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searching for Affinity maturation 23 found (57 total)

alternate case: affinity maturation

Ian Calman Muir MacLennan (231 words) [view diff] exact match in snippet view article find links to article

classic experiments led him propose a role for germinal centres in affinity maturation of antibody responses by a process of hypermutation followed by antigen-mediated
ImmTAC (652 words) [view diff] exact match in snippet view article find links to article
increased 1-5 million fold to low picomolar values through phage display affinity maturation. To provide the soluble, affinity enhanced TCR with a biological
Framework region (1,096 words) [view diff] exact match in snippet view article find links to article
of antibodies occur in cells by somatic hypermutation and during affinity maturation of the antibody. In vitro, mutations of FR may occur by natural cause
Peter G. Schultz (2,078 words) [view diff] exact match in snippet view article find links to article
hypermutation maintains antibody thermodynamic stability during affinity maturation". Proceedings of the National Academy of Sciences of the United States
Centrocyte (469 words) [view diff] exact match in snippet view article find links to article
(January 2007). "Imaging of germinal center selection events during affinity maturation". Science. 315 (5811): 528–31. Bibcode:2007Sci...315..528A. doi:10
Synthetic immunology (767 words) [view diff] exact match in snippet view article find links to article
specific manner, or providing integrated signals to B cells to induce affinity maturation and isotype switching during antibody production. Such engineered
Systems immunology (3,351 words) [view diff] exact match in snippet view article find links to article
been used to explore special pathways in the immune system such as affinity maturation and hypermutation in the humoral immune system and tolerance to pathologic
CD83 (2,266 words) [view diff] exact match in snippet view article find links to article
that CD83 acts as a brake on proliferation. CD83 does not affect affinity maturation of antibodies, but its deficiency enhances immunoglobulin E class
Bruton's tyrosine kinase (2,319 words) [view diff] exact match in snippet view article find links to article
fungal origin positive regulation of type I hypersensitivity B cell affinity maturation negative regulation of B cell proliferation cellular response to
Affibody molecule (2,165 words) [view diff] exact match in snippet view article find links to article
and binders with picomolar affinity have been obtained following affinity maturation. Affibodies conjugated to weak electrophiles bind their targets covalently
Bacterial display (1,944 words) [view diff] case mismatch in snippet view article find links to article
(2010). "Bacterial Display Enables Efficient and Quantitative Peptide Affinity Maturation". Protein Eng Des Sel. 23 (1): 9–17. doi:10.1093/protein/gzp065.
Insulin-like growth factor 2 receptor (1,664 words) [view diff] exact match in snippet view article find links to article
of repeat element insertions in the preceding intron. A six-fold affinity maturation then followed during therian evolution, coincident with the onset
Broadly neutralizing HIV-1 antibodies (897 words) [view diff] exact match in snippet view article find links to article
isotype is 7 fold. This implies that bNAbs develop from intense affinity maturation in the germinal centers hence the reason for high sequence variability
Garnett H. Kelsoe (616 words) [view diff] exact match in snippet view article find links to article
the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. Journal of Experimental
Trogocytosis (2,135 words) [view diff] exact match in snippet view article find links to article
peptide-MHC complexes by T cells through trogocytosis contribute to affinity maturation of T cell response by selecting high-affinity T cell down-modulation
Immunodominance (1,086 words) [view diff] exact match in snippet view article find links to article
for subsequent T helper stimulation, allowing for class switching, affinity maturation and thus, resulting in immunodominance to that particular epitope
Lymphatic system (6,313 words) [view diff] exact match in snippet view article find links to article
activation by antigens. Activation leads to clonal expansion, and affinity maturation. Mature lymphocytes recirculate between the blood and the secondary
Michael Meyer-Hermann (866 words) [view diff] exact match in snippet view article find links to article
Michael Meyer-Hermann, Gabriel D Victora: Visualizing antibody affinity maturation in germinal centers. In: Science 351(6277), 2016, S. 1048–1054, doi:10
Kinetic exclusion assay (2,005 words) [view diff] exact match in snippet view article find links to article
antibody via novel application of recombination signal sequence–based affinity maturation". Journal of Biological Chemistry. 298 (2): 101533. doi:10.1016/j
Phage display (4,627 words) [view diff] exact match in snippet view article find links to article
DR, Barbas CF (December 1995). "CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range".
Ashraf Brik (1,573 words) [view diff] case mismatch in snippet view article find links to article
Journal of the American Chemical Society 142 (18), 8203-8210 2020: Affinity Maturation of Macrocyclic Peptide Modulators of Lys48‐linked Diubiquitin by
Multiple sclerosis (17,622 words) [view diff] exact match in snippet view article find links to article
B-cells, expressing IGHV 3–7 genes entered the CSF and underwent affinity maturation after facing GlialCAM, which led consequently to the production of
DNA-encoded chemical library (4,738 words) [view diff] exact match in snippet view article find links to article
oligonucleotide displaying a known binder to the target, thus enabling affinity maturation strategies. Two individual sublibraries can be assembled combinatorially