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searching for Autoantibody 168 found (240 total)

Demyelinating disease (2,701 words) [view diff] no match in snippet view article find links to article

A demyelinating disease refers to any disease affecting the nervous system where the myelin sheath surrounding neurons is damaged. This damage disrupts

Encephalomyelitis (302 words) [view diff] exact match in snippet view article find links to article

phenotype neuromyelitis optica and in general all the spectrum of MOG autoantibody-associated demyelinating diseases. Eastern equine encephalitis, Japanese

Latent autoimmune diabetes in adults (3,080 words) [view diff] exact match in snippet view article find links to article

decarboxylase autoantibodies (GADA), islet cell autoantibodies (ICA), insulinoma-associated (IA-2) autoantibodies, and zinc transporter autoantibodies (ZnT8)

Antithyroid autoantibodies (1,515 words) [view diff] exact match in snippet view article find links to article

Antithyroid autoantibodies (or simply antithyroid antibodies) are autoantibodies targeted against one or more components on the thyroid. The most clinically

Cold sensitive antibodies (1,683 words) [view diff] exact match in snippet view article find links to article

malignancy, or any other underlying disease. Cold agglutinins (CA) are autoantibodies that agglutinate RBCs with a temperature optimum of 3-4 °C but may also

PTPRN (2,025 words) [view diff] exact match in snippet view article find links to article

Diabetes. Islet cell autoantibodies are detected in serum, including ICA (islet cell cytoplasma autoantibodies), IAA (autoantibodies to insulin), GAD (glutamic

Serostatus (360 words) [view diff] exact match in snippet view article find links to article

spread of the disease. Researchers have investigated the effects of autoantibody serostatus on autoimmune disease presentation. Study of seronegative

Pemphigus vulgaris (1,941 words) [view diff] exact match in snippet view article find links to article

acantholysis, or breaking apart of intercellular connections through an autoantibody-mediated response. Over time the condition inevitably progresses without

Mixed connective tissue disease (3,271 words) [view diff] exact match in snippet view article find links to article

characterized by the presence of elevated blood levels of a specific autoantibody, now called anti-U1 ribonucleoprotein (RNP), together with a mix of symptoms

Ian Calman Muir MacLennan (231 words) [view diff] exact match in snippet view article find links to article

the basis of the multi-step selection process that protects against autoantibody production. He also first discovered marginal zone B cells and identified

ADAMTS (409 words) [view diff] exact match in snippet view article find links to article

described. Most cases of thrombotic thrombocytopenic purpura arise from autoantibody-mediated inhibition of ADAMTS13. Like ADAMs, the name of the ADAMTS family

Ian Hart (neurologist) (181 words) [view diff] exact match in snippet view article

member of the Walton Centre Clinical Neuroimmunology Group researching on autoantibody-associated neurological diseases. Hart was born in Cathcart, Glasgow

GAD2 (290 words) [view diff] exact match in snippet view article find links to article

identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This

Avacopan (1,164 words) [view diff] exact match in snippet view article find links to article

name Tavneos, is a medication used to treat anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Avacopan is a complement 5a receptor antagonist

MOG antibody disease (2,803 words) [view diff] exact match in snippet view article find links to article

dependent upon the overall clinical manifestation. The presence of anti-MOG autoantibodies has been described in association with the following conditions: Seronegative

Anti-AQP4 disease (1,889 words) [view diff] exact match in snippet view article find links to article

auto-antibodies against aquaporin 4. After the discovery of anti-AQP4 autoantibody in neuromyelitis optica, it was found that it was also present in some

Ruplizumab (117 words) [view diff] exact match in snippet view article find links to article

Satoh T, Kawai M, Hirakata M, Kaburaki J, et al. (February 2006). "Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia

Chemiluminescent immunoassay (88 words) [view diff] exact match in snippet view article find links to article

2017). "Chemiluminescent immunoassay technology: what does it change in autoantibody detection?". Auto Immun Highlights. 8 (1): 9. doi:10.1007/s13317-017-0097-2

Thermal amplitude (medical) (196 words) [view diff] exact match in snippet view article

amplitude or thermal range refers to the temperature range in which a cold autoantibody or cold-reacting alloantibody binds to its antigen. Cold antibodies that

Warm antibody autoimmune hemolytic anemia (796 words) [view diff] exact match in snippet view article find links to article

[citation needed] There are two models for this: the hapten model and the autoantibody model. The hapten model proposes that certain drugs, especially penicillin

Atypical hemolytic uremic syndrome (4,154 words) [view diff] exact match in snippet view article find links to article

membrane cofactor protein), or is occasionally due to acquired neutralizing autoantibody inhibitors of these complement system components, for example anti–factor

PhIP-Seq (117 words) [view diff] exact match in snippet view article find links to article

of binding of antibodies to epitopes. It has been used to study the autoantibody repertoire of autoimmune diseases like multiple sclerosis, type 2 diabetes

HLA-DR11 (829 words) [view diff] exact match in snippet view article find links to article

Hsu P (2006). "HLA-DR11 and HLA-DR2 are negatively associated with autoantibody production in chronic hepatitis C." Ann Rheum Dis. 65 (1): 138–9. doi:10

Autoimmune disease in women (5,184 words) [view diff] exact match in snippet view article find links to article

before autoantibody levels are detectable. Most autoantibody assays are more sensitive than they are specific; that is, a negative autoantibody test is

Type II hypersensitivity (486 words) [view diff] exact match in snippet view article find links to article

Disease Autoantibody target Autoimmune hemolytic anemia Red blood cells Goodpasture syndrome Glomerular basement membrane Graves disease Thyroid stimulating

60S ribosomal protein L12 (739 words) [view diff] exact match in snippet view article find links to article

28 S ribosomal RNA and effect on the accessibility to anti-28 S RNA autoantibody". J. Biol. Chem. 272 (6): 3302–8. doi:10.1074/jbc.272.6.3302. PMID 9013569

Autoimmune hemolytic anemia (3,079 words) [view diff] exact match in snippet view article find links to article

IgM-mediated. AIHA cannot be attributed to any single autoantibody. To determine the autoantibody or autoantibodies present in a patient, the Coombs test, also

Desmocollin (732 words) [view diff] exact match in snippet view article find links to article

M; Zhao, Qili; Healey, Jeff S; Ackerman, Michael J (2018-11-21). "An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates

List of medical abbreviations: I (10 words) [view diff] exact match in snippet view article find links to article

iodine or radioiodine) IA intra-arterial intra-articular IAA insulin autoantibody IABP intra-aortic balloon pump IAI intra-amniotic infection IBC inflammatory

ITPR3 (1,057 words) [view diff] exact match in snippet view article find links to article

Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic

Membranous glomerulonephritis (2,291 words) [view diff] exact match in snippet view article find links to article

though given the current lack of clinical assays (other than for PLA2R autoantibodies) this may be several years off still. Traditionally 85% of MGN cases

TRIM21 (1,478 words) [view diff] exact match in snippet view article find links to article

degrade immune complexes in the lysosome results in the leakage of autoantibodies into the cytosol that can bind to TRIM21 and enhance NF-κB signaling

Roman Dziarski (5,581 words) [view diff] exact match in snippet view article find links to article

peptidoglycan and other polyclonal B cell activators in the induction of autoantibody responses in various models of autoimmunity. In his subsequent research

Anti-neurofascin demyelinating diseases (696 words) [view diff] exact match in snippet view article find links to article

Jun-ichi; Yamasaki, Ryo; Ogata, Hidenori (2019-11-01). "Anti-neurofascin autoantibody and demyelination". Neurochemistry International. Emerging focus areas

Aquaporin-4 (3,030 words) [view diff] exact match in snippet view article find links to article

predominant autoimmune target in 2/3 neuromyelitis optica and higher AQP4 autoantibody levels are associated with the occurrence of optic neuritis (ON), however

Calreticulin (2,452 words) [view diff] exact match in snippet view article find links to article

antibodies. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin, but calreticulin is not a Ro/SS-A antigen

Physical urticaria (674 words) [view diff] exact match in snippet view article find links to article

urticarias.[better source needed] The cascade of events that link the autoantibody-antigen reaction with the production and release of histamine is not

FCER1 (749 words) [view diff] exact match in snippet view article find links to article

crosslink the receptor. Such crosslinking and potentially pathogenic autoantibodies to the FcεRIα have been isolated from human cord blood, which suggest

Inflammatory demyelinating diseases of the central nervous system (11,716 words) [view diff] exact match in snippet view article find links to article

disorders. The subject is under intense research and the list of MS autoantibodies is expected to grow in the near future. As of 2014 several previous

Exosite (282 words) [view diff] exact match in snippet view article find links to article

Picard, V; Jandrot-Perrus, M; Aiach, M; Rendu, F (15 September 1994). "An autoantibody directed against human thrombin anion-binding exosite in a patient with

Autoimmune polyendocrine syndrome type 1 (1,018 words) [view diff] exact match in snippet view article find links to article

a CT scan, a biopsy (with histological testing), and serum endocrine autoantibody screening. Autoimmune polyendocrine syndrome type 1 treatment is based

Urticarial vasculitis (715 words) [view diff] exact match in snippet view article find links to article

against self proteins are known as autoantibodies, and are not found in healthy individuals. These autoantibodies can be used to detect certain diseases

ITPR2 (965 words) [view diff] exact match in snippet view article find links to article

Asada K, et al. (2007). "Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic

Cajal body (1,021 words) [view diff] exact match in snippet view article find links to article

LE, Chan EK, Raska I, Peebles CL, Roos G, Tan EM (June 1991). "Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization

Anti-dsDNA antibodies (2,924 words) [view diff] exact match in snippet view article find links to article

whole nuclei. Subsequently, in 1957, antibodies to dsDNA were the first autoantibodies to be identified in patients with SLE. Although the exact mechanism

Transitional B cell (854 words) [view diff] exact match in snippet view article find links to article

marrow, are subjected to peripheral checks to prevent the production of autoantibodies. Transitional B cells that survive selection against autoreactivity

Laminin, beta 2 (1,373 words) [view diff] exact match in snippet view article find links to article

Suzuki M, Itoh F, Nishioka K, Kato T (Dec 2004). "Identification of a new autoantibody in patients with chronic hepatitis". Human Immunology. 65 (12): 1530–8

Pyruvate dehydrogenase (1,279 words) [view diff] exact match in snippet view article find links to article

acute liver failure patients in one study exhibited a nonmitochondrial autoantibody against tissue transglutaminase. Other mitochondrial autoantigens include

Eggerthella lenta (639 words) [view diff] exact match in snippet view article find links to article

symptoms of rheumatoid arthritis in which the immune system produces autoantibodies that mistakenly target and attack the body's tissues and cells insted

Barraquer–Simons syndrome (1,507 words) [view diff] exact match in snippet view article find links to article

serum C3 levels, normal levels of C1 and C4, and high levels of C3NeF (autoantibody), which may indicate the presence of renal involvement. Antinuclear antibodies

Neuronal lineage marker (3,768 words) [view diff] exact match in snippet view article find links to article

neuronal lineage marker can be a neuronal antigen that is recognized by an autoantibody for example Hu, which is highly restricted to neuronal nuclei. By immunohistochemistry

Nakajo syndrome (887 words) [view diff] exact match in snippet view article find links to article

elevated C-reactive protein (CRP) levels and hyper-gamma-globulinemia. Autoantibody titers rise as the disease progresses in some but remain negative in

SERPINA2 (1,045 words) [view diff] exact match in snippet view article find links to article

Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis". Arthritis & Rheumatology. 69 (5): 1054–1066.

Desmoglein-3 (1,387 words) [view diff] exact match in snippet view article find links to article

"Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering". The Journal of Clinical Investigation. 123

Pulmonary alveolar proteinosis (2,251 words) [view diff] exact match in snippet view article find links to article

presence of anti-GM-CSF autoantibodies in patients with PAP, and duplicated that syndrome with the infusion of these autoantibodies into mice. Familial or

Acute disseminated encephalomyelitis (5,266 words) [view diff] exact match in snippet view article find links to article

currently unknown if all the cases of ADEM are positive for anti-MOG autoantibody; in any case, it appears to be strongly related to ADEM diagnosis. While

Coilin (1,351 words) [view diff] exact match in snippet view article find links to article

Andrade LE, Chan EK, Raska I, Peebles CL, Roos G, Tan EM (1991). "Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization

Thyroid's secretory capacity (5,004 words) [view diff] exact match in snippet view article find links to article

pattern and thyroid volume, and (with negative direction) to thyroid autoantibody titres, which reflect organ destruction due to autoimmunity. Elevated

Neonatal fragment crystallizable receptor (4,071 words) [view diff] exact match in snippet view article find links to article

the levels of disease-causing IgG autoantibody binding to FcRn, thereby increasing disease-causing IgG autoantibody removal. More recent approaches involve

Thyroid's secretory capacity (5,004 words) [view diff] exact match in snippet view article find links to article

pattern and thyroid volume, and (with negative direction) to thyroid autoantibody titres, which reflect organ destruction due to autoimmunity. Elevated

Signal recognition particle (1,203 words) [view diff] exact match in snippet view article find links to article

Fertig N, Oddis CV (January 2004). "Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy"

Nuclear bodies (1,585 words) [view diff] exact match in snippet view article find links to article

malignant or hyperstimulated animal cells identified using anti-sp100 autoantibodies from primary biliary cirrhosis and subsequently the promyelocytic leukemia

Functional holography (1,048 words) [view diff] exact match in snippet view article find links to article

the autoantibody repertoire in healthy newborns and adults revealed by system level informatics of antigen microarray data. of the autoantibody repertoire

B1 cell (1,484 words) [view diff] exact match in snippet view article find links to article

RR, Herzenberg LA (1986). "Peritoneal Ly-1 B cells: genetic control, autoantibody production, increased lambda light chain expression". European Journal

Hashimoto's thyroiditis (7,729 words) [view diff] exact match in snippet view article find links to article

Diagnosis is confirmed with blood tests for TSH, T4, and antithyroid autoantibodies. Other conditions that can produce similar symptoms include Graves'

Myelin oligodendrocyte glycoprotein (1,940 words) [view diff] exact match in snippet view article find links to article

extracellular space" and consequently allows autoantibodies easy access. and therefore is easily accessible to autoantibodies too. The MOG "primary nuclear transcript

UACA (478 words) [view diff] exact match in snippet view article find links to article

Okamura T, Yoshida A, et al. (August 2004). "Detection of the novel autoantibody (anti-UACA antibody) in patients with Graves' disease". Biochemical and

Fibrillarin (1,583 words) [view diff] exact match in snippet view article find links to article

PMC 452965. PMID 1714385. Okano Y, Steen VD, Medsger TA (Jan 1992). "Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic

Endoglycosidase (747 words) [view diff] exact match in snippet view article find links to article

removes the IgG-associated sugar domain in vivo and interferes with autoantibody-mediated proinflammatory processes in a variety of autoimmune models

Automatic tachycardia (1,296 words) [view diff] exact match in snippet view article find links to article

beta-adrenergic receptor stimulating autoantibody, beta-adrenergic receptor supersensitivity, muscarinic receptor autoantibody or hyposensitivity, impaired baroreflex

Experimental autoimmune encephalomyelitis (2,134 words) [view diff] exact match in snippet view article find links to article

"The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients". Front Immunol. 10: 1189

Ba Denian (249 words) [view diff] exact match in snippet view article find links to article

specialist in tumor immunology. He discovered the natural thymocytotoxic autoantibody. Ba also proposed a theory to illustrate the relationship between some

Dihydrolipoyl transacetylase (2,483 words) [view diff] exact match in snippet view article find links to article

Primary biliary cirrhosis (PBC) is an autoimmune disease characterized by autoantibodies against mitochondrial and nuclear antigens. These are called anti-mitochondrial

Toll-like receptor 9 (2,551 words) [view diff] exact match in snippet view article find links to article

Shlomchik MJ (September 2006). "Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a

Collagen, type VII, alpha 1 (2,218 words) [view diff] exact match in snippet view article find links to article

Imamura S (May 1994). "Epitope mapping for epidermolysis bullosa acquisita autoantibody by molecularly cloned cDNA for type VII collagen". The Journal of Investigative

DPYSL5 (576 words) [view diff] exact match in snippet view article find links to article

PMID 10956643. Yu Z, Kryzer TJ, Griesmann GE, et al. (2001). "CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity". Ann. Neurol

LSM7 (789 words) [view diff] exact match in snippet view article find links to article

Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis and

TRIM68 (501 words) [view diff] exact match in snippet view article find links to article

Hachula E, et al. (September 2001). "SS-56, a novel cellular target of autoantibody responses in Sjögren syndrome and systemic lupus erythematosus". The

Olga Ornatsky (2,055 words) [view diff] exact match in snippet view article find links to article

bone marrow signaling and homeostasisWS/PP-086-04 Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics

LSM5 (617 words) [view diff] exact match in snippet view article find links to article

PMID 12477932. Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum

Purpura fulminans (2,455 words) [view diff] exact match in snippet view article find links to article

post-infection purpura fulminans, new lesions will occur while neutralising autoantibodies are present (1–2 weeks after presentation). A multi-disciplinary care

LSM3 (876 words) [view diff] exact match in snippet view article find links to article

Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis and

Aplastic anemia (4,363 words) [view diff] exact match in snippet view article find links to article

transfused and transfusion-naive patients, suggesting that antikinectin autoantibody development was not due to transfusion-related alloreactivity. Negative

LSM1 (802 words) [view diff] exact match in snippet view article find links to article

PMID 10851237. Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum

Paracoccidioidomycosis (2,494 words) [view diff] exact match in snippet view article find links to article

lesions, stabilisation of body weight, negative as well as negative autoantibody tests. There is insufficient data to support the benefits of above drugs

Autoimmune hepatitis (3,705 words) [view diff] exact match in snippet view article find links to article

infection. The disease is strongly associated with anti-smooth muscle autoantibodies. The exact genes and triggers responsible remain undefined, but studies

Fina Kurreeman (465 words) [view diff] exact match in snippet view article find links to article

Scott; Ardlie, Kristin; Thomson, Brian (2011-01-07). "Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort

LSM6 (523 words) [view diff] exact match in snippet view article find links to article

PMID 10851237. Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum

AKAP12 (1,020 words) [view diff] exact match in snippet view article find links to article

Fujii Y, Yamakawa Y, Fukai I, Kiriyama M, Nonaka M, Sasaki M (2001). "Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients

Mycoplasma hyorhinis (338 words) [view diff] exact match in snippet view article find links to article

(2004). "Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice". Clin Exp Immunol. 137 (2): 288–97. doi:10.1111/j.1365-2249

LSM4 (726 words) [view diff] exact match in snippet view article find links to article

PMID 10931946. Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum

Postural orthostatic tachycardia syndrome (9,368 words) [view diff] exact match in snippet view article find links to article

levels of autoantibodies against the adrenergic alpha 1 receptor and against the muscarinic acetylcholine M4 receptor. Elevations of autoantibodies targeting

M. Amin Arnaout (722 words) [view diff] exact match in snippet view article find links to article

years. Arnaout was the first to show that C3 nephritic factor is an autoantibody to the complement C3bBb convertase that activates the alternative complement

Ataxia (5,964 words) [view diff] exact match in snippet view article find links to article

Hampe CS (2017). "Pathogenic Roles of Glutamic Acid Decarboxylase 65 Autoantibodies in Cerebellar Ataxias". Journal of Immunology Research. 2017: 2913297

Astrogliosis (2,179 words) [view diff] exact match in snippet view article find links to article

CNS inflammation and a form of multiple sclerosis Rasmussen's syndrome autoantibody destruction of astrocytes causes seizures In Alexander's disease, a dominant

Autoimmune GFAP astrocytopathy (653 words) [view diff] exact match in snippet view article find links to article

with neuromyelitis optica clinical cases. The reason that anti-GFAP autoantibodies appear is currently unknown. There is the possibility that GFAP is not

Primary sclerosing cholangitis (3,993 words) [view diff] exact match in snippet view article find links to article

of small animal models of PSC. Most people with PSC have evidence of autoantibodies and abnormal immunoglobulin levels. For example, approximately 80% of

Sum activity of peripheral deiodinases (4,203 words) [view diff] exact match in snippet view article find links to article

Conversely, it was observed that SPINA-GD is reduced in persons positive for autoantibodies to selenoprotein P, which is assumed to be involved in transport and

LSM8 (742 words) [view diff] exact match in snippet view article find links to article

PMID 10369684. Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum

HLA-DR4 (2,119 words) [view diff] exact match in snippet view article find links to article

arthritis, Autoimmune hepatitis, type 1 diabetes. DRB1*04:06: caspase-8 autoantibodies silicosis-systemic sclerosis (SSc)-systemic lupus erythematosus (SLE)

LSM4 (726 words) [view diff] exact match in snippet view article find links to article

PMID 10931946. Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum

Myasthenia gravis (5,999 words) [view diff] exact match in snippet view article find links to article

(August 2016). "Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system". Journal of Neuroinflammation

Thrombotic thrombocytopenic purpura (3,902 words) [view diff] exact match in snippet view article find links to article

understood causes of TTP are due to autoimmunity (acquired TTP), caused by autoantibodies targeting ADAMTS13, or congenital TTP: an inherited deficiency of ADAMTS13

Mycoplasma (5,460 words) [view diff] exact match in snippet view article find links to article

The P1 receptor is also expressed on erythrocytes which can lead to autoantibody agglutination from mycobacteria infection. Mycoplasma and Ureaplasma

C1D (989 words) [view diff] exact match in snippet view article find links to article

G, Egberts WV, Raijmakers R, Pruijn GJ (July 2007). "C1D is a major autoantibody target in patients with the polymyositis-scleroderma overlap syndrome"

HLA-DQ4 (1,658 words) [view diff] exact match in snippet view article find links to article

Yamagami S, Noma H, Araie M, Hori S (2005). "Glutamic acid decarboxylase autoantibody prevalence and association with HLA genotype in patients with younger-onset

Agglutination-PCR (584 words) [view diff] exact match in snippet view article find links to article

of magnitude. For example, ADAP allows to detect anti-thyroglobulin autoantibodies from human patient plasma with a 1000-fold increased sensitivity over

Acquired C1 esterase inhibitor deficiency (2,260 words) [view diff] exact match in snippet view article find links to article

variable manifestations from mild symptoms to multiorgan involvement. The autoantibody component involved in SLE has been investigated and is thought to be

LSM2 (1,309 words) [view diff] exact match in snippet view article find links to article

Eystathioy T, Peebles CL, Hamel JC, Vaughn JH, Chan EK (Mar 2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis and

Mary O'Riordan (527 words) [view diff] exact match in snippet view article find links to article

neutrophil extracellular traps from lupus neutrophils, which trigger autoantibody formation and contribute to blood vessel clotting. O'Riordan was inducted

McDonald criteria (2,409 words) [view diff] exact match in snippet view article find links to article

Viglietta V, et al. (2008). "Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis"

Anne Schaefer (scientist) (2,946 words) [view diff] exact match in snippet view article

Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science. 2003 Sep 5;301(5638):1374-7

LRBA deficiency (1,110 words) [view diff] exact match in snippet view article find links to article

loss of CTLA4. Because the predominant features of the disease include autoantibody-mediated disease (AIHA, ITP), Treg defects (resembling those found in

Noel Rose (751 words) [view diff] exact match in snippet view article find links to article

antigen, called Thyroglobulin, on experimental rabbits and discovered an autoantibody that affected the thyroid gland, this was the first instance of autoimmunity

Amgen (8,066 words) [view diff] exact match in snippet view article find links to article

drug treatment for rare diseases called anti-neutrophil cytoplasmic autoantibody-associated vasculitis—which was approved last year. In December, the

Hemolytic–uremic syndrome (5,697 words) [view diff] exact match in snippet view article find links to article

S. K.; Bagga, A.; et al. (2010). "Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome". J Am Soc Nephrol. 21 (12): 2180–2187

The Environmental Determinants of Diabetes in the Young (930 words) [view diff] exact match in snippet view article find links to article

the close monitoring of TEDDY subjects through methods such as regular autoantibody testing and oral glucose tolerance tests. Earlier diagnosis of T1D is

Macroprolactin (616 words) [view diff] exact match in snippet view article find links to article

Hattori, T Ishihara, K Ikekubo, K Moridera, M Hino, H Kurahachi (1992). "Autoantibody to human prolactin in patients with idiopathic hyperprolactinemia". J

Charles Surh (1,046 words) [view diff] exact match in snippet view article find links to article

in immunology in 1989. He research topic was on target antigens for autoantibody formation associated with primary biliary cirrhosis. Working as a postdoc

Epitope mapping (2,664 words) [view diff] exact match in snippet view article find links to article

that most interactions between antigens and antibodies, particularly autoantibodies and protective antibodies (e.g., in vaccines), rely on binding to discontinuous

Georgia M. Dunston (1,360 words) [view diff] exact match in snippet view article find links to article

; Castro, Oswaldo; Alarif, Lamya (May 1986). "Association of HLA and autoantibody in transfused sickle cell disease patients". American Journal of Hematology

Anti–Saccharomyces cerevisiae antibody (1,690 words) [view diff] exact match in snippet view article find links to article

Burmeister J, Plaschke A, Rosemeier D, Widjaja A, Egberts EH (2006). "Autoantibody profiles in microscopic colitis". J. Gastroenterol. Hepatol. 21 (6):

Multiple sclerosis (17,263 words) [view diff] exact match in snippet view article find links to article

cases of MS were presenting anti-MOG autoantibodies, mainly overlapping with the Marburg variant. Anti-MOG autoantibodies were found to be also present in

Fc receptor (4,735 words) [view diff] exact match in snippet view article find links to article

inhibit the development of TFH cells, a key subset for the generation of autoantibody producing autoreactive plasma B cells. A balance among costimulatory

DiaSorin (2,873 words) [view diff] exact match in snippet view article find links to article

(2017-06-24). "Chemiluminescent immunoassay technology: what does it change in autoantibody detection?". Auto-Immunity Highlights. 8 (1): 9. doi:10.1007/s13317-017-0097-2

UBTF (2,154 words) [view diff] exact match in snippet view article find links to article

PMID 12498690. S2CID 16352280. Chan EK, Imai H, Hamel JC, Tan EM (1991). "Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of

Peptide microarray (2,209 words) [view diff] exact match in snippet view article find links to article

(9 February 2017). "Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy". Journal of Proteome

John W. Semple (417 words) [view diff] exact match in snippet view article find links to article

immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody". J Clin Invest. 102 (7): 1393–1402. doi:10.1172/JCI4238. PMC 508987

Michael R. Gold (634 words) [view diff] exact match in snippet view article find links to article

natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses". The Journal of Immunology. 183 (9): 5673–84. doi:10.4049/jimmunol

Cold autoimmune hemolytic anemia (1,220 words) [view diff] exact match in snippet view article find links to article

Cold autoimmune hemolytic anemia caused by cold-reacting antibodies. Autoantibodies that bind to the erythrocyte membrane leading to premature erythrocyte

Testosterone (15,647 words) [view diff] exact match in snippet view article find links to article

substitution therapy with testosterone leads to a decrease in thyroid autoantibody titres and an increase in thyroid's secretory capacity (SPINA-GT). Testosterone

Anaplastic large-cell lymphoma (5,218 words) [view diff] exact match in snippet view article find links to article

Detection of circulating autoantibody against ALK supports the diagnosis. Individuals with low levels of these autoantibodies are at an increase risk of

Interleukin-17A (6,247 words) [view diff] exact match in snippet view article find links to article

a chronic disorder with symptoms include chronic joint inflammation, autoantibody production, which lead to the destruction of cartilage and bone. Th17

Exosome complex (4,585 words) [view diff] exact match in snippet view article find links to article

within the molecule. Several proteins in the exosome are the target of autoantibodies in patients with specific autoimmune diseases (especially the PM/Scl

Autoimmune neutropenia (844 words) [view diff] exact match in snippet view article find links to article

occurs in infancy. In autoimmune neutropenia, the immune system produces autoantibodies directed against the neutrophilic protein antigens in white blood cells

Lesional demyelinations of the central nervous system (4,846 words) [view diff] exact match in snippet view article find links to article

et al. (December 2008). "Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis"

YWHAZ (3,619 words) [view diff] exact match in snippet view article find links to article

PMID 25917817. Qin J, Wang S, Wang P, Wang X, Ye H, Song C, et al. (May 2019). "Autoantibody against 14-3-3 zeta: a serological marker in detection of gastric cancer"

Non-celiac gluten sensitivity (7,541 words) [view diff] exact match in snippet view article find links to article

are always negative in those with NCGS; in addition to specific IgA autoantibody levels, it is necessary to determine total IgA levels. IgG tTGA antibodies

PRDM1 (2,688 words) [view diff] exact match in snippet view article find links to article

Z, Zan H, Casali P (December 2020). "Epigenetics of the antibody and autoantibody response". Current Opinion in Immunology. Autoimmunity. 67: 75–86. doi:10

Stable isotope standards and capture by anti-peptide antibodies (1,399 words) [view diff] exact match in snippet view article find links to article

conventional immunoassays (e.g., ELISA assays). Elimination of such autoantibody interferences drove the adoption of SISCAPA as an alternative to immunoassays

Computed tomography of the thyroid (5,765 words) [view diff] exact match in snippet view article find links to article

to clinically correlate this with a thyroid function test and serum autoantibody levels. During embryogenesis, the bi-lobed thyroid migrates inferiorly

Homocitrulline (1,162 words) [view diff] exact match in snippet view article find links to article

(RA) joints. In rodents they may affect T-cell triggering and possibly autoantibody formation, and possibly also in humans. In another metabolic disorder

Biomarkers of multiple sclerosis (7,797 words) [view diff] exact match in snippet view article find links to article

biomarker that predicts a response to therapy is the presence of anti-MOG autoantibodies in blood. Anti-MOG seropositive patients do not respond to approved

Osteopontin (8,315 words) [view diff] exact match in snippet view article find links to article

Masuko-Hongo K, Nakamura H, Matsui T, Sudo A, et al. (July 2001). "Autoantibodies to osteopontin in patients with osteoarthritis and rheumatoid arthritis"

Conditions comorbid to autism spectrum disorders (7,919 words) [view diff] exact match in snippet view article find links to article

may be autoantibodies to the alpha folate receptor (FRα). These autoantibodies have been associated with cerebral folate deficiency. Autoantibodies can bind

Cholestasis (12,671 words) [view diff] exact match in snippet view article find links to article

cholangiogram. Unlike primary biliary cholangitis, PSC lacks a diagnostic autoantibody or reliable biomarker of disease progression. Although a liver biopsy

Autoimmune encephalitis (3,413 words) [view diff] exact match in snippet view article find links to article

encephalitis Reasonable exclusion of alternative causes Criteria for autoantibody-negative but probable autoimmune encephalitis (all four criteria met):

Eating disorder (25,930 words) [view diff] exact match in snippet view article find links to article

direct correlation between autoantibody levels and associated psychological traits. Later study revealed that autoantibodies reactive with alpha-MSH are

Benaroya Research Institute (3,007 words) [view diff] exact match in snippet view article find links to article

research grant from the Lupus Research Alliance. She is studying an autoantibody called IgA that’s present in about half of people with lupus. She aims

Bruce Beutler (12,100 words) [view diff] exact match in snippet view article find links to article

Shlomchik, Mark J. (September 2006). "Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a

Sickle cell nephropathy (2,872 words) [view diff] exact match in snippet view article find links to article

carcinoma and due to multiple blood transfusions, serologies of the autoantibody and complement levels of HIV, hepatitis B and C should also be done.

Undifferentiated connective tissue disease (2,693 words) [view diff] exact match in snippet view article find links to article

raised ESR (erythrocyte sedimentation rate) values, without typical autoantibody specificities. Some 20% of the general population, and up to 15% of completely

Anti-VGKC-complex encephalitis (1,570 words) [view diff] exact match in snippet view article find links to article

paper published by Finn E. Somnier 15 April 2015 shows co-currence of autoantibodies. Some of the patients have tumours. The number of patients with anti-LGI1

Zilucoplan (584 words) [view diff] exact match in snippet view article find links to article

Complement C5 Inhibitor for the Treatment of Acetylcholine Receptor Autoantibody-Positive Generalized Myasthenia Gravis". Expert Opinion on Investigational

Cambridge Antibody Technology (8,495 words) [view diff] exact match in snippet view article find links to article

to 2 in favour of approving Benlysta "to treat patients with active, autoantibody-positive lupus who are receiving standard therapy, including corticosteroids

Nutriepigenomics (4,722 words) [view diff] exact match in snippet view article find links to article

autoantibody development compared to babies who are exposed to solid foods later in life. While the pathogenesis behind development of autoantibodies

HLA A1-B8-DR3-DQ2 (4,876 words) [view diff] exact match in snippet view article find links to article

The association with class I would be unusual since T-helper mediated autoantibody production is characteristic of disease, whereas class I mediated cytotoxicity

Pathophysiology of multiple sclerosis (9,022 words) [view diff] exact match in snippet view article find links to article

2016). "Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive

Eshel Ben-Jacob (3,846 words) [view diff] exact match in snippet view article find links to article

Neuroscience Vol. 5 article 46 pp 1–16 (2011) ^ "Organization of the autoantibody repertoire in healthy newborns and adults revealed by system level informatics

Pathology of multiple sclerosis (17,161 words) [view diff] exact match in snippet view article find links to article

remarkably, also respect the response to the specific potassium channel autoantibody Kir4.1. For some authors, what we call MS in reality is a heterogeneous

William N. Rom (2,953 words) [view diff] exact match in snippet view article find links to article

William N.; Tan, Eng M.; Zhang, Jian-Ying (2017). "Identification of autoantibodies to ECH1 and HNRNPA2B1 as potential biomarkers in the early detection

Ludvig Sollid (1,516 words) [view diff] exact match in snippet view article find links to article

transglutaminase 2, an enzyme to which celiac disease patients generate autoantibodies, can posttranslationally modify gluten peptides by converting certain

Multisystem inflammatory syndrome in children (13,372 words) [view diff] exact match in snippet view article find links to article

monocytes, in conjunction with B cell and plasma cell activation, and autoantibody production. It is unknown to what extent the pathophysiology resembles

Pancreatic beta cell function (1,783 words) [view diff] exact match in snippet view article find links to article

tolerance test for 3-year prediction of clinical onset in persistently autoantibody-positive offspring and siblings of type 1 diabetic patients". The Journal

George Tsokos (3,386 words) [view diff] exact match in snippet view article find links to article

patterns. For example, they provide excessive help to B cells to produce autoantibodies they fail to raise cytotoxic responses, and although they do not produce

BC-007 (1,148 words) [view diff] exact match in snippet view article find links to article

rovunaptabin. Since the 1990s, the binding of G protein coupled receptors to autoantibodies (GPCR-AABs) was investigated as a possible factor in the pathology of

Epigenetics of neurodegenerative diseases (13,392 words) [view diff] exact match in snippet view article find links to article

2012.222. PMC 3658191. PMID 23073311. Lazaridis K, Tzartos SJ (2020). "Autoantibody Specificities in Myasthenia Gravis; Implications for Improved Diagnostics

Epigenetics of autoimmune disorders (7,760 words) [view diff] exact match in snippet view article find links to article

inflammation and the overexpression of T-cell and B-cell lymphocytes. Autoantibodies, antibodies that react with self-antigens, in RA then affect the structures