor associated protein like 1 (608 words) [view diff] exact match in snippet view article find links to article
M, Boyer-Guittaut M (2011). "GABARAPL1 (GEC1): original or copycat?". Autophagy. 7 (10): 1098–107. doi:10.4161/auto.7.10.15904. PMID 21597319. Rozenknop
Eukaryotic translation initiation factor 4 gamma 1 (1,633 words) [view diff] exact match in snippet view article find links to article
• positive regulation of cell proliferation • negative regulation of autophagy • negative regulation of peptidyl-threonine phosphorylation • positive
Hydroxyflutamide (455 words) [view diff] exact match in snippet view article find links to article
effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: Differential effects
Interleukin 10 receptor, alpha subunit (1,290 words) [view diff] exact match in snippet view article find links to article
organization • cytokine-mediated signaling pathway • negative regulation of autophagy • positive regulation of JAK-STAT cascade • ubiquitin-dependent endocytosis
Ormeloxifene (1,152 words) [view diff] exact match in snippet view article find links to article
breast activity of ormeloxifene is mediated via induction of apoptosis and autophagy. 37th annual conference of the endocrine society of India. 30 nov-2 dec
Glucocerebrosidase (1,920 words) [view diff] exact match in snippet view article find links to article
positive regulation of neuronal action potential • positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization • autophagosome
Alpha-1A adrenergic receptor (1,323 words) [view diff] exact match in snippet view article find links to article
concentration • positive regulation of vasoconstriction • negative regulation of autophagy • positive regulation of cardiac muscle hypertrophy • positive regulation
Maureen Murphy (scientist) (397 words) [view diff] exact match in snippet view article
human and murine ARF tumor suppressor protein is required for autophagy induction. Autophagy 2013; Aug 7;9(10). Murphy ME. The HSP70 family and cancer. Carcinogenesis
Bcl-2 homologous antagonist killer (2,571 words) [view diff] exact match in snippet view article find links to article
death pathway initiated by photodamage to the endoplasmic reticulum". Autophagy. 2 (3): 238–40. doi:10.4161/auto.2730. PMID 16874066. Mignard V, Lalier
RALB (1,583 words) [view diff] exact match in snippet view article find links to article
RalB specifically interacts with Exo84 to assemble the beclin-1–VPS34 autophagy initiation complex, and with Sec5 to activate the innate immune response
Breakthrough Prize in Life Sciences (1,691 words) [view diff] exact match in snippet view article find links to article
biology. Yoshinori Ohsumi, Tokyo Institute of Technology, for elucidating autophagy, the recycling system that cells use to generate nutrients from their
Ectodysplasin A (1,148 words) [view diff] exact match in snippet view article find links to article
1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes". Nature Communications. 7: 11942. Bibcode:2016NatCo
CLTC (1,046 words) [view diff] exact match in snippet view article find links to article
cell polarity pathway • regulation of mitotic spindle organization • autophagy • microtubule-based movement • cell cycle • cell division • membrane organization
CSNK2A2 (666 words) [view diff] exact match in snippet view article find links to article
transcription, DNA-templated • protein phosphorylation • regulation of autophagy of mitochondrion • cell cycle • apoptotic process • regulation of signal
TRIM5alpha (1,636 words) [view diff] exact match in snippet view article find links to article
transcription factor activity • regulation of protein localization • autophagy • positive regulation of NF-kappaB transcription factor activity • defense
ALS Association (1,249 words) [view diff] exact match in snippet view article find links to article
C.; Collins, Mark O. (2017-02-02). "TBK1: a new player in ALS linking autophagy and neuroinflammation". Molecular Brain. 10 (1): 5. doi:10.1186/s13041-017-0287-x
Interferon type II (1,142 words) [view diff] exact match in snippet view article find links to article
direct to the growth inhibition or cell death, and apoptosis through autophagy Interferon gamma Kosmidis C., Sapalidis K., Koletsa T., Kosmidou M., Efthimiadis
PIM2 (gene) (1,887 words) [view diff] exact match in snippet view article
apoptotic process • apoptotic mitochondrial changes • positive regulation of autophagy • positive regulation of macroautophagy • negative regulation of protein
Nelfinavir (1,461 words) [view diff] exact match in snippet view article find links to article
broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo". Clinical Cancer Research. 13 (17):
Viroplasm (1,650 words) [view diff] exact match in snippet view article find links to article
1016/0042-6822(80)90105-1. PMID 18631647. Wileman T (May 2006). "Aggresomes and autophagy generate sites for virus replication". Science. 312 (5775): 875–8. Bibcode:2006Sci
FOXO3 (1,938 words) [view diff] exact match in snippet view article find links to article
migration • insulin receptor signaling pathway • positive regulation of autophagy • positive regulation of muscle atrophy • response to starvation Sources:Amigo
Japan Academy Prize (academics) (1,357 words) [view diff] exact match in snippet view article
Molecules Yoshinori Ohsumi -Molecular Mechanism and Physiological Function of Autophagy Atsuto Suzuki -Studies of Antineutrino Science Ken Sakamura -Research
Nutrient sensing (1,414 words) [view diff] exact match in snippet view article find links to article
mediates histone H3 hypermethylation (H3R17me2), leading to enhanced autophagy. In addition, O-GlcNAc transferase (OGT) signals glucose availability
LAMP1 (2,064 words) [view diff] exact match in snippet view article find links to article
Eskelinen EL (2006). "Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy". Molecular Aspects of Medicine. 27 (5–6): 495–502. doi:10.1016/j.mam
Graphene quantum dot (1,952 words) [view diff] exact match in snippet view article find links to article
studies observe a distinct decrease of cell viability and the induction of autophagy after exposure of the cells to GQDs and one in vivo study in zebrafish
DCAF17 (394 words) [view diff] exact match in snippet view article find links to article
Sowa ME, Gygi SP, Harper JW (2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. doi:10.1038/nature09204. PMC 2901998
ABL2 (1,434 words) [view diff] exact match in snippet view article find links to article
phosphorylation • innate immune system • signal transduction • regulation of autophagy • regulation of endocytosis • regulation of cell adhesion • cell differentiation
Kinase (3,774 words) [view diff] exact match in snippet view article find links to article
Shokat, K. M.; Williams, R. L. (25 March 2010). "Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34". Science. 327
Arylsulfatase B (1,877 words) [view diff] exact match in snippet view article find links to article
to nutrient • post-translational modification • response to estrogen • autophagy • regulation of epithelial cell migration • central nervous system development
FBXO7 (1,430 words) [view diff] exact match in snippet view article find links to article
to mitochondrion • negative regulation of lymphocyte differentiation • autophagy of mitochondrion • regulation of protein stability • negative regulation
XPA (1,386 words) [view diff] exact match in snippet view article find links to article
repair • UV protection • protein localization to nucleus • regulation of autophagy • nucleotide-excision repair, DNA duplex unwinding • nucleotide-excision
FBXO7 (1,430 words) [view diff] exact match in snippet view article find links to article
to mitochondrion • negative regulation of lymphocyte differentiation • autophagy of mitochondrion • regulation of protein stability • negative regulation
Frontotemporal dementia (3,597 words) [view diff] exact match in snippet view article find links to article
CYLD, OPTN, SQSTM1 and TBK1. These genes have been implicated in the autophagy pathway. No genetic causes of FUS pathology in FTD have yet been reported
Ubiquitin carboxy-terminal hydrolase L1 (2,578 words) [view diff] exact match in snippet view article find links to article
K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system". Cellular and Molecular Life Sciences. 72 (9): 1811–24
MCL1 (898 words) [view diff] exact match in snippet view article find links to article
apoptotic process • protein transmembrane transport • negative regulation of autophagy • intrinsic apoptotic signaling pathway in response to DNA damage • negative
Osteoclast (2,750 words) [view diff] exact match in snippet view article find links to article
Laëtitia (2015). "Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases". International Journal of Environmental Research
NHLRC1 (447 words) [view diff] exact match in snippet view article find links to article
• cytosol • endoplasmic reticulum • cell nucleus Biological process • autophagy • protein polyubiquitination • glycogen biosynthetic process • positive
DHRSX (387 words) [view diff] exact match in snippet view article find links to article
Cellular component • extracellular region Biological process • oxidation-reduction process • positive regulation of autophagy Sources:Amigo / QuickGO
PLEKHM1 (573 words) [view diff] exact match in snippet view article find links to article
nucleolus • intracellular membrane-bounded organelle Biological process • autophagy • protein transport • intracellular signal transduction • lysosome localization
EVA1A (205 words) [view diff] exact match in snippet view article find links to article
(August 2007). "TMEM166, a novel transmembrane protein, regulates cell autophagy and apoptosis". Apoptosis. 12 (8): 1489–502. doi:10.1007/s10495-007-0073-9
Sirtuin 2 (3,637 words) [view diff] exact match in snippet view article find links to article
cell cycle • positive regulation of DNA binding • negative regulation of autophagy • cellular response to hypoxia • negative regulation of cell proliferation
FIS1 (1,699 words) [view diff] exact match in snippet view article find links to article
(2008). "High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1777 (7–8): 860–6
Parkinson's disease (14,696 words) [view diff] exact match in snippet view article find links to article
2015). "Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease". Autophagy. 11 (9): 1443–57. doi:10.1080/15548627.2015.1067364
Vesicle (biology and chemistry) (3,091 words) [view diff] exact match in snippet view article
also used to destroy defective or damaged organelles in a process called autophagy. They fuse with the membrane of the damaged organelle, digesting it. Transport
PARK7 (1,812 words) [view diff] exact match in snippet view article find links to article
regulation of hydrogen peroxide-induced cell death • positive regulation of autophagy of mitochondrion • response to hydrogen peroxide • detoxification of copper
NPRL2 (415 words) [view diff] exact match in snippet view article find links to article
phosphorylation • cellular response to nitrogen starvation • positive regulation of autophagy • regulation of autophagosome assembly Sources:Amigo / QuickGO
Stress granule (12,886 words) [view diff] exact match in snippet view article find links to article
C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy". Nature Communications. 9 (1): 2794. Bibcode:2018NatCo...9.2794C. doi:10
RHEB (2,608 words) [view diff] exact match in snippet view article find links to article
is a protein kinase that begins a phosphorylation cascade leading to autophagy. In rat studies, RHEB activates AMPK. RHEB has also been found to interact
Sterol regulatory element-binding protein 1 (2,112 words) [view diff] exact match in snippet view article find links to article
• response to lipid • cellular response to fatty acid • regulation of autophagy of mitochondrion • regulation of protein targeting to mitochondrion •
IRF8 (2,290 words) [view diff] exact match in snippet view article find links to article
of transcription from RNA polymerase II promoter • cellular response to interferon-gamma • autophagy • immune system process Sources:Amigo / QuickGO
Leptin receptor (1,961 words) [view diff] exact match in snippet view article find links to article
reserve metabolic process • response to leptin • negative regulation of autophagy • regulation of bone remodeling • phagocytosis • positive regulation of
Calcium signaling (2,153 words) [view diff] exact match in snippet view article find links to article
unfolded protein response, can cause ER associated degradation (ERAD) and autophagy. Ca2+ influx during fertilization has been observed in many species as
Rotavirus (9,441 words) [view diff] exact match in snippet view article find links to article
by NSP4 acting as a viroporin. This increase in calcium ions leads to autophagy (self destruction) of the infected enterocytes. NSP4 is also secreted
SBF2 (629 words) [view diff] exact match in snippet view article find links to article
perinuclear region of cytoplasm Biological process • regulation of GTPase activity • myelination • protein tetramerization • autophagy Sources:Amigo / QuickGO
Cyclin-dependent kinase 7 (2,081 words) [view diff] exact match in snippet view article find links to article
covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma". Cancer Letters. 471: 27–37
Neuroimmunology (2,707 words) [view diff] exact match in snippet view article find links to article
"HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS". Nature. 447 (7146): 859–863. doi:10.1038/nature05853. PMID 17568747
Class III PI 3-kinase (479 words) [view diff] exact match in snippet view article find links to article
calmodulin in vivo are not understood. Vps34 activity is required for autophagy in yeast, and has been strongly implicated in this process in mammals
MID2 (784 words) [view diff] exact match in snippet view article find links to article
extracellular exosome • cytoskeleton Biological process • positive regulation of autophagy • positive regulation of sequence-specific DNA binding transcription factor
SUPT20H (583 words) [view diff] exact match in snippet view article find links to article
• SAGA complex • cell nucleus • fibrillar center Biological process • autophagy • multicellular organism development • gastrulation • regulation of nucleic
MAP1S (648 words) [view diff] exact match in snippet view article find links to article
• regulation of chromatin disassembly • nervous system development • autophagy • brain development • microtubule bundle formation • mitochondrion transport
Ubiquilin 4 (257 words) [view diff] exact match in snippet view article find links to article
• cell nucleus • chromosome • site of DNA damage Biological process • autophagy • negative regulation of autophagosome maturation • regulation of proteasomal
Apelin (3,173 words) [view diff] exact match in snippet view article find links to article
by activating an AMPK-dependent mitochondria biogenesis, it promotes autophagy and decreases inflammation in aged mice. Moreover, apelin receptor is
Eukaryotic translation elongation factor 1 alpha 1 (2,607 words) [view diff] exact match in snippet view article find links to article
to epidermal growth factor stimulus • regulation of chaperone-mediated autophagy • protein biosynthesis • protein methylation • neutrophil degranulation
PIP4K2C (111 words) [view diff] exact match in snippet view article find links to article
phosphorylation • phosphatidylinositol phosphorylation • regulation of autophagy • phosphatidylinositol biosynthetic process • regulation of phosphatidylinositol
Glial fibrillary acidic protein (3,055 words) [view diff] exact match in snippet view article find links to article
proliferation • long-term synaptic potentiation • regulation of chaperone-mediated autophagy • intermediate filament organization Sources:Amigo / QuickGO
VDAC3 (2,521 words) [view diff] exact match in snippet view article find links to article
(VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy". The Journal of Biological Chemistry. 287 (48): 40652–60. doi:10.1074/jbc
Mitochondrion (15,623 words) [view diff] exact match in snippet view article find links to article
selective fusion govern mitochondrial segregation and elimination by autophagy". The EMBO Journal. 27 (2): 433–446. doi:10.1038/sj.emboj.7601963. PMC 2234339
TOLLIP (1,137 words) [view diff] exact match in snippet view article find links to article
• cell-cell signaling • positive regulation of protein sumoylation • autophagy • protein localization to endosome • innate immune system • inflammatory
VDAC2 (2,597 words) [view diff] exact match in snippet view article find links to article
(VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy". The Journal of Biological Chemistry. 287 (48): 40652–60. doi:10.1074/jbc
Wiley Prize (1,118 words) [view diff] exact match in snippet view article find links to article
how cells recycle their components in an orderly manner. This process, autophagy (self-eating), is critical for the maintenance and repair of cells and
SR9009 (329 words) [view diff] exact match in snippet view article find links to article
muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy". Nat. Med. 19 (8): 1039–46. doi:10.1038/nm.3213. PMC 3737409. PMID 23852339
VPS18 (614 words) [view diff] exact match in snippet view article find links to article
Biological process • endosome to lysosome transport • endosome organization • autophagy • protein transport • viral entry • intracellular protein transport •
TRIM14 (1,267 words) [view diff] exact match in snippet view article find links to article
nucleus. TRIM14 acts in cell proliferation, differentiation, morphogenesis, autophagy and in the initiation of the anti-viral immune response by innate immunity
Max Planck Institute for Biology of Ageing (764 words) [view diff] exact match in snippet view article find links to article
Metabolic and Genetic Regulation of Ageing (Martin Denzel/ Research Group) Autophagy Regulation (Martin Graef/ Max Planck Research Group) ADP-ribosylation
NRBF2 (496 words) [view diff] exact match in snippet view article find links to article
DNA-templated • response to endoplasmic reticulum stress • transcription, DNA-templated • regulation of lipid kinase activity • autophagy Sources:Amigo / QuickGO
Dopamine receptor D3 (2,669 words) [view diff] exact match in snippet view article find links to article
transmission, dopaminergic • G-protein coupled receptor signaling pathway • autophagy • negative regulation of apoptotic process • regulation of neurotransmitter
NCOA4 (1,589 words) [view diff] exact match in snippet view article find links to article
Triantafellow E, et al. (November 2014). "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis
Metal–organic framework (17,278 words) [view diff] exact match in snippet view article find links to article
group performed in vitro studies and determined that "the autophagy-related proteins and autophagy flux in HeLa cells treated with 3-MA@ZIF-8 NPs show that
Ionophore (1,884 words) [view diff] exact match in snippet view article find links to article
hepatitis C virus replication by chloroquine targeting virus-associated autophagy". Journal of Gastroenterology. 45 (2): 195–203. doi:10.1007/s00535-009-0132-9
Institute of Molecular Biotechnology (796 words) [view diff] exact match in snippet view article find links to article
Fumiyo Ikeda: Linear ubiquitination in inflammation, cell death and autophagy. Jürgen Knoblich: Brain development and disease. Bon-Kyoung Koo: Homeostatic
Cathepsin K (1,724 words) [view diff] exact match in snippet view article find links to article
• proteolysis • toll-like receptor signaling pathway • regulation of autophagy of mitochondrion • collagen catabolic process • proteolysis involved in
TRIM22 (586 words) [view diff] exact match in snippet view article find links to article
• regulation of transcription, DNA-templated • positive regulation of autophagy • interferon-gamma-mediated signaling pathway • protein trimerization
VPS11 (625 words) [view diff] exact match in snippet view article find links to article
protein targeting to mitochondrion • endosome to lysosome transport • autophagy • positive regulation of early endosome to late endosome transport • protein
PTEN (gene) (3,333 words) [view diff] exact match in snippet view article
Xu XM (2012). "Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury". PLOS One
Annexin A7 (1,162 words) [view diff] exact match in snippet view article find links to article
homeostasis • Lipid bilayer fusion • negative regulation of gene expression • autophagy • response to calcium ion • regulation of cell shape • social organism
Systems biology (4,267 words) [view diff] exact match in snippet view article find links to article
Iman (2015). Dynamics of Cell Fate Decision Mediated by the Interplay of Autophagy and Apoptosis in Cancer Cells. Springer Theses. Springer International
Lacritin (4,270 words) [view diff] exact match in snippet view article find links to article
Lacritin promotes survival and homeostasis by transiently stimulating autophagy. The mechanism appears to involve lacritin stimulated acetylation of the
PGA5 (744 words) [view diff] exact match in snippet view article find links to article
lumen Biological process • cellular protein metabolic process • digestion • protein catabolic process • proteolysis • autophagy Sources:Amigo / QuickGO
List of Nobel laureates affiliated with the University of Tokyo (873 words) [view diff] exact match in snippet view article find links to article
graduate Faculty (1977-1996) "for his discoveries of mechanisms for autophagy". 2018 Tasuku Honjo Assistant Professor (1974-1979) "for their discovery
Honokiol (2,840 words) [view diff] exact match in snippet view article find links to article
Chang, K. H.; Yan, M. D. (Nov 2013). "Honokiol-induced apoptosis and autophagy in glioblastoma multiforme cells". Oncology Letters. 6 (5): 1435–1438
GSK3B (1,750 words) [view diff] exact match in snippet view article find links to article
exocytosis • neuron projection organization • positive regulation of autophagy • regulation of circadian rhythm • regulation of long-term synaptic potentiation